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个人信息：
1
博士生导师
硕士生导师
电子邮箱：fuanwang@whu.edu.cn
入职时间：2014-07-01
性别：男
职称：教授
学科：



个人简介
课题组主页：http://wangfuan.whu.edu.cn
1999.09 – 2003.07 郑州大学化学系，化学学士
2003.09 – 2009.01 中科院长春应化所，分析化学博士
2009.02 – 2014.06 耶路撒冷希伯来大学，博士后
2014.07 – 现 在 武汉大学化学与分子科学学院，教授、博导
主要研究兴趣
主要从事生物纳米复合材料与智能医学诊疗等研究，致力于开发肿瘤早期诊疗新方法、核酸信号扩增和多功能核酸纳米药物；在活细胞和活体内高灵敏度成像研究领域积累了丰富的经验，取得了一些进展和系统性、原创成果。截至目前，在相关领域国际权威学术期刊发表论文100余篇（包括34篇通讯作者论文和20篇一作论文，其中影响因子大于10的21篇），一作及通讯作者论文包括1篇Chem. Rev.，1篇Matter，4篇J. Am. Chem. Soc.，6篇Angew. Chem. Int. Ed.，2篇ACS Nano，1篇Nano lett.，1篇Nucleic Acids Res.，1篇Adv. Mater.，6篇Chem. Sci.，3篇Small，8篇Anal. Chem.等。申请并获批美国及中国专利各一项，参与编写关于核酸纳米机器和核酸信号扩增反应的书目章节三个。欢迎参加武汉大学“优秀大学生暑期夏令营”的并参观“功能核酸纳米技术实验室”；欢迎有相关化学、生物、医学、材料背景的优秀学子报考“功能核酸纳米技术实验室”的推免硕士研究生和博士研究生（每年均有足额推免招生指标，欢迎报考），基于个性化教育科研理念，提供宽松的工作学习氛围。因研究需要，本课题组长期招募优秀的博士后研究员（年薪20-30万）和研究助理，共同进步，享受武汉大学相关福利政策，待遇优厚，欢迎来信垂询。

独立工作后发表文章
1. Qing Wang, Kaiyue Tan, Hong Wang, Jinhua Shang, Yeqing Wan, Xiaoqing Liu, Xiaocheng Weng, Fuan Wang*, An Orthogonal Demethylase-Activated Deoxyribozyme for Intracellular Imaging and Gene Regulation. J. Am. Chem. Soc. 2021, In Press. DOI: 10.1021/jacs.1c00570
2. Ping Dong, Wenxiao Wang, Min Pan, Wenqian Yu, Yahua Liu, Tianhui Shi, Jialing Hu, Yizhuo Zhou, Shuyi Yu, Fuan Wang, Xiaoqing Liu*, Cascaded Amplifier Nanoreactor for Efficient Photodynamic Therapy. ACS Appl. Mater. Interfaces, 2021, In Press. DOI: 10.1021/acsami.1c01683
3. Jing Wang?, Shanshan Yu?, Qiong Wu, Xue Gong, Shizhen He, Jinhua Shang, Xiaoqing Liu, Fuan Wang*, A self-catabolic multifunctional DNAzyme nanosponge for programmable drug delivery and efficient gene silencing. Angew. Chem. Int. Ed., 2021, In Press. DOI: 10.1002/anie.
4. Huimin Wang?, Dan Luo?, Hong Wang, Fuan Wang, Xiaoqing Liu*, Construction of Smart Stimuli-responsive DNA Nanostructures for Biomedical Applications. Chem. Eur. J. 2021, 27(12), 3929–3943. DOI: 10.1002/chem.
5. Jinhua Shang?, Chunxiao Li?, Fengzhe Li, Qing Wang, Bifeng Yuan, Fuan Wang*, Construction of enzyme-free initiator-replicated hybridization chain reaction circuit for amplified methyltransferase evaluation and inhibitors assay. Anal. Chem., 2021, 93(4), 2403?2410. DOI: 10.1021/acs.analchem.0c04356
6. Keke Gong?, Fengze Li?, Hong Wang, Fuan Wang*, Amplified microRNA analysis based on isothermal enzyme-free nucleic acid amplification. J. Anal. Sci. (分析科学学报), 2020, 36(5), 677–682. DOI: 10.13526/j.issn.1006-6144.2020.05.000
7. Xue Gong, Ruomeng Li, Jing Wang, Jie Wei, Kang Ma, Xiaoqing Liu, Fuan Wang*, A Smart Theranostic Nanocapsule for Spatiotemporally Programmable Photo-genetherapy. Angew. Chem. Int. Ed., 2020, 59(48), 21648–21655. DOI: 10.1002/anie.
