江中兴 （Zhong-Xing Jiang）博士
职务/职称：教授、博士生导师
通讯地址：武汉大学药学院（湖北省武汉市东湖路185号）
课题组地址：武汉大学医学部一号楼六楼


学习与工作简历：1995年9月至1999年7月 西南师范大学化学化工学院获理学学士学位
1999年8月至2004年7月 中科院上海有机化学研究所获化学博士学位
2004年8月至2007年4月 美国犹他大学药学院博士后研究员
2007年4月至2008年8月 美国印第安纳大学医学院博士后研究员
2008年8月至2011年10月 美国马里兰大学药学院研究助理教授
2011年10月至今 武汉大学药学院教授、博士生导师



研究方向：单一分子量聚乙二醇修饰的多肽/蛋白药物
药物的氟-19可视化传输与缓释
含氟药物的合成与其在化学生物学中的应用



研究工作概要：在SCI期刊上发表文章60余篇，文章被引用1000余次，H-index>18；申请专利10余项，授权专利6项；受邀为Theranostics, Chemical Science, Bioconjugate. Chemistry, Chemical Communications, Journal of Organic Chemistry, Molecular Pharmaceutics等10余个SCI期刊审稿人；主持国家自然科学基金面上项目和国家重大研发计划子课题等10余个研究项目；指导多个国家级大学生创新创业项目；担任湖北省药学会委员。



获得荣誉：2015年 武汉大学医学部突出贡献奖

2016年 武汉大学朱裕璧医学奖



主要科研项目：1.“慢阻肺药物个性化干预与治疗的新技术和新方法”，国家重点研发计划，子课题负责人，课题编号2016YFC**，2016年-2020年
2.“基于单一分子量聚乙二醇的生物材料的设计、合成及其在生物大分子药物研发中的应用”，国家自然科学基金面上项目，批准号**，2016年-2019年
3.“F-19 MRI 可视化5-FU 传输载体的合成与应用研究”， 国家自然科学基金面上项目，批准号**，2014年-2017年



