何钦，博士，副教授，博士生导师
华中农业大学园艺林学学院蔬菜系
通讯地址：湖北省武汉市华中农业大学园艺植物生物学教育部重点实验室420,430070
联系方式：heqin@mail.hzau.edu.cn;电话：
教育经历
2012.9-2015.12，华中农业大学，蔬菜学，博士
2013.11-2014.4；2014.8-2015.2；2015.5-2015.10：英国邓迪大学联合培养博士
2009.9-2012.6，华中农业大学，蔬菜学， 硕士
2005.6-2009.6，华中农业大学，园艺，学士
工作经历
2020.1-至今, 华中农业大学, 园艺林学学院, 副教授
2016.5-2019.10,英国邓迪大学，生命科学院植物科学系，博士后
2019.2-2019.3，美国辛普劳（Simplot）公司，植物病理学研究，博士后实习
2015年12月于华中农业大学蔬菜学获得博士学位，主要致力于马铃薯晚疫病抗病分子生物的研究；在博士期间，以联合培养访问博士生加入英国邓迪大学/詹姆斯赫顿研究所Paul Birch教授团队，合作研究晚疫病效应蛋白的致病机理；2016年5月至2019年10月于英国Paul Birch实验室进行博士后研究，主要从事晚疫病致病疫酶效应蛋白与寄主植物互作的研究；2019年3月于美国辛普劳（Simplot）进行博士后实习，合作开展利用感病因子提高植物抗病的研究；2019年获得英国植物病理协会（British Society for Plant Pathology）BSPP Senior Fellowship和Travel grant及英国邓迪大学Future Leader Price奖项；2020年1月至今,任职于华中农业大学园艺林学学院蔬菜系。主要研究工作发表在PNAS, New Phytologist, Plos Gent, J Exp Bot，Plant Communication等国际著名期刊物。
研究兴趣
1）由卵菌致病疫霉（Phytophthora infestans）引起的晚疫病是马铃薯的一种毁灭性病害。致病疫霉分泌大量效应蛋白到植物细胞来干扰寄主的各种免疫反应，最终实现成功侵染，这是晚疫病致病机理中的关键因素。基于马铃薯晚疫病致病疫霉效应蛋白与植物靶标互作的研究，后续研究将通过致病疫霉效应蛋白作为探针，来解析马铃薯抗/感晚疫病的机制，拓展寄主-病原菌互作过程的认知，为植物绿色抗病策略提供思路。
2）环境因素在植物-病原互作中起着十分重要的作用。然而目前研究环境因素对植物易感性影响的工作相对较少。光作为外界环境，为植物提供能量，在植物免疫上也有重要作用。然而光，尤其是蓝光对植物免疫的调节知之甚少。因此，以马铃薯和晚疫病为研究系统， 研究蓝光的感知对植物免疫反应的调节机制，拓展光照对植物免疫调节的认识；为马铃薯晚疫病抗性性状改良提供理论基础。
主持科研项目
1、蓝光受体StPhot1通过感病因子StNRL1调控马铃薯晚疫病抗性免疫应答机制的研究，国家自然基金面上项目，**，58万，2021.1.31-2024.12.31，主持；
2、马铃薯晚疫病利用植物感病因子致病机理的研究，2020CFB171，湖北省自然科学基金基金青年项目，5万，2020.3-2022.3，主持；
3、蓝光受体Phototropins通过NPH3/RPT2家族蛋白调控马铃薯晚疫病抗性机制的研究，105/，华中农业大学高层次人才启动项目，80万，2020.5-2023.5，主持；
4、马铃薯感病因子StNRL1协同14-3-3蛋白调控晚疫病抗性免疫机制的研究，**YLQD001，华中农业大学自主创新项目，20万，2020.4-2023.4，主持；
5、优质、早熟、抗病马铃薯品种选育及产业化技术研究，2020B，广东省重点领域研发计划项目子项目，40万，2020.1-2023.12，子项目负责人；
6、Assess the potential of a new method to prevent potato blight disease and to gain experience of industrial research，355 808331，英国植物病理学会（BSPP），2700英镑，2019.2-2019.3，主持。
国际会议报告
1、23^thJuly 2020The 7th International Horticulture Research Conference - Youth Scholar Forum. Presentation: Potato light blight pathogenPhytophthora infestansutilizes host Susceptibility factor to promote disease (selected talk).中国，线上会议。
2、14-18^thJuly 2019Molecular Plant-Microbe Interactions (MPMI). Flash presentation:A pathogen turns ‘immunity on’ to ‘immunity off’ with a flick of the switch (selected talk)英国，格拉斯哥。
3、10-12^thJuly 2019Oomycete Molecular Genetics Network (OMGN 2019), Oban.Flash presentation:A pathogen turns ‘immunity on’ to ‘immunity off’ with a flick of the switch (selected talk)苏格兰，奥本。
4、5-10^thAugust 201812th Congress of the International Plant Molecular Biology.Poster Presentation: A plant pathogen effector utilizes host Susceptibility factor NRL1 to degrade the immune regulator SWAP70 (selected poster).法国，蒙贝利亚。
5、11^thApril 2018Oomycete Molecular Genetics Network Annual Meeting.Presentation: A plant pathogen effector utilizes host Susceptibility factor NRL1 to degrade the immune regulator SWAP70 (selected talk)中国山东。
6、11^thOct. 2017The International Symposium on Potato Late Blight Resistance.Presentation title: How doPhytophthora infestansRXLR effector use Susceptibility factors?(Invited talk)中国武汉。
7、26^thJuly 2017New Phytologist Next Generation Scientists Symposium. John Innes Centre, Norwich. Presentation title:Phytophthora infestansRXLR effector interacts with S factor NRL1 to promote turnover of SWAP70 (selected talk)英国，诺威奇。
8、11^thMarch 2017Oomycete Molecular Genetics Network Meeting 2017 (OMGN 2017).Asilomar Conference Grounds, US. Presentation title: An Effector-targeted susceptibility factor mediates degradation of the immunity-associated vesicle trafficking regulator SWAP70 (selected talk)美国，阿西罗玛。
9、16^thOct. 2016,Potato workshop in China, Huazhong Agricultural University.presentation title:Ubiquitination-mediated protein degradation: an emerging theme in Plant-Phytophthora infestansinteractions(invited talk)中国武汉。
10、6^thSep. 2016, Dundee Effector Consortium retreat, Birnam Art and Conference Centre. Presentation: Ubiquitination-mediated protein degradation: an emerging theme in Plant-Phytophthora infestans interactions苏格兰，邓迪。

代表性论著
1、He Q*, McLellan H*, Boevink PC, Birch PRJ *. All roads lead to susceptibility: the many modes-of-action of fungal and oomycete intracellular effectors. PLANT COMMUNICATIONS. 2020, doi: https://doi.org/10.1016/j.xplc.2020.100050.(IF待定).
