姓 名：
章焰生性别：
男
职 务：
无职称：
研究员
学 位：
博士通讯地址：
中国科学院武汉植物园 430074
电 话：
**邮政编码：
430074
传 真：
**电子邮件：
zhangys@wbgcas.cn

导师简介：
章焰生，男，博士，中国科学院武汉植物园天然药物生物合成学学科组首席研究员，硕士生、博士生导师。2005年3月于中国科学院植物研究所获植物学博士学位，从事植物次生代谢物的生物合成与分子调控方面的研究；博士毕业后，先后去了美国与加拿大做博士后，从事天然药物生物合成方面的研究；2008年4月-2010年3月在加拿大植物生物技术研究所任研究助理，从事中药“王不留行”中三萜类功能性化合物的生物合成研究；2009年底入选中国科学院“百人计划”，2010年至今在中国科学院武汉植物园工作，从事天然药物合成生物学研究。目前已在Nature、Journal of The American Chemical Society、Journal of Biological Chemistry、New Phytologist、Plant Physiology、Plant Biotechnology Journal、Phytochemistry、 Planta Medica等著名期刊上发表研究论文20多篇。
Dr. Yansheng Zhang is a professor and principal investigator of the Natural Product Biosynthesis Laboratory, The Wuhan botanical garden, Chinese Academy of Science. He received his Ph.D from Institute of Botany, Chinese Academy of Science in 2005, and had postdoctoral trainings in Donald Danforth Plant Science Center of U.S.A and the Plant Biotechnology Institute of Canada. From 04/2008 to 03/2010, he continued to work in Plant Biotechnology Institute of Canada as a research associate and studied on triterpenoid biosynthesis in Saponaria. In 2010, he jointed in the Natural Product Biosynthesis Lab., the Wuhan Botanical Garden, Chinese Academy of Science as a professor. He has been working in natural product biosynthesis area and published over 20 papers in the journals such as Journal of The American Chemical Society、Journal of Biological Chemistry、New Phytologist、Plant Physiology、Plant Biotechnology Journal、Phytochemistry、 Planta Medica etc.
简要履历：
2010年4月至今，中国科学院武汉植物园，研究员

2008年4月-2010年3月，加拿大植物生物技术研究所，研究助理

2006年4月-2008年3月，加拿大植物生物技术研究所，博士后

2005年4月-2006年3月，美国Donald Danforth植物科学中心，博士后

2001年9月-2005年3月，中国科学院植物研究所攻读博士学位

研究领域：
研究组长期的研究方向为植物天然药物合成生物学研究，利用功能基因组、生物化学以及植物化学等手段，以药用植物为研究对象，对其中具有重大药用价值的天然药物的合成进行代谢调控研究；分离天然药物生物合成途径中的关键基因，利用微生物平台，借助合成生物学技术，在微生物中大量而经济地合成植物天然药物。

社会任职：
获奖及荣誉：
代表论著：
Xin Wang, Chen Zhou, Xianpeng Yang, Di Miao,Yansheng Zhang*,De novo transcriptome analysis of Warburgia ugandensis to identify genes involved in terpenoids and unsaturated fattyacids biosynthesis, Plos One, 10(8): e**,2015 (IF=3.2).

Jing Li,Yansheng Zhang*, Modulating betulinic acid production in Saccharomyces cerevisiae by managing the intracellular supplies of the co-factor NADPH and oxygen, Journal of Bioscience and Bioengineering, 119(1): 77-81, 2015 (IF=1.9).

Xin Wang, Shutao Li, Jia Li, Changfu Li, Yansheng Zhang*, De novo transcriptome sequencing in Pueraria lobata to identify putative genes involved in isoflavones biosynthesis, Plant Cell Rep., 34: 733-743, 2015 (IF=3.1).

Zhiqiang Sun, Hailing Meng, Jing Li, Jianfeng Wang, Yong Wang, Yansheng Zhang*,Identification of Novel Knockout Targets for Improving Terpenoids Biosynthesis in Saccharomyces cerevisiae., Plos One,9 (11): e112615,2014 (IF=3.7).

Changfu Li, Fangfang Chen, Yansheng Zhang*, GA3 and other signal regulators (MeJA and IAA)improve xanthumin biosynthesis in different manners in Xanthium strumarium L., Molecules,19, 12898-12908, 2014 (IF=2.1).

Jing Li, Yansheng Zhang*, Modulating betulinic acid production in Saccharomyces cerevisiae by managing the intracellular supplies of the co-factor NADPH and oxygen, Journal of Bioscience and Bioengineering, DOI: 10.1016/j.jbiosc.2014.06.013, 2014 (IF=1.7)

Jia Li, Zhaobo Li, Changfu Li, Junbo Gou,Yansheng Zhang*, Molecular cloning and characterization of an isoflavone 7-O-glucosyltransferase from Pueraria lobata, Plant Cell Reports, 33:1173-1185, 2014 (IF=2.5).

Jing Li, Yansheng Zhang*, Increase of betulinic acid production in Saccharomyces cerevisiae by balancing fatty acids and betulinic acid forming pathways, Applied Microbiology and Biotechnology, 98: 3081-3089, 2014 (IF=3.8).

Zhaobo Li, Changfu Li, Jia Li, Yansheng Zhang*, Molecular cloning and functional characterization of two divergent 4-coumarate:coenzyme A ligases from kudzu (Pueraria lobata), Biol. Pharm . Bull., 37(1):113-122, 2014 (IF=1.8).