最近发表文章：1.Zhang, H.; Li, Y.; Chen, S.; Yuan, Y.; Jiang, Z.-X.;^* Zhou, X.^* “¹²⁹Xe hyper-CEST/¹⁹F MRI multimodal imaging system for sensitive tumor cells detection” ACS Appl. Bio Mater. 2019, 2, 27-32.
2.Zhu, J.; Xiao, Y.; Zhang, H.; Li, Y.; Yuan, Y.; Yang, Z.; Chen, S.; Zheng, X.; Zhou, X.; Jiang, Z.-X.^* “Peptide monodisperse PEG “combs” with fine-tunable LCST and multiple imaging modalities” Biomacromolecules 2019, doi: 10.1021/acs.biomac.8b01693
3.Deng, T.; Mao, X.; Xiao, Y.; Yang, Z.; Zheng, X.; Jiang, Z.-X.^* “Monodisperse oligoethylene glycols modified Camptothecin, 10-hydroxycamptothecin and SN38 prodrugs” Bioorg. Med. Chem. Lett. 2019, 29, 581-584.
4.Li, Y.; Wang, X.; Chen, Y.; Yang, Z.; Jiang, Z.-X.^* “Monodisperse polyethylene glycols “brushes” with enhanced lipophilicity, thermos and plasma stability” Chem. Commun. 2019, 55, 1895-1898.
5.Taraban, M. B.; Deredge, D. J.; Smith, M. E.; Briggs, K. T.; Li, Y.; Jiang, Z.-X.; Wintrode, P. L.;* Yu, Y. B.* “Monitoring dendrimer conformational transition using ¹⁹F and ¹H₂O NMR” Magn. Reson. Chem. 2019, doi: 10.1002/mrc.4849.
6.Xue, D.; Wang, J.; Song, X.; Wang, W.; Ye, L.; Liu, Y.; Zhou, Q.; Jiang, Z.-X.; Liu Z.-J.; Tan, H.^* “Chemical amphiphile replacement strategy for membrane protein research” Langmuir, 2019, doi: 10.1021/acs.langmuir.8b04072
7.Taraban, M. B.; Deredge, D. J.; Smith, M. E.; Briggs, K. T.; Feng, Y.; Li, Y.; Jiang, Z.-X.; Wintrode, P. L.;^* Yu, Y. B.^* “Conformational transition of a non-associative fluorinated amphiphile in aqueous solution. II. Conformational transition vs. supramolecular assembly” RSC Adv. 2019, 9, 1956-1966.
8.Liu, X.; Jiang, Z.-X.; Yu, B. Y.; Jeong, E.-K.^* “Study of kinetics of ¹⁹F-MRI using a fluorinated imaging agent (¹⁹FIT) on a 3T clinical MRI system” Magn. Reson. Mater. Phys. Biol. Med. 2018, doi: 10.1007/s10334-018-0707-7
9.Lv, X.; Zheng, X.; Yang, Z.; Jiang, Z.-X.* “One-pot synthesis of monodisperse dual-functionalized polyethylene glycols through macrocyclic sulfates” Org. Biomol. Chem. 2018, 16, 8537-8545.
10.Jia, Y.; Chen, L.; Zhang, H.; Zheng, Y.; Jiang, Z.-X.; Yang, Z.* “Electrophilic chloro(ω-alkoxy) lation of alkene employing 1-chloro-1,2-benzoidoxol-3-one: facile synthesis of β-chloroethers” Org. Biomol. Chem. 2018, 16, 7203-7213.
11.Deng, T.; Mao, X.; Li, Y.; Bo, S.; Yang, Z.; Jiang, Z.-X.* “Monodisperse oligoethylene glycols modified Propofol prodrugs” Bioorg. Med. Chem. Lett. 2018, 28, 3502-3505.
12.Peng, Q.; Li, Y.; Bo, S.; Yuan, Y.; Yang, Z.; Chen, S.; Zhou, X.; Jiang, Z.-X.* “Paramagnetic nanoemulsions with unified signal for sensitive ¹⁹F MRI cell tracking” Chem. Commun. 2018, 54, 6000-6003.
13.Bo, S.; Yuan, Y.; Chen, Y.; Yang, Z.; Chen, S.; Zhou, X.; Jiang, Z.-X.* “In vivo drug tracking with ¹⁹F MRI at therapeutic dose” Chem. Commun. 2018, 54, 3875-3878.
14.Jia, Y.; Qin, H.; Wang, N.; Jiang, Z.-X.; Yang, Z.* “Fe₂O₃-promoted intermolecular chlorotrifluoro-methylthiolation of alkenes” J. Org. Chem. 2018, 83, 2808-2817.
15.Li, Y.; Shi, Q.; Shao, J.; Yuan, Y.; Yang, Z.; Chen, S.; Zhou, X.; Wen, S.; Jiang, Z.-X.* “Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives” Eur. J. Med. Chem. 2018, 148, 279-290.
16.Yu, Z.; Bo, S.; Wang, H.; Li, Y.; Yang, Z.; Huang, Y.; Jiang, Z.-X.* “Application of monodisperse PEGs in pharmaceutics: monodisperse polidocanols” Mol. Pharm. 2017, 14, 3473-3479.
