华中农业大学信息学院导师教师师资介绍简介-龚静

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博士生导师
硕士生导师
教师姓名：龚静
教师拼音名称：gongjing
电子邮箱：
入职时间：2018-09-01
所在单位：信息学院
学历：博士研究生毕业
性别：女
联系方式：gong.jing@mail.hzau.edu.cn
学位：博士学位
职称：教授
在职信息：在职
毕业院校：华中科技大学
所属院系：信息学院

其他联系方式
暂无内容

个人简介

龚静 博士，教授，博士生导师

2008年获得华中科技大学预防医学学士学位；2013年获得华中科技大学生物信息学博士学位。2013.06-2018.09就职于华中科技大学公共卫生学院，2016年4月－2018年4月在美国德州大学休士顿健康科学中心（UTHealth）进行博士后研究。2018年10月加入华中农业大学信息学院生物信息学系。
研究方向主要为遗传变异的功能解析及实验验证。通过整合生物信息学方法和各种组学数据，系统分析了多种癌症中遗传变异对甲基化、可变剪切及基因表达的调控和影响，鉴定了大量的功能性遗传变异位点并构建了多个高质量的数据共享平台；通过生物信息学与实验“干湿”结合，揭示了多个结直肠癌易感相关的新遗传变异位点和基因。先后主持国家自然科学基金、中国博士后基金等多个项目。以第一作者或通讯作者在Annals of oncology、American Journal of Human Genetics，Nucleic Acids Research（8篇）、Cell Reports、European Journal of Cancer等杂志上发表SCI 文章20余篇，被引1200多次，其中3篇被评为ESI高被引论文。

教育经历

[1]2008.9——2013.6
华中科技大学>博士>博士
[2]2003.9——2008.6
华中科技大学>学士>学士

工作经历

[1]2018.10-至今
华中农业大学>信息学院>教授
[2]2015.7-2018.9
华中科技大学公共卫生学院
教师
[3]2013.7-2015.6
华中科技大学公共卫生与预防医学博后站
博士后

研究方向

（1）生物大数据的整合分析及挖掘。
（2）遗传变异的功能预测和实验验证。

华中农业大学

博士生导师
硕士生导师
教师姓名：龚静
教师拼音名称：gongjing
电子邮箱：
入职时间：2018-09-01
所在单位：信息学院
学历：博士研究生毕业
性别：女
联系方式：gong.jing@mail.hzau.edu.cn
学位：博士学位
职称：教授
在职信息：在职
毕业院校：华中科技大学
所属院系：信息学院

其他联系方式
暂无内容

科学研究
当前位置: 中文主页 > 科学研究
研究领域

研究方向
? 遗传变异的功能预测及验证。主要通过生物信息学、分子流行病学、分子生物学等技术预测及验证遗传变异的功能。近期部分成果：系统分析了多种癌症中遗传变异对甲基化、可变剪切及基因表达的调控和影响，鉴定了大量的功能性遗传变异位点（Nucleic acids research 2015，2017，2018，2020）；鉴定了多个结直肠癌相关的风险位点并阐述其潜在的生物学机制（Annals of oncology，2018）、（European journal of cancer，2018）、（Molecular carcinogenesis，2017）。
? 生物大数据的整合分析及挖掘。高通量测序数据（DNA测序，RNA测序，甲基化测序等）分析及TCGA、ENCODE、GTEx等大型数据库资源的深度学习及挖掘。近期部分成果：利用癌症基因组图谱（The Cancer Genome Atlas，TCGA）数据库33种癌症组织超过10000个样本的多组学数据，系统分析了小核仁RNA（snoRNA）在癌症中的表达量和临床相关性（Cell Reports，2017，封面文章）。
? 长非编码RNA（ncRNA）相关的生物信息学分析及数据库构建。系统分析了SNP对miRNA功能的影响（Human mutation, 2012 引用>250次），SNP对lncRNA功能的影响（Nucleic acids research，2015 高被引论文）及RNA editing 对lncRNA功能的影响（Nucleic acids research，2017）。

