职称职务：副教授、硕士生导师
学科专业：生物化学和分子生物学
研究方向：细胞信号转导与蛋白质降解
实验室位置：生科院5005号房间
联系方式：OfficePhone:**
　　　　　LabPhone:**
Email:　lilianyun@whu.edu.cn

教育与工作经历：
学士.1994-1998，四川大学生物工程系
博士.2000-2005,北京大学生命科学学院
博士后，2005-2009，美国美国国立医学院（NationalInstitutesofHealth）
副教授，2009至今，武汉大学生命科学学院

主要研究领域和兴趣：
表观遗传学与细胞信号传导

代表研究论文
1)WangXiang,JuLin-gao,FanJia-dong,ZhuYuan,LiuXiao-lan,ZhuKun,WuMin*,LiLian-yun*.HistoneH3K4methyltransferaseMll1regulatesproteinglycosylationandtunicamycin-inducedapoptosisthroughtranscriptionalregulation.BiochimBiophysActa.**:2592.(*Authorsforcorrespondence)
2)ShuaikunSu,MinZhang,LianyunLi,MinWu.Polycombgroupgenesasthekeyregulatorsingenesilencing.WuhanUniversityJournalofNaturalSciences.2014,19:1.

3)Quan-yiZhao,Jia-dongFan,WeiHong,Lian-yunLi*,MinWu*.Inhibitionofcancercellproliferationby5-fluoro-2'-deoxycytidine,aDNAmethylationinhibitor,throughactivationofDNAdamageresponsepathway.Springerplus.20121:65.(*Authorsforcorrespondence)

4)XiangWang,KunZhu,Shang-zeLi,Yi-fangLiao,Run-leiDu,Xiao-dongZhang,Hong-bingShu,An-YuanGuo,Lian-yunLi*,MinWu*.MLL1,aHistoneH3K4Methyltransferase,RegulatestheExpressionofTNF-α-mediatedNF-κBDownstreamGenes.J.CellSci.**:4058.(*Authorsforcorrespondence)

5)NiaSoetandyo,Qiu-yanWang,Yi-hongYe*,andLian-yunLi*.RoleofintramembranechargedresiduesinthequalitycontrolofunassembledT-cellreceptor-chainsattheendoplasmicreticulum.J.CellSci.**:1031.(*Authorsforcorrespondence)

6)Lian-yunLi,NiaSoetandyo,Qiu-YanWang,Yi-HongYe.ThezincfingerproteinA20targetsTRAF2tothelysosomesfordegradation.BiochimBiophysActa-MolecularCellResearch.**:346.

7)WeiLi,DaqiTu,Lian-yunLi,ThomasWollert,RodolfoGhirlando,AxelT.Brunger,andYihongYe.Mechanisticinsightsintoactivesite-associatedpolyubiquitinationbytheubiquitin-conjugatingenzymeUbe2g2.ProcNatlAcadSciUSA.**:3722.

8)Lian-yunLi,DaleHailey,NiaSoetandyo,WeiLi,JenniferLippincott-Schwartz,Hong-bingShu,Yi-hongYe.LocalizationofA20toalysosome-associatedcompartmentanditsroleinNF-kappaBsignaling.BiochimBiophysActa-MolecularCellResearch.**:1140.

9)Qiu-yanWang,Lian-yunLi,Yi-hongYe.Inhibitionofp97-dependentproteindegradationbyEeyarestatinI.J.Biol.Chem.**:7445.

10)Qiu-yanWang,Lian-yunLi,Yi-hongYe.Regulationofretrotranslocationbyp97-associateddeubiquitinatingenzymeataxin-3.J.CellBiol.**:963.

11)Lian-yunLi,Liang-huaBin,FuLi,YiLiu,Dan-yingChen,Zhong-heZhaiandHong-bingShu.TRIP6isaRIP2-associatedcommonsignalingcomponentofmultipleNF-kappaBactivationpathways.J.CellSci.**:555.

12)Liang-guoXu,Yan-yiWang,Ke-junHan,Lian-yunLi,Zhong-heZhaiandHong-bingShu.VISAIsanAdapterProteinRequiredforVirus-TriggeredIFN-βSignaling.Mol.Cell200519:727.

13)Yan-yiWang*,Lian-yunLi*,Ke-junHan,Zhong-heZhaiandHong-bingShu.A20isapotentinhibitorofTLR3-andSendaivirus-inducedactivationofNF-kappaBandISREandIFN-betapromoter.FEBSLetters**:86.(*co-firstauthors)

14)Liang-guoXu,Lian-yunLi,Hong-bingShu.TRAF7potentiatesMEKK3-inducedAP1andCHOPactivationandinducesapoptosis.J.Biol.Chem.**:17278.

15)JunHuang,LinTeng,Li-xiaLi,TingLiu,Lian-yunLi,Dan-yingChen,Liang-guoXu,Zhong-heZhaiandHong-bingShu.ZNF216IsanA20-likeandIkappaBkinasegamma-interactinginhibitorofNFkappaBactivation.J.Biol.Chem.**:16847.

16)Lian-yunLi*,Jiang-chengHu*,Liang-huaBin,Li-xiaLi,Ji-kunZha,Liang-guoXu,ZhengZhang,Zhong-heZhaiandHong-bingShu.RecombinantsolubleTRAILinducesapoptosisofcancercells.ChineseScienceBulletin200146:2073.(*co-firstauthors)

17)Lian-yunLiandHong-bingShu.MolecularmechanismsofTRAIL-Inducedapoptosis.ChineseScienceBulletin200146:707.