职称职务：教授
　学科专业：发育神经生物学、干细胞生物学
　研究方向：神经干细胞的命运决定
　实验室位置：生命科学学院1130室
　联系方式：**
Email:　yan.zhou@whu.edu.cn



学习经历：
2000－2002中国协和医科大学医学博士
1997－2000中国协和医科大学理学博士
1991－1997同济医科大学医学学士

主要工作经历与任职情况：
2011至今：武汉大学生命科学学院教授、博士生导师
2007－2011：耶鲁大学副研究科学家(AssociateResearchScientist)
2002－2007：耶鲁大学博士后

主要研究领域及兴趣：
　　本实验室主要应用胚胎学、遗传学和细胞生物学手段研究哺乳动物神经系统发育过程中，神经干细胞如何进行命运选择，特别是神经干细胞如何应用非对称细胞分裂产生分化细胞并同时自我更新。主要研究领域包括：
1）各种外源信号和内源命运决定因子如何共同影响神经干细胞的命运决定；
2）非编码RNA如何调控神经干细胞非对称分裂；
3）神经系统肿瘤发生发展过程中，肿瘤干细胞样细胞的生物学特性。

Ourlong-termgoalistounderstandthemolecularandcellularmechanismsthatgovernthedevelopmentofthemammalianneocortexandthenatureofneuralstem/progenitorcells.TheknowledgeofthesemechanismswouldhelptodeveloprevolutionaryapproachesintreatingcurrentlyincurableneuraldisordersincludingAlzeimer’sdementia,Parkinson’sDiseaseandbraintumors.Inthenearterm,wewillfocusonhowasymmetriccelldivisionregulatesself-renewalofneuralstemcellsandproductionofdifferentiatedcellsusingembryonic,cellularandgeneticapproaches.

主持课题项目：
承担国家重点基础研究发展计划（973）项目子课题和国家自然科学基金面上项目

代表性论文:
1.Zhou,Y.(2012)Corticaldevelopmentandasymmetriccelldivision.FrontiersinBiology.7(4):297-306

2.Zhou,Y.,Atkins,J.,Rompani,S.,Bancescu,D.,Tang,H.,Petersen,P.,Zou,K.,Stewart,S.,Zhong,W.(2007)ThemammalianGolgiregulatesNumbsignalinginasymmetriccelldivisionbyreleasingACBD3duringmitosis.Cell129(1):163-78

3.Zhou,Y.,Du,G.,Hu,X.,Yu,S.,Liu,Y.,Xu,Y.,Huang,X.,Liu,J.,Yin,B.,Fan,M.,Peng,X.,Qiang,B.,Yuan,J.(2005)Nectin-likemolecule1isaprotein4.1Nassociatedproteinandrecruitsprotein4.1Nfromcytoplasmtotheplasmamembrane.BiochimicaetBiophysicaActa-Biomembranes,1669(2):142-54

4.Tang,H.,Rompani,S.B.,Atkins,J.B.,Zhou,Y.,Osterwalder,T.,andZhong,W.(2005).NumbProteinsSpecifyAsymmetricCellFatesviaanEndocytosis-andProteasome-IndependentPathway.MolecularCellularBiology25:2899-2909.

5.Yang,H.,Zhou,Y.,Hu,X.,Xu,Y.,Yin,B.,Zhu,S.,Fan,W.,Fan,M.,Qiang,B.,Yuan,J.,andPeng,X.(2005)Humannectin-like1,anovelmembraneproteininteractingwithprotein4.1R.ProgressinNaturalScience,15(2):189-192.

6.Huang,X.,Yang,H.,Zhou,Y.,Liu,J.,Yin,B.,Peng,X.,Qiang,B.,andYuan,J.(2004).Overexpressionofhumanreticulon3(hRTN3)inastrocytoma.ClinicalNeuropathology,23:1-7.

7.Zhou,Y.,Hu,S.,Huang,X.,Zhou,H.,Tan,X.,Peng,X.,Qiang,B.,Yuan,J.(2002)ConstructionofhumanandmousebraincDNAlibrariesandisolationoffull-lengthcDNAs.ProgressinNaturalScience,12(6):477-480

8.Liu,Y.,Fan,M.,Yu,S.,Zhou,Y.,Wang,J.,Yuan,J.,andQiang,B.(2002).cDNAcloning,chromosomallocalizationandexpressionpatternanalysisofhumanLIM-homeoboxgeneLHX4.BrainResearch928:147-155.

9.Wang,J.,Zhou,Y.,Yin,B.,Du,G.,Huang,X.,Li,G.,Shen,Y.,Yuan,J.,andQiang,B.(2001).ASH2L:alternativesplicinganddownregulationduringinducedmegakaryocyticdifferentiationofmultipotentialleukemiacelllines.JournalofMolecularMedicine,79,399-405.

10.Liu,Y.,Yu,S.,Zhou,Y.,Wang,J.,Liu,S.,Yuan,J.,Qiang,B,Fan,M.(2001).cDNAisolation,chromosomalmappingandgenomicanalysisofhumanhomeoboxgeneLHX4.ChineseJournalofBiochemistryandMolecularBiology,17(5):552-556

11.Zhou,H.,Huang,X.,Zhou,Y.,Li,G.,Yin,B.,Ma,Y.,Peng,X.,Yuan,J.,Qiang,B.CloningandprokaryoticexpressionofHGLPcDNA.(2001)ChineseScienceBulletin,46(13),1089-1092

12.Du,G.,Pan,M.,Zhou,Y.,Chen,J.,Yao,H.,Yuan,J.,Qiang,B.(2000)CloningofhumanandmouseGRY-RBPcDNA.ChineseScienceBulletin,45(4),343-350

13.Chen,J.,Luo,W.,Zhou,Y.,Tan,X.,Li,G.,Huang,X.,Zhou,H.,Li,W.,Yuan,J.,Qiang,B.(2000)CloningandeukaryoticexpressionofHumanHCLcDNA.ProgressinNaturalScience,10(11):1001-1005

14.Du,G.,Zhou,Y.,Chen,J.,Wang,J.,Yin,B.,Yuan,J.,Qiang,B.(2000).ClonngandexpressionanalysisofMBLLcDNA.ChineseScienceBulletin,45(7):620-625.

15.Du,G.,Zhou,Y.,Chen,J.,Wang,J.,Huang,X.,Yuan,J.,Qiang,B.(1999)ExpressionofhumanGRY-RBPandanalysisofitsRNAbindingactivities.ChineseJournalofBiochemistryandMolecularBiology,15(6):866-870

16.Zhou,Y.,Du,G.,Wang,J.,Chen,J.,Yuan,J.,Qiang,B.(1999)IsolationandcloningofanovelcDNALDB1encodinghumanLIMdomainbindingprotein.ChineseScienceBulletin,44(12):1114-1119.

17.Wang,J.,Du,G.,Zhou,Y.,Yin,B.,Yuan,J.,Qiang,B.(1999)CloningandidentificationofPHF2cDNAanditsalternativelysplicedtranscripts.ChineseScienceBulletin,44(15),1382-1387

18.《基因组学》主译：袁建刚周严强伯勤(原著：GenomesbyBrown,T.A.,2000)ISBN7-03-010114-6/Q.1136,507页