代表论文
1. Jiang Li, Yawen Xue, Muhammad Talal Amin, Yanbo Yang, Jiajun Yang, Wen Zhang, Wenqian Yang, Xiaohui Niu, Hong-Yu Zhang, and Jing Gong*. ncRNA-eQTL: a database to systematically evaluate the effects of SNPs on non-coding RNA expression across cancer types. Nucleic acids research. (2020) 48, D956-D963. (IF:11.5)
2. Yanbo Yang, Qiong Zhang, Ya-Ru Miao, Jiajun Yang, Wenqian Yang, Fangda Yu, Dongyang Wang, An-Yuan Guo*, and Jing Gong*. SNP2APA: a database for evaluating effects of genetic variants on alternative polyadenylation in human cancers. Nucleic acids research. (2020) 48, D226-D232. (IF:11.5)
3. Gong, J.,Tian, J., Li, J., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Zhong, R., Chang, J., Miao, X. (2018) A polymorphic MYC response element in KBTBD11 influences colorectal cancer risk, especially in interaction with a MYC regulated SNP rs**. Annals of oncology. 29(3), 632-639. (IF: 18.2)
4. Gong, J., Li, Y., Liu, C.J., Xiang, Y., Li, C., Ye, Y., Zhang, Z., Hawke, D.H., Park, P.K., Diao, L., Putkey, J.A., Yang, L., Guo, A.Y., Lin, C. and Han, L. (2017) A Pan-cancer Analysis of the Expression and Clinical Relevance of Small Nucleolar RNAs in Human Cancer. Cell reports, 21, 1968-1981. (IF: 8.3, 2017.11.14 Volume 21, Issue 7, 封面文章)
5. Gong, J., Mei, S., Liu, C., Xiang, Y., Ye, Y., Zhang, Z., Feng, J., Liu, R., Diao, L., Guo, A.Y., Miao, X., and Han, L. (2018) PancanQTL: systematic identification of cis-eQTLs and trans-eQTLs in 33 cancer types, Nucleic Acids Research. 46, D971-D976. (IF:11.5)

其它一作或通讯作者文章
6. Jin W., Zhu Q., Yang Y., Yang W., Wang D., Yang J., Niu X., Yu D.*, and Gong J*. Animal-APAdb: a comprehensive animal alternative polyadenylation database. Nucleic acids research. (2021) 49, D47-D54.
7. Gao Y., Yang Z., Yang W., Yang Y., Gong J.*, Yang Q. Y.*, and Niu X*. Plant-ImputeDB: an integrated multiple plant reference panel database for genotype imputation. Nucleic acids research. (2021) 49, D1480-D1488.
8. Wenqian Yang, Yanbo Yang, Cecheng Zhao, Kun Yang, Dongyang Wang, Jiajun Yang, Xiaohui Niu*, and Jing Gong*. Animal-ImputeDB: a comprehensive database with multiple animal reference panels for genotype imputation. Nucleic acids research. (2020) 48, D659-D667.

