基
本
情
况
姓 名
黄国友
性 别
男
出生年月
1984年9月

学历学位
博士
职 称
副教授
博导/硕导
硕导

邮 编
430072
办公电 话

手 机


通信地址
武汉武昌东湖南路8号武汉大学工学部结构楼426
Email
gyhuang@whu.edu.cn

主
要
经
历
学习经历
2008.09-2013.03 西安交通大学航天航空学院，工学博士
2004.09-2008.07 西安交通大学理学院，理学学士

任职经历
2020.04-至今，武汉大学土木建筑工程学院，副教授
2017.04-2020.03，西安交通大学生命科学与技术学院，副教授
2014.02-2015.02，美国圣路易斯华盛顿大学，医学院及工程和应用科学学院，访问****
2013.04-2017.03，西安交通大学生命科学与技术学院，讲师

主
讲
课
程
本科生课程：《材料力学》

科
学
研
究
主要研究领域
· 生物力学/力学生物学
· 智能生物材料与器件

主要论文著作（^#为共同第一作者, *为通讯作者）
1. L. Niu, Y. Jia, M. Wu, H. Liu, Y. Hong, Y. Hu, X. Zhang, D. Gao, F. Xu, G. Huang*. Matrix stiffness controls cardiac fibroblast differentiation through regulating YAP via AT₁R. Journal of Cellular Physiology, 235(11): 8345-8357, 2020
2. H. Liu^#, M. Wu^#, Y. Jia, L. Niu, G. Huang*, F. Xu*. The shape of fibroblasts regulates their responses to mechanical and biochemical cues in three dimensions. NPG Asia Materials, 12(1): 45, 2020
3. W. Zhang, G. Huang*, F. Xu. Engineering biomaterials and approaches for mechanical stretching of cells in three dimensions. Frontiers in Bioengineering and Biotechnology, 8: 589590, 2020
4. B. Cheng^#, W. Wan^#, G. Huang, Y. Li, G.M. Genin, M.R.K. Mofrad, T.J. Lu, F. Xu, M. Lin*. Nanoscale integrin cluster dynamics controls cellular mechanosensing via FAKY397 phosphorylation. Science Advances, 6(10): eaax1909, 2020
5. G. Jin, W. Li, F. Song, J. Zhao, M. Wang, Q. Liu, A. Li, G. Huang and F. Xu*. Fluorescent conjugated polymer nanovector for in vivo tracking and regulating the fate of stem cells for restoring infarcted myocardium. Acta Biomaterialia, 109: 195-207, 2020
6. G. Zhao, X. Zhang, B. Li, G. Huang, F. Xu, X. Zhang*. Solvent-Free Fabrication of carbon nanotube/silk fibroin electrospun matrices for enhancing cardiomyocyte functionalities. ACS Biomaterials Science & Engineering, 6(3): 1630–1640, 2020
7. M. Wang, B. Cheng, Y. Yang, H. Liu, G. Huang, L. Han, F. Li*, F. Xu*. Microchannel stiffness and confinement jointly induce the mesenchymal-amoeboid transition of cancer cell migration. Nano Letters, 19: 5949?5958, 2019
8. G. Zhao^#, X. Bao^#, G. Huang, F. Xu*, X. Zhang*. Differential effects of directional cyclic stretching on the functionalities of engineered cardiac tissues. ACS Applied Bio Materials, 2(8): 3508-3519, 2019
9. Y. Ji^#, Q. Yang^#, G. Huang, M. Shen, Z. Jian, M.J. Thoraval, Q. Lian, X. Zhang*, F. Xu*. Improved resolution and fidelity of droplet-based bioprinting by upward ejection. ACS Biomaterials Science & Engineering, 5(8): 4112-4121, 2019
10. G. Huang, F. Xu, G.M. Genin, T.J. Lu*. Mechanical microenvironments of living cells: a critical frontier in mechanobiology. Acta Mechanica Sinica, 35(2): 265-269, 2019
11. J. Tian^#, G. Huang^#, M. Lin, J. Qiu, B. Sha, T.J. Lu*, F. Xu*. A mechanoelectrical coupling model of neurons under stretching. Journal of the Mechanical Behavior of Biomedical Materials, 93: 213-221, 2019
12. H. Qing^#, G. Jin^#, G. Zhao, G. Huang, Y. Ma, X. Zhang, B. Sha, Z. Luo, T.J. Lu*, F. Xu*. Heterostructured silk-nanofiber-reduced graphene oxide composite scaffold for SH-SY5Y cell alignment and differentiation. ACS Applied Materials & Interfaces, 10(15), 39228–39237, 2018
