武汉大学第二临床学院研究生导师介绍
谢丛华
专业技术职称
教授，主任医师
院内行政职务
肿瘤放化疗科科主任
国外访学经历
法国南里昂中心医院放疗中心（1997.10－1998.10）
所在二级学科名称
临床医学
所在三级
学科名称
肿瘤学
导师主要研究方向
1.免疫放疗分子机制及临床策略研究
2.放射性肺损伤的分子机制及防治策略

主要学术兼职
（职务及聘任时间）
中华医学会放射肿瘤治疗学分会第九届委员会常委2017
中华医学会放射肿瘤治疗学分会第九届委员会免疫放疗学组组长2018
中国抗癌协会第五届肿瘤临床化疗专委会常委2019
中国抗癌协会肿瘤营养专委会放疗营养学组组长2018
中国医师协会放射肿瘤治疗医师分会第一届营养治疗专业委员会（学组）副主委2016
中国医师协会放射肿瘤治疗医师分会第二届委员会常委2019
中国研究型医院学会放射肿瘤学专业委员会常委2016
中国临床肿瘤学会非小细胞肺癌专家委员会常委2018
湖北省医学会放射肿瘤学会第五、六届委员会主委2017
湖北省抗癌协会肿瘤内科专委会主任委员2016
湖北省医师协会肿瘤分会第二届主任委员2018

主要社会兼职
（职务及聘任时间）
湖北名医工作室负责人 2019
中华放射肿瘤学杂志编委 2014
国际肿瘤学杂志副总编辑 2018
联系方式
办公室电话
027-67812960
Email
chxie_65@whu.edu.cn
近五年科研情况
近五年发表SCI及统计源以上期刊论文共 88 篇（本人为第一作者或通讯作者）
（其中SCI收录 62 篇，单篇论文最高SCI影响因子 24.799 分，累计影响因子 290.316 分）

目前承担的项目共 9 项（国家级 2 项）
近五年有代表性的论文、专著和获奖项等

序
号
成果（论文、专著、获奖项目）名称
成果鉴定、颁奖部门及奖励类别、等级或发表刊物与出版单位、时间
备注如：是否SCI（影响因子）

1
Outcomes in radiotherapy-treated patients with cancer during the COVID-19 outbreak in Wuhan, China
JAMA Oncology, 2020
24.799

2
SARS-COV-2 transmission in patients with cancer at a tertiary care hospital in Wuhan, China
JAMA Oncology, 2020
24.799

3
The management of patients with lung cancer during the outbreak of coronavirus disease 2019
Journal of Thoracic Oncology, 2020
13.357

4
Alert to potential contagiousness: A case of lung cancer with asymptomatic severe acute respiratory syndrome coronavirus 2 infection
Journal of Thoracic Oncology, 2020
13.357

5
Treatment and outcome of a patient with lung cancer infected with severe acute respiratory syndrome coronavirus-2
Journal of Thoracic Oncology, 2020
13.357

6
The potential role of borophene as a radiosensitizer in boron neutron capture therapy (BNCT) and particle therapy (PT)
Biomaterials Science, 2020
6.183

7
Outcomes of novel coronavirus disease 2019 (COVID-19) infection in 107 patients with cancer from Wuhan, China
Cancer, 2020
5.772

8
Clinical outcomes of coronavirus disease 2019 (COVID-19) in cancer patients with prior exposure to immune checkpoint inhibitors
Cancer Communications, 2020
5.627

9
Downregulation of nitric oxide collaborated with radiotherapy to promote anti-tumor immune response via inducing CD8(+) T cell infiltration
International Journal of Biological Sciences, 2020
4.858

10
MFP-FePt-GO nanocomposites promote radiosensitivity of non-small cell lung cancer via activating mitochondrial-mediated apoptosis and impairing DNA damage repair
International Journal of Biological Sciences, 2020
4.858

