姓 名:
　胡炜 性 别:
　男
职 称:
　研究员 学 历:
　研究生
电 话:
　86- 邮 箱:
　huwei#ihb.ac.cn


简历：
胡炜，男，博士，研究员，博士生导师，鱼类基因工程学科组组长，副所长。国家自然科学基金创新研究群体学术带头人，湖北省自然科学基金创新群体学术带头人。先后在南开大学和中国科学院研究生院获学士、硕士和博士学位。国家水产原种和良种审定委员会委员，国家农业转基因生物安全委员会委员，国家蓝色粮仓科技创新重点专项总体专家组成员，中国水产学会淡水养殖分会副主任委员、水产生物技术专业委员会委员，中国动物学会比较内分泌分会理事。Comparative Biochemistry and Physiology、Frontiers in Endocrinology、水生生物学报、遗传、农业生物技术学报、中国农业科技导报和水产学报等学术期刊编委。
主要从事鱼类生殖发育调控、鱼类分子遗传育种和克隆胚胎再程序化机制等研究。先后主持国家****基金、国家自然科学基金重点项目、国家重点研发计划项目、863项目和湖北省****基金、湖北省创新研究群体等项目。发现脊椎动物生殖轴的核心信号GnRH3具有调控性别分化的新功能，中枢神经系统中最主要的抑制性神经递质GABA对鱼类生殖具有双重调控作用，揭示了鱼类生殖轴中重要信号分子在脊椎动物雌雄生殖中的不同功能及调控性腺发育的机理，发现了鱼类生殖轴与生长轴间新的信号调控通路，发现鱼类配子成熟需要RNA的m⁶A甲基化修饰，合作发现神经内分泌激素SN在鱼类生殖、生殖行为及神经血管发育中的新功能。创建了鱼类育性可控的生殖开关新策略，培育出超雄鲤、伪雄鲤和伪雌鲤，合作培育出具有优良养殖性状的冠鲤和生殖发育可控的吉鲤，全面系统地评价了冠鲤的生态安全。首次报道了低溶氧耐受鱼的成功研制。建立了黄鳝、鲤、鲟等重要养殖鱼类高效特异的基因组编辑技术平台，并有效运用于遗传育种和基因功能研究。建立模式动物斑马鱼的克隆技术，获得斑马鱼体细胞再程序化机制及克隆胚发育机理研究的新发现。
在PNAS，Genetics，Endocrinology，Journal of Molecular Cell Biology，Biology of Reproduction，MarineBiotechnology，Aquaculture，中国科学和科学通报等学术期刊上发表SCI论文80余篇，其中封面论文4篇；参编国内外著作5本。获美国发明专利4项，获中国发明专利6项。


研究方向：
鱼类基因工程与生殖发育调控


职务：


社会任职：


获奖及荣誉：

代表论著：

代表性论文目录：
1.Mitchell Kimberly, Zhang Wo Su, Lu Chunyu, Tao Binbin, Chen Lu, Hu Wei*, Trudeau Vance L*.Targeted mutation of secretogranin-2 disrupts sexual behavior andreproduction in zebrafish. PNAS, 2020,doi/10.1073/pnas..
2.Feng Ke, Cui Xuefan, Song Yanlong, Tao Binbin,Chen Ji, Wang Jing, Liu Shaojun, Sun Yonghua, Zhu Zuoyan, Trudeau Vance L. and Hu Wei*. Gnrh3 regulates PGC proliferation and sex differentiation in developing zebrafish. Endocrinology, 2020,161(1). doi: 10.1210/endocr/bqz024
3.XiaHui,ZhongChengrong, WuXingxing, ChenJi,TaoBinbin,XiaXiaoqin, ShiMijuan,ZhuZuoyan,Trudeau Vance L. and HuWei^*.Mettl3 mutation disrupts gamete maturation and reduces fertility in zebrafish. Genetics, 2018,208（2）：729-743.（杂志推介）
4.Tao Binbin, Hu Hongling, Mitchell Kimberly, Chen Ji, Jia Haibo, Zhu Zuoyan, Trudeau Vance L.*, Hu Wei*. Secretogranin-II plays a critical role in zebrafish neurovascular modeling. Journal of Molecular Cell Biology, 2018, 10(5):388–401.(cover paper)
5.Song Yanlong, Tao Binbin, Chen Ji, Jia Shaoting, Zhu Zuoyan, Trudeau Vance L., Hu Wei*. GABAergic Neurons and Their Modulatory Effects on GnRH3 in Zebrafish. Endocrinology,2017, 158(4):874–886.
