职称/职务Academictitle/Position：
病毒学国家重点实验室，教授、主任。ProfessorandDirector,StateKeyLaboratoryofVirology.
武汉生物技术研究院，副院长。VivePresident,WuhanInstituteofBiotechnology.
研究领域ResearchField：微生物学/病毒学Microbiology/Virology
研究方向ResearchInterests:
病毒感染与致病的分子机理。MolecularMechanismsofViralInfectionandPathogenesis.
病毒病与肿瘤诊断和防治新技术。NewApproachestothePreventionandTreatmentofViralDiseasesandCancers.


学习经历　Education：
1993-1996：美国普林斯顿大学，分子生物学，博士后。PostdoctoralAssociateinMolecularBiology,PrincetonUniversity,NJ,USA.
1989-1992：美国爱达华大学，生物化学，博士。Ph.D.inBiochemistry,UniversityofIdaho,ID,USA.
1982-1985：武汉大学，病毒学，硕士。M.S.inVirology,WuhanUniversity,Wuhan,China.
1978-1982：武汉大学，微生物学，学士。B.S.inMicrobiology,WuhanUniversity,Wuhan,China.

工作经历　WorkExperience：
2010-至今：武汉生物技术研究院，副院长。VicePresident,WuhanInstituteofBiotechnology,Wuhan,China.
2005-至今：病毒学国家重点实验室，主任。Director,StateKeyLaboratoryofVirology,Wuhan,China.
1999-至今：教育部****奖励计划，特聘教授。DistinguishedProfessorofVirology,CheungKongScholarsProgram,MinistryofEducation,China.
1999-至今：武汉大学生命科学学院，教授、博士生导师。ProfessorandDoctoralSupervisor,CollegeofLifeSciences,WuhanUniversity,Wuhan,China.
1996-1999：美国普林斯顿大学，研究员。ResearchStaffMember,PrincetonUniversity,NJ,USA.
1992-1993：美国爱达华大学，副研究员。ResearchAssociate,UniversityofIdaho,ID,USA.
1986-1989：美国佐治亚大学，访问学者。VisitingScholar,UniversityofGeorgia,GA,USA.
1985-1986：武汉大学，讲师。Lecturer,WuhanUniversity,Wuhan,China.

学术兼职　CommitteeandBroadMemberships：
1.病毒学国家重点实验室学术委员会，副主任委员。VicePresident,BroadCommittee,StateKeyLaboratoryofVirology.
2.农业微生物国家重点实验室学术委员会，副主任委员。VicePresident,BroadCommittee,StateKeyLaboratoryofAgriculturalMicrobiology.
3.湖北省生物工程学会，理事长。President,HubeiSocietyforBiotechnology.
4.湖北省微生物学会，副理事长。VicePresident,HubeiSocietyforMicrobiology.
5.中国生物工程学会，理事。BroadMember,ChineseSocietyforMicrobiology.
6.中国微生物学会病毒专业委员会，理事。BroadMember,DivisionofVirologyinChineseSocietyforMicrobiology.

科研项目ResearchGrantsandFunding：
主持国家科技重大专项、国家科技部973计划项目、国家自然科学基金重点项目等多项。PrincipleInvestigatorformultiplegrantsfromtheMinistryofScienceandTechnologyofChina,NationalScienceFoundationofChina.

