研究方向：生物医用高分子
联系电话：**
Email:chengsixue@whu.edu.cn,chengsixue@hotmail.com
教育与研究经历
学士：华南理工大学1992年
硕士：中国科学技术大学1995年
博士：新加坡国立大学2000年
2000年1月-2001年1月：新加坡材料研究与工程研究所（研究助理）
2001年1月-2003年11月：武汉大学化学学院生物医用高分子材料教育部重点实验室（副教授）
2003年11月-：武汉大学化学学院生物医用高分子材料教育部重点实验室（教授）
研究领域与兴趣
生物医用高分子
药物及基因传递材料
生物材料的自组装
教学情况
主讲本科生课程《化学应用英语》
主讲研究生课程《专业英语》
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研究方向：生物医用高分子
联系电话：**
Email:chengsixue@whu.edu.cn,chengsixue@hotmail.com
教育与研究经历
学士：华南理工大学1992年
硕士：中国科学技术大学1995年
博士：新加坡国立大学2000年
2000年1月-2001年1月：新加坡材料研究与工程研究所（研究助理）
2001年1月-2003年11月：武汉大学化学学院生物医用高分子材料教育部重点实验室（副教授）
2003年11月-：武汉大学化学学院生物医用高分子材料教育部重点实验室（教授）
研究领域与兴趣
生物医用高分子
药物及基因传递材料
生物材料的自组装
教学情况
主讲本科生课程《化学应用英语》
主讲研究生课程《专业英语》
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代表论文：
Journalpapers
2015
1.ChenB,WuC,ZhuoRX,ChengSX*,Aself-assembledalbuminbasedmultipledrugdeliverynanosystemtoovercomemultidrugresistance,RSCAdv2015,5,6807-6814.
2.LiangP,WangCQ,ChenH,ZhuoRX*,Si-XueCheng*,Multi-functionalheparin–biotin/heparin/calciumcarbonate/calciumphosphatenanoparticlesfortargetedco-deliveryofgeneanddrug,PolymInterDOI10.1002/pi.4824
2014
3.WuJL,WangCQ,ZhuoRX,ChengSX*,Multi-drugdeliverysystembasedonalginate/calciumcarbonatehybridnanoparticlesforcombinationchemotherapy,ColloidsSurfB:Biointerf2014,123,498-505.
4.WangCQ,WuJL,ZhuoRX,ChengSX*,Protaminesulfate/calciumcarbonate/plasmidDNAternarynanoparticlesforefficientgenedelivery,MolBioSyst2014,10,672-678.
5.WangCQ,GongMQ,WuJL,ZhuoRX,ChengSX*,Dual-functionalizedcalciumcarbonatebasedgenedeliverysystemforefficientgenedelivery,RSCAdv2014,4,38623–38629.
6.ZhaoD,WangCQ,ZhuoRX,ChengSX*,Modificationofnanostructuredcalciumcarbonateforefficientgenedelivery,ColloidsSurfB:Biointerf2014,118,111-116.
2013
7.LiangP,LiuCJ,ZhuoRX,ChengSX*,Self-assembledinorganic/organichybridnanoparticleswithmulti-functionalizedsurfacesforactivetargetingdrugdelivery,JMaterChemB2013,1,4243-4250.
8.LiangP,ZhaoD,WangCQ,ZongJY,ZhuoRX,ChengSX*,Facilepreparationofheparin/CaCO3/CaPhybridnano-carrierswithcontrollablesizeforanticancerdrugdelivery,ColloidsSurfB:Biointerf2013,102,783-788.
9.WangJ,ChenB,ZhaoD,PengY,ZhuoRX,ChengSX*,Peptidedecoratedcalciumphosphate/carboxymethylchitosanhybridnanoparticleswithimproveddrugdeliveryefficiency,InterJPharm2013,446,205-210.
2012
10.ChenS,ZhaoD,LiF,ZhuoRX,ChengSX*,Co-deliveryofgeneanddrugwithnanostructuredcalciumcarbonateforcancertherapy,RSCAdv2012,2,1820-1826.
11.ZhaoD,ZhuoRX,ChengSX*,Alginatemodifiednanostructuredcalciumcarbonatewithenhanceddeliveryefficiencyforgeneanddrugdelivery,MolBioSyst2012,8,753-759.
