基本信息

姓名: 谢卡斌 出生年月: 1981.2

性别: 男 硕/博导： 博导

民族: 汉 开设课程： 植物病理生理与分子生物学

职称: 教授 研究方向： 1.水稻抗病机制；2. 植物基因组工程/基因组编辑

学位: 理学博士

联系方式

电子邮件：kabinxie@mail.hzau.edu.cn

个人简介

谢卡斌，男，1981年2月出生，博士，主要研究领域为植物微生物组学、作物抗病机制和基因组编辑。
教育与工作简历
2015.03 - 至今， 华中农业大学植物科学技术学院，教授, 博士生导师；
2008.09 - 2015.02，美国宾夕法尼亚州立大学，博士后；
2003.09 - 2008.08，华中农业大学生命科学与技术学院，生化与分子生物学，博士；
1999.09 - 2003.06，华中农业大学生命科学与技术学院，生物技术基地班，学士。


本课题组致力于从宏基因组学和分子生物学水平解析植物与微生物之间互作机理，开发基因组编辑技术，在理论研究的基础上，寻找促进农作物健康生长的新方法。
本课题组每年招收研究生和博士后，欢迎优秀学子加盟！

科研项目

国家重大科技专项——转基因新品种的培育重点课题，主持（2018-2019）；
国家自然科学基金优秀青年科学基金，主持（2016-2019）；
国家自然科学基金面上项目，主持（2015 - 2019);
国家重大科技专项——转基因新品种的培育，参与（2016-2020）；
华中农业大学科研启动经费，主持 (2015 - 2020);
中央高校基本科研业务费专项资金，主持（2015 - 2018）。
作物遗传改良国家重点实验室人才引进经费，主持（2017-2022）

发明专利及获奖情况

1. 谢卡斌，宋露洋. 一种改进的16S-seq方法及其应用. 申请号：20**.
2. 谢卡斌，陈凯园，丁丹，一种基于CRISPR的基因编辑方法及其应用，申请号：6.6.
3. Yang, Yinong and Xie, Kabin. 2014. Methods and compositions for RNA-guided multiplex genome editing and other RNA technologies. (US Provisional Patent Application No. 62/065,093)
4. Yang, Yinong and Xie, Kabin 2013. Gene targeting and genetic modification of plants via RNA-guided genome editing. (US Patent Application No. 14/291,605; PCT/US2014/040220)
5. 申请号：5.0，发明名称：miR164基因控制水稻根系发育和育性的功能及应用。发明人：熊立仲、谢卡斌、侯昕；申请日：2009.5.13(授权日: 2010年10月14日).