11
Immunomodulation of NK cells by ionizing radiation
Frontiers in Oncology, 2020
4.848

12
The prognostic value of tumor mutational burden and immune cell infiltration in esophageal cancer patients with or without radiotherapy
Aging, 2020
4.831

13
A prognostic eight-gene expression signature for patients with breast cancer receiving adjuvant chemotherapy
Journal of Cellular Biochemistry, 2020
4.237

14
Establishment of the prognostic index of lung squamous cell carcinoma based on immunogenomic landscape analysis
Cancer Cell International, 2020
4.175

15
Stromal microenvironment promoted infiltration in esophageal adenocarcinoma and squamous cell carcinoma: a multi-cohort gene-based analysis
Scientific Reports, 2020
3.998

16
Establishment of the prognostic index reflecting tumor immune microenvironment of lung adenocarcinoma based on metabolism-related genes
Journal of Cancer, 2020
3.565

17
Risk factors of acquired T790M mutation in patients with epidermal growth factor receptor-mutated advanced non-small cell lung cancer
Journal of Cancer, 2020
3.565

18
Pathologic evolution-related gene analysis based on both single-cell and bulk transcriptomics in colorectal cancer
Journal of Cancer, 2020
3.565

19
Gene signature based on B cell predicts clinical outcome of radiotherapy and immunotherapy for patients with lung adenocarcinoma
Cancer Medicine, 2020
3.491

20
Establishment of immune-related gene pair signature to predict lung adenocarcinoma prognosis using ESTIMATE algorithm
Cell Transplantation, 2020
3.341

21
Additional chemotherapy improves survival in stage II-III pulmonary sarcomatoid carcinoma patients undergoing surgery: a propensity scoring matching analysis
Annals of Translational Medicine, 2019
3.297

22
Systematic profiling of immune risk model to predict survival and immunotherapy response in head and neck squamous cell carcinoma
Frontiers in Genetics, 2020
3.258

23
Risk factors of metachronous brain metastasis in patients with EGFR-mutated advanced non-small cell lung cancer
BMC Cancer, 2020
3.15

24
Fear of disease progression and psychological stress in cancer patients under the outbreak of COVID-19
Psycho-Oncology, 2020
3.006

25
The characteristic of tumor immune microenvironment in pulmonary carcinosarcoma
Immunotherapy, 2020
2.964

26
Anti-epidermal growth factor receptor (EGFR) monoclonal antibody combined with cisplatin and 5-fluorouracil in patients with metastatic nasopharyngeal carcinoma after radical radiotherapy: a multicentre, open-label, phase II clinical trial
Annals of Oncology, 2019
14.196

27
Locoregional control and mild late toxicity after reducing target volumes and radiation doses in patients with locoregionally advanced nasopharyngeal carcinoma treated with induction chemotherapy (IC) followed by concurrent chemoradiotherapy: 10-year results of a Phase 2 study
International Journal of Radiation Oncology Biology Physics, 2019
6.203

28
Recent progress of nanoscale metal-organic frameworks in cancer theranostics and the challenges of their clinical application
International Journal of Nanomedicine, 2019
5.115

29
Fept/GO nanosheets suppress proliferation, enhance radiosensitization and induce autophagy of human non-small cell lung cancer cells
International Journal of Biological Sciences, 2019
4.858

30
Mir-195 restrains lung adenocarcinoma by regulating CD4+ T cell activation via the CCDC88C/Wnt signaling pathway: a study based on the Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and bioinformatic analysis
Annals of Translational Medicine, 2019
3.297

31
Evaluation of the association between the -1304T>G polymorphism in the promoter of the MKK4 gene and the risk of colorectal cancer: a PRISMA-compliant meta-analysis
Annals of Translational Medicine, 2019
3.297

32
α-PD-L1 mAb enhances the abscopal effect of hypo-fractionated radiation by attenuating PD-L1 expression and inducing CD8+ T-cell infiltration
Immunotherapy, 2019
2.964