12.ZhaoD,LiuCJ,ZhuoRX,ChengSX*,Alginate/CaCO3hybridnanoparticlesforefficientco-deliveryofanti-tumorgeneanddrug.MolPharm2012,9,2887-2893.
13.ZhaoD,ZhuoRX,ChengSX*,Modificationofcalciumcarbonatebasedgeneanddrugdeliverysystemsbyacell-penetratingpeptide,MolBioSyst2012,8,3288–3294.
2011
14.ZhangQ,LiF,ZhuoRX,ZhangXZ,ChengSX*,Self-assembledcomplexeswithdual-targetingpropertyforgenedelivery,JMaterChem2011,21,4636-4643.
15.ChenS,ChengSX*,ZhuoRX,Self-assemblystrategyforpreparationofpolymer-basednanoparticlesfordrugandgenedelivery,MacromolBiosci2011,11,576-589.(Invitedfeaturearticle)
16.WangJ,ZongJY,ZhaoD,ZhuoRX,ChengSX*,Insituformationofchitosan-cyclodextrinnanospheresfordrugdelivery,ColloidsSurfB:Biointerf2011,87,198-202.
17.ChenS,LiF,ZhuoRX,ChengSX*,Efficientnon-viralgenedeliverymediatedbynanostructuredcalciumcarbonateinsolution-basedtransfectionandsolid-phasetransfection,MolBioSyst2011,7,2841-2847.
2010
18.WangJ,ChenJS,ZongJY,ZhaoD,LiF,ZhuoRX,ChengSX*,Calciumcarbonate/carboxymethylchitosanhybridmicrospheresandnanospheresfordrugdelivery,JPhysChemC2010,114,18940-18945.
19.ZhangQ,ChenS,ZhuoRX,ZhangXZ,ChengSX*,Self-assembledterplexesfortargetedgenedeliverywithimprovedtransfection,BioconjugateChem2010,21,2086-2092.
20.ChenS,ZhuoRX,ChengSX*,Enhancedgenetransfectionwithadditionofacell-penetratingpeptideinsubstrate-mediatedgenedelivery,JGeneMed2010,12,705-713.
21.ZhangL,HuCH,ChengSX*,ZhuoRX*,Hyperbranchedamphiphilicpolymerwithfolatemediatedtargetingproperty,ColloidsSurfB:Biointerf2010,79,427-433.
22.ZhangL,HuCH,ChengSX*,ZhuoRX*,PEIgraftedhyperbranchedpolymerswithpolyglycerolasacoreforgenedelivery,ColloidsSurfB:Biointerf2010,76,427-433.
23.FuHL,LiYQ,ShaoL,ChengSX*,ZhangXZ,ZhuoRX,Geneexpressionmediatedbydendrimer/DNAcomplexesencapsulatedinbiodegradablepolymermicrospheres,JMicroencapsul2010,27,345-354.
24.YuCY,JiaLH,ChengSX*,ZhangXZ,ZhuoRX,Fabricationofmicroparticleproteindeliverysystemsbasedoncalciumalginate,JMicroencapsul2010,27,171-177.
25.付慧莉、程巳雪*、卓仁禧，用于基因传递系统控制释放的可生物降解高分子材料,高分子学报2009,2,97-103.（邀请论文）
2009
26.YuCY,WeiH,ZhangQ,ZhangXZ,ChengSX*,ZhuoRX,Effectofionsonaggregationbehaviorofnaturalpolymeralginate,JPhysChemB2009,113,14839–14843.
27.ZhangQ,ChengSX*,ZhangXZ,ZhuoRX,WatersolublepolymerprotectedLipofectamine2000/DNAcomplexesforsolid-phasetransfection,MacromolBiosci2009,9,1262–1271.
28.YuCY,CaoH,ZhangXC,ZhouFZ,ChengSX*,ZhangXZ,ZhuoRX,Hybridnanospheresandvesiclesbasedonpectinasdrugcarriers,Langmuir2009,25,11720-11726.
29.LiYQ,LiF,ZhangXZ,ChengSX*,ZhuoRX,Threedimensionalfastdegradingpolymerfilmsfordeliveryofcalciumphosphate/DNAco-precipitatesinsolid-phasetransfection,JMaterChem2009,19,6733-6739.
30.ZhangQ,ZhaoD,ZhangXZ,ChengSX*,ZhuoRX*,Calciumphosphate/DNAco-precipitatesencapsulatedfastdegradingpolymerfilmsforsubstrate-mediatedgenedelivery,JBiomedMaterResBApplBiomater2009,91B,172-180.