6.Song Yanlong, Chen Ji, Tao Binbin, Luo Daji, Zhu Zuoyan, Hu Wei^*. Kisspeptin2 Regulates Hormone Expression in Female Zebrafish (Danio rerio) Pituitary. Molecular and Cellular Endocrinology, 2020, 513：doi.org/10.1016/j.mce.2020.110858
7.Jiang Mouyan, Jia Shaoting, Chen Ji, Chen Kuangxin, Ma Wenge, WuXingxing ,Luo Hongrui, Li Yongming, Zhu Zuoyan, Hu Wei*. Timing of gonadal development and dimorphic expression of sex-relatedgenes in gonads during early sex differentiation in the Yellow River carp. Aquaculture, 2020, 518:734825
8.Luo Hongrui, Feng Ke, Chen Ji, Song Yanlong, Hou Mingxi,Jiang Yinjun, Jiang Mouyan, Li Yongming, Tao Binbin, Wang Yaping, Zhu Zuoyan, Hu Wei*. Telophase of the first cleavageis the key stage for optimally inducing mitotic gynogenesis in rice field eel (Monopterusalbus), Aquaculture(2019), doi.org/10.1016/j.aquaculture.2020.735241
9.Chen Ji, Cao Mengxi, Zhang Aidi, Shi Mijuan, Tao Binbin, Li Yongming, Wang Yaping, Zhu Zuoyan, Trudeau Vance L.*, Hu Wei*.Growth hormone overexpression disrupts reproductive status through actions on leptin. Frontiers in Endocrinology, 2018, 9: DOI:10.3389/fendo.2018.00131
10.Chen Ji, Wang Wei, Tian Zhaohui, Dong Ying, Dong Tian, Zhu Hua, Zhu Zuoyan , Hu Hongxia*, Hu Wei*.Efficient gene transferand gene editing in sterlet(Acipenser ruthenus). Frontiers in Genetics, 2018, 9: DOI:10.3389/fgene.2018.00117
11.Feng K, Luo H, Hou M, Li Y, Chen J, Zhu Z, Hu W*. Alternative splicing of GnRH2 and GnRH2-associated peptide plays roles in gonadal differentiation of the rice field eel,Monopterus albus.General and Comparative Endocrinology, 2018, 267: 9-17.
12.Hu Hongling, Tao Binbin,Chen Ji,Zhu Zuoyan, Hu Wei*. Fam60alasa novelfactor involved inreprogrammingof somatic cell nuclear transfer in zebrafish(Danio rerio). International Journal of Biological Sciences, 2018; 14(1):78-86.
13.Jiang Mouyan, Wu Xingxing, Chen Kuangxin, Luo Hongrui, Yu Wei, Jia Shaoting,Li Yongming, Wang Yufeng, Yang Pinhong, Zhu Zuoyan and Hu Wei*. Production of YY super-male and XY physiological female common carp for potential eradication of this invasive species. Journal of the World Aquaculture Society, DOI: 10.1111/jwas.12492.（世界水产学会2018年度最佳应用类论文奖）
14.Luo Daji, Feng Ke, Zhu Zuoyan and Hu Wei*. Generating gene knockout Oryzias Latipesand Rice Field eel using TALENs method. SpringerProtocols,Methods in Molecular Biology, Microinjection: Methods and Protocols.Humana Press, 2018, 489-506.