33
Stereotactic body radiotherapy improves the survival of patients with oligometastatic non-small cell lung cancer
Cancer Medicine, 2019
3.491

34
Value of radiotherapy in addition to esophagectomy for stage II and III thoracic esophageal squamous cell carcinoma: Analysis of surveillance, epidemiology, and end results database
Cancer Medicine, 2019
3.491

35
Small nucleolar RNA 71A promotes lung cancer cell proliferation, migration and invasion via MAPK/ERK pathway
Journal of Cancer, 2019
3.565

36
Impact of radiotherapy concurrent with anti-PD-1 therapy on the lung tissue of tumor-bearing mice
Radiation Research, 2019
2.657

37
Development of a hypoxic nanocomposite containing high-Z element as 5-fluorouracil carrier activated self-amplified chemoradiotherapy co-enhancement
Royal Society Open Science, 2019
2.515

38
Neutrophil-lymphocyte ratio dynamics are useful for distinguishing between recurrence and pseudoprogression in high-grade gliomas
Cancer Management and Research, 2019
2.243

39
Radiotherapy activates autophagy to increase CD8+ T cell infiltration by modulating major histocompatibility complex class-I expression in non-small cell lung cancer
Journal of International Medical Research, 2019
1.281

40
Fept-Cys nanoparticles induce ROS-dependent cell toxicity and enhance chemo-radiation sensitivity of NSCLC cells in vivo and in vitro
Cancer Letters, 2018
6.508

41
Protective role of nuclear factor-erythroid 2-related factor 2 against radiation-induced lung injury and inflammation
Frontiers in Oncology, 2018
4.137

42
Trichosanthin enhanced sensitivity of non-small cell lung cancer (NSCLC) TRAIL-resistant cells
International Journal of Biological Sciences, 2018
4.067

43
β-catenin decreases acquired TRAIL resistance in non-small-cell lung cancer cells by regulating the redistribution of death receptors
International Journal of Oncology, 2018
3.571

44
α7?nAchR agonist GTS?21 reduces radiation?induced lung injury
Oncology Reports, 2018
3.041

45
The change in peripheral blood monocyte count: A predictor to make the management of chemotherapy-induced neutropenia
Journal of Cancer Research and Therapeutics, 2018
1.392

46
PD-1 and PD-L1 expression in 132 recurrent nasopharyngeal carcinoma: the correlation with anemia and outcomes
Oncotarget, 2017
5.168

47
PD-L1 predicts poor prognosis for nasopharyngeal carcinoma irrespective of PD-1 and EBV-DNA load
Scientific Reports, 2017
4.259

48
SBI0206965, a novel inhibitor of Ulk1, suppresses non-small cell lung cancer cell growth by modulating both autophagy and apoptosis pathways
Oncology Reports, 2017
2.662

49
Simultaneous targeting PI3K and PERK pathways promotes cell death and improves the clinical prognosis in esophageal squamous carcinoma
Biochemical and Biophysical Research Communications, 2017
2.6619

50
HDAC6 promotes cell proliferation and confer resistance to temozolomide in glioblastoma
Cancer Letters, 2016
6.375

51
Deubiquitinase USP9X deubiquitinates β-catenin and promotes high grade glioma cell growth
Oncotarget, 2016
5.168

52
The effect of the TLR9 ligand CPG-oligodeoxynucleotide on the protective immune response to radiation-induced lung fibrosis in mice
Molecular Immunology, 2016
3.236

53
HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma
Oncology Reports, 2016
2.662

54
Radiation-induced autophagy promotes esophageal squamous cell carcinoma cell survival via the LKB1 pathway
Oncology Reports, 2016
2.486

55
HDAC6-mediated EGFR stabilization and activation restrict cell response to sorafenib in non-small cell lung cancer cells
Medical Oncology, 2016
2.486

56
β-catenin is regulated by USP9x and mediates resistance to TRAIL-induced apoptosis in breast cancer
Oncology Reports, 2016
2.486