代表性学术论文SelectedPublications(62outof118)：
1.ChenYN,ChenJB,WangH,ShiJJ,WuKL,LiuS,LiuYL,WuJG(2013).HCV-inducedmiR-21contributestoevasionofhostimmunesystembytargetingMyD88andIRAK1.PLoSPathog9(4):e**.(IF:9.629)2.XiaC,ChenYC,GongH,ZengWB,VuGP,TrangP,LuSW,WuJG,LiuFY(2013).InhibitionofhepatitisBvirusgeneexpressionandreplicationbyribonucleaseP.MolTher21(5):995-1003.(IF:6.284)
3.CaoYH,ZhangW,YuY,ZhuCL,ZhangR,SongY,WangQ,BaiL,LiuYL,WuKL,WuJG(2013).IL-27,acytokine,andIL-29,atypeIIIinterferon,arecoordinatedtoregulatevirusreplicationinamannersimilartotypeIinterferon.JImmunol(Accepted)(IF:5.745)
4.XuP,HuangZX,GaoXD,MichelFJ,HirschG,HoganRJ,SakamotoK,HoWZ,WuJG,HeB(2013).Infectionofmice,ferrets,andrhesusmacaqueswithaclinicalmumpsvirusisolate.JVirol87(14):8158-8168.(IF:5.189)
5.YuY,CaoYH,SunZC,ZhangW,WuKL,WuJG(2013).HepatitisBeantigenactivatesthesuppressorofcytokinesignaling-2toantagonizetypeIandtypeIIIinterferonandmediateviralimmuneevasion.EurJImmunol(Inreversion)(IF:4.970)
6.ZhangZ,VuGP,GongH,XiaC,ChenYC,LiuFY,WuJG,LuSW(2013).EngineeredexternalguidesequencesarehighlyeffectiveininhibitinggeneexpressionandreplicationofhepatitisBvirusinculturedcells.PLoSOne8(6):e65268.(IF:4.411)
7.LiuS,HaoQ,WangY,YueX,PengNF,ChenYN,WuJG,ZhuY(2012).Majorvaultprotein:Avirus-inducedhostfactoragainstviralreplicationthroughtheinductionoftype-Iinterferon.Hepatology56(1):57-66.(IF:11.665)
8.YueX,WangH,ZhaoF,LiuS,WuJG,RenW,ZhuY(2012).HepatitisBvirus-inducedcalreticulinproteinisinvolvedininterferonresistance.JImmunol189(1):279-286.(IF:5.745)
9.LiuL,CaoZY,ChenJ,LiR,CaoYH,ZhuCL,WuKL,WuJG,LiuF,ZhuY(2012).InfluenzaAvirusinducesinterleukin-27throughcyclooxygenase-2andproteinkinaseAsignaling.JBiolChem287(15):11899-11910.(IF:5.328)
10.LiYX,ZhangQ,LiuY,LuoZ,KangL,QuJ,LiuWY,XiaXS,LiuYL,WuKL,WuJG(2012).HepatitisCvirusactivatesBcl-2andMMP-2expressionthroughmultiplecellularsignalingpathways.JVirol86(23):12531-12543.(IF:5.189)
11.ZhangQ,GongR,QuJ,ZhouYJ,LiuWY,ChenMZ,LiuYL,ZhuY,WuJG(2012).ActivationoftheRas/Raf/MEKpathwayfacilitatesHCVreplicationviaattenuationoftheINF-JAK-STATpathway.JVirol86(3):1544-1554.(IF:5.189)
12.FangJL,LiuL,LiYK,WuJG,HuoXX,ZhuY(2012).EpigeneticchangesmediatedbymiR29activatecyclooxygenase-2andinterferon-1productionduringviralinfection.JVirol86(2):1010-1020.(IF:5.189)
13.XuP,LuthraPY,LiZ,FuentesS,D’AndreaJ,WuJG,RubinS,RotaP,HeB(2012).TheVproteinofmumpsvirusplaysacriticalroleinpathogenesis.JVirol86(3):1768-1776.(IF:5.189)
