职称职务：教授、博导、“****奖励计划”特聘教授
学科专业：生物化学
研究方向：蛋白质组学
实验室位置：生科院6016号房间

联系电话：OfficePhone:**
LabPhone:**
Email:guol@whu.edu.cn


学　历：
学士.1983，武汉大学生物系
硕士.1986,武汉大学生物系
博士.1991,美国内华达大学生物化学系
博士后，1993－1995，美国弗吉利亚大学
博士后，1995－1998，美国华盛顿大学

主要工作经历与任职：
1998-2005.7，Immunex公司/Amgen公司，美国西雅图，历任初级科学家、科学家、高级科学家
2005.8.–武汉大学生命科学学院教授

目前主要研究领域和兴趣：
　　本实验室以蛋白质组学及生物质谱学为主要研究方法，重点研究感染与天然免疫过程中的蛋白组变化以及蛋白质信号传导通路。

教学情况：
　　每年秋季，本科生生物化学必修课（弘毅班与国际班），研究生蛋白质组学课程；
　　每年春季，本科生蛋白质组学选修课。

代表性论文
Zeng,H.L.,Rao,X.,Zhang,L.K.,Zhao,X.,Zhang,W.P.,Wang,J.,Xu,F.,andGuo,L.(2014)Quantitativeproteomicsrevealsolfactoryinput-dependentalterationsinthemouseolfactorybulbproteome,JProteomics109,125-142
Yao,Q.,Liu,B.Q.,Li,H.,McGarrigle,D.,Xing,B.W.,Zhou,M.T.,Wang,Z.,Zhang,J.J.,Huang,X.Y.,andGuo,L.(2014)C-terminalSrckinase(Csk)-mediatedphosphorylationofeukaryoticelongationfactor2(eEF2)promotesproteolyticcleavageandnucleartranslocationofeEF2,JBiolChem289,12666-12678

Zhao,X.,Sidoli,S.,Wang,L.,Wang,W.,Guo,L.,Jensen,O.N.,andZheng,L.(2014)Comparativeproteomicanalysisofhistonepost-translationalmodificationsuponischemia/reperfusion-inducedretinalinjury,JProteomeRes13,2175-2186

Yan,J.,Tian,H.,Wang,S.,Shao,J.,Zheng,Y.,Zhang,H.,Guo,L.,andDing,Y.(2014)PollendevelopmentaldefectsinZD-CMSricelineexploredbycytological,molecularandproteomicapproaches,JProteomics108C,110-123

Zhang,L.K.,Chai,F.,Li,H.Y.,Xiao,G.,andGuo,L.(2013)IdentificationofhostproteinsinvolvedinJapaneseencephalitisvirusinfectionbyquantitativeproteomicsanalysis,JProteomeRes12,2666-2678

Xing,B.,Wang,L.,Guo,D.,Huang,J.,Espenel,C.,Kreitzer,G.,Zhang,J.J.,Guo,L.,andHuang,X.Y.(2013)AtypicalproteinkinaseClambdaiscriticalforgrowthfactorreceptor-induceddorsalruffleturnoverandcellmigration,JBiolChem288,32827-32836

Wu,Y.,Zhao,S.,Tian,H.,He,Y.,Xiong,W.,Guo,L.,andWu,Y.(2013)CPK3-phosphorylatedRhoGDI1isessentialinthedevelopmentofArabidopsisseedlingsandleafepidermalcells,JExpBot64,3327-3338

Li,X.S.,Pan,Y.N.,Zhao,Y.,Yuan,B.F.,Guo,L.,andFeng,Y.Q.(2013)Preparationoftitanium-graftedmagneticmesoporoussilicafortheenrichmentofendogenousserumphosphopeptides,JChromatogrA1315,61-69

Hou,D.,Zhang,L.,Deng,F.,Fang,W.,Wang,R.,Liu,X.,Guo,L.,Rayner,S.,Chen,X.,Wang,H.,andHu,Z.(2013)ComparativeProteomicsRevealFundamentalStructuralandFunctionalDifferencesbetweentheTwoProgenyPhenotypesofaBaculovirus,JVirol87,829-839

Chen,X.,Zhao,Y.,Li,G.-M.,andGuo,L.(2013)Proteomicanalysisofmismatchrepair-mediatedalkylatingagent-inducedDNAdamageresponse,Cell&Biosciences3,37

Xu,H.,Zhang,W.,Gao,Y.,Zhao,Y.,Guo,L.,andWang,J.(2012)Proteomicanalysisofembryodevelopmentinrice(Oryzasativa),Planta235,687-701

