武汉大学第二临床学院研究生导师网页介绍
徐焱成
专业技术职称
教授、一级主任医师
院内行政职务

国外访学经历

所在二级学科名称
内科学
所在三级
学科名称
内分泌与代谢学
导师主要研究方向
糖尿病及其发病机制的研究
主要学术兼职
（职务及聘任时间）

主要社会兼职
（职务及聘任时间）
中国研究型医院学会全国糖尿病学分会副主任委员
中国老年医学学会全国内分泌代谢分会副主任委员
中国非公医协会全国内分泌代谢分会副主任员
中国医学基金会糖尿病专业委员会副主任委员
中华医学会湖北省内分泌代谢科分会名誉主任委员
中国医师协会湖北省内分泌代谢医师分会主任委员
联系方式
办公室电话
027-67813107
Email
oxyc@163.com
近五年科研情况
近五年发表SCI及统计源以上期刊论文共 63 篇（本人为第一作者或通讯作者）
（其中SCI收录 30 篇，单篇论文最高SCI影响因子 5.571 分，累计影响因子 75.013 分）

目前承担的项目共 8 项（国家级 4 项）
近五年有代表性的论文、专著和获奖项等

序
号
成果（论文、专著、获奖项目）名称
成果鉴定、颁奖部门及奖励类别、等级或发表刊物与出版单位、时间
备注如：是否SCI（影响因子）

1
Nr2e1 ablation impairs liver glucolipid metabolism and induces inflammation, high-fat diets amplify the damage
Biomed Pharmacother
. 2019 Dec;120:109503
IF:3.743

2
Effects of Uric Acid on Diabetes Mellitus and Its Chronic Complications
Int J Endocrinol
. 2019 Oct 13;2019:9691345.
IF:2.287

3
Formononetin ameliorates high glucose-induced endothelial dysfunction by inhibiting the JAK/STAT signaling pathway
Mol Med Rep
. 2019 Sep;20(3):2893-2901
IF:
1.851

4
Mitochondrial unfolded protein response gene CLPP changes mitochondrial dynamics and affects mitochondrial function
PeerJ
. 2019 Jul 2;7:e7209.
IF:2.353

5
Phlorizin administration ameliorates cognitive deficits by reducing oxidative stress, tau hyper-phosphorylation, and neuroinflammation in a rat model of Alzheimer's disease
JOURNAL OF FOOD BIOCHEMISTRY. DEC 2018;6 : e12644
IF:
1.358

6
Sodium butyrate mitigates type 2 diabetes by inhibiting PERK-CHOP pathway of endoplasmic reticulum stress
Environ Toxicol Pharmacol. 2018 Dec;64:112-121.
IF:
3.061

7
Verapamil Ameliorates Hepatic Metaflammation by Inhibiting Thioredoxin-Interacting Protein/NLRP3 Pathways
Front Endocrinol (Lausanne). 2018 Oct 31;9:640.
IF:3.634

8
Comparison of Androgen Levels, Endocrine and Metabolic Indices, and Clinical Findings in Women with Polycystic Ovary Syndrome in Uygur and Han Ethnic Groups from Xinjiang Province in China
Med Sci Monit. 2018 Sep 25;24:6774-6780.
IF:1.98

9
Sall2 knockdown exacerbates palmitic acid induced dysfunction and apoptosis of pancreatic NIT-1 beta cells
Biomed Pharmacother. 2018 Aug;104:375-382.
IF:
3.743

10
The association between elevated serum uric acid levels and islet beta-cell function indexes in newly diagnosed type 2 diabetes mellitus: a cross-sectional study
PeerJ. 2018 Mar 9;6:e4515.
IF:2.353

11
TAp63 is correlated with chronic inflammation in patients with newly diagnosed type 2 diabetes mellitus
J Diabetes Complications. 2018 Mar;32(3):335-341.
IF:
2.684

12
Adsorption Mechanism of Typical Gases Exhaled by Lung Cancer Patients on the Anatase TiO2 (101) Surface
JOURNAL OF SENSORS .2018

