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华中农业大学植物科学技术学院导师教师师资介绍简介-刘文

本站小编 Free考研考试/2021-07-29


基本信息

姓名: 刘文 出生年月: 1986.8

性别: 男 硕/博导: 专业硕士导师


民族: 汉 开设课程: 植物病虫害研究法


职称: 副教授 研究方向: 昆虫发育可塑性的内分泌调控


学位: 理学博士


联系方式 办公电话:
电子邮件:liuwen@mail.hzau.edu.cn


个人简介 学习经历
2005.09-2009.06,西北大学,生物科学专业本科学习,获理学学士学位;
2009.09-2014.06,山东大学,生物化学与分子生物学专业硕博连读,获理学博士学位

工作经历
2014.07 -至今,华中农业大学植物科学技术学院植物保护系,从事教学科研工作,专注于昆虫发育可塑性(滞育)的内分泌机制研究,创新害虫绿色防控策略,服务于区域蔬菜的健康安全生产。

研究内容简述
多种温带昆虫在长期进化过程中形成了滞育特性,即在不良环境(高温,低温,干旱,事物缺乏等)到来之前,可预先编程从而进入一种发育停滞的状态,类似于动物休眠或冬眠。滞育昆虫常表现出发育停滞、代谢降低、脂肪堆积、衰老延缓、寿命延长,因此可作为代谢调控,动物肥胖、衰老和长寿的研究模型。在农业生态系统中,多种害虫可利用其滞育特性有力规避不良环境,保证种群延续,进而成灾。因此,通过人工干预滞育可将害虫暴露于不利环境中,进而诱导害虫“生态自杀”。另外,通过调控天敌昆虫滞育,可有效延长天敌货架期,优化天敌田间使用策略。
基于以上考虑,我们以具生殖滞育特性的农业害虫和天敌昆虫为材料,整合传统生理学、现代分子生物学和细胞生物学等方法和技术,试图解析1)昆虫在滞育诱导期如何感受环境因子光周期、2)光周期如何调控内分泌系统进而决定昆虫滞育,3)内分泌信号如何调控滞育生理。通过回答这些问题,我们将逐步解析昆虫滞育调控的关键基因和通路,为基于滞育调节进而控制害虫成灾的绿色防控策略提供基因靶标,同时从比较生理学的角度为动物、乃至人类肥胖、衰老和长寿研究提供参考。




科研项目 1. 蜕皮激素信号抑制大猿叶虫生殖滞育准备的分子机制研究,国家自然科学基金,2018-2021,参加2. 异色瓢虫生殖滞育准备中体内低水平保幼激素的维持机制,国家自然科学基金,2018-2020,参加
3. JH-Met信号调控大猿叶虫卵黄发生关键基因转录的机制研究,国家自然科学基金,2016-2018,主持
4. 大猿叶虫幼虫期对光周期滞育诱导的分子应答,国家自然科学基金,2016-2019,参加
5. ILPs调控大猿叶甲滞育准备期营养吸收和能量储存的分子机制,华中农业大学新进博士科研启动专项,2014-2015,主持



发明专利及获奖情况



发表的论文及著作 #Equal contribution, *Co-responding author
以第一或通讯作者发表的论文
1. Liu W(刘文)#, Tan Q-Q#, Zhu L, Li Y, Zhu F, Lei CL, Wang X-P*: Absence of juvenile hormone signalling regulates the dynamic expression profiles of nutritional metabolism genes during diapause preparation in the cabbage beetle Colaphellus bowringi. Insect Molecular Biology 2017, 26(5):530-542.
2. Zhu L, Yin T-Y, Sun D, Liu W(刘文)*, Zhu F, Lei C-L, Wang X-P: Juvenile hormone regulates the differential expression of putative juvenile hormone esterases via methoprene-tolerant in non-diapause-destined and diapause-destined adult female beetle. Gene 2017, 627:373-378.
3. Zhu L, Liu W(刘文)*, Tan Q-Q, Lei C-L, Wang X-P: Differential expression of circadian clock genes in two strains of beetles reveals candidates related to photoperiodic induction of summer diapause. Gene 2017, 603:9-14.
4. Tan Q-Q, Liu W(刘文)*, Zhu F, Lei C-L, Wang X-P*: Fatty acid synthase 2 contributes to diapause preparation in a beetle by regulating lipid accumulation and stress tolerance genes expression. Scientific Reports 2017, 7:40509.
5. 周睿琦,谈倩倩,王小平,刘文*: 大猿叶虫滞育品系和非滞育品系交配行为的比较. 环境昆虫学报 2017, 39(1): 167-171.
6. Liu W(刘文), Li Y, Zhu L, Zhu F, Lei C-L, Wang X-P*: Juvenile hormone facilitates the antagonism between adult reproduction and diapause through the methoprene-tolerant gene in the female Colaphellus bowringi. Insect Biochemistry and Molecular Biology 2016, 74:50-60.
7. Liu W(刘文), Li Y, Guo S, Yin H, Lei C-L, Wang X-P*: Association between gut microbiota and diapause preparation in the cabbage beetle: a new perspective for studying insect diapause. Scientific Reports 2016, 6:38900.
8. Liu W(刘文), Cai M-J, Zheng C-C, Wang J-X, Zhao X-F*: Phospholipase cγ1 connects the cell membrane pathway to the nuclear receptor pathway in insect steroid hormone signaling. Journal of Biological Chemistry 2014, 289(19):13026-13041.
9. Liu W(刘文), Cai M-J, Wang J-X, Zhao X-F*: In a nongenomic action, steroid hormone 20-hydroxyecdysone induces phosphorylation of cyclin-dependent kinase 10 to promote gene transcription. Endocrinology 2014, 155(5):1738-1750.
10. Liu W(刘文), Zhang F-X, Cai M-J, Zhao W-L, Li X-R, Wang J-X, Zhao X-F*: The hormone-dependent function of Hsp90 in the crosstalk between 20-hydroxyecdysone and juvenile hormone signaling pathways in insects is determined by differential phosphorylation and protein interactions. Biochim Biophys Acta 2013, 1830(11):5184–5192.