15.Feng Ke, Luo Hongrui, LiYongming, Chen Ji, Wang Yaping, SunYonghua, Zhu Zuoyan and Hu Wei*, High efficient gene targeting in rice field eel Monopterus albusby transcription activator-like effector nucleases. Science Bulletin, 2017, 62:162-164.
16.Dillon F. Da Fonte1, Christopher J. Martyniuk, Lei Xing, Adrian Pelin, Nicolas Corradi, Wei Hu& Vance L. Trudeau. Secretoneurin A regulates neurogenic and infammatory transcriptional networks in goldfsh (Carassius auratus) radial glia.Scientific Reports,7: 14930,DOI:10.1038/s41598-017-14930-8
17.俞薇，曹梦西，陈戟，贾少婷，李勇明，朱作言，胡炜*。鲤性腺GnRH-GtH旁分泌系统的发现及其在生长/生殖调控中的作用，农业生物技术学报，2017, 25(9): 1516-1525.
18.朱作言，胡炜，转基因鱼及其安全性。科学，2017，69（6）：25-27.
19.Chen Ji.Cui Xiaojuan, Jia Shaoting, Luo Daji, Cao Mengxi, Zhang Yunsheng,Hu Hongling, Huang Kaiyao, Zhu Zuoyan & Hu Wei*. Disruption of dmc1 produces abnormal sperm in medaka (Oryzias latipes).Scientific Reports,2016, 6, 30912; doi: 10.1038/srep30912.
20.Mikwar M, Navarro-Martin L, Volkoff H, Hu Weiand Trudeau V.L. Stimulatory effect of the secretogranin-ll derived peptide secretoneurin on food intake and locomotion in female goldfish(Carassius auratus), Peptides, 2016 Apr;78:42-50.
21.Peng Wei, Cao Mengxi, Chen Ji, Li Yongming, Wang Yaping, Zhu Zuoyan, Hu Wei*.GnIH plays a negative role in regulating GtH expression in the commoncarp, Cyprinus carpio L. General and Comparative Endocrinology, 2016,235 :18–28.
22.Shu Yuqin, Lou Qiyong, Dai Ziru, Dai Xiangyan, He Jiangyan, Hu Wei*& Yin Zhan*, The basal function of teleostprolactin as a key regulator on ionuptake identified with zebrafishknockout models.Scientific Reports, 2016, 6:18597,DOI: 10.1038/srep18597.
23.Zhu T. B, Zhang L. H,Zhang T. L, WangY. P, Hu W, Ring？ E.and Zhu Z. Y. ^.Effects of sustained predation by fast-growingtransgeniccommon carp (Cyprinus carpio Linnaeus, 1758) on gastropodsin artificial environments. J. Appl. Ichthyol. 2016; DOI:10.1111/jai.13130
24.胡炜*，朱作言。美国转基因大西洋鲑产业化对我国的启示。中国工程科学，2016，18（3）：105-109。
25.Zhang Yunsheng, Chen Ji, Cui Xiaojuan, Luo Daji, Xia Hui, Dai Jun, Zhu Zuoyan, Hu Wei*. A controllable on-off strategy for the reproductive containment of fish. Scientific Reports, 2015,5,7614; DOI:10.1038/srep07614.
26.Song Yanlong, DuanXiaohai, Chen Ji, Zhu Zuoyan, Hu Wei*. The distribution of Kiss1- and Kiss2-positive neurones and their connections with GnRH3 neurones in the zebrafish brain. Journal of Neuroendocrinology, 2015, 27(3):198–211. (cover paper)
27.Luo Daji, Liu Yun, Chen Ji, Xia Xiaoqin, Cao Mengxi, Cheng Bin, Wang Xuejuan, Gong Wuming, Qiu Chao, Zhang Yunsheng, Cheng Christopher Hon Ki, Zhu Zuoyan & Hu Wei*. Direct production of XY^DMY？sex reversal female medaka (Oryzias latipes) by embryo microinjection of TALENs. Scientific Reports,5:14057, DOI: 10.1038/srep14057
28.Tang Haipei, Liu Yun, Luo Daji, Ogawa Satoshi, Yin Yike,Li Shuisheng, Zhang Yong, Hu Wei, Parhar Ishwar S, Lin Haoran,Liu Xiaochun, Cheng Christopher H.K..The kiss/kissr systems are dispensable for zebrafishreproduction: evidence from gene knockout studies. Endocrinology, 2015,156:589-599.
