职称职务：教授、博士生导师
研究方向：（1）分子与细胞病毒学；（2）病毒感染与新药设计
实验室位置：生科院5109室
联系方式：**
Email:　liwxlab@whu.edu.cn
Labpage:http://vmolab.whu.edu.cn

学　　历
1973～1977中山大学生物系学习
1982～1985法国巴黎十一大学学习，获博士学位

主要工作经历与任职
1978～至今武汉大学生命科学学院，教学和科研
1991～1992法国里昂一大学，访问研究
1993～1996法国巴黎十一大学居里研究所，访问研究
1997～至今武汉大学生命科学学院，教授和科研，武汉大学副校长

目前主要研究领域和兴趣
多年来一直从事肿瘤细胞及分子生物学研究，其“无血清细胞培养研究”成果在国内外具有较大影响，提出了细胞表面受体的多功能性，证实了转化细胞自分泌生长因子的内源性刺激作用。目前主要从事与抗病毒和抗肿瘤密切相关蝎毒素分子生物学和人早期胚胎新基因功能的科学研究。

教学情况
病毒与细胞的关系，36学时，授课对象：研究生

代表性论文：
1.YibaoMa,RuimingZhao,YawenHe,SongryongLi,JunLiu,YingliangWu,ZhijianCao*andWenxinLi*.TranscriptomeanalysisofthevenomglandofthescorpionScorpiopsjendeki:implicationfortheevolutionofthescorpionvenomarsenal.BMCGenomics-2009,inpress

2.ShijinYin,LingJiang,HongYi,SongHan,DaiwenYang,MailiLiu,HuiLiu,ZhijianCao,YingliangWu*,WenxinLi*.DifferentresiduesinchannelturretdeterminingtheselectivityofADWX-1inhibitorpeptidebetweenKv1.1andKv1.3channels.JournalofProteomeResearch,2008,7(11):4890-4897

3.DaiC,MaY,ZhaoZ,ZhaoR,WangQ,WuY,CaoZ*,LiW*.Mucroporin,thefirstcationichostdefencepeptidefromthevenomofLychasmucronatus.AntimicrobAgentsChemother,2008,52(11):3967-3972

4.DiWang,Ming-XiongGuo,Zhou-ZhouZhao,Hong-LingQiu,Hai-MingHu,Huan-JieShao,Chen-GangZhu,LuXue,Yun-BoShiandWen-XinLi*.HumanT-cellleukemiavirustype1oncoproteintaxrepressesZNF268expressionthroughthecAMP-responsiveElement-bindingProtein/ActivatingTranscriptionFactorpathway.JournalofBiologicalChemistry,2008,283(24):16299-308.

5.SongHan,HongYi,Shi-JinYin,Zong-YunChen,HuiLiu,Zhi-JianCao,Ying-LiangWu*,andWen-XinLi*.StructuralBasisofaPotentPeptideInhibitorDesignedforKv1.3Channel,aTherapeuticTargetofAutoimmuneDisease.JournalofBiologicalChemistry,2008,283:19058-19065

6.LiuWH,LiuZC,CaoXB,CaoZJ,XueL,ZhuF,HeXH*,andLiWX*.Recombinanthumanfoamyvirus,anovelvectorforneurologicaldisordersgenetherapy,drivesproductionofGADinculturedastrocytes.MolecularTherapy,2007,15(10):1834-1841

7.HongYi,ZhijianCao,ShijinYin,ChaoDai,YingliangWu*,WenxinLi*.InteractionSimulationofhERGK+ChannelwithitsspecificBekm-1peptide:InsightsintotheSelectivityofMolecularRecognition.JournalofProteomeResearch,2007,6:611-620

8.Ming-XiongGuo,DiWang,Huan-JieShao,Hong-LingQiu,LuXue,Zhou-ZhouZhao,Chen-GangZhu,Yun-BoShi,andWen-XinLi*.TranscriptionofHumanZincFingerZNF268GeneRequiresanIntragenicPromoterElement.JournalofBiologicalChemistry,2006,281(34):24623-36

9.LuoFeng,ZengXianchun,LiWenxin*.Genomicorganizationoffournovelnondisulfide-bridgepeptidesfromMesobuthusmartensiiKarsch:insightintotheevolutionarymechanism.Peptides,2005,26:2427-2433

10.Wu,YL;Cao,ZJ;Yi,H;Jiang,DH;Mao,X;Liu,H;Li,WX*.SimulationoftheinteractionbetweenScyTxandsmallconductancecalcium-activatedpotassiumchannelbydockingandMM-PBSA.BiophysicalJournal,2004,87(1):105-112

11.D.M.Gou,L.M.C.Chow,N.Q.Chen,D.H.Jiang,W.X.Li*.ConstructionandcharacterizationofacDNAlibraryfrom4-week-oldhumanembryo.Gene,2001,278:141-147.

12.Cao,ZJ;Xiao,F;Peng,F;Jiang,DH;Mao,X;Liu,H;Li,WX*;Hu,D;Wang,T.Expression,purificationandfunctionalcharacterizationofarecombinantscorpionvenompeptideBmTXKbeta.Peptides,2003,24(2):187-192

13.Peng,F;Zeng,XC;He,XH;Pu,J;Li,WX*;Zhu,ZH;Liu,H.Molecularcloningandfunctionalexpressionofageneencodinganantiarrhythmiapeptidederivedfromthescorpiontoxin.EuropeanJournalofBiochemistry,2002,269(18):4468-4475

14.Zhu,SY;Li,WX*;Cao,ZJ.Anaturallyoccurringnon-codingfusiontranscriptderivedfromscorpionvenomgland:implicationfortheregulationofscorpiontoxingeneexpression.FEBSLetters,2001,508(2):241-244

15.Zhu,SY;Li,WX*;Zeng,XC;Jiang,DH;Mao,X;Liu,H.Molecularcloningandsequencingoftwo’shortchain’andtwo’longchain’K+channel-blockingpeptidesfromtheChinesescorpionButhusmartensiiKarsch.FEBSLetters,1999,457:509-514