31.YuCY,YinBC,ZhangW,ChengSX*,ZhangXZ,ZhuoRX,Compositemicroparticledrugdeliverysystemsbasedonchitosan,alginateandpectinwithimprovedpH-sensitivedrugreleaseproperty,ColloidsSurfB:Biointerf2009,68,245-249.
32.张桥、汪军、赵东、程巳雪*，负载肝素及生物素化肝素修饰的纳米粒子的基质介导基因传递系统，高分子学报2011,8,824-831.（邀请论文）
2008
33.YuCY,JiaLH,YinBC,ZhangXZ,ChengSX*,ZhuoRX,Fabricationofnanospheresandvesiclesasdrugcarriersbyself-assemblyofalginate,JPhysChemC2008,112,16774–16778.
34.FuHL,ChengSX*,ZhangXZ,ZhuoRX,Dendrimer/DNAcomplexesencapsulatedfunctionalbiodegradablepolymerforsubstrate-mediatedgenedelivery,JGeneMed2008,10,1334–1342.
35.ChenS,ZhangXZ,ChengSX*,ZhuoRX,GuZW,Functionalizedamphiphilichyperbranchedpolymersfortargeteddrugdelivery,Biomacromolecules2008,9,2578-2585.
36.YuCY,ZhangXC,ZhouFZ,ZhangXZ,ChengSX*,ZhuoRX*,Sustainedreleaseofantineoplasticdrugsfromchitosan-reinforcedalginatemicroparticledrugdeliverysystems,InterJPharm2008,357,15-21.
37.ZhouYX,LiSL,FuHL,ChengSX*,ZhangXZ,ZhuoRX,Fabricationandinvitrodrugreleasestudyofmicrospheredrugdeliverysystemsbasedonamphiphilicpoly-α,β-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(L-lactide)graftcopolymers,ColloidsSurfB:Biointerf2008,61,164-169.
2007
38.FuHL,ChengSX*,ZhangXZ,ZhuoRX,Dendrimer/DNAcomplexesencapsulatedinawatersolublepolymerandsupportedonfastdegradingstarpoly(DL-lactide)forlocalizedgenedelivery,JControlRelease2007,124,181-188.
39.FuHL,ZouT,ChengSX*,ZhangXZ,ZhuoRX,Cholicacidfunctionalizedstarpoly(DL-lactide)forpromotingcelladhesionandproliferation,JTissueEngRegenMed2007,1,368-376.
40.ZhangH,TongSY,ZhangXZ,ChengSX*,ZhuoRX,LiH,Novelsolvent-freemethodsforfabricationofnano-andmicrospheredrugdeliverysystemsfromfunctionalbiodegradablepolymers,JPhysChemC2007,111,12681-12685.
41.ZouT,LiSL,ZhangXZ,WuXJ,ChengSX*,ZhuoRX*,Synthesisandcharacterizationofabiodegradableamphiphiliccopolymerbasedonbranchedpoly(ε-caprolactone)andpoly(ethyleneglycol),JPolymSciAPolymChem2007,45,5256-5265.
42.ZouT,LiSL,ChengSX*,ZhangXZZhuoRX*,Fabricationandinvitrodrugreleaseofdrug-loadedstaroligo/poly(DL-lactide)microspheresmadebynovelultrasonicdispersionmethod,JBiomedMaterResA2007,83A,696-702.
43.ZouT,LiSL,HuZY,ChengSX*,ZhuoRX,Synthesisandpropertiesofstaroligo/poly(trimethylenecarbonate)swithcholicacidmoietiesascores,JBiomaterSciPolymEdn2007,18,519-530.
44.FuHL,YuL,ZhangH,ZhangXZ,ChengSX*,ZhuoRX,Synthesisofnovelcholicacidfunctionalizedbranchedoligo/poly(ε-caprolactone)sforbiomedicalapplications,JBiomedMaterResA2007,81A,186-194.
45.ZouT,ChengSX*,ZhangXZ,ZhuoRX*,Novelcholicacidfunctionalizedstaroligo/poly(DL-lactide)sforbiomedicalapplications,JBiomedMaterResBApplBiomater2007,82B,400-407.
2006
46.MiaoZM,ChengSX*,ZhangXZ,ZhuoRX*,Studyondrugreleasebehaviorsofpoly-α,β-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(ε-caprolactone)nano-andmicroparticles,Biomacromolecules2006,7,2020-2026.