29.Chu Lianhe, Li Jianzhen, Liu Yun, Hu Wei*, Cheng Christopher H.K*..Targeted gene disruption in zebrafish reveals noncanonical functions of Lh signaling in reproduction. Molecular Endocrinology, 2014, 28(11):1785-95.
30.Cao Mengxi, Chen Ji, Peng Wei, Wang Yaping, Liao Lanjie, Li Yongming, Trudeau Vance L., Zhu Zuoyan, Hu Wei*. Effects of growth hormone over-expression on reproduction in the common carp CyprinuscarpioL. General and Comparative Endocrinology, 2014,195:47-57.
31.Garcia-ReyeroNatàlia, Tingaud-SequeiraAngèle, Cao Mengxi, Zhu Zuoyan, Perkins Edward, Hu Wei. Endocrinology: Advances through omics and related technologies, General and Comparative Endocrinology, 2014, 203:262-273.(Invited review)
32.Liu Y, Luo D, Lei Y, Zhao H, Hu W*, Cheng HK*, A highly effective TALEN-mediated approach for targeted gene disruption in Xenopustropicalisand zebrafish, Methods, 2014, 69:58–66.
33.Qiu Chao, Cheng Bin, Zhang Yunsheng, Huang Rong, Liao Lanjie, Luo Daji, Hu Wei*, Wang Yaping*. Efficient Knockout of Transplanted Green Fluorescent Protein Gene in Medaka using TALENs. MarineBiotechnology. 2014, 16(6):674-83(cover paper)
34.Zhong C, Song Y, Wang Y, Zhang T, Duan M, Li Y, Liao L, Zhu Z, Hu W*.Increased food intake in growth hormone-transgenic common carp (CyprinuscarpioL.) may be mediated by upregulating Agouti-related protein (AgRP). General and Comparative Endocrinology，2013，192, 81-88.
35.ChenJi, Hu Wei* & Zhu ZuoYan. Progress in studies of fish reproductive development regulation. Chinese Science Bulletin, 2013,58:7-16.陈戟，胡炜，朱作言，鱼类生殖发育调控研究进展。科学通报，2013,58:103-114.
36.Lian Hao, Hu Wei, Huang Rong, Du Fukuan, Liao Lanjie, Zhu Zuoyan, Wang Yaping. Transgenic Common Carp Do Not Have the Ability to Expand Populations. plos one, 2013, 8(6): e65506.
37.Liu Yun, Luo Daji, Zhao Hui, Zhu Zuoyan, Hu Wei*, Cheng Christopher H. K*.. Inheritable and Precise Large Genomic Deletions of Non-Coding RNA Genes in Zebrafish Using TALENs. plos one, 2013, 8(10): e76387.
38.ZhongChengrong, Song Yanlong, Wang Yaping, Li Yongming, Liao Lanjie, XieShouqi, Zhu Zuoyan, Hu Wei*. Growth hormone transgene effects on growth performance are inconsistent among offspring derived from different homozygous transgenic common carp (CyprinuscarpioL.). Aquaculture, 2012, 356–357: 404–411.
39.Cao Mengxi, DuanJundan, Cheng Nana, ZhongXueping, Wang Zequn, Hu Wei*, Zhao Haobin*. Sexually dimorphic and ontogenetic expression of dmrt1, cyp19a1a and cyp19a1b in Gobiocyprisrarus. Comparative Biochemistry and Physiology, Part A, 2012, 162: 303–309.
40.Cao Mengxi, Yang Yuhui, Xu Hongyan, DuanJundan, Cheng Nana, Wang Jialin, Hu Wei, Zhao Haobin. Germ cell specific expression of Vasa in rare minnow, Gobiocyprisrarus,Comparative Biochemistry and Physiology, Part A, 2012, 162:163–170.