13. G. Zhao, H. Qing, G. Huang, G.M. Genin, T.J. Lu, Z. Luo, F. Xu*, X. Zhang*. Reduced graphene oxide functionalized nanofibrous silk fibroin matrices for engineering excitable tissues. NPG Asia Materials, 10, 982-994, 2018
14. C. Ji^#, F. Song^#, G. Huang^#, S. Wang, H. Liu, S. Liu, L. Huang, S. Liu, J. Zhao, T.J. Lu*, F. Xu*. The protective effects of acupoint gel embedding on rats with myocardial ischemia-reperfusion injury. Life Sciences, 211: 51-62, 2018
15. Y. Ma^#, M. Lin^#, G. Huang, Y. Li, S. Wang, H. Yang, A. Li, T. J. Lu, F. Xu*. Three-dimensional spatiotemporal mechanical microenvironment: a hydrogel-based platform for guiding stem cell fate. Advanced Materials, **, 2018
16. 徐峰, 张晓慧*, 鲍雪娇, 赵国旭, 刘付生, 黄国友, 李昱辉和卢天健. 基于先进生物材料的心肌细胞力–电微环境体外构建. 力学进展, 48: 320-359, 2018
17. W. Zhang, G. Huang*, K. Ng, Y. Ji, B. Gao, Q. Huang, J. Zhou, T.J. Lu, F. Xu. Engineering ellipsoidal cap-like hydrogel particles as building blocks or sacrificial templates for three-dimensional cell culture. Biomaterials Science, 6(4): 885-892, 2018
18. 胡焱, 洪源, 师念园, 黄国友和赵昕*. 基于甲基丙烯酸酯明胶的神经干细胞三维微环境的构建调控. 中国科技论文, 12(24): 2770-2776, 2017
19. G. Huang^#, F. Li^#, X. Zhao, Y. Ma, Y. Li, M. Lin, G. Jin, T.J. Lu, G.M. Genin and F. Xu*. Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment. Chemical Reviews, 117(20): 12764-12850, 2017
20. B. Cheng, M. Lin, G. Huang, Y.H. Li, B.H. Ji, G.M. Genin, V.S. Deshpande, T.J. Lu and F. Xu*. Energetics: An emerging frontier in cellular mechanosensing: Reply to comments on “Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses”. Physics of Life Reviews, 22-23: 130-135, 2017
21. B. Cheng, M. Lin, G. Huang, Y.H. Li, B.H. Ji, G.M. Genin, V.S. Deshpande, T.J. Lu and F. Xu*. Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses. Physics of Life Reviews, 22-23: 88-119, 2017
22. Y.L. Han^#, M.X. Li^#, Q.Z. Yang^#, G. Huang, H. Liu, Y.D. Qin, G.M. Genin, T.J. Lu* and F. Xu*. Collective wetting of a natural fibrous system and its application in pump-free droplet transfer. Advanced Functional Materials, 27(22): **, 2017
23. G. Huang, M.X. Li, Q.Z. Yang, Y.H. Li, H. Liu, H. Yang and F. Xu*. Magnetically actuated droplet manipulation and its potential biomedical applications. ACS Applied Materials & Interfaces, 9(2): 1155-1166, 2017
24. B. Cheng, M. Lin, Y.H. Li, G. Huang, H. Yang, Guy M. Genin, Vikram S. Deshpande, T.J. Lu and F. Xu*. An integrated stochastic model of matrix-stiffness-dependent filopodial dynamics. Biophysical Journal, 111(9): 2051-2061, 2016
25. K.W. Yong, Y.H. Li, F.S. Liu, B. Gao, T.J. Lu, W.A.B. Wan Abas, W.K.Z. Wan Safwani, B. Pingguan-Murphy, Y. Ma, F. Xu and G. Huang*. Paracrine effects of adipose-derived stem cells on matrix stiffness-induced cardiac myofibroblast differentiation via angiotensin II type 1 receptor and Smad7. Scientific Reports, 6: 33067, 2016
26. G. Huang, L.M. Tian, K.-K. Liu, B. Hu, F. Xu, T.J. Lu, R.R. Naik and S. Singamaneni*. Elastoplastic deformation of silk micro- and nanostructures. ACS Biomaterials Science & Engineering, 2(6): 893-899, 2016
27. Y.H. Li^#, G. Huang^#, M. Li, L. Wang, E.L. Elson, T. J. Lu, G.M. Genin* and F. Xu*. An approach to quantifying 3D responses of cells to extreme strain. Scientific Reports, 6: 19550, 2016