8. Yangjie Zhou?, Shanshan Yu?, Jinhua Shang, Yingying Chen, Qing Wang, Xiaoqing Liu and Fuan Wang*, Construction of an Exonuclease III-propelled Integrated DNAzyme Amplifier for Highly Efficient MicroRNA Detection and Intracellular Imaging with Ultralow Background. Anal. Chem., 2020, 92(22), 15069–15078. DOI: 10.1021/acs.analchem.0c03073
9. Meijuan Liang, Yanbing Wang, Kang Ma, Shanshan Yu, Yingying Chen, Zhao Deng, Yi Liu, Fuan Wang*, Engineering Inorganic Nanoflares with Elaborate Enzymatic Specificity and Efficiency for Versatile Biofilm Eradication. Small, 2020, 16(41), **. DOI: 10.1002/smll.
10. Keke Gong?, Qiong Wu?, Hong Wang, Shizhen He, Jinhua Shang, Fuan Wang*, Autocatalytic DNAzyme Assembly for Amplified Intracellular Imaging. Chem. Commun., 2020, 56(77), 11410–11413. DOI: 10.1039/d0cc05257d (HOT PAPER)
11. Huimin Wang?, Yuqi Chen?, Jinhua Shang, Hong Wang, Kang Ma, Xiaoqing Liu, Xiang Zhou, Fuan Wang*, Multifunctional Hypoxia-Involved Gene Silencing Nanoplatform for Sensitizing Photochemotherapy. ACS Appl. Mater. Interfaces, 2020, 12(31), 34588–34598. DOI: 10.1021/acsami.0c08315
12. Jie Feng?, Wenqian Yu?, Zhen Xu, Jialing Hu, Jing Liu, Fuan Wang* Multifunctional siRNA-Laden Hybrid Nanoplatform for Non-Invasive PA/IR Dual-Modal Imaging-Guided Enhanced Photogenetherapy. ACS Appl. Mater. Interfaces, 2020, 12(20), 22613–22623. DOI: 10.1021/acsami.0c04533
13. Jie Wei, Huimin Wang, Xue Gong, Qing Wang, Hong Wang, Yangjie Zhou, Fuan Wang*, A Proteinase-Free DNA Replication Machinery for in Vitro and in Vivo Amplified MicroRNA Imaging. Nucleic Acids Res., 2020, 48(10), e60. DOI: 10.1093/nar/gkaa250
14. Jialing Hu, Fuan Wang, Feng Liu, Wentong Sun, Qunying Jiang, Yahua Liu, Yun Zhao, Xiaoqing Liu*, Effective nanotherapeutic approach for metastatic breast cancer treatment by supplemental oxygenation and imaging-guided phototherapy. Nano Research, 2020, 13(4), 1111–1121. DOI: 10.1007/s12274-020-2753-5
15. Wenqian Yu, Junlin Sun, Feng Liu, Shuyi Yu, Zhen Xu, Fuan Wang, Xiaoqing Liu*, Enhanced Immunostimulatory Activity of CpG Immunomodulator by the Assembly of Polymer DNA Wires and Spheres. ACS Appl. Mater. Interfaces, 2020, 12(15), 17167–17176. DOI: 10.1021/acsami.9b21075
16. Meijuan Liang?, Minyi Zhang?, Shanshan Yu, Qiong Wu, Kang Ma, Yingying Chen, Xiaoqing Liu, Chunsen Li,* Fuan Wang*, Silver–Laden Black Phosphorus Nanosheets for an Efficient in Vivo Antimicrobial Application. Small, 2020, 16(13), **. DOI: 10.1002/smll.
17. Jie Wei, Huimin Wang, Qiong Wu, Xue Gong, Kang Ma, Xiaoqing Liu and Fuan Wang*, A Smart Autocatalytic DNAzyme Biocircuit for in vivo MRI-Guided MicroRNA Imaging. Angew. Chem. Int. Ed., 2020, 59(15), 5965–5971. DOI: 10.1002/anie. (HOT PAPER)
18. Kang Ma?, Pei Dong?, Meijuan Liang, Shanshan Yu, Yingying Chen, Fuan Wang*, Facile Assembly of Multifunctional Antibacterial Nanoplatform Leveraging Synergistic Sensitization between Silver Nanostructure and Vancomycin. ACS Appl. Mater. Interfaces, 2020, 12(6), 6955–6965. DOI: 10.1021/acsami.9b22043
19. Jie Feng?, Wenqian Yu?, Zhen Xu, Fuan Wang*, Intelligent ZIF-8-Gated Polydopamine nanoplatform for in vivo Cooperatively Enhanced Combinational Phototherapy. Chem. Sci., 2020, 11, 1649–1656. DOI: 10.1039/c9sc06337d.