41.Guan Bo, Ma Hong, Wang Yaping, Hu Yuanlei, Lin Zhongping, Zhu Zuoyan, Hu Wei*. Vitreoscilla Hemoglobin (VHb) Overexpression Increases Hypoxia Tolerance in Zebrafish (Daniorerio). Marine Biotechnology, 2011, 13（2）: 336-344. (cover paper)
42.Li Deliang, FU Cuizhang, Wang Yaping, Zhu Zuoyan, Hu Wei*. The hematological response to exhaustive exercise in ‘all-fish’ growth hormone transgenic common carp (CyprinuscarpioL.). Aquaculture, 2011,311:263-268.
43.Luo Daji, Hu Wei*, Chen Shangping, Zhu Zuoyan. Critical Developmental Stages For The Efficiency Of Somatic Cell Nuclear Transfer In Zebrafish. International Journal of Biological Sciences, 2011,7: 476-486.
44.Xu Jing, Huang Wei, ZhongChengrong, Luo Daji, Li Shuangfei, Zhu Zuoyan and Hu Wei*, Defining Global Gene Expression Changes of the Hypothalamic-Pituitary-Gonadal Axis in Female sGnRH-Antisense Transgenic Common Carp (Cyprinuscarpio).plos one,2011, 6(6): e21057.
45.Xu Zhuwei, Li Qi, Wang Yun, Song Chaojun, Zhang Tao, Chen Lihua, JiJianguo, Yang Angang, Zhu Zuoyan, Hu Wei*, Jin Boquan*. Production, characterization, and applications of mouse monoclonal antibodies against gonadotropin, somatolactin, and prolactin from common carp (Cyprinuscarpio). General and Comparative Endocrinology, 2010, 167:373-378.
46.Tang Bin, Hu Wei*, Hao Jun and Zhu Zuoyan. Developmental expression of steroidogenic factor-1, cyp19a1a and cyp19a1b from common carp (Cyprinuscarpio). General and Comparative Endocrinology, 2010,167:408-416.
47.Dai J, Cui X, Zhu Z, Hu W*. Non-Homologous End Joining Plays a Key Role in Transgene Concatemer Formation in Transgenic Zebrafish Embryos. International Journal of Biological Sciences, 2010; 6:756-768.
48.Duan M., Zhang T., Hu W*., Guan B., Wang Y., Li Z. & Zhu Z.. Increased mortality of “all-fish” growth hormone transgenic common carp (CyprinuscarpioL.) under a short-term risk of predation. Journal of Applied Ichthyology, 2010,26:908–912.
49.Guan Bo, HU Wei*, ZHANG Tanglin, DUAN Ming, LI Deliang, WANG Yaping, Zhu Zuoyan. Acute and chronic un-ionized ammonia toxicity to ‘all-fish’ growth hormone transgenic common carp (CyprinuscarpioL.). Chinese Science Bulletin, 2010, 55:4032-4036.
50.Hu Weiand Zhu Zuoyan*. Integration mechanisms of transgenes and population fitness of GH transgenic fish. Science in China Ser C-Life Sci, 2010, 53:401-408.
51.Luo Yu-Shan, Hu Wei*, Liu Xiao-Chun, Lin Hao-Ran, Zhu Zuo-Yan. Molecular cloning and mRNA expression pattern of Sox9 during sex reversal inorange-spotted grouper (Epinepheluscoioides). Aquaculture, 2010,306:322-328.
52.Luo D, Hu W*, Chen S, Xiao Y, Sun Y, Zhu Z. Identification of Differentially Expressed Genes Between Cloned and Zygote-Developing Zebrafish (Daniorerio) Embryos at the Dome Stage Using Suppression Subtractive Hybridization. Biology of Reproduction, 2009，80：674-684.
53.Guan B, Hu W*, Zhang T, Wang Y, Zhu Z. Metabolism traits of 'all-fish' growth hormone transgenic common carp (CyprinuscarpioL.). Aquaculture, 2008; 284: 217-223.