28. Y.H. Li, G. Huang*, B. Gao, M.X. Li, G.M. Genin, T.J. Lu and F. Xu*. Magnetically-actuated cell-laden microscale hydrogels for probing strain-induced cell responses in three dimensions. NPG Asia Materials, 8: e238, 2016
29. H. Qi*, G. Huang, Y.L. Han, L. Wang*, S.Q. Wang, T.J. Lu and F. Xu. In vitro spatially organizing the differentiation in individual multicellular stem cell aggregates. Critical Reviews in Biotechnology, 36(1): 20-31, 2016
30. L. Wang^#, Y.H. Li^#, G. Huang, X. Zhang, B. Pingguan-Murphy, B. Gao, T.J. Lu and F. Xu*. Hydrogel-based methods for engineering cellular microenvironment with spatiotemporal gradients. Critical Reviews in Biotechnology, 36(3): 553-565, 2016
31. Q.C. Zhang, X. Yang, P. Li, G. Huang, S. Feng, C. Shen, B. Han, X. Zhang, F. Jin, F. Xu* and T.J. Lu*. Bioinspired engineering of honeycomb structure – Using nature to inspire human innovation. Progress in Materials Science, 74: 332-400, 2015
32. K.W. Yong, Y.H. Li, G. Huang, T.J. Lu, W.K.Z. Wan Safwani, B. Pingguan-Murphy and F. Xu*. Mechano-regulation of cardiac myofibroblast differentiation: Implications for cardiac fibrosis and therapy. American Journal of Physiology-Heart and Circulatory Physiology, 309(4): H532-H542, 2015
33. D.T. Chong, X.S. Liu, H.J. Ma, G. Huang, Y.L. Han, X.Y. Cui, J.J. Yan and F. Xu*. Advances in fabricating double-emulsion and their biomedical applications. Microfluidics and Nanofluidics, 19(5): 1071-1090, 2015
34. Y.F. Ma, Y. Ji, G. Huang, K. Ling, X.H. Zhang* and F. Xu*. Bioprinting 3D cell-laden hydrogel microarray for screening human periodontal ligament stem cells response to extracellular matrix. Biofabrication, 7(4): 044105, 2015
35. K. Ling, G. Huang, J. Liu, X. Zhang, Y. Ma, T.J. Lu* and F. Xu*. Bioprinting-based high-throughput fabrication of three-dimensional MCF-7 human breast cancer cellular spheroids. Engineering, 1(2): 269-274, 2015
36. F.S. Liu, C.H. Li, S.B. Liu, G.M. Genin, G. Huang, T.J. Lu* and F. Xu*. Effect of viscoelasticity on skin pain sensation. Theoretical and Applied Mechanics Letters, 5(6): 222-226, 2015
37. L. Wang, M. Qiu, Q. Yang, Y. Li, G. Huang, M. Lin, T.J. Lu and F. Xu*. Fabrication of microscale hydrogels with tailored microstructures based on liquid bridge phenomenon. ACS Applied Materials & Interfaces, 7: 11134-11140, 2015
38. Z. Liu, Z. Wei, X.L. Zhu, G. Huang, F. Xu, J.H. Yang, Y. Osada, M. Zrínyi, J.H. Li* and Y.M. Chen*. Dextran-based hydrogel formed by thiol-Michael addition reaction for 3D cell encapsulation. Colloids and Surfaces B: Biointerfaces, 128: 140-148, 2015
39. S. Liu^#, P. Wang^#, G. Huang, L. Wang, J. Zhou, T.J. Lu, F. Xu and M. Lin*. Reaction-induced swelling of ionic gels. Soft Matter, 11(3): 449-455, 2015
40. 刘灏, 黄国友*, 李昱辉, 张晓慧, 卢天健和徐峰*. 基于水凝胶的“自下而上”组织工程技术研究进展. 中国科学-生命科学, 45(3): 256-270, 2015
41. Y.H. Li^#, G. Huang^#, X.H. Zhang, L. Wang, Y.N. Du, T.J. Lu and F. Xu*. Engineering cell alignment in vitro. Biotechnology Advances, 32: 347–365, 2014
42. H. Qi, G. Huang, Y.L. Han, Y.H. Li, X.H. Zhang, B. Pingguan-Murphy, T.J. Lu, F. Xu and L. Wang. Engineering artificial machines from designable DNA materials for biomedical applications. Tissue Engineering Part B: Reviews, 21(3): 288-297, 2014