14.ZengWB,ChenYC,BaiY,TrangP,VuGP,LuSW,WuJG,LiuFY(2012).Effectiveinhibitionofhumanimmunodeficiencyvirus1replicationbyengineeredRNasePribozyme.PLoSOne7(12):e51855.(IF:4.411)
15.LiCW,YuS,ZhongXL,WuJG,LiXD(2012).Circadianrhythmsoffetallivertranscriptionpersistintheabsenceofcanonicalcircadianclockgeneexpressionrhythmsinvivo.PLoSOne7(2):e30781.(IF:4.411)
16.LiCW,YuS,ZhongXL,WuJG,LiXD(2012).Transcriptomecomparisonbetweenfetalandadultmouselivers:Implicationsforcircadianclockmechanisms.PLoSOne7(2):e31292.(IF:4.411)
17.ChenYN,ShenA,RiderPJ,YuY,WuKL,MuYX,HaoQ,LiuYL,GongH,ZhuY,LiuFY,WuJG(2011).Aliver-specificmicroRNAbindstoahighlyconservedRNAsequenceofhepatitisBvirusandnegativelyregulatesviralgeneexpressionandreplication.FASEBJ25(12):4511-4521.(IF:6.515)
18.YuY,GongR,MuYX,ChenYN,ZhuCL,SunZC,ChenMZ,LiuYL,ZhuY,WuJG(2011).HepatitisBvirusinducesanovelinflammationnetworkinvolvingthreeinflammatoryfactors,interleukin-29,interleukin-8,andcyclooxygenase-2.JImmunol187(9):4844-4860.(IF:5.745)
19.LiuQY,ChenJW,LiuL,ZhangJ,WangDF,MaL,HeYM,LiuYL,LiuZS,WuJG(2011).TheXproteinofHBVinhibitsapoptosisinhepatomacellsthroughenhancingMAT2AexpressionandreducingSAMproduction.JBiolChem286(19):17168-17180.(IF:5.328)
20.LiuQY,LiuL,ZhaoYH,ZhangJ,WangDF,ChenJW,HeYM,WuJG,ZhangZL,LiuZS(2011).HypoxiainducesgenomicDNAdemethylationthroughtheactivationofHIF-1aandtranscriptionalup-regulationofMAT2Ainhepatomacells.MolCancerTher10(6):1113-1123.(IF:5.225)
21.LiuMY,LiuWY,LuoJ,LiuYL,ZhuY,BermanH,WuJG(2011).Characterizationofanoutbreakofhand,foot,andmouthdiseaseinNanchang,Chinain2010.PLoSOne6(9):e25287.(IF:4.411)
22.QuJ,YangZH,ZhangQ,LiuWY,LiYX,DingQ,LiuF,LiuYL,PanZS,HeB,ZhuY,WuJG(2011).Humanimmunodeficiencyvirus-1RevproteinactivateshepatitisCvirusgeneexpressionbydirecttargetingHCV5’-untranslatedregion.FEBSLett585(24):4002-4009.(IF:3.601)
23.LuoM,QuX,PanR,ZhuD,ZhangY,WuJG,PanZS(2011).Thevirus-inducedsignalingadaptormoleculeenhancesDNA-raisedimmuneprotectionagainstH5N1influenzavirusinfectioninmice.Vaccine29(14):2561-2567.(IF:3.572)
24.XuP,LiZ,SunDY,LinY,WuJG,RotaP,HeB(2011).Rescueofwild-typemumpsvirusfromastrainassociatedwithrecentoutbreakshelpstodefinetheroleoftheSHORFinthepathogenesisofmumpsvirus.Virology417(1):126-136.(IF:3.305)
25.LiW,SunW,LiuL,YangF,LiY,ChenY,FangJ,ZhangW,WuJG,ZhuY(2010).IL-32:AhostproinflammatoryfactoragainstinfluenzaviralreplicationisupregulatedbyaberrantepigeneticmodificationsduringinfluenzaAvirusinfection.JImmunol185(9):5056-5065.(IF:5.745)
