王湘如
系所
预防兽医学系
职称
七级副教授
办公房间
生猪健康养殖协同创新中心304
email
wangxr228@mail.hzau.edu.cn
讲授课程
《动物传染病学》、《动物传染病学实验》、《细胞生物学C》

个人简介 王湘如，男，湖北宜昌人。华中农业大学副教授、博士生导师，生猪健康养殖协同创新中心骨干研究人员。目前研究方向为动物细菌性传染病的分子致病及免疫机理，主要开展重要致神经系统感染病原菌突破宿主血脑屏障和诱发中枢炎症损伤的分子机制和重要药物靶点研究。同时开展以副猪嗜血杆菌和肠外致病性大肠杆菌为主的细菌病的病原学、分子流行病学、新型疫苗研制和抗体检测方法的建立等应用研究，并以华中农业大学动物疫病诊断中心为依托，长期开展临床病原的检测、分离鉴定及技术培训工作。先后主持国家自然科学基金青年基金项目，面上项目，国家重点研发计划子课题项目，并作为研究骨干人员参与国家自然科学基金重点项目，重大专项，国家自然科学基金创新群体项目等课题研究。在国内外学术期刊发表SCI研究论文20篇，其中第一作者或通讯作者文章12篇，单篇最高影响因子7.0，获批国家授权发明专利1项。
教育经历 2004.09 - 2009.06， 华中农业大学，动物医学专业毕业，农学学士
2009.09 - 2014.06， 华中农业大学，预防兽医学专业毕业，农学博士
工作经历 2012.02-2012.08，上海国家人类基因组南方研究中心合作研究
2012.10-2014.04，美国约翰霍普金斯大学医学院联合研究
研究领域 人兽共患细菌性传染病流行病学、致病机制；猪群重要细菌性疾病的新型疫苗与分子诊断制剂开发
科研成果 A著作类
B论文类
1.Xiangru Wang, Xiaojuan Xu, Shu Zhang, Fengjuan Guo, Xuwang Cai, Huanchun Chen. Identification and analysis of potential virulence-associated genes in Haemophilus parasuis based on genomic subtraction. Microb Pathog, 2011, 51: 291–296. (IF=2.0)
2.Xiangru Wang, Xiaojuan Xu, Yucong Wu, Lanying Li, Ruijuan Cao, Xuwang Cai, Huanchun Chen. Polysaccharide biosynthesis protein CapD is a novel pathogenicity-associated determinant of Haemophilus parasuis involved in serum-resistance ability. Vet Microbiol, 2013, 164: 184-189. (IF=3.327)
3.Xiangru Wang, Haihong Hao, Zhuofei Xu, Huajun Zheng, Canying Liu, Liuya Wei, Ruixuan Zhang, Dingren Bi, Huanchun Chen, Chen Tan. Plasmid-mediated multidrug resistance and virulence in an avian pathogenic Escherichia coli strain isolated in China. J Global Antimicrob Resist, 2014, 2: 57-58. (IF=1.086)
4.Liping Chen, Xuwang Cai, Xiangru Wang, Xueli Zhou, Dongfang Wu, Xiaojuan Xu, Huanchun Chen. Characterization of plasmid-mediated lincosamide resistance in a field isolate of Haemophilus parasuis. J Antimicrob Chemother, 2010, 65: 2256-8. (IF=5.068)
5.陈西, 王湘如, 徐晓娟, 郭凤娟, 陈焕春, 蔡旭旺. 副猪嗜血杆菌细胞致死膨胀毒素的细胞毒性研究, 畜牧兽医学报, 2011, 42 (12): 1750-1755.
6.Canying Liu, Huajun Zheng, Minjun Yang, Zhuofei Xu, Xiangru Wang, Liuya Wei, Biao Tang, Feng Liu, Yanyan Zhang, Yi Ding, Xibiao Tang, Bin Wu, Timothy J. Johnson, Huanchun Chen, Chen Tan. Genome analysis and in vivo virulence of porcine extraintestinal pathogenic Escherichia coli strain PCN033. BMC Genomics, 2015, 16(1): 717. (IF=3.986)
7.Yi Ding, Dongmei Zhu, Jianmin Zhang, Longsheng Yang, Xiangru Wang, Huanchun Chen, Chen Tan. Virulence determinants, antimicrobial susceptibility, and molecular profiles of Erysipelothrix rhusiopathiae strains isolated from China. Emerg Microbes Infec, (2015) 4, e69 (IF=4.012)
8.Jing Chen, Lijie Su, Xiangru Wang, Tao Zhang, Feng Liu, Huanchun Chen, Chen Tan. Polyphosphate Kinase Mediates Antibiotic Tolerance in Extraintestinal Pathogenic Escherichia coli PCN033. Front Microbiol, 2016, 19(7): 724. doi: 10.3389/fmicb.2016.00724. (IF=4.165)
9.Yan Zhang, Dandan Ding, Manli Liu, Xiaopei Yang, Bingbing Zong, Xiangru Wang, Huanchun Chen, Weicheng Bei, Chen Tan. Effect of the glycosyltransferases on the capsular polysaccharide synthesis of Streptococcus suis serotype 2. Microbiol Res. 2016, 185: 45-54. (IF=2.723)
10.Ying Peng, Xiangru Wang, Jin Shou, Bingbing Zong, Yan Zhang, Jia Tan, Jing Chen, Linlin Hu, Yongwei Zhu, Huanchun Chen, Chen Tan. Roles of Hcp family proteins in the pathogenesis of the porcine extraintestinal pathogenic Escherichia coli type VI secretion system. Sci Rep. 2016, 27(6): 26816. (IF=5.228)