发表的论文及著作

(#通讯作者)
1. Xie K(#), Guo L, Bai Y, Liu W, Yan J, Bucher M(#). Microbiomics and Plant Health: An Interdisciplinary and International Workshop on the Plant Microbiome. Mol Plant, 2019, 12(1): 1-3. doi: 10.1016/j.molp.2018.11.004. (meeting report)
2. Minkenberg B, Zhang J, Xie K, Yang Y(#). CRISPR-PLANT v2: an online resource for highly specific guide RNA spacers based on improved off-target analysis. Plant Biotechnol J, 2019, 17:5-8. doi: 10.1111/pbi.13025.
3. Dan Ding, Kaiyuan Chen, Yuedan Chen, Hong Li, and Kabin Xie (#), Engineering introns to express RNA guides for Cas9- and Cpf1-mediated multiplex genome editing. Mol Plant. 2018, 11(4):542-552.
4. Yang Yang, Kaiyu Zhu, Huailin Li, Shaoqing Han, Qingwei Meng, Shahid Ullah Khan, Chuchuan Fan, Kabin Xie, Yongming Zhou. Precise editing of CLAVATA genes in Brassica napus L. regulates multilocular silique development. Plant Biotech J. 2018, 16(7):1322-1335. DOI: 10.1111/pbi.12872.
5. Jianqiang Shen, Juhong Liu, Kabin Xie, Feng Xing, Fang Xiong, Jinghua Xiao, Xianghua Li and Lizhong Xiong (#), Translational repression by a miniature inverted-repeat transposable element in the 3’ untranslated region. Nature Commun. 2017, (17)14651, DOI: doi:10.1038/ncomms14651.
6. Hao Liu, Yuduan Ding, Yanqing Zhou, Wenqi Jin, Kabin Xie (#), Ling-Ling Chen (#). CRISPR-P 2.0: an improved CRISPR-Cas9 tool for genome editing in plants. Molecular Plant. 2017, 10(3): 530-532 (IF: 6.1, # co-corresponding author)
7. Fengping Dong(*), Kabin Xie(*), Yueying Chen, Yinong Yang, Yingwei Mao. Polycistronic tRNA and CRISPR guide-RNA enables highly efficient multiplexed genome engineering in human cells. Biochemical and Biophysical Research Communications. 2016, 482(4): 889-895 (IF: 2.3, * equal contribution)
8. Bastian Minkenberg, Kabin Xie, Yinong Yang. Discovery of rice essential genes by characterizing CRISPR-edited mutation of closely related rice MAP kinase genes. Plant Journal, 2017, 89(3): 636-648. (IF: 5.4)
9. Yuduan Ding, Hong Li, Ling-Ling Chen (#) and Kabin Xie (#). Recent advances in genome editing using CRISPR/Cas9. Front. Plant Sci. 2016, 7:703. (IF: 3.9, # co-corresponding author)
10. Kabin Xie, Bastian Minkenberg and Yinong Yang. Boosting CRISPR/Cas9 multiplex editing capability with the endogenous tRNA-processing system. PNAS. 2015, 112(11): 3570-3575. (IF: 9.8)
11. Kabin Xie, Jianping Chen, Qin Wang, Yinong Yang. Direct phosphorylation and activation of a mitogen-activated protein kinase by a calcium-dependent protein kinase. Plant Cell. 2014, 26(7): 3077-3089. (IF: 9.5)
12. Kabin Xie, Jianwei Zhang and Yinong Yang. Genome-wide prediction of highly specific guide RNA spacers for the CRISPR-Cas9-mediated genome editing in model plants and major crops. Mol Plant. 2014, 7(5): 923-926. (IF: 6.1)
13. Yujie Fang, Kabin Xie, Lizhong Xiong. Conserved miR164-targeted NAC genes negatively regulate drought resistance in rice. J. Exp. Bot. 2014, 65 (8): 2119-2135. (IF: 5.2)
14. Kabin Xie and Yinong Yang. RNA-guided genome editing in plants using a CRISPR-Cas system. Mol Plant. 2013, 6(6):1975-1983. (cover story, IF: 6.1)
15. Kabin Xie, Jianqiang Shen, Xin Hou, Jialing Yao, Xianghua Li, Jinghua Xiao, Lizhong Xiong. Gradual increase of miR156 regulates temporal expression changes of numerous genes during leaf development in rice. Plant Physiol. 2012, 158(3):1382-94. (IF: 6.5)
16. Jianqiang Shen(*), Kabin Xie(*), Lizhong Xiong. Global expression profiling of rice microRNAs by one-tube stem-loop reverse transcription quantitative PCR revealed important roles of microRNAs in abiotic stress responses. Mol Genet Genomics. 2010, 284(6):477-88. (^*co-first author. IF:2.45 )
17. Yujie Fang, Kabin Xie, Xin Hou, Honghong Hu, Lizhong Xiong. Systematic analysis of GT factor family of rice reveals a novel subfamily involved in stress responses. Mol Genet Genomics. 2010, 283(2):157-69. (IF: 2.45)
18. Xin Hou, Kabin Xie, Jialing Yao, Zhuyun Qi, and Lizhong Xiong. A homolog of human ski-interacting protein in rice positively regulates cell viability and stress tolerance. PNAS. 2009, 106(15): 6410-6415. (IF: 9.43)
19. Xipeng Ding, Xin Hou, Kabin Xie, Lizhong Xiong. Genome-wide identification of BURP domain-containing genes in rice reveals a gene family with diverse structures and responses to abiotic stresses. Planta. 2009, 230(1):149-63. (IF: 3.37 )
20. Tingting Lu, Xuehui Huang, Chuanrang Zhu, Tao Huang, Qiang Zhao, Kabin Xie, Lizhong Xiong, Qifa Zhang and Bin Han. RICD: A rice indica cDNA database resource for rice functional genomics. BMC Plant Biology. 2008, 8:118. (IF: 4.0)
21. Yujie Fang, Jun You, Kabin Xie, Weibo Xie and Lizhong Xiong. Systematic sequence analysis and identification of tissue-specific or stress-responsive genes of NAC transcription factor family in rice. Mol Genet Genomics. 2008, 280(6):547-563. (IF: 2.83)
22. Kabin Xie, Congqing Wu, Lizhong Xiong. Genomic organization, differential expression, and interaction of SQUAMOSA promoter-binding-like transcription factors and microRNA156 in rice. Plant Physiol. 2006, 142(1): 280-293. (IF: 6.1)
23. Congqing Wu, Honghong Hu, Ya Zeng, Dacheng Liang, Kabin Xie, Jianwei Zhang, Zhaohui Chu, Lizhong Xiong. Identification of novel stress-responsive transcription factor genes in rice by cDNA array analysis. J Integr Plant Biol. 2006, 48(10): 1216?1224. (IF: 0.5)
24. Jing Ning, Bin Yuan, Kabin Xie, Honghong Hu, Congqing Wu, Lizhong Xiong. Isolation and identification of SA and JA inducible protein kinase gene OsSJMK1 in rice. J Gene Genomics. 2006, 33 (7): 625-633.
25. Jianwei Zhang, Qi Feng, Caoqing Jin, Deyun Qiu, Lida Zhang, Kabin Xie, Dejun Yuan, Bin Han, Qifa Zhang, Shiping Wang. Features of the expressed sequences revealed by a large-scale analysis of ESTs from a normalized cDNA library of the elite indica rice cultivar Minghui 63. Plant J. 2005, 42 (5):772-80. （IF: 6.5）
26. Kabin Xie, Jianwei Zhang, Yong Xiang, Qi Feng, Bin Han, Zhaohui Chu, Shiping Wang, Qifa Zhang, Lizhong Xiong. Isolation and annotation of 10828 putative full length cDNAs from indica rice. Science in China Series C. 2005, 48(5):445-451. (IF: 0.5)


（#其他著作）
1. 李红, 谢卡斌，植物CRISPR基因组编辑技术的新进展，生物工程学报，2017,33(10):1700~1711
2. Kabin Xie, Bastian Minkenberg, and Yinong Yang. 2014. Targeted gene mutation in rice using a CRISPR-Cas9 system. Bio-protocol 4(17): e1225. http://www.bio-protocol.org/e1225
3. Wenhua Liu, Kabin Xie, and Yinong Yang. 2013. Genomic and bioinformatic resources for rice research. Methods in Molecular Biology: Rice Protocols (956): 327-332.