职　　称：教授、博士、国家优秀青年基金获得者
　　　　　Professor,PhD
学科专业：微生物学/病毒学
研究方向：病毒感染及其防治
实验室位置：生命科学学院大楼5114房间
联系电话/Tel：86-**(Lab)
Email:zjcao@whu.edu.cn

教育经历/Education：
1999/09-2004/06，武汉大学，博士/WuhanUniversity,PhD
1994/09-1998/07，武汉大学，学士/WuhanUniversity,Bachelor'sDegree

工作经历/ProfessionalExperience：
2004/07-至今：武汉大学生命科学学院/CollegeofLifeSciences,WuhanUniversity
2014/02-2015/01：美国梅哈里医学院/MeharryMedicalCollege,USA
1998/07-1999/08：湖南省畜牧兽医研究所/AnimalhusbandryandveterinaryinstituteofHunanprovince

研究方向/ResearchFields：
1)病毒感染及其防治/Viralinfection,preventionandcure
2)抗病原微生物多肽的药用基础/Medicinalbasisofpeptidesagainstpathogenvirusesandbacteria
3)毒素多肽生物学/Toxicpeptidebiology

基金资助/Fundsupport：
1)国家优秀青年基金：蝎毒素遗传资源的保护、认识与利用研究
2)湖北省杰出青年基金：靶向抗肿瘤蝎氯毒素的药用基础研究
3)中央高校基本科研基金：蝎毒素多肽的药用基础研究

研究概述/ResearchDescription：
我过去以蝎为代表开展毒素多肽生物学研究，创建了蝎毒素多肽资源库，发现了蝎毒素多肽的分子多样性，首绘了蝎全基因组图谱，揭示了蝎毒素多肽分子多样性的产生机制，发掘了蝎毒素多肽的抗肿瘤、抗菌、抗病毒功能及作用机制，开拓了蝎毒素多肽研究和药用新领域。现在主要开展离子通道在病毒感染中作用以及在此基础上抗病毒多肽的筛选与设计研究。/Before,Ifocusedonthebiologyoftoxinpeptides(e.g.scorpion),involvinginthelibraryconstruction,diversityanditsmechanism,pharmacologicalrolesandtheirmechanismsofscorpiontoxins.Today,Iaminterestinginthefunctionsofionchannelsintheinfectionsofviruses,andthenthediscoveryofantiviralpeptides.

代表性学术论文/SelectedPublications：
1)SongY,GongK,YanH,HongW,WangL,WuYL,LiWH*,LiWX*,CaoZJ*.(2014).Sj7170,auniquedual-functionalpeptidewithaspecificα-chymotrypsininhibitoryactivityandapotenttumoractivatingeffectfromscorpionvenom.JBiolChem.289(17):11667-80.
2)CaoZ^#,YuY^#,WuY^#,HaoP^#,DiZ^#,HeY^#,ChenZ,YangW,ShenZ,HeX,ShengJ,XuX,PanB,FengJ,YangX,HongW,ZhaoW,LiZ,HuangK,LiT,KongY,LiuH,JiangD,ZhangB,HuJ,HuY,WangB,DaiJ,YuanB,FengY,HuangW,XingX,ZhaoG,LiX,LiY,LiW.(2013).ThegenomeofMesobuthusmartensiirevealsauniqueadaptationmodelofarthropods.NatCommun.4:2602.

3)HongW,ZhangR,DiZ,HeY,ZhaoZ,HuJ,WuY,LiW,CaoZ*.(2013).Designofhistidine-richpeptideswithenhancedbioavailabilityandinhibitoryactivityagainsthepatitisCvirus.Biomaterials.34(13):3511-3522.

4)HeY,ZhaoR,DiZ,LiZ,XuX,HongW,WuY,ZhaoH,LiW,CaoZ*.(2013).MoleculardiversityofChaerilidaevenompeptidesrevealsthedynamicevolutionofscorpionvenomcomponentsfromButhidaetonon-Buthidae.JProteomics.89:1-14.

5)ZhaoZ,HongW,ZengZ,WuY,HuK,TianX,LiW*,CaoZ*.(2012).Mucroporin-M1inhibitsHepatitisBvirusreplicationbyactivatingthemitogen-activatedproteinkinase(MAPK)Pathwayanddown-regulatingHNF4αinvitroandinvivo.JBiolChem.287(36):30181-30190.