C. J. Paddon, P. J. Westfall, ….,Y. Zhang, …..,N. S. Renninger, J. D. Newman, High-level production of semi-synthetic artemisinin, a potent antimalarial, Nature, 496(7446): 528-532, 2013 (IF=38.6).

Fangfang Chen, Fuhua Hao, Changfu Li, Junbo Gou, Dayan Lu, Fujun Gong, Huiru Tang*, and Yansheng Zhang*, Identifying three ecological chemotypes of Xanthium strumarium glandular trichomes using a combined NMR and LC-MS method, Plos One, 8(10):e76621, 2013 (IF=3.7).

Qian Li, Zhiqiang Sun, Jing Li, Yansheng Zhang*, Enhancing beta-carotene production in Saccharomyces cerevisiae by metabolic engineering, FEMS Microbiology Letters, 345: 94-101, 2013 (IF=2.0).

Lili Huang, Hong Wang, Hechun Ye, Zhigao Du, Yansheng Zhang*, Ludger Beerhues, Benye Liu*, Differential expression of benzophenone synthase and chalcone synthase in Hypericum sampsonii, Natural Product Communication, 7: 1615-1618, 2012 (IF=1.2).

Lili Huang, Jia Li, Hechun Ye, Changfu Li, Hong Wang, Benye Liu, Yansheng Zhang*, Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus, Planta, 236: 1571-1581, 2012 (IF=3.0).

Yechun Wang, Coralie Halls, Juan Zhang, Michiyo Matsuno, Yansheng Zhang, Oliver Yu, Stepwise increase of resveratrol biosynthesis in Saccharomyces cerevisiae by metabolic engineering, Metabolic engineering, 13: 455-463, 2011 (IF=6.9).

Lies Maes¹, Filip Nieuwerburgh¹, Yansheng Zhang¹, Darwin Reed, Jacob Pollier, Sofie R. F. Vande Casteele, Dirk Inze, Patrick Covello, Dieter L. D. Deforce and Alain Goossens, Dissection of the response of Artemisia annua plants to phytohormones identifies genes involved in terpene biosynthesis and the development of glandular trichomes, New Phytologist, 189: 176-189, 2011 (¹ co-first author, IF=6.7).

Yansheng Zhang, Goska Nowak, Darwin Reed, Patrick Covello, The production of artemisinin precursors in tobacco, Plant Biotechnology Journal, 9: 445-454, 2011 (IF=6.3).

Jianchun Qin, Lin Zhu, Mingjun Gao, Xian Wu, Hongyu Pan, Yansheng Zhang*, Xiang Li*, Cloning and functional characterization of a chalcone isomerase from Trigonella foenum-graecum L., Planta Medica, 77: 765-770, 2011 (IF=2.3).

Devin Polichuk¹, Yansheng Zhang¹, Darwin Reed, Janice Schmidt, Patrick Covello, A glandular trichome-specific monoterpene alcohol dehydrogenase from Artemisia annua, Phytochemistry, 71: 1264-1269, 2010 (¹ co-first author, IF=3.0).

Hao Zhang, Guangzhi Sun, Xiang Li, Hongyu Pan*, and Yansheng Zhang*, A new geldanamycin analogue from Streptomyces hygroscopicus, Molecules, 15: 1161-1167, 2010 (IF=2.4).

Yansheng Zhang, Keat Teoh, Darwin Reed, Patrick Covello, Molecular cloning and characterization of Dbr1, a 2-alkenal reductase from Artemisia annua, Botany, 87: 643-649, 2009 (IF=1.2).

Zhang Y, Liu ZH, Jia L, Peng ZL, Jaworski J, Wang XM, Jez J., Chen F, Yu O , Using unnatural protein fusions to engineer resveratrol biosynthesis in yeast and mammalian cells. Journal of American Chemical Society, 128: 13030-13031, 2006 (IF = 10.7).

Yansheng Zhang, Keat H. Teoh, Darwin W. Reed, Lies Maes, Alain Goossens, Douglas J.F. Olson, Andrew R.S. Ross, and Patrick S. Covello, The molecular cloning of artemisinic aldehyde Δ 11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua. J. Biol. Chem., 283: 21501-21508, 2008 (IF = 4.7).

Yansheng Zhang, Hechun Ye, Guofeng Li, Molecular Cloning a classical plant peroxidase from A. annua and its effect on the biosynthesis of artemisinin in vitro, Acta Botanica Sinica, 46: 1338-1346 , 2004 (此杂志已更名为Journal of Integrative Plant Biology, IF = 3.8).

Zhang J., Subramanian S., Zhang Y., Yu O., Flavone synthases from Medicago truncatula are flavanone-2-hydroxylases and are important for nodulation, Plant Physiology, 144(2): 741-751, 2007 (IF=6.6).

承担科研项目情况：
中国科学院武汉植物园"百人计划"启动经费 (2010-2012)
中国科学院"百人计划"择优项目(2011-2013)
非粮油能源植物的含油量与脂肪酸组成等指标的分析”(国家基础性重大项目之子课题)(2010-2011)
中国科学院方向性项目 (2011-2013)
国家自然科学基金面上项目 (2012-2015)
公司横向合作项目 (2012-2013)
教育部留学回国启动基金(2012-2013)
科技部863项目 (2012.11-2016.11)
国家自然科学基金面上非连续项目(2013.1-2013.12)
公司横向合作项目 (2013.1-2017.12)
国家自然科学基金面上项目(2014-2017)
公司横向合作项目 (2014.1-2016.12)
公司横向合作项目 (2014.8-2017.8)

课题组其他成员主持或参加的项目

国家自然科学基金青年基金项目(2014-2016)