9. Jianbo Tian#, Jiang Chang#, Jing Gong#, Jiao Lou, Mingpeng Fu, Jiaoyuan Li, Juntao Ke, Ying Zhu, Yajie Gong, Yang Yang, Danyi Zou, Xiating Peng, Nan Yang, Shufang Mei, Xiaoyang Wang, Rong Zhong, Kailin Cai, and Xiaoping Miao*. Systematic functional interrogation of genes in GWAS loci identified ATF1 as a key driver in colorectal cancer modulated by a promoter-enhancer interaction. The American Journal of Human Genetics. (2019) 105, 29-47.
10. Gong, J., Liu, C., Liu, W., Xiang, Y., Diao, L., Guo, A.Y. and Han, L. (2017) LNCediting: a database for functional effects of RNA editing in lncRNAs. Nucleic acids research, 45, D79-D84. (IF:11.8)
11. Gong, J., Liu, W., Zhang, J., Miao, X. and Guo, A.Y. (2015) lncRNASNP: a database of SNPs in lncRNAs and their potential functions in human and mouse. Nucleic acids research, 43, D181-186. (IF:10.2, 引用70次，ESI高被引论文)
12. Gong, J., Tong, Y., Zhang, H.M., Wang, K., Hu, T., Shan, G., Sun, J. and Guo, A.Y. (2012) Genome-wide identification of SNPs in microRNA genes and the SNP effects on microRNA target binding and biogenesis. Human mutation, 33, 254-263. (IF:4.6, 引用255次)
13. Gong, J.*, Wan, H., Mei, S., Ruan, H., Zhang, Z., Liu, C., Guo, A.Y., Diao, L., Miao, X*. and Han, L*. (2019) Pancan-meQTL: a database to systematically evaluate the effects of genetic variants on methylation in human cancer. Nucleic acids research. (IF: 11.8)
14. Tian J, Wang Z, Mei S, Yang N, Yang Y, Ke J, Zhu Y, Gong Y, Zou D, Peng X, Wang X, Wan H, Zhong R, Chang J, Gong J*, Han L*, Miao X*. (2019) CancerSplicingQTL: a database for genome-wide identification of splicing QTLs in human cancer. Nucleic acids research. (IF: 11.8)
15. Zou, D., Lou, J., Ke, J., Mei, S., Li, J., Gong, Y., Yang, Y., Zhong, R., Chang, J.,Gong, J.,* and Miao, X.* (2018) Integrative eQTL-based analysis of colorectal cancer identified a functional polymorphism regulating SLC22A5 expression. European journal of cancer. 93, 1-9. (IF:7.0)
16. Ke, J., Tian, J., Li, J., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Zhong, R., Chang, J. and Gong, J*. (2017) Identification of a functional polymorphism affecting microRNA binding in the susceptibility locus 1q25.3 for colorectal cancer. Molecular carcinogenesis, 56, 2014-2021. (IF:4.2)
17. Gong, J., Tian, J., Lou, J., Ke, J., Li, L., Li, J., Yang, Y., Gong, Y., Zhu, Y., Zhang, Y., Zhong, R., Chang, J. and Miao, X. (2016) A functional polymorphism in lnc-LAMC2-1:1 confers risk of colorectal cancer by affecting miRNA binding. Carcinogenesis, 37, 443-451. (IF:5.1, ESI高被引论文)
18. Ke, J., Lou, J., Zhong, R., Chen, X., Li, J., Liu, C., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Chang, J. and Gong, J.* (2016) Identification of a Potential Regulatory Variant for Colorectal Cancer Risk Mapping to 3p21.31 in Chinese Population. Scientific reports, 6, 25194. (IF:4.3)
19. Ke, J., Lou, J., Chen, X., Li, J., Liu, C., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Tian, J., Chang, J., Zhong, R., Gong, J.* and Miao, X.* (2016) Identification of a functional variant for colorectal cancer risk mapping to chromosome 5q31.1. Oncotarget, 7, 35199-35207.
20. Ke, J., Lou, J., Chen, X., Li, J., Liu, C., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y. and Gong, J.* (2015) Identification of a Potential Regulatory Variant for Colorectal Cancer Risk Mapping to Chromosome 5q31.1: A Post-GWAS Study. PloS one, 10, e**. (IF:2.8)
21. Gong, J., Liu, C., Liu, W., Wu, Y., Ma, Z., Chen, H. and Guo, A.Y. (2015) An update of miRNASNP database for better SNP selection by GWAS data, miRNA expression and online tools. Database : the journal of biological databases and curation, 2015, bav029. (IF:3.3)
22. Xia, X., Chen, W., Li, J., Chen, X., Rui, R., Liu, C., Sun, Y., Liu, L., Gong, J.* and Yuan, P*. (2014) Body mass index and risk of breast cancer: a nonlinear dose-response meta-analysis of prospective studies. Scientific reports, 4, 7480. (IF:4.3)
23. Gong, J., Wu, Y., Zhang, X., Liao, Y., Sibanda, V.L., Liu, W. and Guo, A.Y. (2014) Comprehensive analysis of human small RNA sequencing data provides insights into expression profiles and miRNA editing. RNA biology, 11, 1375-1385. (IF:3.9)
24. Gong, J., Shen, N., Zhang, H.M., Zhong, R., Chen, W., Miao, X., and Guo, A.Y. (2014). A genetic variant in microRNA target site of TGF-beta signaling pathway increases the risk of colorectal cancer in a Chinese population. Tumour biology, 35, 4301-4306.
25. Hong, Y., Chen, X.Q., Li, J.Y., Liu, C., Shen, N., Zhu, B.B., Gong, J.,* and Chen, W.* (2014). Current evidence on the association between rs** of C6orf97 and breast cancer risk: a meta-analysis. Asian Pacific journal of cancer prevention : APJCP 15, 8051-8055.
26. Liu, D.^＃, Gong, J.^#, Dai, W., Kang, X., Huang, Z., Zhang, H.M., Liu, W., Liu, L., Ma, J., Xia, Z., Chen, Y., Chen, Y., Wang, D., Ni, P., Guo, A.Y. and Xiong, X. (2012) The genome of Ganoderma lucidum provides insights into triterpenes biosynthesis and wood degradation. PloS one, 7, e36146. (IF:2.8)
27. 龚静, 柳纯洁, 缪小平, 郭安源. 人类长链非编码RNA 相关SNP 鉴定与功能预测的研究进展[J].生物技术通报,2015,11:1-8.

