职称职务：特聘教授，博导，病毒学国家重点实验室副主任
出　　生：1965年4月于河南省
学　　位：博士
毕业学校：联邦德国布伦瑞克理工大学
学科专业：微生物学、病毒学、分子生物学
实验室位置：生科院大楼4026

联系电话：办公室电话：**（O）；**（O）
实验室电话：**
Email:dguo@whu.edu.cn
Labpage:http://virology.whu.edu.cn

主要研究领域：
RNA病毒（冠状病毒和丙肝病毒）的基因组复制和与宿主细胞相互作用的分子机理；
病毒免疫逃逸的分子机制；
基于RNA干扰（RNAi）的艾滋病毒基因治疗。


近五年主要论文：
1.YuChen,HuiCai,Ji’anPan,NianXiang,PoTien,TeroAhola,DeyinGuo(2009).FunctionalscreenrevealsSARScoronavirusnonstructuralproteinnsp14asanovelcapN7methyltransferase.ProceedingsoftheNationalAcademyofSciencesoftheUnitedStatesofAmerica106,3484-9.

2.JunweiLi,MusaratIshaq,MabialaPrudence,XiaoXi,TaoHu,QingzhenLiu,DeyinGuo(2009)Singlemutationattheaminoacidposition627ofPB2thatleadstoincreasedvirulenceofanH5N1avianinfluenzavirusduringadaptationinmicecanbecompensatedbymultiplemutationsatothersitesofPB2.VirusResearch144,123-9.

3.TaoHu,QiongFu,PingChen,LiMa,OnsamSinandDeyinGuo(2009)ConstructionofanArtificialMicroRNAExpressionVectorforSimultaneousInhibitionofMultipleGenesinMammalianCells.InternationalJournalofMolecularSciences10,2158-2168.

4.YalingYang,SnawarHussain,HaoWang,MinKe,DeyinGuo(2009)TranslationalcontrolofthesubgenomicRNAsofsevereacuterespiratorysyndromecoronavirus.VirusGenes39,10-18.

5.PingChen,TaoHu,MiaoJiang,DeyinGuo.(2009).SynthesisinE.colicellsandcharacterizationoftheactiveexoribonucleaseofsevereacuterespiratorysyndromecoronavirus.MolecularBiology3,410-417.

6.KeZhang,YuChen,Ji’anPan,TeroAhola,DeyinGuo(2009)Lentiviralvector-derivedshRNAsconferenhancedsuppressionofSemlikiforestvirusreplicationinBHK-21cellscomparedtoshRNAsexpressedfromplasmids.BiotechnologyLetters31,501-508.

7.TaoHu,QiongFu,PingChen,KeZhang,DeyinGuo(2009)Generationofastablemammaliancelllineforsimultaneousexpressionofmultiplegenesbyusing2Apeptide-basedlentiviralvector.BiotechnologyLetters31,353-359.

8.MusaratIshaq,LiMa,XiaoyunWu,YongxinMu,Ji’anPan,JiajieHu,TaoHu,QiongFuandDeyinGuo(2009).TheDEAD-boxRNAhelicaseDDX1interactswithRelAandenhancesnuclearfactorkappaB-mediatedtranscription.JournalofCellularBiochemistry106,296-305.

9.XiaoyunWu,YouZhou,KeZhang,QingzhenLiu&DeyinGuo(2008).Isoform-specificinteractionofpyruvatekinasewithhepatitisCvirusNS5B.FEBSLetters582,2155-2160.

10.Ji’AnPan,XiaoxuePeng,YajingGao,ZhilinLi,XiaoluLu,YingzhaoChen,MusaratIshaq,DanLiu,MartaL.DeDiego,LuisEnjuanesandDeyinGuo.(2008).Genome-wideanalysisofprotein-proteininteractionsandinvolvementofviralproteinsinSARS-CoVreplication.PLoSONE3,e3299.

11.XiaoyunWu,MusaratIshaq,JiajieHu,DeyinGuo(2008).HCVNS3/4AproteinactivatesHIV-1transcriptionfromitslongterminalrepeat.VirusResearch135,155-160.

12.MusaratIshaq,JiajieHu,XiaoyunWu,QingzhenLiuandDeyinGuo.(2008).KnockdownofcellularRNAhelicaseDDX3byshorthairpinRNAssuppressesHIV-1viralreplicationwithoutinducingapoptosis.MolecularBiotechnology39,231-238.

13.YalingYang,QuanWang,DeyinGuo(2008).ANovelStrategyforAnalyzingRNA-ProteinInteractionsbySurfacePlasmonResonanceBiosensor.MolecularBiotechnology40,87-93.

14.JunweiLi,HuiCai,QingzhenLiu&DeyinGuo(2008).MolecularandpathologicalcharacterizationoftwoH5N1avianinfluenzavirusesisolatedfromwildducks.VirusGenes37,88-95.

15.DeyinGuo,Minna-LeenaRajam?ki&JariValkonen.(2008).Protein-proteininteractions:theyeasttwo-hybridsystem.MethodsinMolecularBiology451,421-439.

16.ZuoxiangXiao,YongXiong,LindiTan,ElanaEhrlich,DeyinGuoandXiao-FangYu(2007).CharacterizationofaNovelCullin5BindingDomaininHIV-1Vif.JournalofMolecularBiology373,541-550.

17.PingChen,MiaoJiang,TaoHu,QingzhenLiu,XiaojiangS.Chen,DeyinGuo(2007)BiochemicalcharacterizationofexoribonucleaseencodedbySARScoronavirus.JournalofBiochemistry&MolecularBiology40,649-655.

18.XiaoxuePeng,Ji’anPan,RuiGong,YangLiu,ShuliKang,HuixingFeng,GangQiu,DeyinGuo,PoTien,andGengfuXiao.(2007).Functionalcharacterizationofsyncytin-A,anewlymurineendogenousvirusenvelopeprotein:implicationforitsfusionmechanism.JournalofBiologicalChemistry282,381-9.

19.ZhaoyangLi,YongXiong,YuPeng,Ji’anPan,YuChen,XiaoyunWu,SnawarHussain,PoTien,DeyinGuo.(2005).SpecificinhibitionofHIV-1replicationbyshorthairpinRNAstargetinghumancyclinT1withoutinducingapoptosis.FEBSLetters579,3100-6.

20.SnawarHussain,Ji’anPan,YuChen,YalinYang,JingXu,YuPeng,YingWu,ZhaoyangLi,YingZhu,PoTien,DeyinGuo.(2005).IdentificationofnovelsubgenomicRNAsandnoncanonicaltranscriptioninitiationsignalsofsevereacuterespiratorysyndromecoronavirus.JournalofVirology79,5288-95.