职称职务：博士、教授（PhD,Professor）
　　学科专业：生物化学与分子生物学
　　科研方向：血细胞生成和恶变、肿瘤发生
　　　　　　　(Hematopoiesisandpathogenesisof
　　　　　　　hematopoieticmalignancies;
　　　　　　　Tumorigenesis)

　　实验室位置：生命科学学院5021、5130室
　　联系电话:**

　　Email:z-huangATwhu.edu.cn



学习经历：
1990－1994武汉大学生命科学学院学士1994－1998武汉大学生命科学学院硕士
2001－2006LoyolaUniversityChicago博士
2006UniversityofChicago博士后
2007－2010NorthwesternUniversity博士后

主要工作经历与任职情况：
1998－2000上海市儿童医院、上海市医学遗传研究所讲师2001LoyolaUniversityChicago研究助理
2010－至今武汉大学生命科学学院教授

主要研究领域及兴趣：
　　本实验室研究方向是血细胞生成和功能调控的分子机制、肿瘤和血液恶性病变（包括骨髓增殖性肿瘤、骨髓异常综合症、急性髓系白血病）发生机理和干预，目前主要研究内容有：1）血细胞生成的分子机制：主要集中在造血干/祖细胞向成熟巨核细胞发育分化中的信号转导、转录调控、表观遗传调控，鉴定巨核细胞发育、增殖、分化中的新功能分子及其作用的分子机制。
2）血细胞恶性病变发生的分子机制和干预的基础研究：主要研究骨髓增殖性肿瘤（原发性骨髓纤维化）和骨髓增殖异常综合症中巨核细胞生成异常的分子基础及其对疾病发生的作用和机理，探讨靶向巨核细胞生成异常来治疗这类疾病的可行性。其次，研究影响急性白血病细胞增殖、存活和恶变的新分子功能，为相关疾病诊疗提供生物学标志物或靶标。?
3）胚胎发育相关新基因功能和作用机理研究：实验室建立了完整的人类和小鼠胚胎发育表达谱数据库，鉴定了一系列与胚胎发育密切相关的新基因，开展了新基因在血细胞生成、免疫反应和肿瘤发生中的功能和作用机理的研究。

Researchinterests:
Ourlaboratoryfocusesonthemolecularmechanismofhematopoieticcelldevelopmentandfunctionregulationaswellaspathogenesisofhematopoieticmalignanciesincludingacutemyeloidleukemia,myeloproliferativeneoplasm,myelodysplasticsyndrome,andtumorigenesis.Majorprojectsincludes:
1.Hematopoiesis:Signaltransduction,transcriptionalandepigeneticregulationofmegakaryopoiesis,particularlyinterestedinfunctionandmechanismstudyonnovelgenescontrollingmegakaryocytedevelopment,proliferation,anddifferentiation.
2.Pathogenesisandinterventionofhematopoieticmalignancies:Dissectthemolecularmechanismofaberrantmegakaryopoiesisinmyeloproliferativeneoplasmandmyelodysplasticsyndromeandwhat’sroleandhowitact;investigatetheinterventionofthesediseasebytargetingabnormalmegakaryocytes.FunctionstudyonnovelmoleculesaffectingAcuteMyeloidLeukemiacellproliferation,survivalortransformationtoprovidetargetorbiomarkerfortherapyordiagnosis.
3.Studyonthefunctionandmechanismofnovelembryodevelopment-relatedgenes:Wehaveanalyzedtheexpressionprofileofhumanandmouseembryodevelopmentandidentifiednovelgenesassociatedwithembryodevelopment.Wewillfurtherexplorethefunctionandmechanismofthesegenesinhematopoiesis,hematopoieticmalignancies,immunity,andtumorigenesis.

承担课程（coursedirector）：
1、生物化学（本科）Biochemistryforundergraduates
2、造血细胞发育与分化（研究生）Hematopoiesisforgraduates

主持课题项目（funding）：
1.自然科学青年基金（2008-2010）NaturalScienceFoundationCommittee2.自然科学基金面上项目（2011-2013）NaturalScienceFoundationCommittee
3.自然科学基金面上项目（2014-2017）NaturalScienceFoundationCommittee
4.教育部博士点基金（2012-2014）Ph.D.ProgramsFoundation
5.教育部“新世纪优秀人才支持计划”（2013-2015）NewCenturyExcellentTalentsinUniversity

代表性论文（SelectedPublications）:
1.LuB,SunX,ChenY,JinQ,LiangQ,LiuS,LiY,ZhouY,LiW,HuangZ.NovelfunctionofPITHdomain-containing1asanactivatorofinternalribosomalentrysitetoenhanceRUNX1expressionandpromotemegakaryocytedifferentiation.CellularandMolecularLifeSciences:CMLS.2015.72(4):821-832
2.LinY,LiD,LiangQ,LiuS,ZuoX,LiL,SunX,LiW,GuoM,HuangZ.miR-638RegulatesDifferentiationandProliferationinLeukemicCellsbyTargetingCyclin-dependentKinase2.TheJournalofbiologicalchemistry.2015.290(3):1818-1828

3.SunX,LuB,HuB,XiaoW,LiW,HuangZ.Novelfunctionofthechromosome7openreadingframe41genetopromoteleukemicmegakaryocytedifferentiationbymodulatingTPA-inducedsignaling.BloodCancerJournal.2014.4:e198