57
Antagonism of mir-21 reverses radiation-induced EMT in alveolar epithelial cells via PI3K/Akt pathway
International Journal of Clinical and Experimental Pathology, 2016
1.706

58
Expression of beta-catenin and OPG in human non-small cell lung cancer and their clinical
International Journal of Clinical and Experimental Pathology, 2016
1.706

59
ATG7 promotes the tumorigenesis of lung cancer but might be dispensable for prognosis predication: a clinicopathologic study
OncoTargets and Therapy, 2016
1.653

60
Radiation-induced lung fibrosis in a tumor-bearing mouse model is associated with enhanced type-2 immunity
Journal of Radiation Research, 2016
1.536

61
Microrna-320 regulates the radiosensitivity of cervical cancer cells C33AR by targeting β-catenin
Oncology, 2016
1.39

62
A tumor marker panel scoring system to improve clinical stage in gastric cancer
International Journal of Clinical and Experimental Medicine, 2016
1.069

63
脑部放疗的选择对驱动基因阳性非小细胞肺癌脑转移患者生存的影响
中华放射医学与防护杂志，2020


64
局限期小细胞肺癌手术治疗的疗效分析及辅助治疗模式
中华肿瘤杂志，2020


65
去水淫羊藿黄素对非小细胞肺癌细胞的放射协同作用
武汉大学学报（医学版），2020


66
鼻咽癌调强放射治疗锁野计划对低剂量区的影响
武汉大学学报（医学版），2020


67
丝氨酸转运蛋白SFXN1在非小细胞肺癌中的表达及临床意义
肿瘤代谢与营养电子杂志，2020


68
非共面容积旋转调强在食管癌治疗中的应用
中国医学物理学杂志，2020


69
不同骨盆勾画及限量方式下宫颈癌术后IMRT计划的剂量学研究
医学放射物理，2019


70
胸段食管鳞癌术后复发模式及淋巴结复发规律
中华放射肿瘤学杂志，2019


71
Agrin在肿瘤免疫微环境中的研究进展
国际免疫学杂志，2019


72
放射治疗联合免疫疗法在癌症治疗中的研究进展
临床与病理杂志，2019


73
立体定向放疗应用于肺寡转移灶的疗效与预后
中华放射医学与防护杂志，2019


74
PBK和基质金属蛋白酶9在宫颈癌中的表达及对同步放化疗疗效的影响
中华放射医学与防护杂志，2018


75
FePt/GO纳米复合材料在放化疗中的应用
中国医学物理学杂志，2018


76
非小细胞肺癌甲状腺转移一例并文献复习
中华肺部疾病杂志，2018


77
绿色荧光蛋白标记的Lewis肺癌小鼠原位模型的建立及鉴定
武汉大学学报（医学版），
2018


78
化疗早期重度粒细胞下降与小细胞肺癌预后相关性分析
实用肿瘤学杂志，2018


79
小细胞肺癌的分子生物学研究进展
国际肿瘤学杂志，2018


80
头颈部肿瘤放疗者营养与支持治疗专家共识
中华放射肿瘤学杂志，2018


81
半胱胺修饰的FePt纳米颗粒对HeLa细胞的毒性
武汉大学学报（理学版），2017


82
肺寡转移瘤 SBRT疗效及预后因素分析
中华放射肿瘤学杂志，2017


83
抑制泛素特异性蛋白酶9X表达对胶质瘤U251细胞生长及凋亡的影响
武汉大学学报（医学版），2017


84
胸部放疗过程中胸肌体积的变化及其临床意义
实用肿瘤学杂志，2017


85
宫颈癌调强放疗后骨盆衰竭骨折的发生率
中华放射医学与防护杂志，2017


86
抑制泛素特异性蛋白酶9X表达对胶质瘤U251细胞生长及凋亡的影响
武汉大学学报（医学版），2017


87
胸部放疗过程中胸肌体积的变化及其临床意义
实用肿瘤学杂志，2017


88
程序性死亡分子1/程序性死亡分子1配体信号通路在肺癌细胞株上的表达及其生物学意义
中华实验外科杂志，2016


武汉大学第二临床学院研究生导师介绍