Liu,G.,Tian,H.,Huang,Y.Q.,Hu,J.,Ji,Y.X.,Li,S.Q.,Feng,Y.Q.,Guo,L.,andZhu,Y.G.(2012)AlterationsofMitochondrialProteinAssemblyandJasmonicAcidBiosynthesisPathwayinHonglian(HL)-typeCytoplasmicMaleSterilityRice,JBiolChem287,40051-40060

Kang,X.,Chen,X.,He,Y.,Guo,D.,Guo,L.,Zhong,J.,andShu,H.B.(2012)DDB1isacellularsubstrateofNS3/4AproteaseandrequiredforhepatitisCvirusreplication,Virology

Chen,C.,Wu,D.,Zhang,L.,Zhao,Y.,andGuo,L.(2012)Comparativephosphoproteomicsstudiesofmacrophageresponsetobacterialvirulenceeffectors,JProteomics77,251-261

Yu,J.L.,andGuo,L.(2011)QuantitativeproteomicanalysisofSalmonellaentericaserovarTyphimuriumunderPhoP/PhoQactivationconditions,JProteomeRes10,2992-3002

Yao,Q.,Li,H.,Liu,B.Q.,Huang,X.Y.,andGuo,L.(2011)SUMOylation-regulatedProteinPhosphorylation,EvidencefromQuantitativePhosphoproteomicsAnalyses,JBiolChem286,27342-27349

Xu,H.,Zhang,W.,Gao,Y.,Zhao,Y.,Guo,L.,andWang,J.(2011)Proteomicanalysisofembryodevelopmentinrice(Oryzasativa),Planta

Wu,J.H.,Li,X.S.,Zhao,Y.,Zhang,W.,Guo,L.,andFeng,Y.Q.(2011)Applicationofliquidphasedepositedtitaniananoparticlesonsilicaspherestophosphopeptideenrichmentandhighperformanceliquidchromatographypackings,JChromatogrA1218,2944-2953

Shao,J.,Zhang,Y.,Yu,J.,Guo,L.,andDing,Y.(2011)IsolationofThylakoidMembraneComplexesfromRicebyaNewDouble-StripsBN/SDS-PAGEandBioinformaticsPredictionofStromalRidgeSubunitsInteraction,PLoSOne6,e20342

Chen,X.,Wu,D.,Zhao,Y.,Wong,B.H.,andGuo,L.(2011)IncreasingphosphoproteomecoverageandidentificationofphosphorylationmotifsthroughcombinationofdifferentHPLCfractionationmethods,JChromatogrBAnalytTechnolBiomedLifeSci879,25-34

Wu,J.H.,Zhao,Y.,Li,T.,Xu,C.,Xiao,K.,Feng,Y.Q.,andGuo,L.(2010)Theuseofliquidphasedepositionpreparedphosphonategraftedsilicananoparticle-depositedcapillariesintheenrichmentofphosphopeptides,JSepSci33,1806-1815

Wang,R.,Deng,F.,Hou,D.,Zhao,Y.,Guo,L.,Wang,H.,andHu,Z.(2010)ProteomicsoftheAutographacalifornicanucleopolyhedrovirusbuddedvirions,JVirol84,7233-7242

Ma,Y.,Zhao,Y.,Zhao,R.,Zhang,W.,He,Y.,Wu,Y.,Cao,Z.,Guo,L.,andLi,W.(2010)MoleculardiversityoftoxiccomponentsfromthescorpionHeterometruspetersiivenomrevealedbyproteomicandtranscriptomeanalysis,Proteomics10,2471-2485

Zhou,Z.,Fan,J.B.,Zhu,H.L.,Shewmaker,F.,Yan,X.,Chen,X.,Chen,J.,Xiao,G.F.,Guo,L.,andLiang,Y.(2009)Crowdedcell-likeenvironmentacceleratesthenucleationstepofamyloidogenicproteinmisfolding,JBiolChem284,30148-30158

Deng,M.,Li,F.,Ballif,B.A.,Li,S.,Chen,X.,Guo,L.,andYe,X.(2009)Identificationandfunctionalanalysisofanovelcycline/cdk2substrateankrd17,JBiolChem284,7875-7888

Lin,B.,Li,T.,Zhao,Y.,Huang,F.K.,Guo,L.,andFeng,Y.Q.(2008)PreparationofaTiO2nanoparticle-depositedcapillarycolumnbyliquidphasedepositionanditsapplicationinphosphopeptideanalysis,JChromatogrA1192,95-102

Deng,F.,Wang,R.,Fang,M.,Jiang,Y.,Xu,X.,Wang,H.,Chen,X.,Arif,B.M.,Guo,L.,andHu,Z.(2007)ProteomicsanalysisofHelicoverpaarmigerasinglenucleocapsidnucleopolyhedrovirusidentifiedtwonewocclusion-derivedvirus-associatedproteins,HA44andHA100,JVirol81,9377-9385