4.LiuL,WenQ,GongR,GillesL,StankiewiczMJ,LiW,GuoM,LiL,SunX,CrispinoJD,HuangZ.PSTPIP2dysregulationcontributestoaberrantterminaldifferentiationinGATA-1-deficientmegakaryocytesbyactivatingLYN.CellDeath&Disease.2014.5:e988

5.CaiJ,GongR,YanF,YuC,LiuL,WangW,LinY,GuoM,LiW,HuangZ.ZNF300KnockdownInhibitsForcedMegakaryocyticDifferentiationbyPhorbolandErythrocyticDifferentiationbyArabinofuranosylCytidineinK562Cells.PLoSOne.2014.9(12):e114768

6.WangW,CaiJ,WuY,HuL,ChenZ,HuJ,LiW,GuoM,HuangZ.NovelactivityofKRABdomainthatfunctionstoreinforcenuclearlocalizationofKRAB-containingzincfingerproteinsbyinteractingwithKAP1.CellularandMolecularLifeSciences:CMLS.2013.70(20):3947-3958

7.KhanI,HuangZ,WenQ,StankiewiczMJ,GillesL,GoldensonB,SchultzR,DieboldL,GurbuxaniS,FinkeCM,LashoTL,KoppikarP,PardananiA,SteinB,AltmanJK,LevineRL,TefferiA,CrispinoJD.AKTisatherapeutictargetinmyeloproliferativeneoplasms.Leukemia.2013.27(9):1882-1890

8.WenQ,GoldensonB,SilverSJ,SchenoneM,DancikV,HuangZ,WangLZ,LewisTA,AnWF,LiX,BrayMA,ThiollierC,DieboldL,GillesL,VokesMS,MooreCB,Bliss-MoreauM,VerplankL,TollidayNJ,MishraR,VemulaS,ShiJ,WeiL,KapurR,LopezCK,GerbyB,BalleriniP,PflumioF,GillilandDG,GoldbergL,BirgerY,IzraeliS,GamisAS,SmithFO,WoodsWG,TaubJ,SchererCA,BradnerJE,GohBC,MercherT,CarpenterAE,GouldRJ,ClemonsPA,CarrSA,RootDE,SchreiberSL,SternAM,CrispinoJD.IdentificationofRegulatorsofPolyploidizationPresentsTherapeuticTargetsforTreatmentofAMKL.Cell.2012.150(3):575-589

9.WangW,GuoM,HuL,CaiJ,ZengY,LuoJ,ShuZ,LiW,HuangZ.ThezincfingerproteinZNF268isoverexpressedinhumancervicalcancerandcontributestotumorigenesisviaenhancingNF-kappaBsignaling.JBiolChem.2012.287(51):42856-42866

10.SmallS,KeerthivasanG,HuangZ,GurbuxaniS,CrispinoJD.Overexpressionofsurvivininitiateshematologicmalignanciesinvivo.Leukemia.2010.24(11):1920-1926

11.MaD,HuangH,HuangZ.STAT1signalingisrequiredforoptimalTh1celldifferentiationinmice.ChineseScienceBulletin.2010.55(11):1032-1040

12.HuangQQ,PerlmanH,HuangZ,BirkettR,KanL,AgrawalH,MisharinA,GurbuxaniS,CrispinoJD,PopeRM.FLIP:anovelregulatorofmacrophagedifferentiationandgranulocytehomeostasis.Blood.2010.116(23):4968-4977

13.GaoZ,HuangZ,OliveyHE,GurbuxaniS,CrispinoJD,SvenssonEC.FOG-1-mediatedrecruitmentofNuRDisrequiredforcelllineagere-enforcementduringhaematopoiesis.EMBOJ.2010.29(2):457-468

14.HuangZ,DoreLC,LiZ,OrkinSH,FengG,LinS,CrispinoJD.GATA-2reinforcesmegakaryocytedevelopmentintheabsenceofGATA-1.MolCellBiol.2009;29(18):5168-5180.

15.ChouST,KhandrosE,BaileyLC,NicholsKE,VakocCR,YaoY,HuangZ,CrispinoJD,HardisonRC,BlobelGA,WeissMJ.GradedrepressionofPU.1/Sfpi1genetranscriptionbyGATAfactorsregulateshematopoieticcellfate.Blood.2009;114(5):983-994.

16.HuangZ,RichmondTD,MunteanAG,BarberDL,WeissMJ,CrispinoJD.STAT1promotesmegakaryopoiesisdownstreamofGATA-1inmice.JClinInvest.2007;117(12):3890-3899.

17.HuangZ,XinJ,ColemanJ,HuangH.IFN-gammasuppressesSTAT6phosphorylationbyinhibitingitsrecruitmenttotheIL-4receptor.JImmunol.2005;174(3):1332-1337.

18.HuangZ,ColemanJM,SuY,MannM,RyanJ,ShultzLD,HuangH.SHP-1regulatesSTAT6phosphorylationandIL-4-mediatedfunctioninacelltype-specificmanner.Cytokine.2005;29(3):118-124.

专利（Patent）：
JohnD.Crispino，QiangWen，ZanHuang，AndrewM.RobertJ.Stern，Dimethylfasudilforinducingpolyploidizationofmegakaryocytesandfortreatingbloodandbonemarrowdiseasesanddisorders，UnitedStates，**。