6)FanZ,CaoL,HeY,HuJ,DiZ,WuY,LiW*,CaoZ*.(2011).Ctriporin,anewanti-methicillin-resistantStaphylococcusaureuspeptidefromthevenomofthescorpionChaerilustricostatus.AntimicrobAgentsChemother.55(11):5220-5229.

7)YuXF,SunZ,LiM,XiangY,WangQQ,TangF,WuY,CaoZ*,LiW*.(2010).Neurotoxin-conjugatedupconversionnanoprobesfordirectvisualizationoftumorsundernear-infraredirradiation.Biomaterials.31(33):8724-8731.

8)DiZ,YuY,WuY,HaoP,HeY,ZhaoH,LiY,ZhaoG,LiX*,LiW*,CaoZ*.Genome-wideanalysisofhomeoboxgenesfromMesobuthusmartensiirevealsHoxgeneduplicationinscorpions.InsectBiochemMolBiol.2015Jun;61:25-33.

9)HongW,LiT,SongY,ZhangR,ZengZ,HanS,ZhangX,WuY,LiW,CaoZ*.Inhibitoryactivityandmechanismoftwoscorpionvenompeptidesagainstherpessimplexvirustype1.AntiviralRes.102:1-10,2014.

10)MaY,HeY,ZhaoR,WuY,LiW*,CaoZ*.Extremediversityofscorpionvenompeptidesandproteinsrevealedbytranscriptomicanalysis:Implicationforproteomeevolutionofscorpionvenomarsenal.JProteomics.75(5):1563-1576,2012.

11)ZhaoR,MaY,HeY,DiZ,WuY,CaoZ*,LiW*.ComparativevenomglandtranscriptomeanalysisofthescorpionLychasmucronatusrevealsintraspecifictoxicgenediversityandnewvenomouscomponents.BMCGenomics.11:452,2010.

12)MaY,ZhaoY,ZhaoR,ZhangW,HeY,WuY,CaoZ*,GuoL*,LiW*.MoleculardiversityoftoxiccomponentsfromthescorpionHeterometruspetersiivenomrevealedbyproteomicandtranscriptomeanalysis.Proteomics.10(13):2471-2485,2010.

13)LiZ,XuX,MengL,ZhangQ,CaoL,LiW,WuY,CaoZ*.Hp1404,anewantimicrobialpeptidefromthescorpionHeterometruspetersii.PLoSOne.9(5):e97539,2014.

14)ChenY,CaoL,ZhongM,ZhangY,HanC,LiQ,YangJ,ZhouD,ShiW,HeB,LiuF,YuJ,SunY,CaoY,LiY,LiW,GuoD,CaoZ*,YanH*.Anti-HIV-1activityofanewscorpionvenompeptidederivativeKn2-7.PLoSOne.7(4):e34947,2012.

15)CaoL,DaiC,LiZ,FanZ,SongY,WuY,CaoZ*,LiW*.AntibacterialactivityandmechanismofascorpionvenomPeptidederivativeinvitroandinvivo.PLoSOne.7(7):e40135,2012.

16)ZhaoR,DaiH,QiuS,LiT,HeY,MaY,ChenZ,WuY,LiW*,CaoZ*.SdPI,thefirstfunctionallycharacterizedKunitz-typetrypsininhibitorfromscorpionvenom.PLoSOne.6(11):e27548,2011.

17)CaoZ^#,DiZ,WuY,LiW.OverviewofscorpionspeciesfromChinaandtheirtoxins.Toxins(Basel).6(3):796-815,2014.

18)CaoL,LiZ,ZhangR,WuY,LiW,CaoZ*.StCT2,anewantibacterialpeptidecharacterizedfromthevenomofthescorpionScorpiopstibetanus.Peptides.36(2):213-220,2012.

19)YanR,ZhaoZ,HeY,WuL,CaiD,HongW,WuY,CaoZ*,ZhengC*,LiW*.Anewnaturalα-helicalpeptidefromthevenomofthescorpionHeterometruspetersiikillsHCV.Peptides.32:11-19,2011.

20)YuanW,CaoL,MaY,MaoP,WangW,ZhaoR,WuY,CaoZ*,LiW*.CloningandfunctionalcharacterizationofanewantimicrobialpeptidegeneStCT1fromthevenomofthescorpionScorpiopstibetanus.Peptides.31(1):22-26,2010.

21)ChenZ,HuY,HanS,YinS,HeY,WuY,CaoZ*LiW*.ImKTx1,anewKv1.3channelblockerwithauniqueprimarystructure.JBiochemMolToxicol.25(4):244-251,2011.