20. Jinhua Shang, Jie Wei, Qing Wang, Jing Wang, Yangjie Zhou, Shanshan Yu, Xiaoqing Liu, Fuan Wang*, Adaption of an autonomously cascade DNA circuit for amplified detection and intracellular imaging of polynucleotide kinase with ultralow background. Biosens. Bioelectron., 2020, 152, 111994. DOI: 10.1016/j.bios.2019.111994
21. Haomiao Su, Jinglei Xu, Qi Wang, Fuan Wang, Xiang Zhou*, High-efficiency and integrable DNA arithmetic and logic system based on strand displacement synthesis. Nat. Commun., 2019, 10, 5390. DOI: 10.1038/s41467-019-13310-2
22. Lingyu Wu, Min Pan, Yuqi Chen, Haiyan Huang, Xiaoe Zhang, Fuan Wang*, Xiang Zhou*, Construction of DNAzyme-based Logic Gates for Amplified MicroRNA Detection and Cancer Recognition. Analyst, 2019, 144, 7278?7282. DOI: 10.1039/c9an01977d
23. Yangjie Zhou, Lei Yang, Jie Wei, Kang Ma, Xue Gong, Jinghua Shang, Shanshan Yu, Fuan Wang*, An autonomous nonenzymatic concatenated DNA circuit for amplified imaging of intracellular ATP. Anal. Chem., 2019, 91(23), 15229?15234. DOI: 10.1021/acs.analchem.9b04126
24. Hong Wang, Huimin Wang, Qiong Wu, Meijuan Liang, Xiaoqing Liu, Fuan Wang*, DNAzyme-amplified DNA Circuit for Highly Accurate MicroRNA Detection and Intracellular Imaging. Chem. Sci., 2019, 10, 9597–9604. DOI: 10.1039/c9sc03552d
25. Kaiyue Tan, Yingying Chen, Kang Ma, Qing Wang, Xiaoqing Liu, Fuan Wang*, Spatiotemporally Tracking the Programmable Mitochondrial Membrane Potential Evolutions by a Robust Molecular Rotor. Small, 2019, 15, **. DOI: 10.1002/smll.
26. Qiong Wu, Hong Wang, Keke Gong, Jinhua Shang, Xiaoqing Liu, Fuan Wang*, Construction of an Autonomous Nonlinear Hybridization Chain Reaction for Extracellular Vesicles-Associated microRNAs Discrimination. Anal. Chem., 2019, 91, 10172–10179. DOI: 10.1021/acs.analchem.9b02181
27. Qiong Wu?, Gang Chen?, Keke Gong, Jing Wang, Xiaoxiao Ge, Xiaoqing Liu, Shaojun Guo*, Fuan Wang*, MnO2-Laden Black Phosphorus for MRI-Guided Synergistic PDT/PTT/Chemotherapy. Matter, 2019, 1, 496–512. DOI: 10.1016/j.matt.2019.03.007
28. Lana Zou, Qiong Wu, Yangjie Zhou, Xue Gong, Xiaoqing Liu, Fuan Wang*, DNAzyme-Powered Cross-Catalytic Circuit for Amplified Intracellular Imaging. Chem. Commun., 2019, 55, 6519–6522. DOI: 10.1039/c9cc02637a
29. Jing Wang, Huimin Wang, Hong Wang, Shizhen He, Ruomeng Li, Zhao Deng, Xiaoqing Liu, Fuan Wang*, Nonviolent Self-Catabolic DNAzyme Nanosponges for Smart Anticancer Drug Delivery. ACS Nano, 2019, 13, 5852?5863. DOI: 10.1021/acsnano.9b01589
30. Huimin Wang, Yuqi Chen, Hong Wang, Xiaoqing Liu, Xiang Zhou, Fuan Wang*, DNAzyme-Loading MOFs for Self-Sufficient Gene Therapy. Angew. Chem. Int. Ed., 2019, 58, 7380–7384. DOI: 10.1002/anie. (HIGHLY CITED PAPER)
31. Xue Gong, Jie Wei, Jing Liu, Ruomeng Li, Xiaoqing Liu, Fuan Wang*. Programmable Intracellular DNA Biocomputing Circuits for Reliable Cell Recognitions. Chem. Sci., 2019, 10, 2989–2997. DOI: 10.1039/c8sc05217d
32. Junlin Sun, Feng Liu, Wenqian Yu, Qunying Jiang, Jialing Hu, Yahua Liu, Fuan Wang, Xiaoqing Liu*. Highly Sensitive Glutathione Assay and Intracellular Imaging with Functionalized Semiconductor Quantum Dots. Nanoscale, 2019, 11, 5014–5020. DOI: 10.1039/c8nr09801h
33. Lei Yang?, Qiong Wu?, Yuqi Chen, Xiaoqing Liu, Fuan Wang*, Xiang Zhou, Amplified MicroRNA Detection and Intracellular Imaging based on an Autonomous and Catalytic Assembly of DNAzyme. ACS Sensors, 2019, 4, 110–117. DOI: 10.1021/acssensors.8b01000
34. Yahua Liu, Min Pan, Wenxiao Wang, Qunying Jiang, Fuan Wang, Dai-Wen Pang, Xiaoqing Liu*, Plasmonic and Photothermal Immunoassay via Enzyme-Triggered Crystal Growth on Gold Nanostars. Anal. Chem., 2019, 91, 2086–2092. DOI: 10.1021/acs.analchem.8b04517