26.LiW,YangF,LiuY,GongR,LiuL,FengY,HuP,SunW,HaoQ,KangL,WuJG,ZhuY(2009).NegativefeedbackregulationofIL-32productionbyiNOSactivationinresponsetodsRNAorinfluenzavirusinfection.EurJImmunol39(4):1019-1024.(IF:4.942)
27.MukhtarMM,LiSF,LiW,WanT,MuYX,WeiW,KangL,RasoolST,XiaoYB,ZhuY,WuJG(2009).Single-chainintracellularantibodiesinhibitinfluenzavirusreplicationbydisruptinginteractionofproteinsinvolvedinviralreplicationandtranscription.IntJBiochemCellBiol41(3):554-560.(IF:4.956)
28.ZhuCL,ZhangR,LiuL,RasoolST,MuYX,SunW,HaoQ,LiuF,ZhuY,WuJG(2009).HepatitisBvirusenhancesinterleukin-27expressionbothinvivoandinvitro.ClinImmunol131(1):92-97.(IF:3.932)
29.XiaLM,HuangWJ,WuJG,YangYB,ZjangQ,ZhouZZ,ZhuHF,LeiP,ShenGX,TianGA(2009).HBxproteininducesexpressionofMIGandincreasesmigrationofleukocytesthroughactivationofNF-kappaB.Virology385(2):335-342.(IF:3.305)
30.PengGQ,YanY,ZhuCL,WangSQ,YanXH,LuLL,LiW,HuJ,WeiW,MuYX,ChenYN,FengY,GongR,WuKL,ZhangFM,ZhangXL,ZhuY,WuJG(2008).BornadiseasevirusPproteinaffectsneuraltransmissionthroughinteractingwithgamma-aminobutyricacidreceptor-associatedprotein.JVirol82(24):12487-12497.(IF:5.189)
31.WangK,ZhangY,LiX,ChenL,WangH,WuJG,ZhengJ,WuD(2008).CharacterizationoftheKremen-bindingsiteonDkk1andelucidationoftheroleofKremeninDkk-mediatedWntantagonism.JBiolChem283(34):23371-23375.(IF:5.328)
32.LuLL,WeiL,PengGQ,MuYX,WuKL,KangL,YanXH,ZhuY,WuJG(2008).NS3proteinofhepatitisCvirusregulatescyclooxygenase-2expressionthroughmultiplesignalingpathways.Virology371:61-70.(IF:3.305)
33.FengY,WangSQ,LuoFL,RuanY,KangL,XiangXH,PengGQ,ZhuCL,MuYX,ZhangXL,WuJG(2008).Anovelrecombinantbacterialvaccinestrainexpressingdualviralantigensinducesmultipleimmuneresponsestothegagandgp120proteinsofHIV-1inimmunizedmice.AntivirRes80:272-279.(IF:4.439)
34.LiW,LiuY,MukhtarMM,GongR,PanY,RasoolST,GaoY,KangL,HaoQ,PengGQ,ChenYN,ChenX,WuJG,ZhuY(2008).Activationofinterleukin-32proinflammatorypathwayinresponsetoinfluenzaAvirusinfection.PLoSOne3(4):e1985.(IF:4.411)
35.LiuM,YangYB,GuCF,YueYP,WuKK,WuJG,ZhuY(2007).SpikeproteinofSARS-CoVstimulatescyclooxygenase-2expressionviabothcalcium-dependentandcalcium-independentproteinkinaseCpathways.FASEBJ21(7):1586-1596.(IF:6.515)
36.PengGQ,ZhangFM,ZhangQ,WuKL,ZhuF,WuJG(2007).BornadiseasevirusPproteininhibitsnitricoxidesynthasegeneexpressioninastrocytes.Virology366:446-452.(IF:3.305)
37.ZhangX,WuKL,WangD,YueX,SongDG,ZhuY,WuJG(2007).NucleocapsidproteinofSARS-CoVactivatesinterleukin-6expressionthroughcellulartranscriptionfactorNF-kappaB.Virology365(2):324-335.(IF:3.305)