17.Peng, Q.; Yuan, Y.; Zhang, H.; Bo, S.; Li, Y.; Chen, S.; Yang, Z.; Zhou, X.; Jiang, Z.-X.* “¹⁹F CEST imaging probes for metal ion detection” Org. Biomol. Chem. 2017, 15, 6441-6446.
18.Liu, X.; Yuan, Y.; Bo, S.; Li, Y.; Yang, Z.; Zhou, X.; Chen, S.*; Jiang, Z.-X.* “Monitoring fluorinated dendrimer-based self-assembled drug-delivery systems with ¹⁹F magnetic resonance” Eur. J. Org. Chem. 2017, 4461-4468.
19.Xing, H.; Chen, L.; Jia. Y.; Jiang, Z.-X.*; Yang, Z.* “Fe₂O₃-catalyzed Pummerer rearrangement of acyl chlorides and sulfoxides: facile synthesis of alkylthiomethyl ester” Tetrahedron Lett. 2017, 58, 2199-2202.
20.Wang, M.; Lei, D.; Liu, Z.; Chen, S.; Sun, L.; Lv, Z.; Huang, P.; Jiang, Z.-X.*; You, Z.* “A poly(glycerol sebacate) based photo/thermo dual curable biodegradable and biocompatible polymer for biomedical applications” J. Biomater. Sci., Polymer Ed. 2017, 28, 1728-1739.
21.Shi, Q.; Li, Y.; Bo, S.; Li, X.; Zhao, P.; Liu, Q.; Yang, Z.; Cong, H.; Deng, H.; Chen, M.; Chen, S.; Zhou, X.; Ding, H.; Jiang, Z.-X.* “Discovery of a ¹⁹F MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells” Chem. Commun. 2016, 52, 5136-5139.
22.Zhao, P.; Xia, G.; Dong, S.; Jiang, Z.-X.; Chen, M.* “An iTEP-salinomycin nanoparticle that specifically and effectively inhibits metastases of 4T1 orthotopic breast tumors” Biomaterials 2016, 93, 1-9.
23.Li, Y.; Xia, G.; Guo, Q.; Wu, L.; Chen, S.; Yang, Z.; Wang, W.; Zhang, Z.-Y.; Zhou, X.; Jiang, Z.-X.* “Design, synthesis and evaluation of novel ¹⁹F magnetic resonance sensitive protein tyrosine phosphatase inhibitors” MedChemComm 2016, 7, 1672-1680.
24.Wan, Z.; Yu, L.; Bo, S.; Gao, M.; Wang, X.; Zeng, K.; Tao, X.; Li, X.; Yang, Z.*; Jiang, Z.-X.* “Amide bond-containing monodisperse poly(ethylene glycol)s beyond 10000 Da” Org. Biomol. Chem. 2016, 14, 7912-7919 (Hot paper of the month and the year).
25.Chen, L.; Xing, H.; Zhang, H.; Jiang, Z.-X.*; Yang, Z.* “Copper-catalyzed intermolecular chloroazidation of α, β-unsaturated amides” Org. Biomol. Chem. 2016, 14, 7463-7467.
26.Fu, M.; Chen, L.; Jiang, Y.; Jiang, Z.-X.*; Yang, Z.* “Copper-catalyzed intermolecular chloro- and bromotrifluoromethylation of alkenes” Org. Lett. 2016, 18, 348-351.
27.Li, X.; Feng, Z.; Jiang, Z.-X.*; Zhang, X.* “Mild nickel-catalyzed reductive cross-coupling of (hetero)aryl iodides with fluorinated secondary alkyl bromides” Org. Lett. 2015, 17, 5570-5573.
28.Xia, G.; Li, Y.; Yang, Z.; Jiang, Z.-X.* “Development of a scalable process for α-amino-ω-methoxyl-dodecaethylene glycol” Org. Process Res. Dev. 2015, 19, 1769-1773.
29.Li, Y.; Qiu, X.-L.; Jiang, Z.-X.* “Macrocyclic sulfates as versatile building blocks in the synthesis of monodisperse poly(ethylene glycol)s and monofunctionalized derivatives” Org. Process Res. Dev. 2015, 19, 800-805.
30.Bo, S.; Song, C.; Li, Y.; Yu, W.; Chen, S.; Zhou, X.; Yang, Z.; Zheng, X.*; Jiang, Z.-X.* “Design and synthesis of fluorinated amphiphile as ¹⁹F MRI/fluorescence dual-imaging agent by tuning the self-assembly” J. Org. Chem. 2015, 80, 6360-6366.
31.Yu, W.; Yang, Y.; Bo, S.; Li, Y.; Chen, S.; Yang, Z.; Zheng, X.; Jiang, Z.-X.*; Zhou, X. “Design and synthesis of fluorinated dendrimers for sensitive ¹⁹F MRI” J. Org. Chem. 2015, 80, 4443-4447.
32.Zhang, H.; Li, X.; Shi, Q.; Li, Y.; Xia, G.; Chen, L.; Yang, Z.; Jiang, Z.-X.* “Highly efficient synthesis of monodisperse poly(ethylene glycols) and derivatives through macrocyclization of oligo(ethylene glycols)” Angew. Chem., Int. Ed. 2015, 54, 3763-3767.