11.Jiachen Huang1, Xiangru Wang1, Qi Cao, Fenfen Feng, Xiaojuan Xu, Xuwang Cai. ClpP participates in stress tolerance and negatively regulates biofilm formation in Haemophilus parasuis. Vet Microbiol, 2016, 182: 141-9. (Co-first, IF=2.511)
12Xiangru Wang, Liuya Wei, Bin Wang, Ruixuan Zhang, Canying Liu, Dingren Bi, Huanchun Chen, Chen Tan. Complete genome sequence and characterization of avian pathogenic Escherichia coli field isolate ACN001. Stand. Genomic Sci., 2016, 11:13. (IF=1.594)
13Ruicheng Yang, Wentong Liu, Ling Miao, Xiaopei Yang, Jiyang Fu, Beibei Dou, Aoling Cai, Xin Zong, Chen Tan, Huanchun Chen, Xiangru Wang#. Induction of VEGFA and Snail-1 by meningitic Escherichia coli mediates disruption of the blood-brain barrier. Oncotarget, 2016, 7(39): 63839-63855. doi: 10.18632/oncotarget.11696. (Corresponding author, IF=5.008, 5 year IF=5.415)
14.Xiangru Wang, Ravi Maruvada, Andrew J Morris, Jun O Liu, Michael J. Wolfgang, Dong Jae Baek, Robert Bittman and Kwang Sik Kim. Sphingosine 1-Phosphate Activation of EGFR as a Novel Target for Meningitic Escherichia coli Penetration of the Blood–Brain Barrier. PLoS Pathog, 2016, 12(10): e**. doi:10.1371/journal.ppat.** (IF=7.003, 5 year IF=7.758)
15.Xiaopei Yang, Jiyang Fu, Ruicheng Yang, Wentong Liu, Tao Zhang, Bo Yang, Ling Miao, Beibei Dou, Chen Tan, Huanchun Chen, Xiangru Wang#. EGFR transactivation contributes to neuroinflammation in Streptococcus suis meningitis. J Neuroinflamm, 2016, 13: 274. doi: 10.1186/s12974-016-0734-0 (IF=4.667, 5 year IF=5.366)
16.Ruicheng Yang, Fei Huang, Jiyang Fu, Beibei Dou, Bojie Xu, Ling Miao, Wentong Liu, Xiaopei Yang, Chen Tan, Huanchun Chen, Xiangru Wang#. Differential transcription profiles of long non-coding RNAs in primary human brain microvascular endothelial cells in response to meningitic Escherichia coli. Sci Rep. 2016, 6:38903 (IF=5.228, 5 year IF=5.525)
17.Feng Liu, Jiyang Fu, Canying Liu, Jing Chen, Minhua Sun, Huanchun Chen, Chen Tan, Xiangru Wang#. Characterization and distinction of two flagellar systems in extraintestinal pathogenic Escherichia coli PCN033. Microbiol Res. 2017, 196: 69-79. (IF=2.723, 5 year IF=2.695)
18.Pei Li, Rui Wang, Wenqi Dong, Linlin Hu, Bingbing Zong, Yanyan Zhang, Xiangru Wang, Aizhen Guo, Anding Zhang, Yaozu Xiang, Huanchun Chen, Chen Tan. Comparative proteomics analysis of human macrophages infected with virulent Mycobacterium bovis. Front Cell Infect Microbiol. 2017, 7: 65. (IF=5.218)
19.Bingbing Zong, Liuya Wei, Yan Zhang, Xiangru Wang, Huanchun Chen, Chen Tan. Effect of kpsM on the virulence of porcine extraintextinal pathogenic Escherichia coli. FEMS Microbiol Lett. 2016, Oct 12. pii: fnw232. (IF=1.858)
20.Qi Cao, Fenfen Feng, Huan Wang, Xiaojuan Xu, Huanchun Chen, Xuwang Cai, Xiangru Wang#. Haemophilus parasuis CpxRA two-component system confers bacterial tolerance to environmental stresses and macrolide resistance. Microbiol Res. 2018, 206: 177-185. (IF=3.04)
科研项目 1. 华中农业大学校自主科技创新基金“致脑膜炎大肠杆菌突破血脑屏障的新型分子靶标鉴定及信号通路研究”, 2014-2017
2. 国家自然科学基金青年基金“EGFR在肠外致病性大肠杆菌突破宿主血脑屏障中的作用及其机制研究”, **, 2016-2018
3. 国家自然科学基金面上项目“LncRSPH9-4调控致脑膜炎大肠杆菌破坏血脑屏障的作用机制研究”, **, 2018-2021
4. 国家重点研发计划“病原入侵中枢神经系统的机制研究”, 2016YFD**, 2016.07-2020.12
主要奖励 1. 湖北省畜牧兽医学会2014-2016年度优秀学术论文一等奖、二等奖、三等奖各1项
2. 华中农业大学2017年本科生创新论文（设计）指导奖。