论文成果
暂无内容

专利
暂无内容

著作成果
暂无内容

科研项目
暂无内容

华中农业大学

博士生导师
硕士生导师
教师姓名：龚静
教师拼音名称：gongjing
电子邮箱：
入职时间：2018-09-01
所在单位：信息学院
学历：博士研究生毕业
性别：女
联系方式：gong.jing@mail.hzau.edu.cn
学位：博士学位
职称：教授
在职信息：在职
毕业院校：华中科技大学
所属院系：信息学院

其他联系方式
暂无内容

研究领域
当前位置: 中文主页 > 科学研究 > 研究领域

研究方向
? 遗传变异的功能预测及验证。主要通过生物信息学、分子流行病学、分子生物学等技术预测及验证遗传变异的功能。近期部分成果：系统分析了多种癌症中遗传变异对甲基化、可变剪切及基因表达的调控和影响，鉴定了大量的功能性遗传变异位点（Nucleic acids research 2015，2017，2018，2020）；鉴定了多个结直肠癌相关的风险位点并阐述其潜在的生物学机制（Annals of oncology，2018）、（European journal of cancer，2018）、（Molecular carcinogenesis，2017）。
? 生物大数据的整合分析及挖掘。高通量测序数据（DNA测序，RNA测序，甲基化测序等）分析及TCGA、ENCODE、GTEx等大型数据库资源的深度学习及挖掘。近期部分成果：利用癌症基因组图谱（The Cancer Genome Atlas，TCGA）数据库33种癌症组织超过10000个样本的多组学数据，系统分析了小核仁RNA（snoRNA）在癌症中的表达量和临床相关性（Cell Reports，2017，封面文章）。
? 长非编码RNA（ncRNA）相关的生物信息学分析及数据库构建。系统分析了SNP对miRNA功能的影响（Human mutation, 2012 引用>250次），SNP对lncRNA功能的影响（Nucleic acids research，2015 高被引论文）及RNA editing 对lncRNA功能的影响（Nucleic acids research，2017）。

代表论文
1. Jiang Li, Yawen Xue, Muhammad Talal Amin, Yanbo Yang, Jiajun Yang, Wen Zhang, Wenqian Yang, Xiaohui Niu, Hong-Yu Zhang, and Jing Gong*. ncRNA-eQTL: a database to systematically evaluate the effects of SNPs on non-coding RNA expression across cancer types. Nucleic acids research. (2020) 48, D956-D963. (IF:11.5)
2. Yanbo Yang, Qiong Zhang, Ya-Ru Miao, Jiajun Yang, Wenqian Yang, Fangda Yu, Dongyang Wang, An-Yuan Guo*, and Jing Gong*. SNP2APA: a database for evaluating effects of genetic variants on alternative polyadenylation in human cancers. Nucleic acids research. (2020) 48, D226-D232. (IF:11.5)
3. Gong, J.,Tian, J., Li, J., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Zhong, R., Chang, J., Miao, X. (2018) A polymorphic MYC response element in KBTBD11 influences colorectal cancer risk, especially in interaction with a MYC regulated SNP rs**. Annals of oncology. 29(3), 632-639. (IF: 18.2)
4. Gong, J., Li, Y., Liu, C.J., Xiang, Y., Li, C., Ye, Y., Zhang, Z., Hawke, D.H., Park, P.K., Diao, L., Putkey, J.A., Yang, L., Guo, A.Y., Lin, C. and Han, L. (2017) A Pan-cancer Analysis of the Expression and Clinical Relevance of Small Nucleolar RNAs in Human Cancer. Cell reports, 21, 1968-1981. (IF: 8.3, 2017.11.14 Volume 21, Issue 7, 封面文章)
5. Gong, J., Mei, S., Liu, C., Xiang, Y., Ye, Y., Zhang, Z., Feng, J., Liu, R., Diao, L., Guo, A.Y., Miao, X., and Han, L. (2018) PancanQTL: systematic identification of cis-eQTLs and trans-eQTLs in 33 cancer types, Nucleic Acids Research. 46, D971-D976. (IF:11.5)