54.Hu Wei, Li Shuangfei, Tang Bin, Wang Yaping, Lin Haoran，Liu Xiaochun, Zou Jun & Zhu Zuoyan*. Antisense for gonadotropin-releasing hormone reduces gonadotropin synthesis and gonadal development in transgenic common carp (Cyprinuscarpio). Aquaculture, 2007, 271: 498–506.
55.Hu Wei, Wang Yaping& Zhu Zuoyan*. Progress in the evaluation of transgenic fish for possible ecological risk and its containment strategies. Science in China Ser C-Life Sci. 2007, 50:573-579.胡炜，汪亚平，朱作言。转基因鱼生态风险评价及其对策研究进展。中国科学C辑：（生命科学），2007,37:377-381。
56.Wang Yun, Hu Wei*, Liu Weiyi, Wang Yaping, Zhu Zuoyan. Identification and characterization of a novel alternative splicing transcript of gonadotropin alpha subunit in the common carp (CyprinusCarpio). Journal of Fish Biology, 2007, 71: 1082–1094.
57.Hu Wei, Wang Yaping and Zhu Zuoyan*. Perspective of fish gonad manipulation for biotechnical applications. Chinese Science Bulletin,2006,51(18):1-7.胡炜，汪亚平，朱作言。鱼类性腺发育调控的生物技术前景分析。科学通报，2005,50:2689-2694.
58.Hu W, Wang Y, Chen S and Zhu Z*. Nuclear transplantation in different strains of zebrafish, Chinese Science Bulletin, 2002, 47(15):1277-1280.
发明专利目录：
1.Hu Wei,Jiang Mouyan, li Yongming, Tao Binbin, Chenji and Zhu Zuoyan. Method for production YY super-male and XY physiological female common carps.美国发明专利，公开号：US2018/**A1，2020年3月获授权通知。
2.Hu Wei, Zhang Yunsheng, Dai Jun and Zhu Zuoyan.Controllable on-off method for fish reproduction. United States Patent and Trademark Office,2015年获美国发明专利，专利号：US 9,187,764B2
3.Hu Wei, Zhu Z, Ma H, Guan B, Lin Z, and Hu R. Recombinant gene which enhances the ability of fish to tolerate low dissolved oxygen stress and the use thereof. United States Patent and Trademark Office, 2013年获美国发明专利，专利号：US8, 546, 644B2.
4.Hu Wei, Zhu Zuoyan, Wang Yaping and Li Shuangfei. Method for preparing a sterile transgenic carp. United States Patent and Trademark Office, 2007年获美国发明专利，专利号：US7,230,156B2.
5.胡炜，冯科，陈戟，朱作言。一种黄鳝基因编辑的方法。2019年获中国发明专利，专利号：ZL2.1
6.胡炜，蒋谋炎，李勇明，陶彬彬，陈戟，朱作言。一种超雄鲤鱼和遗传雄性而生理雌性鲤鱼的制备方法。2018年获中国发明专利授权，专利号：ZL6.9
7.胡炜，罗红瑞，冯科，蒋谋炎，侯明喜，朱作言。一种控制黄鳝受精卵第一次卵裂的方法及其应用。申请号：4.8，公开号：A。
8.胡炜，汤斌，汪亚平，朱作言，一种雌性鲤鱼性逆转为雄性鲤鱼的培育方法，2012年获中国发明专利，专利号：ZL9.X
9.胡炜，张运生，戴军，朱作言，一种控制鱼类生殖的方法。2013年获中国发明专利，专利号：ZL1.5
10.胡炜，朱作言，汪亚平，黎双飞。不育转基因鱼的制备方法，2007年获中国发明专利授权，专利号：ZL。
11.胡炜，朱作言，黎双飞，汪亚平。一种壳聚糖甲基睾酮缓释药条的制备方法，2007年获中国发明专利授权，专利号：ZL8.9。
12.吴玉萍，朱作言，胡炜，徐安龙。鱼类基因原位修饰育种的方法，2006年获中国发明专利授权，专利号：ZL7.7