魏永长
专业技术职称
主任医师
副教授
院内行政职务
科副主任，亚专科/病区主任
国外访学经历
2012.01-2013 MD Anderson肿瘤中心
2014.01-2014斯坦福国际研究院 博士后
所在二级学科名称
肿瘤学
所在三级
学科名称
放化疗
导师主要研究方向
1、肿瘤的微环境与放疗
2、肿瘤综合治疗
主要学术兼职
（职务及聘任时间）
1.湖北省临床肿瘤学会免疫治疗委员会副主任委员
2.湖北省抗癌协会肿瘤热疗专业委员会常务委员委
3.湖北省肿瘤精准医学研究中心免疫研究所副所长
4.湖北省抗癌协会肿瘤内科治疗专业委员会常委

联系方式
办公室电话
027-67811728
Email
weiyongchang8@163.com
近五年科研情况
近五年发表SCI及统计源以上期刊论文共16篇（本人为第一作者或通讯作者）
（其中SCI收录9篇，单篇论文最高SCI影响因子8.911分，累计影响因子 66.831 分）

目前承担的项目共 2项（国家级1项；省级 1项）
近五年有代表性的论文、专著和获奖项等
序号
成果（论文、专著、获奖项目）名称
成果鉴定、颁奖部门及奖励类别、等级或发表刊物与出版单位、时间
备注
如：是否SCI
（影响因子）

1
miR-15b-5p Promotes Growth and Metastasis in Breast Cancer by Targeting HPSE2
Front Oncol. 2020
4.137

2
Increasing the targeting scope and efficiency of base editing with Proxy-BE strategy
FEBS Lett. 2019
2.675

3
MRPS30-DT Knockdown Inhibits Breast Cancer Progression by Targeting Jab1/Cops5
Front Oncol. 2019
4.137

4
TGF-β receptor inhibitor LY2109761 enhances the radiosensitivity of gastric cancer by inactivating the TGF-β/SMAD4 signaling pathway
Aging (Albany NY). 2019
5.515

5
Reactive Oxygen Species Are Involved in the Development of Gastric Cancer and Gastric Cancer-Related Depression through ABL1-Mediated Inflammation Signaling Pathway
Oxid Med Cell Longev. 2019
4.868

6
Therapeutic Potential of Natural Killer Cells in Gastric Cancer
Front Immunol. 2019
4.716

7
Let-7d inhibits growth and metastasis in breast cancer by targeting Jab1/Cops5
Cellular Physiology and Biochemistry，2018

5.104

8
Jab1/Csn5-thioredoxin signaling in relapsed acute monocytic leukemia under oxidative stress
Clinical Cancer Research, 2017，
8.911

9
P53 and Ki-67 as prognostic markers in triple-negative breast cancer patients
PLoS One. 2017
2.776

10
Potential prognostic value of clinical characteristics, hormone status and major depressive disorder in breast cancer
Future Oncology. 2017

2.279

11
Leptin-LepRb Expressed in Gastric Cancer Patients and Related to Cancer-Related Depression
Biomed Research International. 2017

2.197

12
Depression accelerates the development of gastric cancer through reactive oxygen species-activated ABL1 (Review)
Oncology Reports,
2016.