43. L. Wang^#, G. Huang^#,*, B.Y. Sha, S.Q. Wang, Y.L. Han, J.H. Wu, T.J. Lu and F. Xu*. Engineering three-dimensional cardiac microtissues for potential drug screening applications. Current Medicinal Chemistry, 21(22): 2497-2509, 2014
44. Y. Han^#, S. Wang^#, X.H. Zhang, Y.H. Li, G. Huang, H. Qi, B. Pingguan-Murphy, Y.H. Li, T.J. Lu* and F. Xu*. Engineering physical microenvironment for stem cell based regenerative medicine. Drug Discovery Today, 16: 763-773, 2014
45. Y.L. Han, W.Q. Wang, J. Hu, G. Huang, S.Q. Wang, W.G. Lee, T.J. Lu* and F. Xu*. Benchtop fabrication of three-dimensional reconfigurable microfluidic device from paper/polymer composite, Lab on a Chip, 3(24): 4745-4749, 2013
46. X. He, P.F. Wang, G. Huang, S.B. Liu, M.L. Xu, F. Xu, T.J. Lu, Development of a micro-indentation device for measuring the mechanical properties of soft materials. Theoretical & Applied Mechanics Letters, 3(5): 054004, 2013
47. Y.H. Li^#, G. Huang^#, X.H. Zhang, B.Q. Li, Y.M. Chen, T.L. Lu, T.J. Lu* and F. Xu*. Magnetic hydrogels and their potential biomedical applications, Advanced Functional Materials, 23(6): 660-672, 2013
48. G. Huang, S.H. Wang, X. He, X.H. Zhang, T.J. Lu* and F. Xu*. Helical spring template fabrication of cell-laden microfluidic hydrogels for tissue engineering. Biotechnology & Bioengineering, 110(3): 980-989, 2013
49. G. Huang, X.H. Zhang, Z.P. Xiao, Q.C. Zhang, J.X. Zhou, F. Xu* and T.J. Lu*. Cell-encapsulating microfluidic hydrogels with enhanced mechanical stability. Soft Matter, 8(41): 10687-10694, 2012
50. G. Huang^#, L. Wang^#, S.Q. Wang, Y.L. Han, J.H. Wu, Q.C. Zhang, F. Xu* and T.J. Lu*. Engineering three-dimensional cell mechanical microenvironment with hydrogels. Biofabrication, 4(4): 042001, 2012
51. Y. Fan^#, F. Xu^#,*, G. Huang, T.J. Lu and W.L. Xing*. Single neuron capture and axonal development in three-dimensional microscale hydrogels. Lab on a Chip, 12(22): 4724-4731, 2012
52. G. Huang^#, L.H. Zhou^#, Q.C. Zhang, Y.M. Chen, W. Sun, F. Xu* and T.J. Lu*. Microfluidic hydrogels for tissue engineering. Biofabrication, 3(1): 012001, 2011
53. L.H. Zhou, G. Huang, S.Q. Wang, J.H. Wu, W.G. Lee, Y.M. Chen, F. Xu* and T.J. Lu*. Advances in cell-based biosensors using three-dimensional cell-encapsulating hydrogels, Biotechnology Journal, 6(12): 1466-1476, 2011
54. J.X. Zhou, G. Huang, M.E. Li and A.K. Soh*. Stress evolution in a phase-separating polymeric gel. Modelling and Simulation in Materials Science and Engineering, 18(2): 025002, 2010
55. 黄国友, 徐峰, 周丽宏, 周进雄, 陈咏梅和卢天健*. 载细胞水凝胶体系中微通道结构对营养物输送能力的影响. 西安交通大学学报, 45(4): 115-120, 2010
56. 周丽宏, 陈自强, 黄国友, 翟晓, 陈咏梅, 徐峰和卢天健*. 细胞打印技术及应用. 中国生物工程杂志, 30(12): 95-104, 2010
专利
1. 沙保勇，黄国友，徐峰，“磁控高通量药物筛选血脑屏障模拟装置”，中国发明专利，2017.12.19，专利号：ZL2.5
2. 徐峰，黄国友，凌楷和卢天健, “一种基于水凝胶微孔板的细胞球原位制备方法”，中国发明专利，2017.06.06，专利号：ZL5.8
3. 徐峰，何翔，王琳，王鹏飞，黄国友和卢天健，“多层PEG-DMA水凝胶的制备方法”，中国发明专利，2015.07.15，专利号：ZL8.0
4. 黄国友，卢天健，徐峰和周丽宏，“一种力学增强型载细胞微通道水凝胶的制备方法”，中国发明专利，2013.10.16，专利号：ZL4.5
5. 黄国友，卢天健，徐峰和周丽宏，“一种基于蔗糖纤维模板的载细胞微通道水凝胶的制备方法”，中国发明专利，2013.07.10，专利号：ZL0.x
6. 徐峰，卢天健和黄国友，“一种基于活细胞的复杂三维微通道多孔支架的制备方法”，中国发明专利，2013.10.16，专利号：ZL9.4