合作发表的论文
1. Chen C-H, Pan J, Di YQ, Liu W(刘文), Hou L, Wang J-X, Zhao X-F*: Protein kinase C delta phosphorylates ecdysone receptor B1 to promote gene expression and apoptosis under 20-hydroxyecdysone regulation. Proc Natl Acad Sci U S A 2017, 114(34):E7121-E7130.
2. Quan W-L, Liu W(刘文), Zhou R-Q, Chen R, Ma W-H, Lei C-L, Wang X-P*: Difference in diel mating time contributes to assortative mating between host plant-associated populations of Chilo suppressalis. Scientific Reports 2017, 7.
3. Tan Q-Q, Liu W(刘文), Zhu F, Lei C-L, Hahn DA*, Wang X-P*: Describing the Diapause-Preparatory Proteome of the Beetle Colaphellus bowringi and Identifying Candidates Affecting Lipid Accumulation Using Isobaric Tags for Mass Spectrometry-Based Proteome Quantification (iTRAQ). Frontiers in Physiology 2017, 8(251).
4. Tan Q-Q, Zhou R-Q, Liu W(刘文), Feng L, Wang X-P*: Biological characteristics of a non-photoperiodic-diapause strain of the cabbage beetle Colaphellus bowringi (Coleoptera: Chrysomelidae). Entomological Science 2017, 20(1):50-56.
5. Quan W-L, Liu W(刘文), Zhou R-Q, Qureshi SR, Ding N, Ma W-H, Lei C-L, Wang X-P*: Do differences in life-history traits and the timing of peak mating activity between host-associated populations of Chilo suppressalis have a genetic basis? Ecology and Evolution 2016, 6(13):4478-4487.
6. Tan Q-Q, Feng L, Liu W(刘文), Zhu L, Lei C-L, Wang X-P*: Differences in the pre-diapause and pre-oviposition accumulation of critical nutrients in adult females of the beetle Colaphellus bowringi. Entomologia Experimentalis et Applicata 2016, 160(2):117-125.
7. Jing Y-P, Liu W(刘文), Wang J-X, Zhao X-F*: The steroid hormone 20-hydroxyecdysone via nongenomic pathway activates Ca2+/calmodulin-dependent protein kinase II to regulate gene expression. Journal of Biological Chemistry 2015, 290(13):8469-8481.
8. Dong D-J, Jing Y-P, Liu W(刘文), Wang J-X, Zhao X-F*: The Steroid Hormone 20-Hydroxyecdysone Up-regulates Ste-20 Family Serine/Threonine Kinase Hippo to Induce Programmed Cell Death. Journal of Biological Chemistry 2015, 290(41):24738-24746.
9. Tan Q-Q, Zhu L, Li Y, Liu W(刘文), Ma W-H*, Lei C-L, Wang X-P*: A de novo transcriptome and valid reference renes for quantitative Real-Time PCR in Colaphellus bowringi. PLoS One 2015, 10(2):e**.
10. Cai M-J, Liu W(刘文), Pei X-Y, Li X-R, He H-J, Wang J-X, Zhao X-F*: Juvenile hormone prevents 20-hydroxyecdysone-induced metamorphosis by regulating the phosphorylation of a newly identified broad protein. Journal of Biological Chemistry 2014, 289(38):26630-26641.
11. Cai M-J, Dong D-J, Wang Y, Liu P-C, Liu W(刘文), Wang J-X, Zhao X-F*: G-protein-coupled receptor participates in 20-hydroxyecdysone signaling on the plasma membrane. Cell Communication and Signaling 2014, 12(1):9.
12. Zhao W-L, Liu C-Y, Liu W(刘文), Wang D, Wang J-X, Zhao X-F*: Methoprene-tolerant 1 regulates gene transcription to maintain insect larval status. Journal of Molecular Endocrinology 2014, 53(1):93–104.
13. Ren J, Li X-R, Liu P-C, Cai M-J, Liu W(刘文), Wang J-X, Zhao X-F*: G-protein alphaq participates in the steroid hormone 20-hydroxyecdysone nongenomic signal transduction. Journal of Steroid Biochemistry and Molecular Biology 2014, 144PB:313-323.
14. Dong D-J, Liu W(刘文), Cai M-J, Wang J-X, Zhao X-F*: Steroid hormone 20-hydroxyecdysone regulation of the very-high-density lipoprotein (VHDL) receptor phosphorylation for VHDL uptake. Insect Biochemistry and Molecular Biology 2013, 43(4):328-335.
15. Liu C-Y, Liu W(刘文), Zhao W-L, Wang J-X, Zhao X-F*: Upregulation of the expression of prodeath serine/threonine protein kinase for programmed cell death by steroid hormone 20-hydroxyecdysone. Apoptosis 2013, 18(2):171-187.
16. Hou L, Cai M-J, Liu W(刘文), Song Q, Zhao X-F*: Small GTPase Rab4b participates in the gene transcription of 20-hydroxyecdysone and insulin pathways to regulate glycogen level and metamorphosis. Developmental Biology 2012, 371(1):13-22.
17. Cai M-J, Liu W(刘文), He H-J, Wang J-X, Zhao X-F*: Mod(mdg4) participates in hormonally regulated midgut programmed cell death during metamorphosis. Apoptosis 2012, 17(12):1327-1339.





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