职称职务：教授
学科专业：微生物学
研究方向：极端古菌分子生物学，重点探讨极端嗜盐、嗜热古菌适应极端环境的分子
机理，目前正致力于极端古菌蛋白分泌机制的研究。
实验室位置：生科院6012室
联系电话：**
E-mail：tangxf@whu.edu.cn　

学习经历
1996.10-2001.3日本京都大学大学院工学研究科合成及生物化学专业博士
1989.9-1992.7武汉大学生命科学学院微生物学专业硕士
1985.9-1989.7武汉大学生物系微生物学专业学士

工作经历
2003.11-现在武汉大学生命科学学院微生物学系副教授、教授
2001.4-2003.8日本国立产业技术综合研究所生物情报解析研究中心博士后(JSPSFellow)
1992.7-1996.9武汉大学生命科学学院微生物学系助教、讲师

承担课程
1、Microbiology，全英文教学，本科生
2、微生物学实验，本科生
3、生命科学导论（部分），全校通识课
4、高级微生物（部分），硕士研究生

教学获奖
1、2013年湖北省高等学校教学成果一等奖（排名二）
2、2008年国家级教学团队（微生物学系列课程教学团队主要成员）
3、2005年国家级教学成果二等奖（排名第三）
4、2005年湖北省高等学校教学成果一等奖（排名第三）

主持和参加课题
　　主持国家自然科学基金3项、教育部留学回国人员科研启动基金1项，参加973项目子项目。主持武汉大学教改项目1项，参加多项国家级省部级教改项目。

主要社会兼职
　　中国微生物学会会员，美国微生物学会(AmericanSocietyforMicrobiology)会员，中国遗传学会会员。

发表的论文（*通讯作者）
1.DuX,LiM,TangW,ZhangY,ZhangL,WangJ,LiT,TangB,TangXF*.(2015)SecretionofTat-dependenthalolysinSptAcapableofautocatalyticactivationanditsrelationtohaloarchaealgrowth.MolMicrobiol.96(3):548-65.
2.ZhangY,WangM,DuX,TangW,ZhangL,LiM,WangJ,TangB,TangXF*.(2014)Chitinacceleratesactivationofanovelhaloarchaealserineproteasethatdeproteinizeschitin-containingbiomass.ApplEnvironMicrobiol.80(18):5698-708.

3.ZengJ,GaoX,DaiZ,TangB,TangXF*.(2014)Effectsofmetalionsonstabilityandactivityofhyperthermophilicpyrolysinandfurtherstabilizationofthisenzymebymodi?cationofaCa²⁺-bindingsite.ApplEnvironMicrobiol80(9):2763-72.

4.FengJ,WangJ,ZhangY,DuX,XuZ,WuY,TangW,LiM,TangB,TangXF*.(2014)ProteomicanalysisofthesecretomeofhaloarchaeonNatrinemasp.J7?2.JProteomeRes13(3):1248-58.

5.FengJ,LiuB,ZhangZ,RenY,LiY,GanF,HuangY,ChenX,ShenP,WangL,TangB*,TangXF*.(2012)ThecompletegenomesequenceofNatrinemasp.J7-2,ahaloarchaeoncapableofgrowthonsyntheticmediawithoutaminoacidsupplements.PLoSONE7(7):e41621.Epub2012Jul23.

6.DaiZ,FuH,ZhangY,ZengJ,TangB,TangXF*.(2012)InsightsintothematurationofhyperthermophilicpyrolysinandtherolesofitsN-terminalpropeptideandlongC-terminalextension.ApplEnvironMicrobiol78(12):4233-41.

7.XuZ,DuX,LiT,GanF,TangB,TangXF*.(2011)FunctionalInsightintotheC-TerminalExtensionofHalolysinSptAfromHaloarchaeonNatrinemasp.J7.PLoSONE6(8):e23562.Epub2011Aug19.

8.WangL,ChengG,RenY,DaiZ,ZhaoZS,LiuF,LiS,WeiY,XiongJ,TangXF,TangB*.(2015)DegradationofintactchickenfeathersbyThermoactinomycessp.CDFandcharacterizationofitskeratinolyticprotease.ApplMicrobiolBiotechnol99(9):3949-59.

9.ZhuH,XuBL,LiangX,YangYR,TangXF,TangB*.(2013)Molecularbasisforauto-andhetero-catalyticmaturationofathermostablesubtilasefromthermophilicBacillussp.WF146.JBiolChem288(48):34826-38.