主要科研项目
1. 血管紧张素II-1型受体在纤维化力学信号转导中的作用机制，国家自然科学基金面上项目，2019/01-2022/12，主持
2. 三维基质硬化和软化对心肌肌成纤维细胞表型转化的作用及机制研究，国家自然科学基金青年科学基金，2017/01-2019/12，主持
3. 基质塑性影响成纤维细胞向化表型转的作用研究，中国博士后科学基金特别资助，2019/06-2020/04，主持
4. 细胞纤维化表型记忆的力学生物学机制及干预作用，西安交通大学基本科研业务费青年人才培育项目，2018/01-2020/04，主持
5. 基质硬度调控下间充质干细胞对心肌肌成纤维细胞表型转化的作用，陕西省自然科学基础研究计划面上项目，2017/01-2018/12，主持
6. 基于磁力的高通量工程化心肌组织力学调控研究，西安交通大学基本科研业务费综合交叉类面上项目，2014/01-2016/12，主持

获
奖
及
荣
誉
2019，陕西高等学校科学技术奖一等奖（排名第二）
2012，国家奖学金，优秀学生，西安交通大学
2007，国家励志奖学金，优秀学生，西安交通大学

主要社会和
学术兼职
中国力学学会会员
中国生物医学工程学会会员
中国生物材料学会会员


《力学与实践》编委


国际学术期刊评审专家：Biomaterials, Bioactive Materials, Biophysical Journal, Biofabrication, Acta Mechanica Sinica, Acta Biomaterialia, Journal of the Mechanical Behavior of Biomedical Materials, ACS Biomaterials Science & Engineering, Frontiers in Bioengineering and Biotechnology, Colloids and Surfaces B: Biointerfaces, Life Sciences, Biomedical Materials