35. Jie Feng, Zhen Xu, Ping Dong, Wenqian Yu, Feng Liu, Qunying Jiang, Fuan Wang, Xiaoqing Liu*, Stimuli-Responsive Multifunctional Metal-Organic Framework Nanoparticles for Enhanced Chemo-Photothermal Therapy. J. Mater. Chem. B, 2019, 7, 994–1004. DOI: 10.1039/c8tb02815j
36. Yahua Liu, Ping Dong, Qunying Jiang, Fuan Wang, Dai-Wen Pang, Xiaoqing Liu*. Assembly-enhanced fluorescence from metal nanoclusters and quantum dots for highly sensitive biosensing. Sens. Actuators B Chem., 2019, 279, 334–341. DOI: 10.1016/j.snb.2018.10.016
37. Min Pan, Zhen Xu, Qunying Jiang, Jie Feng, Junlin Sun, Fuan Wang, Xiaoqing Liu*. Interfacial engineering of carbon dots with benzenediboronic acid for fluorescent biosensing. Nanoscale Adv., 2019, 1, 765–771. DOI: 10.1039/c8na00166a
38. Huimin Wang, Chunxiao Li, Xiaoqing Liu, Xiang Zhou, Fuan Wang*. Construction of an enzyme-free concatenated DNA circuit for signal amplification and intracellular imaging. Chem. Sci., 2018, 9, 5842–5849. DOI: 10.1039/c8sc01981a (HIGHLY CITED PAPER)
39. Jie Feng, Zhen Xu, Feng Liu, Yun Zhao, Wenqian Yu, Min Pan, Fuan Wang, Xiaoqing Liu*. Versatile Catalytic Deoxyribozyme Vehicles for Multimodal Imaging-Guided Efficient Gene Regulation and Photothermal Therapy. ACS Nano, 2018, 12, 12888–12901. DOI: 10.1021/acsnano.8b08101
40. Min Pan?, Meijuan Liang?, Junlin Sun, Xiaoqing Liu*, Fuan Wang*. Lighting Up Fluorescent Silver Clusters via Target-Catalyzed Hairpin Assembly for Amplified Biosensing. Langmuir, 2018, 34, 14851?14857. DOI: 10.1021/acs.langmuir.8b01576
41. Chunxiao Li?, Huimin Wang?, Jinhua Shang, Xiaoqing Liu, Bi-Feng Yuan, Fuan Wang*. Highly sensitive assay of methyltransferase activity based on an autonomous concatenated DNA circuit. ACS Sensors, 2018, 3, 2359?2366. DOI: 10.1021/acssensors.8b00738
42. Meijuan Liang, Min Pan, Jialing Hu, Fuan Wang, Xiaoqing Liu*. Electrochemical Biosensor for MicroRNA Detection Based on Cascade Hybridization Chain Reaction. ChemElectroChem, 2018, 5, 1380–1386. DOI: 10.1002/celc.
43. Qiong Wu, Meijuan Liang, Simin Zhang, Xiaoqing Liu, Fuan Wang*. Development of functional black phosphorus nanosheets with remarkable catalytic and antibacterial performance. Nanoscale, 2018, 10, 10428–10435. DOI: 10.1039/c8nr01715h.
44. Jie Wei, Xue Gong, Qing Wang, Min Pan, Xiaoqing Liu, Jing Liu, Fan Xia, Fuan Wang*. Construction of an autonomously concatenated hybridization chain reaction for signal amplification and intracellular imaging. Chem. Sci., 2018, 9, 52–61. DOI: 10.1039/c7sc03939e (HIGHLY CITED PAPER, COVER PAPER)
45. Qing Wang, Min Pan, Jie Wei, Xiaoqing Liu, Fuan Wang*. Evaluation of DNA Methyltransferase Activity and Inhibition via Isothermal Enzyme-Free Concatenated Hybridization Chain Reaction. ACS Sensors, 2017, 2, 932–939. DOI: 10.1021/acssensors.7b00168
46. Jing Wang, Min Pan, Jie Wei, Xiaoqing Liu, Fuan Wang*. A C-HCR assembly of branched DNA nanostructures for amplified uracil-DNA glycosylase assays. Chem. Commun., 2017, 53, 12878–12881. DOI: 10.1039/c7cc07057h (COVER PAPER)
47. Yuqi Chen, Yanyan Song, Zhiyong He, Zijing Wang, Wenting Liu, Fuan Wang, Xiaolian Zhang, and Xiang Zhou*. pH-controlled DNAzymes: Rational design and their applications in DNA-machinery devices. Nano Research, 2016, 9, 3084–3092. DOI: 10. 1007/s12274-016-1191-x
博士后期间发表文章
48. Masayuki Endo, Yuki Suzuki, Tomoko Emura, Kumi Hidaka, Fuan Wang, Itamar Willner, Hiroshi Sugiyama. Single-Molecule Visualization of the Zn2+-Dependent DNAzyme Functions. Angew. Chem. Int. Ed. 2015, 54, 10550–10554. DOI: 10.1002/anie.