其它一作或通讯作者文章
6. Jin W., Zhu Q., Yang Y., Yang W., Wang D., Yang J., Niu X., Yu D.*, and Gong J*. Animal-APAdb: a comprehensive animal alternative polyadenylation database. Nucleic acids research. (2021) 49, D47-D54.
7. Gao Y., Yang Z., Yang W., Yang Y., Gong J.*, Yang Q. Y.*, and Niu X*. Plant-ImputeDB: an integrated multiple plant reference panel database for genotype imputation. Nucleic acids research. (2021) 49, D1480-D1488.
8. Wenqian Yang, Yanbo Yang, Cecheng Zhao, Kun Yang, Dongyang Wang, Jiajun Yang, Xiaohui Niu*, and Jing Gong*. Animal-ImputeDB: a comprehensive database with multiple animal reference panels for genotype imputation. Nucleic acids research. (2020) 48, D659-D667.

9. Jianbo Tian#, Jiang Chang#, Jing Gong#, Jiao Lou, Mingpeng Fu, Jiaoyuan Li, Juntao Ke, Ying Zhu, Yajie Gong, Yang Yang, Danyi Zou, Xiating Peng, Nan Yang, Shufang Mei, Xiaoyang Wang, Rong Zhong, Kailin Cai, and Xiaoping Miao*. Systematic functional interrogation of genes in GWAS loci identified ATF1 as a key driver in colorectal cancer modulated by a promoter-enhancer interaction. The American Journal of Human Genetics. (2019) 105, 29-47.
10. Gong, J., Liu, C., Liu, W., Xiang, Y., Diao, L., Guo, A.Y. and Han, L. (2017) LNCediting: a database for functional effects of RNA editing in lncRNAs. Nucleic acids research, 45, D79-D84. (IF:11.8)
11. Gong, J., Liu, W., Zhang, J., Miao, X. and Guo, A.Y. (2015) lncRNASNP: a database of SNPs in lncRNAs and their potential functions in human and mouse. Nucleic acids research, 43, D181-186. (IF:10.2, 引用70次，ESI高被引论文)
12. Gong, J., Tong, Y., Zhang, H.M., Wang, K., Hu, T., Shan, G., Sun, J. and Guo, A.Y. (2012) Genome-wide identification of SNPs in microRNA genes and the SNP effects on microRNA target binding and biogenesis. Human mutation, 33, 254-263. (IF:4.6, 引用255次)
13. Gong, J.*, Wan, H., Mei, S., Ruan, H., Zhang, Z., Liu, C., Guo, A.Y., Diao, L., Miao, X*. and Han, L*. (2019) Pancan-meQTL: a database to systematically evaluate the effects of genetic variants on methylation in human cancer. Nucleic acids research. (IF: 11.8)
14. Tian J, Wang Z, Mei S, Yang N, Yang Y, Ke J, Zhu Y, Gong Y, Zou D, Peng X, Wang X, Wan H, Zhong R, Chang J, Gong J*, Han L*, Miao X*. (2019) CancerSplicingQTL: a database for genome-wide identification of splicing QTLs in human cancer. Nucleic acids research. (IF: 11.8)
15. Zou, D., Lou, J., Ke, J., Mei, S., Li, J., Gong, Y., Yang, Y., Zhong, R., Chang, J.,Gong, J.,* and Miao, X.* (2018) Integrative eQTL-based analysis of colorectal cancer identified a functional polymorphism regulating SLC22A5 expression. European journal of cancer. 93, 1-9. (IF:7.0)
16. Ke, J., Tian, J., Li, J., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Zhong, R., Chang, J. and Gong, J*. (2017) Identification of a functional polymorphism affecting microRNA binding in the susceptibility locus 1q25.3 for colorectal cancer. Molecular carcinogenesis, 56, 2014-2021. (IF:4.2)