3.041

13
MicroRNAs serve as a bridge between oxidative stress and gastric cancer (Review)
International Journal of Oncology, 2016,

3.571

14
Activation of HERV-K Env protein is essential for tumorigenesis and metastasis of breast cancer cells
Oncotarget, 2016,

5.168

15
A novel curcuminoid exhibits enhanced antitumor activity in nasopharyngeal carcinoma
International Journal of Oncology, 2016

3.571

16
Expression and Diagnostic
Value of HE4 in Pancreatic
Adenocarcinoma
International Journal of Molecular Sciences,2015

4.183

17
大学生科研创新能力培养的实践及效果分析
中国医学教育技术，?
2015
第一作者

武汉大学第二临床学院研究生导师介绍
周福祥
专业技术职称
教授
主任医师
院内行政职务
无
国外访学经历
法国尼斯大学 2010.6
所在二级学科名称
肿瘤学
所在三级
学科名称
肿瘤放化疗及靶向治疗
导师主要研究方向
1、恶性肿瘤放化疗的基础与临床
2、恶性肿瘤分子分型与治疗敏感性
主要学术兼职
（职务及聘任时间）
中国抗癌协会肿瘤营养专业委员会常委兼代谢调节治疗学组副组长（2013年-至今）
中国临床肿瘤学会胆道肿瘤专委会常务委员（2019年-至今）
中华医学会放射肿瘤学分会第七届青年委员（2012年-2017）
中华医学会放射肿瘤学分会放射生物学组成员（2012年-至今）
湖北省药物与器械临床评价学会肿瘤诊疗专委会主任委员（2018年-至今）
湖北省抗癌协会肿瘤营养与代谢专业委员会主任委员（2016年-至今）
湖北省抗癌协会放射肿瘤专业委员会副主任委员(2013年-至今)
湖北省抗癌协会肿瘤分子标志专业委员会副主任委员(2013年-至今)
主要社会兼职
（职务及聘任时间）
《Gene Therapy》杂志特约审稿人（2012至今）
《肿瘤营养与代谢》杂志副主编（2014至今）
《中华放射医学与防护》杂志编委（2010至今）
国家科学技术奖励评审委员（2014至今）
国家食品药品监督管理局药品审评中心核查员（2016至今）
联系方式
办公室电话
027-67813155
Email
happyzhoufx@sina.com
近五年科研情况
发表中国科技论文与引文数据库（CSTPCD）期刊收录论文共48篇
（其中SCI收录33篇，单篇论文最高SCI影响因子6.402 分，累积影响因子87.709分）

目前承担的项目共 4项（国家级2项；省级2项）

拥有专利项目两项（排名第一和第三）
近五年有代表性的论文、专著和获奖项等

序
号
成果（论文、专著、获奖项目）名称
成果鉴定、颁奖部门及奖励类别、等级或发表刊物与出版单位、时间
备注如：是否SCI（影响因子）

1.
Predictive value of pancreatic dose-volume metrics on sarcopenia rate in gastric cancer patients treated with adjuvant chemoradiotherapy.
J Clin Nutr?2019 Aug;38(4):1713-1720. doi: 10.1016/j.clnu.2018.07.035

6..402,JCR医学2区top， 营养学1区


2.
Disruption of the menin-MLL interaction triggers menin protein degradation via ubiquitin-proteasome pathway.
Am J Cancer Res 2019;9(8):

4.737，医学 2区

3.
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway
Am J Transl Res. 2020 Feb 15;12(2):428-446.()

3.402

4.
Long non-coding RNA 520 is a negative prognostic biomarker and exhibits pro-oncogenic function in nasopharyngeal carcinoma carcinogenesis through regulation of miR-26b-3p/USP39 axis. Gene.
2019 Jul 30;707:44-52. doi: 10.1016/j.gene.2019.02.093. Epub 2019 Mar 18.
?2.498

5.
Aberrant high expression level of MORC2 is a common character in multiple cancer
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Biomed Pharmacother.2018
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2-Methoxyestradiol enhances radiosensitivity in radioresistant melanoma MDA-MB-435R cells by regulating glycolysis via HIF-1 alpha/PDK1 axis
Int J Oncol.2017
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Identifying biomarkers of papillary renal cell carcinoma associated with pathological stage by weighted gene co-expression network analysis
ONCOTARGET,2017
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Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.
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Oncology Letters,2016

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Cancer Medicine,2016
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