47.WanT,LiuY,YuJQ,ChenS,LiF,ZhangXZ,ChengSX*,ZhuoRX,Synthesisandcharacterizationofstaroligo/poly(2,2-dimethyltrimethylenecarbonate)scontainingcholicacidmoiety,JPolymSciAPolymChem2006,44,6688-6696.
48.YuL,ZhangH,ChengSX*,ZhuoRX,LiH,Studyonthedrugreleasepropertyofcholesterylend-functionalizedpoly(ε-caprolactone)microspheres,JBiomedMaterResBApplBiomater2006,77B,39-46.
49.ZouT,LiF,ChengSX*,ZhuoRX,Synthesisandcharacterizationofend-cappedbiodegradableoligo/poly(trimethylenecarbonate)s,JBiomaterSciPolymEdn2006,17,1093-1106.
2005
50.WanT,ZouT,ChengSX*,ZhuoRX,Synthesisandcharacterizationofbiodegradablecholesterylend-cappedpolycarbonates,Biomacromolecules2005,6,524-529.
51.ZhangL,WangQR,JiangXS,ChengSX*,ZhuoRX,Studiesonfunctionalizationofpoly(ε-caprolactone)bycholesterylmoiety,JBiomaterSciPolymEdn2005,16,1095-1108.
52.ZouT,ChengSX*,ZhuoRX,Synthesisandenzymaticdegradationofend-functionalizedbiodegradablepolyesters,ColloidandPolymSci2005,283,1091-1099.
2004
53.ZhangL,PengT,ChengSX*,ZhuoRX,Destabilizationofliposomesbyunchargedhydrophilicandamphiphilicpolymers,JPhysChemB2004,108,7763-7770.
2003
54.ChengSX,ZhangJT,ZhuoRX,Macroporouspoly(N-isopropylacrylamide)hydrogelswithfastresponseratesandimprovedproteinreleaseproperties,JBiomedMaterRes2003,67A,96-103.
55.ChengSX,MiaoZM,WangLS,ZhuoRX,Synthesisandcharacterizationofnovelbiodegradablecopolymersof5-benzyloxy-1,3-dioxan-2-oneandglycolide,MacromolRapidCommun2003,24,1066-1069.
56.ChengSX,ChungTS,WangR,VoraRH,Gas-sorptionpropertiesof6FDA-durene/1,4-phenylenediamine(pPDA)and6FDA-durene/1,3-phenylenediamine(mPDA)copolyimides,JApplPolymSci2003,90,2187-2193.
2002
57.ChengSX,ChungTS,Investigationoftheeffectofanethermoietyontheliquidcrystallinitybythinfilmpolymerization,MacromolChemPhys2002,203,122-128.
58.ChengSX,ChungTS,Effectofafluorinelateralmoietyontheliquidcrystallinityofwhollyaromaticpolyester-amides,Polymer2002,43,7433-7441.
2000
59.ChengSX,ChungTS,Dynamicresponsesofathermotropicmain-chainliquidcrystallinepolyesterduringpolymerizationunderelectricfields,JPhysChemB2000,104,10506-10512.
60.ChengSX,ChungTS,Configurationeffectsofortho,metaandparalinkagesonliquidcrystallinityduringthinfilmpolymerizationofpoly(ester-amide)s,JPolymSciBPolymPhys2000,38,2221-2231.
1999
61.ChengSX,ChungTS,Phaseseparationandcoalescence,annihilationofliquidcrystaltexturesduringpolymerizationofmain-chainliquidcrystallinepolyesters,JPhysChemB1999,103,4923-4932.
62.ChengSX,ChungTS,MullickS,Novelthin-filmpolymerizationandtimeevolutionofliquidcrystaltextureduringpolymerization,ChemEngSci1999,54,663-674.
63.ChengSX,ChungTS,MullickS,Effectsofmonomerstructuresonevolutionofliquid-crystaltextureandcrystallizationduringthin-filmpolymerization,JPolymSciBPolymPhys1999,37,3084-3096.
1996
64.ChengSX,BaiRK,ZouYF,PanCY,Electro-opticalpropertiesofpolymerdispersedliquidcrystalmaterials,JApplPhys1996,80,1991-1995.
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主讲本科生课程《化学应用英语》
主讲研究生课程《专业英语》
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