49. Wei-Ching Liao, Chun-Hua Lu, Raimo Hartmann, Fuan Wang, Yang Sung Sohn, Wolfgang J. Parak,* Itamar Willner,* Adenosine Triphosphate-Triggered Release of Macromolecular and Nanoparticle Loads from Aptamer/DNA-Cross-Linked Microcapsules. ACS Nano 2015, 9, 9078–9086. DOI: 10.1021/nn503223e
50. Sivan Lilienthal, Zohar Shpilt, Fuan Wang, Ron Orbach, Itamar Willner*. Programmed DNAzyme-Triggered Dissolution of DNA-Based Hydrogels: Means for Controlled Release of Biocatalysts and for the Activation of Enzyme Cascades. ACS Appl. Mater. Interfaces. 2015, 7, 8923–8931. DOI: 10.1021/acsami.5b02156
51. Lina Freage, Alexander Trifonov, Ran Tel-Vered, Eyal Golub, Fuan Wang, John S. McCaskill, Itamar Willner*. Addressing, amplifying and switching DNAzyme functions by electrochemically-triggered release of metal ions. Chem. Sci. 2015, 6, 3544-3549. DOI: 10.1039/c5sc00744e
52. Fuan Wang, Xiaoqing Liu, Itamar Willner*. DNA Switches: From Principles to Applications. Angew. Chem. Int. Ed. 2015, 54, 1098-1129. DOI: 10.1002/anie.
53. Weiwei Guo, Chun-Hua Lu, Ron Orbach, Fuan Wang, Xiu-Juan Qi, Alessandro Cecconello, Dror Seliktar, Itamar Willner*. pH Stimulated DNA Hydrogels Exhibiting Shape-Memory Properties. Adv. Mater. 2015, 27, 73–78. DOI: 10.1002/adma.
54. Lina Freage, Fuan Wang, Itamar Willner*. Multiplexed Analysis of Genes and of Metal Ions Using Enzyme/DNAzyme Amplification Machineries. Anal. Chem. 2014, 86, 11326–11333. DOI: 10.1021/ac**
55. Natalie Enkin, Fuan Wang, Etery Sharon, Itamer Willner*. Multiplexed Analysis of Genes Using Nucleic Acid-Stabilized Ag Nanocluster Quantum Dots. ACS Nano 2014, 8, 11666–11673. DOI: 10.1021/nn504983j
56. Yuwei Hu, Fuan Wang, Chun-Hua Lu, Julia Girsh, Eyal Golub, Itamar Willner*. Switchable Enzyme/DNAzyme Cascades by the Reconfiguration of DNA Nanostructures. Chem. Eur. J. 2014, 20, 16203–16209. DOI: 10.1002/chem.
57. Zhanxia Zhang, Fuan Wang, Sohn Yang Sung, Rachel Nechushtai, Itamar Willner*. Gated Mesoporous SiO2 Nanoparticles using K+-Stabilized G-Quadruplexes. Adv. Funct. Mater. 2014, 36, 5662–5670). DOI: 10.1002/adfm. (selected as the Cover of the issue 36 on 2014.)
58. Zhanxia Zhang, Fuan Wang, Dora Balogh, Itamar Willner*. pH-Controlled Release of Substrates from Mesoporous SiO2 Nanoparticles Gated By Metal Ion-Dependent DNAzymes. J. Mater. Chem. B 2014, 2, 4449–4455. DOI: 10.1039/c4tb00558a
59. Ron Orbach, Fuan Wang, Oleg Lioubashevski, Raphael D. Levine, Fran?oise Remacle, Itamar Willner*. A Full-Adder Based on Reconfigurable DNA-Hairpin Inputs and DNAzyme Computing Modules. Chem. Sci. 2014, 5, 3381–3387. DOI: 10.1039/c4sc00914b (selected as the Back Cover of the issue 5 on 2014.)
60. Fuan Wang, Chun-Hua Lu Itamar Willner*. From Cascaded Catalytic Nucleic Acids to Enzyme-DNA Nanostructures: Controlling Reactivity, Sensing, Logic Operations and Assembly of Complex Structures. Chem. Rev. 2014, 114, 2881–2941. DOI: 10.1021/cr400354z (selected as the Cover of the issue 5 on 2014.)