17. Gong, J., Tian, J., Lou, J., Ke, J., Li, L., Li, J., Yang, Y., Gong, Y., Zhu, Y., Zhang, Y., Zhong, R., Chang, J. and Miao, X. (2016) A functional polymorphism in lnc-LAMC2-1:1 confers risk of colorectal cancer by affecting miRNA binding. Carcinogenesis, 37, 443-451. (IF:5.1, ESI高被引论文)
18. Ke, J., Lou, J., Zhong, R., Chen, X., Li, J., Liu, C., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Chang, J. and Gong, J.* (2016) Identification of a Potential Regulatory Variant for Colorectal Cancer Risk Mapping to 3p21.31 in Chinese Population. Scientific reports, 6, 25194. (IF:4.3)
19. Ke, J., Lou, J., Chen, X., Li, J., Liu, C., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Tian, J., Chang, J., Zhong, R., Gong, J.* and Miao, X.* (2016) Identification of a functional variant for colorectal cancer risk mapping to chromosome 5q31.1. Oncotarget, 7, 35199-35207.
20. Ke, J., Lou, J., Chen, X., Li, J., Liu, C., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y. and Gong, J.* (2015) Identification of a Potential Regulatory Variant for Colorectal Cancer Risk Mapping to Chromosome 5q31.1: A Post-GWAS Study. PloS one, 10, e**. (IF:2.8)
21. Gong, J., Liu, C., Liu, W., Wu, Y., Ma, Z., Chen, H. and Guo, A.Y. (2015) An update of miRNASNP database for better SNP selection by GWAS data, miRNA expression and online tools. Database : the journal of biological databases and curation, 2015, bav029. (IF:3.3)
22. Xia, X., Chen, W., Li, J., Chen, X., Rui, R., Liu, C., Sun, Y., Liu, L., Gong, J.* and Yuan, P*. (2014) Body mass index and risk of breast cancer: a nonlinear dose-response meta-analysis of prospective studies. Scientific reports, 4, 7480. (IF:4.3)
23. Gong, J., Wu, Y., Zhang, X., Liao, Y., Sibanda, V.L., Liu, W. and Guo, A.Y. (2014) Comprehensive analysis of human small RNA sequencing data provides insights into expression profiles and miRNA editing. RNA biology, 11, 1375-1385. (IF:3.9)
24. Gong, J., Shen, N., Zhang, H.M., Zhong, R., Chen, W., Miao, X., and Guo, A.Y. (2014). A genetic variant in microRNA target site of TGF-beta signaling pathway increases the risk of colorectal cancer in a Chinese population. Tumour biology, 35, 4301-4306.
25. Hong, Y., Chen, X.Q., Li, J.Y., Liu, C., Shen, N., Zhu, B.B., Gong, J.,* and Chen, W.* (2014). Current evidence on the association between rs** of C6orf97 and breast cancer risk: a meta-analysis. Asian Pacific journal of cancer prevention : APJCP 15, 8051-8055.
26. Liu, D.^＃, Gong, J.^#, Dai, W., Kang, X., Huang, Z., Zhang, H.M., Liu, W., Liu, L., Ma, J., Xia, Z., Chen, Y., Chen, Y., Wang, D., Ni, P., Guo, A.Y. and Xiong, X. (2012) The genome of Ganoderma lucidum provides insights into triterpenes biosynthesis and wood degradation. PloS one, 7, e36146. (IF:2.8)
27. 龚静, 柳纯洁, 缪小平, 郭安源. 人类长链非编码RNA 相关SNP 鉴定与功能预测的研究进展[J].生物技术通报,2015,11:1-8.

华中农业大学