38.LiPF,WanQ,FengY,LiuM,WuJG,ChenXW,ZhangXL(2007).EngineeringofN-glycosylationofhepatitisCvirusenvelopeproteinE2enhancesTcellresponsesforDNAimmunization.Vaccine25:1544-1551.(IF:3.572)
39.WuKL,MuYX,HuJ,LuL,ZhangX,YangYB,LiY,LiuF,SongDG,ZhuY,WuJG(2007).SimultaneouslyinhibitionofHIVandHBVreplicationthroughadualsmallinterferingRNAexpressionsystem.AntivirRes74:142-149.(IF:4.439)
40.MukhtarMM,RasoolST,SongD,ZhuCL,HaoQ,ZhuY,WuJG(2007).OriginofhighlypathogenicH5N1avianinfluenzavirusinChinaandgeneticcharacterizationofdonorandrecipientviruses.JGenVirol88:3094-3099.(IF:3.568)
41.YanXH,HaoQ,MuYX,TimaniKT,YeLB,ZhuY,WuJG(2006).NucleocapsidproteinofSARS-CoVactivatestheexpressionofcyclooxygenase-2bybindingdirectlytoregulatoryelementsfornuclearfactor-kappaBandCCAAT/enhancerbindingprotein.IntJBiochemCellBiol38(8):1417-1428.(IF:4.956)
42.HuangWJ,LiuZC,WeiW,WangGH,WuJG,ZhuF(2006).HumanendogenousretroviralpolRNAandproteindetectedandidentifiedinthebloodofindividualswithschizophrenia.SchizophrRes83(2-3):193-199.(IF:4.374)
43.WeiW,HuangWJ,PanY,ZhuF,WuJG(2006).FunctionalswitchofviralproteinHBxoncellapoptosis,transformation,andtumorigenesisinassociationwithoncoproteinRas.CancerLett244(1):119-128.(IF:4.864)
44.EckerDJ,SampathR,BlynLB,EshooMW,IvyC,EckerJA,LibbyB,SamantV,Sannes-LoweryKA,MeltonRE,RussellK,FreedN,BarrozoC,WuJG,etal.(2005).Rapididentificationandstraintypingofrespiratorypathogensforepidemicsurveillance.ProcNatlAcadSciUSA102(22):8012-8017.(IF:9.771)
45.CrumNF,RussellKL,KaplanEL,WallaceMR,WuJG,AshtariP,MorrisDJ,HaleBR(2005).PneumoniaoutbreakassociatedwithgroupaStreptococcusspeciesatamilitarytrainingfacility.ClinInfectDis40(4):511-518.(IF:8.161)
46.PanQ,ZhangXL,WuHY,HePW,WangF,ZhangMS,HuJM,XiaB,WuJG(2005).AptamersthatpreferentiallybindtypeIVBpiliandinhibithumanmonocytic-cellinvasionbySalmonellaentericaserovartyphi.AntimicrobAgentsCh49(10):4052-4060.(IF:4.672)
47.MetzgarD,OsunaM,YingstS,RakhaM,EarhartK,ElyanD,EsmatH,SaadMD,KajonA,WuJG,GrayGC,RyanMA,RussellKL(2005).PCRanalysisofegyptianrespiratoryadenovirusisolates,includingidentificationofspecies,serotypes,andcoinfections.JClinMicrobiol43(11):5743-5752.(IF:4.220)
48.SunG,GuoM,ShenA,MeiF,PengX,GongR,GuoDY,WuJG,TienP,XiaoGF(2005).BovinePrPCdirectlyinteractswithalphaB-crystalline.FEBSLett579:5419-5424.(IF:3.601)
49.WangF,ZhangXL,ZhouY,YeLB,QiZT,WuJG(2005).TypeIVBpiliatedSalmonellatyphienhanceIL-6andNF-kappaBproductioninhumanmonocyticTHP-1cellsthroughactivationofproteinkinaseC.Immunobiology210:283-293.(IF:4.114)