61. Fuan Wang, Chun-Hua Lu, Xiaoqing Liu, Lina Freage, Itamar Willner*. Amplified and Multiplexed Detection of DNA Using the Dendritic Rolling Circle Amplified Synthesis of DNAzyme Reporter Units. Anal. Chem. 2014, 86, 1614–1621. DOI: 10.1021/ac**
62. Ron Orbach, Weiwei Guo, Fuan Wang, Oleg Lioubashevski, Itamar Willner*. Self-Assembly of Luminescent Ag Nanocluster Nanowires. Langmuir 2013, 29, 13066–13071. DOI: 10.1021/la402888b
63. Zhanxia Zhang, Dora Balogh, Fuan Wang, Sohn Yang Sung, Rachel Nechushtai, Itamar Willner*. Biocatalytic Release of an Anticancer Drug from Nucleic-Acids-Capped Mesoporous SiO2 Using DNA or Molecular Biomarkers as Triggering Stimuli. ACS Nano 2013, 7, 8455–8468. DOI: 10.1021/nn403772j
64. Fuan Wang, Lina Freage, Ron Orbach, Itamar Willner*. Autonomous Replication of Nucleic Acids by Polymerization/Nicking Enzyme/DNAzyme Cascades for the Amplified Detection of DNA and the Aptamer-Cocaine Complex. Anal. Chem. 2013, 85, 8196–8203. DOI: 10.1021/ac** Highlight by HispanicBusiness
65. Xiaoqing Liu, Fuan Wang, Ruth Aizen, Omer Yehezkeli, Itamar Willner*. Graphene Oxide/Nucleic Acid-Stabilized Silver Nanoclusters: Functional Hybrid Materials for Optical Aptamer Sensing and Multi-plexed Analysis of Pathogenic DNAs. J. Am. Chem. Soc. 2013, 135, 11832–11839. DOI: 10.1021/ja403485r
66. Fuan Wang, Xiaoqing Liu, Chun-Hua Lu, Itamar Willner. Cysteine-Mediated Aggregation of Au Nanoparticles: A Process for the Sensitive Detection of H2O2 and the Development of Oxidase-Based Biosensors. ACS Nano 2013, 7, 7278–7286. DOI: 10.1021/nn402810x
67. Fuan Wang, Bilha Willner, Itamar Willner* DNA Nanotechnology with One-Dimensional Self-Assembled Nanostructures. Curr. Opin. Biotechnol. 2013, 24, 562–574. DOI: 10.1016/j.copbio.2013.02.005
68. Zhanxia Zhang, Dora Balogh, Fuan Wang, Ran Tel-Vered, Naomi Levy, Sohn Yang Sung, Rachel Nechushtai, Itamar Willner*. Light-Induced and Redox-Triggered Uptake and Release of Substrates to and from Mesoporous SiO2 Nanoparticles. J. Mater. Chem. B 2013, 1, 3159–3166. DOI: 10.1039/c3tb20292e
69. Zhanxia Zhang, Dora Balogh, Fuan Wang, Itamar Willner*. Smart Mesoporous SiO2 Nanoparticles for the DNAzyme-Induced Multiplexed Release of Substrates. J. Am. Chem. Soc. 2013, 135, 1934–1940. DOI: 10.10021/ja311385y
70. Fuan Wang, Xiaoqing Liu, Itamar Willner* Integration of Photoswitchable Proteins, Photosynthetic Reaction Centers and Semiconductor/Biomolecule Hybrids with Electrode Supports for Optobioelectronic Applications. Adv. Mater. 2013, 25, 349–377. DOI: 10.1002/adma.
71. Xiaoqing Liu, Fuan Wang, Angelica Niazov-Elkan, Weiwei Guo, Itamar Willner*. Probing Biocatalytic Transformations with Luminescent DNA/Silver Nanoclusters. Nano Lett. 2013, 13, 309–314. DOI: 10.1021/nl304283c
72. Xiaoqing Liu, Angelica Niazov-Elkan, Fuan Wang, Itamar Willner*. Switching Photonic and Electrochemical Functions of a DNAzyme by DNA Machines. Nano Lett. 2013, 13, 219–225. DOI: 10.1021/nl303894h
73. Johann Elbaz?, Fuan Wang?, Raphael D. Levine, Francoise Remacle, Itamar Willner*. Programmable Functional Logic Circuits Driven by Modular DNAzyme Libraries. Nano Lett. 2012, 12, 6049?6054. DOI: 10.1021/nl300051g (? Equal contributor) (selected as the Cover of the issue 12 on 2012.)
74. Fuan Wang, Ron Orbach, Itamar Willner* Detection of Metal Ions (Cu2+, Hg2+) and of Cocaine Using a Ligation DNAzyme Machinery. Chem. Eur. J. 2012, 18, 16030–16036. DOI: 10.1002/chem.
75. Ron Orbach, Lena Mostinski, Fuan Wang, Itamar Willner* Nucleic Acid-Driven DNA Machineries Synthesizing Mg2+-Dependent DNAzymes: An Interplay Between DNA Sensing and Logic Gate Operations. Chem. Eur. J. 2012, 18, 14689–14694. DOI: 10.1002/chem.
76. Fuan Wang, Johann Elbaz, Itamar Willner*. Enzyme-Free Amplified Detection of DNA by an Autonomous Ligation and Replication DNAzyme Machinery. J. Am. Chem. Soc. 2012, 134, 5504–5507. DOI: 10.1021/ja300616w
77. Chunhua Lu?, Fuan Wang?, Itamar Willner* Zn2+-Ligation DNAzyme-Driven Enzymatic and Non-Enzymatic Cascades for the Amplified Detection of DNA. J. Am. Chem. Soc. 2012, 134, 10651–10658. (? Equal contributor), DOI: 10.1021/ja**
78. Chunhua Lu?, Fuan Wang?, Itamar Willner* Amplified Optical Aptasensors through the Endonuclease-Stimulated Regeneration of the Analyte. Chem. Sci. 2012, 3, 2616–2622. (? Equal contributor), DOI: 10.1039/c2sc20426f
79. Johann Elbaz, Zhengang Wang, Fuan Wang, Itamar Willner*. Programmed Dynamic Topologies in DNA Catenanes. Angew. Chem. Int. Ed. 2012, 51, 2349-2353. DOI: 10.1002/anie. (Selected as the Inside Cover of the issue 10 on 2012.)