2、He Q; McLellan H; Hughes RK; Boevink PC; Armstrong M; Lu Y; Banfield MJ; Tian Z * & Birch PRJ *,Phytophthora infestanseffector SFI3 targets potato UBK to suppress early immune transcriptional responses,New Phytologist, 2019. 222(1): 438 454(IF=7.299)
3、He Q^#; Naqvi S^#; McLellan H; Boevink PC; Champouret N; Hein I; Birch PRJ, Plant pathogen effector utilizes host susceptibility factor NRL1 to degrade the immune regulator SWAP70,Proc Natl Acad Sci U S A, 2018. 14; 115(33)(IF=9.58)
4、Orosa B^#;He Q^#; Mesmar J; Gilroy EM; McLellan H; Yang C; Craig A; Bailey M; Zhang C; Moore JD; Boevink PC; Tian Z; Birch PR; Sadanandom A, BTB-BACK Domain Protein POB1 Suppresses Immune Cell Death by Targeting Ubiquitin E3 ligase PUB17 for Degradation,PLoS Genet. 2017. 13(1):e**.(IF=5.54)
5、He Q; McLeIlan H; Boevink PC; Sadanandom A; Xie CH; Birch PRJ; Tian ZD, U-BOX E3 ubiquitin ligase PUB17 acts in the nucleus to promote specific immune pathways triggered by Phytophthora infestans,J Exp Bot, 2015. 66(11): 3189-3199(IF=5.36)
6、McLellan H; Chen K;He Q; Wu X; Boevink PC; Tian Z *; Birch PRJ*, The ubiquitin E3 ligase PUB17 positively regulates immunity by targeting a negative regulator, KH17, for degradation,Plant Communications, 2020. doi:https://doi.org/10.1016/j.xplc.2020.100020(IF待定)
7、Liu X, Chen L, Shi W , Xu X, Li Z, Liu T,He Q,Xie Ca, Nie B , Song B. Comparative transcriptome reveals distinct starch-sugar interconversion patterns in potato genotypes contrasting for cold-induced sweetening capacity. Food Chem, 2021, 334:127550(IF=6.306)
8、Murphy F, He Q, Armstrong M, Giuliani LM, Boevink PC, Zhang W, Tian Z, Birch PRJ, Gilroy EM, The Potato MAP3K StVIK Is Required for thePhytophthora infestansRXLR Effector Pi17316 to Promote Disease,Plant Physiol, 2018. 177(1):398-410(IF=6.305)
9、Wang S; McLellan H; Bukharova T;He Q; Murphy F; Shi J; Sun S; Weymers P; Ren Y; Thilliez G; Wang H; Chen X; Engelhardt S; Vleeshouwers V; Gilroy EM; Whisson SC; Hein I; Wang X; Tian Z; Birch PRJ and Petra BC, Phytophthora infestans RXLR effectors act in concert at diverse subcellular localisations to enhance host colonization,J Exp Bot, 2018.doi: 10.1093/jxb/ery360(IF=5.36)
9、Boevink PC; McLellan H; Gilroy EM; Naqvi S;He Q; Yang L; Wang X; Turnbull D; Armstrong MR; Tian Z; Birch PR, Oomycetes Seek Help from the Plant:Phytophthora infestansEffectors Target Host Susceptibility Factors,Mol Plant, 2016. 9(5): 636-8(IF=10.812)
10、Yang L; McLellan H; Naqvi S;He Q; Boevink PC; Armstrong M; Giuliani LM; Zhang W; Tian Z; Zhan J; Gilroy EM; Birch PR, Potato NPH3/RPT2-Like Protein StNRL1, Targeted by a Phytophthora infestans RXLR Effector, Is a Susceptibility Factor,Plant Physiol, 2016. 171(1): 645-57(IF=6.305)
11、Boevink P; Wang X; McLellan H;He Q;Naqvi S; Armstrong M; Wei Z; Hein I; Gilroy E; Tian Z; Birch PRJ, APhytophthora infestansRXLR effector targets plant PP1c isoforms that promote late blight disease,Nature Communications, 2015. 7: 10311. doi: 10.1038/ncomms10311(IF=11.878)
12、Tian ZD;He Q; Wang HX; Liu Y; Zhang Y; Shao F and Xie CH, The Potato ERF Transcription Factor StERF3 Negatively Regulates Resistance toPhytophthora infestansand Salt Tolerance in Potato,Plant Cell Physiol, 2015. 56(5):992-1005（IF=4.319）

信息更新于2021年3月