50.BlasioleD,MetzgarD,DaumL,RyanM,WuJG,WillsC,LeC,FreedNE,HansenC,GrayG,RussellKL(2004).Molecularanalysisofadenovirusisolatesfromvaccinatedandunvaccinatedyoungadults.JClinMicrobiol42(4):1686-1693.(IF:4.220)
51.WuJG,OhtaN,ZhaoJ,NewtonA(1999).Anovelbacterialtyrosinekinaseessentialforcelldivisionanddifferentiation.ProcNatlAcadSciUSA96:13068-13073.(IF:9.771)
52.WuJG,OhtaN,NewtonA(1998).Anessential,multi-componentsignaltransductionpathwayrequiredforcellcycleregulationinCaulobacter.ProcNatlAcadSciUSA95:1443-1448.(IF:9.771)
53.WuJG,MillerBL(1997).Aspergillusasexualreproductionandsexualreproductionaredifferentiallyaffectedbytranscriptionalandtranslationalmechanismsregulatingstuntedgeneexpression.MolCellBiol17:6191-6201.(IF:6.188)
54.WuJG,OhtaN,BensonAK,NinfaA,NewtonA(1997).Purification,characterization,andreconstitutionofDNA-dependentRNApolymerasesfromCaulobactercrescentus.JBiolChem272:21558-21564.(IF:5.328)
55.WuJG,NewtonA(1997).RegulationoftheCaulobacterflagellargenehierarchy;notjustformotility.MolMicrobiol24:33-239.(IF:4.819)
56.WuJG,NewtonA(1997).TheCaulobacterheatshocksigmafactorgenerpoHispositivelyautoregulatedfromasigma32-dependentpromoter.JBacteriol179:514-521.(IF:3.726)
57.WuJG,NewtonA(1996).Isolation,identification,andtranscriptionalspecificityoftheheatshocksigmafactorsigma32fromCaulobactercrescentus.JBacteriol178:2094-2101.(IF:3.726)
58.WuJG,BensonAK,NewtonA(1995).Globalregulationofasigma54-dependentflagellargenefamilyinCaulobactercrescentusbythetranscriptionactivatorFlbD.JBacteriol177:3241-3250.(IF:3.726)
59.MillerKY,WuJG,MillerBL(1992).StuAisrequiredforcellpatternformationinAspergillus.GeneDev6:1770-1782.(IF:12.889)
60.WuJG,MillerLK(1989).Sequence,transcription,andtranslationofalategeneoftheAutographacalifornicanuclearpolyhedrosisvirusencodinga34.8Kpolypeptide.JGenVirol70:2449-2459.(IF:3.368)
61.TomalskiMD,WuJG,MillerLK(1988).Thelocation,sequence,transcription,andtranslationofabaculovirusDNApolymerasegene.Virology167:591-600.(IF:3.305)
62.WuJG,LuWJ,TienP(1986).MultiplicationofVelvettobaccomottlevirusinNocotianaclevelandiiprotoplastsisresistanttoalpha-Amanitin.JGenVirol67:2757-2762.(IF:3.368)

部分奖励及荣誉SelectedAwardsandHonors：
2011年：吴建国。药明康德生命化学研究二等奖。
2011年：吴建国。中国侨联特聘专家。
2011年：吴建国。湖北省创新创业人才。
2010年：吴建国，叶林柏，朱应，刘映乐，邬开朗。湖北省自然科学奖一等奖。
2010年：吴建国。湖北省十大有突出贡献中青年专家。
2010年：吴建国。湖北省人民政府编钟奖。
2010年：吴建国。武汉东湖高新区3551人才。
2009年：吴建国。湖北省新侨创业先进个人。
1999年：吴建国。教育部****特聘教授。

联系方式/ContactInformation：
电话/Tel:86-**(O);86-**(Lab)
传真/Fax:86-**
电子邮箱/E-mail:jwu@whu.edu.cn