80. Simcha Shimron?, Fuan Wang?, Ron Orbach, Itamar Willner* Amplified Detection of DNA through the Enzyme-Free Autonomous Assembly of Hemin/G-Quadruplex DNAzyme Nanowires. Anal. Chem. 2012, 84, 1042-1048. DOI: 10.1021/ac202643y (? Equal contributor)
81. Fuan Wang, Johann Elbaz, Ron Orbach, Nimrod Magen, Itamar Willner*. Amplified Analysis of DNA by the Autonomous Assembly of Polymers Consisting of DNAzyme Wires. J. Am. Chem. Soc. 2011, 133, 17149-17151. DOI: 10.1021/ja** Highlight by Life Science Weekly on December 20, 2011
82. Fuan Wang, Johann Elbaz, Carsten Teller, Itamar Willner*. Amplified Detection of DNA through the Autocatalytic, Catabolic Generation of the Analyte by a DNAzyme. Angew. Chem. Int. Ed. 2011, 50, 295-299. DOI: 10.1002/anie.
83. Johann Elbaz, Oleg Lioubashevski, Fuan Wang, Fran?oise Remacle, Raphael D. Levine, Itamar Willner*. DNA computing circuits using libraries of DNAzyme subunits. Nat. Nanotechnol. 2010, 5, 417-422. DOI: 10.1038/nnano.2010.88 Highlight by New Scientist
硕博连读期间发表文章
84. Ming Zhou, Fuan Wang, Shaojun Dong *. Boolean logic gates based on oxygen-controlled biofuel cell in "one pot". Electrochim. Acta 2011, 56, 4112-4118. DOI: 10.1016/j.electacta.2011.01.113
85. Xiaoqing Liu, Fuan Wang, Shuang Han, Lihong Shi, Guobao Xu*. Self-Assembly of gold nanoparticles/electroactive polyelectrolyte multilayer films for tunable electrocatalysis. Electroanalysis 2010, 22, 963-968. DOI: 10.1002/elan.
86. Li Wang, Fuan Wang, Li Shang, Chengzhou Zhu, Wen Ren, Shaojun Dong*. AuAg bimetallic nanoparticles film fabricated based on H2O2-mediated silver reduction and its application. Talanta 2010, 82, 113-117. DOI: 10.1016/j.talanta.2010.04.009
87. Xiaoqing Liu, Haijuan Li, Fuan Wang, Yuling Wang, Shuyun Zhu, Guobao Xu*. Functionalized single-walled carbon nanohorns for electrochemical biosensing. Biosens. Bioelectron. 2010, 25, 2194-2199. DOI: 10.1016/j.bios.2010.02.027
88. Fuan Wang, Xiaoqing Liu, Gaiping Li, Dan Li, Shaojun Dong*. Selective Electrodissolution of Inorganic Ions/DNA Multilayer Film for Tunable DNA Release. J. Mater. Chem. 2009, 19, 286-291. DOI: 10.1039/B812940A
89. Jianlong Wang, Fuan Wang, Shaojun Dong*. Methylene Blue as an Indicator for Sensitive Electrochemical Detection of Adenosine Based on Aptamer Switch. J. Electroanal. Chem. 2009, 626, 1-5. DOI: 10.1016/j.jelechem.2008.08.008
90. Yan Du, Bingling Li, Fuan Wang, Shaojun Dong*. Au Nanoparticles Grafted Sandwich Platform Used Amplified Small Molecule Electrochemical Aptasensor. Biosens. Bioelectron. 2009, 24, 1979-1983. DOI: 10.1016/j.bios.2008.10.019
91. Liu Deng, Lihua Zhang, Li Shang, Shaojun Guo, Dan Wen, Fuan Wang, Shaojun Dong*. Electrochemiluminescence Detection of NADH, Ethanol Based on Partial Sulfonation of Sol-gel Network with Gold Nanoparticles. Biosens. Bioelectron. 2009, 24, 2273-2276. DOI: 10.1016/j.bios.2008.10.031
92. Ming Zhou, Yuling Wang, Yueming Zhai, Junfeng Zhai, Wen Ren, Fuan Wang, Shaojun Dong*. Controlled Synthesis of Large-Area and Patterned Electrochemically Reduced Graphene Oxide Films. Chem. Eur. J. 2009, 15, 6116-6120. DOI: 10.1002/chem.
