杜宇昊博士,副教授
研究方向：化学生物学 有机化学 表观遗传学
联系电话：
Email:dyh@whu.edu.cn




2012.4-至今,武汉大学,化学与分子科学学院,副教授
2010.9-2011.12,Wake Forest University,博士后,合作导师:Lindsay R. Comstock
2009-2010 Univerity of Virginia，访问****，导师：Lin Pu
2007-2008 法国University of Grenoble 3，联合培养，导师：Jean-Francois Constant
2004.9–2010.7, 武汉大学, 有机化学, 博士, 导师:周翔教授
2000.9–2004.7, 武汉大学, 化学, 学士, 导师:周翔教授


一直从事化学生物学的研究，在小分子探针、修饰核酸、蛋白抑制剂领域有着扎实的工作基础和经验积累。所在实验室为周翔教授主持的核酸化学生物学实验室。在博士期间就从事与核酸分子探针的研究，接着在青年基金《新型可诱导DNA甲基转移酶和组蛋白甲基转移酶抑制剂的设计合成，构效关系和活性研究》及面上项目《DNA中甲基、羟甲基、醛基胞嘧啶多位点检测及胞嘧啶羟甲基修饰的方法研究》的资助下，开展了独立研究工作。


发表论文：
(1) Liu, Yinong ; Zhong, Cheng ; He, Zhiyong ; Rao, Shuang; Su, Haomiao; Wu, Fan; Fu, Boshi; Wu, Jinjun; Song, Yanyan; ; Zhou, Xiang; Du, Yuhao; Reversible photoregulation of DNA B-Z transition by a photochromic nucleoside. Sensors and Actuators B: Chemical 2018，2151-2154.
(2) Rao, Shuang ; Chen, Yuqi; Hong, Tingting; He, Zhiyong; Guo, Shan; Lai Han; Guo, Ge; ; Zhou, Xiang; Du, Yuhao; Simultaneous and Sensitive Detection of Multisite 5-Methylcytosine Including Non-CpG Sites at Single-5mC-Resolution. Anal. Chem. 2017, 88(21), 10547~10551.
(3) He, Zhiyong ; Chen, Yuqi; Wang, Yafen; Wang, Jiaqi; Mo, Jing; Fu, Boshi; Wang, Zijing; ; Zhou, Xiang; Du, Yuhao; A rapidly photo-activatable light-up fluorescent nucleoside and its application in DNA base variation sensing. Chem Commun (Camb) 2016, 52(55), 8545~8548.
(4) Hendrick, Charles E; Frye, Krysta S; Comstock, Lindsay R; Du, Yuhao, Fluorescent DNA labeling by N-mustard analogues of S-adenosyl-L-methionine. ChemBioChem 2012, 13(15), 2225~2233.
(5) Zhou, Xiang; Du, Yuhao; Targeting non-B-form DNA in living cells. Chem. Rec. 2013, 13(4), 371~384.
(6) Turlington, Mark; Ostrum, Samuel G; Santosh, Vishaka; Du, Yuhao; Wren, Kathryne; Lin, Tony; Sabat, Michal; Pu, Lin; From highly enantioselective catalytic reaction of 1,3-diynes with aldehydes to facile asymmetric synthesis of polycyclic compounds. J. Am. Chem. Soc. 2011, 133(30), 11780~11794.
(7) Weng, Xiaocheng; Huang, Jing; Zhang, Dan; Ma, Heng; Chen, Du, Yuhao, Dong; Zhou, Xiang ; Constant, Jean-Francois; Oligonucleotide-selenide conjugate: synthesis and its inducible sequence-specific alkylation of DNA. Bioorg. Med. Chem. 2010, 18(11), 4149-4153.
(8) Zhang, Dan; Chen, Wei; Zhang, Ming; Zhou, Yangyang; Zhou, Du, Yuhao , Xiang; Cationic N-confused porphyrin derivative as a better molecule scaffold for G-quadruplex recognition. Bioorg. Med. Chem. 2010, 8(3), 1111~11168.
(9) Turlington, Mark; Zhou, Xiang; Pu, Lin; Du, Yuhao; Highly enantioselective addition of linear alkyl alkynes to linear aldehydes. Tetrahedron Letters 2010, 51(38), 5024~5027.
(10) Huang, Jing; Weng, Xiaocheng; Zhou, XiangDu, Yuhao; Specific Recognition of DNA by Small Molecules. Current Medicinal Chemistry 2010, 17(2), 173~189