10.LiXG*,YangJ,WangR,TangXF,MengJJ,QinHJ,LiuX,GuoF,WanSB*.(2013)Effectsofectopicallyexpressedhyperthermophilicarchaeon(Pyrococcusfuriosus)ribulose-1,5-bisphosphatecarboxylase/oxygenaseontobaccophotosynthesis.Photosynthetica51(3):387-94.

11.LiangX,BianY,TangXF,XiaoG,TangB*.(2010)Enhancementofkeratinolyticactivityofathermophilicsubtilasebyimprovingitsautolysisresistanceandthermostabilityunderreducingconditions.ApplMicrobiolBiotechnol87:999–1006.

12.FangN,ZhongCQ,LiangX,TangXF,TangB*.(2010)ImprovementofextracellularproductionofathermophilicsubtilaseexpressedinEscherichiacolibyrandommutagenesisofitsN-terminalpropeptide.ApplMicrobiolBiotechnol85(5):1473-81.

13.ZhongCQ,SongS,FangN,LiangX,ZhuH,TangXF,TangB*.(2009)Improvementoflow-temperaturecaseinolyticactivityofathermophilicsubtilasebydirectedevolutionandsite-directedmutagenesis.BiotechnolBioeng104(5):862-70.

14.ChengG,ZhaoP,TangXF,TangB*.(2009)Identificationandcharacterizationofanovelspore-associatedsubtilasefromThermoactinomycessp.CDF.Microbiology-SGM55:3661-72.

15.ZengC,ZhaoYZ,CuiCZ,ZhanH,ZhuJY,TangXF,ShenP,HuangYP*,ChenXD*.(2009)CharacterizationoftheHaloarculahispanicaamyHgenepromoter,anarchaealpromoterthatconferspromoteractivityinEscherichiacoli.Gene442:1–7.

16.YangYR,ZhuH,FangN,LiangX,ZhongCQ,TangXF,ShenP,TangB*.(2008)Cold-adaptedmaturationofthermophilicWF146proteasebymimickingthepropeptidebindinginteractionsofpsychrophilicsubtilisinS41.FEBSLett582(17):2620-6.

17.ShiW,TangXF,HuangY,GanF,TangB*,ShenP.（2006）AnextracellularhalophilicproteaseSptAfromahalophilicarchaeonNatrinemasp.J7:genecloning,expressionandcharacterization.Extremophiles10:599–606.

18.BianY,LiangX,FangN,TangXF,TangB*,ShenP,PengZ.（2006）TherolesofsurfaceloopinsertionsanddisulfidebondinthestabilizationofthermophilicWF146protease.FEBSLett580:6007–14.

19.TangXF,ShenY,MatsuiE,MatsuiI*.(2004)DomaintopologyoftheDNApolymeraseDcomplexfromahyperthermophilicarchaeonPyrococcushorikoshii.Biochemistry43(37):11818-27.

20.ShenY,TangXF,YokoyamaH,MatsuiE,MatsuiI*.(2004)A21-aminoacidpeptidefromthecysteineclusterIIofthefamilyDDNApolymerasefromPyrococcushorikoshiistimulatesitsnucleaseactivitywhichisMre11-likeandprefersmanganeseionasthecofactor.NucleicAcidsRes32:158-68.

21.ShenY,TangXF,MatsuiE,MatsuiI*.(2004)SubunitinteractionandregulationofactivitythroughterminaldomainsofthefamilyDDNApolymerasefromPyrococcushorikoshii.BiochemSocTrans32:245-9.

22.ShenY,TangXF,MatsuiI*.(2003)SubunitinteractionandregulationofactivitythroughterminaldomainsoffamilyDDNApolymerasefromPyrococcushorikoshii.JBiolChem278:21247-57.

23.TangXF,EzakiS,AtomiH,ImanakaT*.(2001)AnthranilatesynthasewithoutanLLESmotiffromahyperthermophilicarchaeonisinhibitedbytryptophan.BiochemBiophysResCommun281:858-65.

24.MatsudaT,FujikawaM,HarukiM,TangXF,EzakiS,ImanakaT,MorikawaM,KanayaS*.(2001)InteractionofTIP26fromahyperthermophilicarchaeonwithTFB/TBP/DNAternarycomplex.Extremophiles5:177-82.

25.TangXF,EzakiS,AtomiH,ImanakaT*.(2000)Biochemicalanalysisofathermostabletryptophansynthasefromahyperthermophilicarchaeon.EurJBiochem267:6369-77.

26.TangX,EzakiS,FujiwaraS,TakagiM,AtomiH,ImanakaT*.(1999)ThetryptophanbiosynthesisgeneclustertrpCDEGFBAfromPyrococcuskodakaraensisKOD1isregulatedatthetranscriptionallevelandexpressedasasinglemRNA.MolGenGenet262:815-21.