93. Fuan Wang, Jianlong Wang, Yueming Zhai, Dan Li, Gaiping Li, Shaojun Dong*. Layer-by-layer Assembly of Biologically Inert Inorganic Ions/DNA Multilayer Films for Tunable DNA Release by Chelation. J. Controlled Release 2008, 132, 65-73. DOI: 10.1016/j.jconrel.2008.08.016
94. Fuan Wang, Dan Li, Gaiping Li, Xiaoqing Liu, Shaojun Dong*. Electrodissolution of Inorganic ions/DNA Multilayer Film for Tunable DNA Release. Biomacromolecules 2008, 9, 2645-2652. DOI: 10.1021/bm800766t
95. Fuan Wang, Jianlong Wang, Xiaoqing Liu, Shaojun Dong*. Nanoparticle-amplified Surface Plasmon Resonance Study of Protein Conformational Change at Interface. Talanta 2008, 77, 628-634. DOI: 10.1016/j.talanta.2008.06.042
96. Liu Deng, Fuan Wang, Hongjun Chen, Li Shang, Liang Wang, Tie Wang, Shaojun Dong*. A Biofuel Cell with Enhanced Performance by Multilayer Biocatalyst Immobilized on Highly Ordered Macroporous Electrode. Biosens. Bioelectron. 2008, 24, 329-333. DOI: 10.1016/j.bios.2008.04.006
97. Jianlong Wang, Fuan Wang, Hongjun Chen, Xiaohua Liu, Shaojun Dong*. Electrochemical Surface Plasmon Resonance Detection of Enzymatic Reaction in Bilayer Lipid Membranes. Talanta 2008, 75, 666-670. DOI: 10.1016/j.talanta.2007.11.062
98. Lihua Zhang, Fuan Wang, Shaojun Dong*. Layer-by-layer Assembly of Functional Silica and Au Nanoparticles for Fabricating Electrogenerated Chemiluminescence Sensor. Electrochim. Acta 2008, 53, 6423-6427. DOI: 10.1016/j.electacta.2008.04.059
99. Liu Deng, Yizhe Wang, Li Shang, Dan Wen, Fuan Wang, Shaojun Dong*. A Sensitive NADH and Glucose Biosensor Tuned by Visible Light Based on Thionine Bridged Carbon Nanotubes and Gold Nanoparticles Multilayer. Biosens. Bioelectron. 2008, 24, 951-957. DOI: 10.1016/j.bios.2008.07.066
100. Fuan Wang, Jianlong Wang, Hongjun Chen, Shaojun Dong*. Assembly Process of CuHCF/MPA Multilayers on Gold Nanoparticles Modified Electrode and Characterization by Electrochemical SPR. J. Electroanal. Chem. 2007, 600, 265-274. DOI: 10.1016/j.jelechem.2006.10.008
101. Jianlong Wang, Fuan Wang, Xiangqin Zou, Zhiai Xu, Shaojun Dong*. Surface Plasmon Resonance and Electrochemistry for Detection of Small Molecules Using Catalyzed Deposition of Metal Ions on Gold Substrate. Electrochem. Commun. 2007, 9, 343-347. DOI: 10.1016/j.elecom.2006.09.011
102. Jianlong Wang, Fuan Wang, Zhiai Xu, Yizhe Wang, Shaojun Dong*. Surface Plasmon Resonance and Electrochemistry Characterization of Layer-by-Layer Self-Assembled DNA and Zr4+ Thin Films and Their Interaction with Cytochrome c. Talanta 2007, 74, 104-109. DOI: 10.1016/j.talanta.2007.05.033
103. Na Gao, Zhiai Xu, Fuan Wang, Shaojun Dong*. Sensitive Biomimetic Sensor Based on Molecular Imprinting at Functionalized Indium Tin Oxide Electrodes. Electroanalysis 2007, 19, 1655-1660. DOI: 10.1002/elan.
104. Liu Deng, Ying Liu, Guocheng Yang, Li Shang, Dan Wen, Fuan Wang, Zhiai Xu, Shaojun Dong*. Molecular "Wiring" Glucose Oxidase in Supramolecular Architecture. Biomacromolecules 2007, 8, 2063-2071. DOI: 10.1021/bm061049l
105. Jianlong Wang, Yong Shao, Yongdong Jin, Fuan Wang, Shaojun Dong*. Electrochemical Thinning of Thick Gold Film with Controlled Thickness for SPR Sensing. Anal. Chem. 2005, 77, 5760-5765. DOI: 10.1021/ac**
参与编写的著作
1. Hong Wang, Huimin Wang, Fuan Wang*. "Chapter 10: High-performanced biosensing based on autonomous enzyme-free DNA circuit." in " DNA Nanotechnology: From Structure to Functionality" for Top. Curr. Chem. Edited by Chunhai Fan and Yonggang Ke. Springer Press.
2. Fuan Wang, Bilha Willner, Itamar Willner*. "Chapter 2: DNA-Based Machines." in "Molecular Machines and Motors: Recent Advances and Perspectives" for Top. Curr. Chem. Edited by Alberto Credi, Silvi Serena and Margherita Venturi. Springer Press.
3. Fuan Wang, Chun-Hua Lu, Itamar Willner*. "Chapter 2: DNA Switches and Machines." in "DNA in Supramolecular Chemistry and Nanotechnology" Edited by Eugen Stulz Guido H. Clever. 2015 John Wiley & Sons, Ltd.
社会兼职
Nat. Catal., Nat. Comm., JACS, Angew. Chem., Adv. Mater., ACS Nano, Nano Lett., Chem. Mater., NPG Asia Mater., Small, Chem. Sci., Anal. Chem.等权威期刊审稿人。




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研究方向
[1].核酸纳米技术