IF:2.024

13
Short-term phlorizin treatment attenuates adipose tissue inflammation without alerting obesity in high-fat diet fed mice
JOURNAL OF FOOD BIOCHEMISTRY. DEC 2017; e12407
IF:
1.358

14
Salicylates promote mitochondrial biogenesis by regulating the expression of PGC-1 alpha in murine 3T3-L1 pre-adipocytes
Biochem Biophys Res Commun. 2017 Sep 16;491(2):436-441.
IF:
2.705

15
Interleukin 6 (IL-6) and Tumor Necrosis Factor a (TNF-alpha) Single Nucleotide Polymorphisms (SNPs), Inflammation and Metabolism in Gestational Diabetes Mellitus in Inner Mongolia
Med Sci Monit. 2017 Aug 28;23:4149-4157.
IF:1.98

16
Association between serum osteocalcin and glucose/lipid metabolism in Chinese Han and Uygur populations with type 2 diabetes mellitus in Xinjiang: two cross-sectional studies
Lipids Health Dis. 2017 Jul 21;16(1):139
IF:2.651

17
Wogonin mitigates nonalcoholic fatty liver disease via enhancing PPAR alpha/AdipoR2, in vivo and in vitro
Biomed Pharmacother. 2017 Jul;91:621-631
IF:
3.743

18
Involvement of receptor-interacting protein 140 in palmitate-stimulated macrophage infiltration of pancreatic beta cells
Exp Ther Med. 2017 Jul;14(1):483-494.
IF:
1.448

19
In Vitro Reconstitution and Optimization of the Entire Pathway to Convert Glucose into Fatty Acid
ACS Synth Biol. 2017 Apr 21;6(4):701-709.

IF:5.571

20
Hesperetin ameliorates cardiac inflammation and cardiac fibrosis in streptozotocin-induced diabetic rats by inhibiting NF-kappa B signaling pathway
BIOMEDICAL RESEARCH-INDIA
.2017
IF:0.219

21
Liraglutide attenuates lipopolysaccharide-induced acute lung injury in mice
Eur J Pharmacol. 2016 Nov 15;791:735-740.
IF:3.17

22
Nr2e1 Deficiency Augments Palmitate-Induced Oxidative Stress in Beta Cells
Oxid Med Cell Longev. 2016;2016:9648769.
IF:
4.868

23
Nuclear orphan receptor TLX affects gene expression, proliferation and cell apoptosis in beta cells
Biochem Biophys Res Commun. 2015 Dec 4-11;468(1-2):387-93.
IF:2.705

24
Decreased expression levels of Nurr1 are associated with chronic inflammation in patients with type 2 diabetes
Mol Med Rep. 2015 Oct;12(4):5487-93.
IF:
1.851

25
High Mannose-Binding Lectin Serum Levels Are Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes
PLoS One. 2015 Jul 2;10(7):e0130665.
IF:2.776

26
The relationship between NR2E1 and subclinical inflammation in newly diagnosed type 2 diabetic patients
J Diabetes Complications. 2015 May-Jun;29(4):589-94.
IF:
2.684

27
Differential Expression and Therapeutic Efficacy of microRNA-346 in Diabetic Nephropathy Mice
Exp Ther Med
. 2015 Jul;10(1):106-112.
IF:1.448

28
Melatonin Protects Podocytes From Angiotensin II-induced Injury in an in Vitro Diabetic Nephropathy Model
ol Med Rep
. 2016 Jul;14(1):920-6.
IF:
1.851

29
Effects of Probiotics Supplement in Patients With Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Trials
Med Clin (Barc)
. 2017 Apr 21;148(8):362-370.
IF:1.227

30
Associations Between Endothelial Nitric Oxide Synthase Polymorphisms and Risk of Diabetic Nephropathy: An Updated Meta-Analysis
Ren Fail
. 2015 Nov;37(10):312-26
IF:1.687