职称职务：副研究员
学科专业：生物化学
研究方向：胆固醇代谢
实验室位置：生命科学学院大楼1132房间
联系方式:　xjshi@whu.edu.cn


教育经历：
2005.09–2010.06　中国科学院水生生物研究所博士
2001.09–2005.06　武汉大学生物科学本科

主要工作经历及任职情况：
2014.07–至今　　　武汉大学生命科学学院　副教授
2014.03–2014.06　中国科学院水生生物研究所　访问学者
2010.08–2013.10　美国匹兹堡大学药学院　博士后

主要研究领域及兴趣：
胆固醇是哺乳动物细胞中含量最丰富的甾醇类分子，为动物细胞生存所必需，具有重要的生理功能。首先胆固醇是动物细胞细胞膜的重要组成成分，占质膜脂类的20%以上，其作为细胞和环境之间的屏障可以调节细胞膜的流动性、通透性和相变。其次胆固醇是体内所有的类固醇激素和胆酸合成的前体物质，参与体内的正常代谢。最后胆固醇在神经系统的发育中也起着重要的作用。胆固醇的代谢紊乱会导致一系列严重的疾病，例如心血管疾病、动脉粥样硬化和胆结石等。有证据表明，肥胖症、糖尿病以及阿尔海默氏病(Alzheimer’sDisease，老年痴呆症)也与胆固醇代谢的紊乱有关。我们的研究兴趣是胆固醇代谢平衡调控与代谢性疾病发生机理。主要研究方向包括：1）小肠胆固醇吸收的分子途径；2）细胞内胆固醇动态运输的分子机制；3）胆固醇代谢调控的信号转导途径和机理；4）胆固醇代谢的药靶系统及新药研发。

代表性论文:

1.XiongjieShi,QiuqiongCheng,LeyuanXu,JiongYan,MengxiJiang,JinhanHe,MeishuXu,MajaStefanovic-Racic,IanSipula,RobertMartinO'Doherty,ShunlinRen,WenXie.CholesterolSulfateandCholesterolSulfotransferaseInhibitGluconeogenesisbyTargetingHNF4α.Mol.Cell.Biol.2014.vol.34no.3485-497
2.JinhanHe,BingfangHu,XiongjieShi,EricRWeidert,PeipeiLu,MeishuXu,MinHuang,EricEKelley,WenXie.ActivationoftheArylHydrocarbonReceptorSensitizesMicetoNonalcoholicSteatohepatitisbyDeactivatingMitochondrialSirtuinDeacetylaseSirt3.Mol.Cell.Biol.2013,33(10)2047-2055

3.ZhiminOu*,XiongjieShi*,RichardKGilroy,LeventKirisci,MarjorieRomkes,CaitlinLynch,HongbingWang,MeishuXu,MengxiJiang,SongrongRen,RobertoGramignoli,StephenCStrom,MinHuang,WenXie.RegulationoftheHumanHydroxysteroidSulfotransferase(SULT2A1)byRORαandRORγandItsPotentialRelevancetoHumanLiverDiseases.MolecularEndocrinology2013,27(1),106-115.*Z.O.andX.S.contributedequallytothiswork.

4.JieGao,JinhanHe,XiongjieShi,MajaStefanovic-Racic,MeishuXu,RobertMartinO’Doherty,AdolfoGarcia-Ocana,WenXie.Sex-specificeffectofestrogensulfotransferaseonmousemodelsoftype2diabetes.Diabetes2012,61(6),1543-1551.

5.XiongjieShi,LeoW.Y.Yeung,PaulK.S.Lam,RudolfS.S.Wu,andBingshengZhou.ProteinProfilesinZebrafish(Daniorerio)EmbryosExposedtoPFOS.Toxicol.Sci.2009,110:334-40.

6.XiongjieShi,ChunshengLiu,GuoqiaoWu,andBingshengZhou.WaterborneexposuretoPFOScausesdisruptionofthehypothalamus-pituitary-thyroidaxisinzebrafishlarvae.Chemosphere.2009,77:1010-8.

7.XiongjieShi,YongbingDu,PaulK.S.Lam,RudolfS.S.WuandBingshengZhou.DevelopmentaltoxicityandalterationofgeneexpressioninzebrafishembryosexposedtoPFOS.ToxicolAppl.pharmacol.2008,230:23-32.

8.XiongjieShi,ChunshengLiu,YuKe,DenJun,LiqinYu,BingshengZhou.ProgressofToxicologicalResearchonEnvironmentalEndocrineDisruptorsandPerspectives.Environ.Chem.(InChinese),2009,21:340-349.

9.XiongjieShi,BingshengZhou.TheRoleofNrf2andMAPKPathwaysinPFOS-inducedOxidativeStressinZebrafishEmbryos.Toxicol.Sci.2010,115:391-400.

10.YanhongWei,XiongjieShi,HongxiaZhang,JiansheWang,BingshengZhou,andJiayinDai.Combinedeffectsofpolyfluorinatedandperfluorinatedcompoundsonprimaryculturedhepatocytesfromrareminnow(Gobiocyprisrarus)usingtoxicogenomicanalysis.Aquat.Toxicol.2009,95:27-36.

11.LiqinYu,JunDeng,XiongjieShi,ChunshengLiu,KeYu,andBingshengZhou.ExposuretoDE-71altersthyroidhormonelevelsandgenetranscriptioninthehypothalamic–pituitary–thyroidaxisofzebrafishlarvae.Aquat.Toxicol.2009,doi:10.1016/j.aquatox.2009.10.022.

12.JunDeng,LiqinYu,ChunshengLiu,KeYu,XiongjieShi,LeoW.Y.Yeung,PaulK.S.Lam,RudolfS.S.WuandBingshengZhou.Hexabromocyclododecane-induceddevelopmentaltoxicityandapoptosisinzebrafishembryos.Aquat.Toxicol.2009,93:29-36.

13.ChunshengLiu,KeYu,XiongjieShi,JingxianWang,PaulK.S.Lam,RudolfS.S.WuandBingshengZhou.InductionofoxidativestressandapoptosisbyPFOSandPFOAinprimaryculturedhepatocytesoffreshwatertilapia(Oreochromisniloticus).Aquat.Toxicol.2007,82:135-143.

14.M.K.So,Y.Miyake,W.Y.Yeung,Y.M.Ho,S.Taniyasu,P.Rostkowski,N.Yamashita,,BingshengZhou,XiongjieShi,J.X.Wang,J.P.Giesy,H.YuandP.K.S.Lam.PerfluorinatedcompoundsinthePearlRiverandYangtzeRiverofChina.Chemosphere.2007,68:2085-2095.

15.YongbingDu,XiongjieShi,ChunshengLiu,KeYuandBingshengZhou.Chroniceffectsofwater-bornePFOSexposureongrowth,survivalandhepatotoxicityinzebrafish:Apartiallife-cycletest.Chemosphere.2009,74:723-9.

16.JingxianWang,XiongjieShi,YongbinDuandBingshengZhou.Effectsofxenoestrogensontheexpressionofvitellogenin(vtg)andcytochromeP450aromatase(cyp19aandb)genesinzebrafish(Daniorerio)larvae.JEnvironSciHealthAToxHazardSubstEnvironEng.2011;46(9):960-7.