一、基本信息
贺妮莎，博士，副教授，硕士生导师，湖北省楚天学子
电子邮箱：nshe1992@163.com
社会兼职：中国微生物学会会员、中国生物工程学会会员
研究领域：分子酶学（酶催化机制解析、酶分子改造）
二、教育背景
2008.09–2012.06 湖北大学生命科学学院，获生物科学学士学位
2012.09–2018.01 中科院上海植物生理生态研究所，获微生物学博士学位，导师：肖友利研究员
三、工作经历
2019.03至今 湖北大学生科院，副教授
2018.03–2020.03，College de France，博士后，合作导师：Marc Fontecave院士
四、科研项目
1. 湖北省教育厅中青年项目（1003），2020.01–2021.12，多氧霉素生物合成途径中关键成环机制的研究，主持
2. 湖北省人才项目，2019.05–2024.05，主持
3. 国家自然科学基金面上项目（**），碳磷裂解酶参与的碳磷键断裂自由基反应机制研究，2016.01–2019.12，参与
4. 国家自然科学基金主任基金（**），PhnJ催化的有机膦化合物中碳磷键断裂的酶反应机制研究，2014.01–2014.12，参与
五、代表性论文（^#共同一作，*通讯作者）
1. Li C, Jiang S, Du C, Lu Z, He N, Zhou Y, Zhang G*. (2021) High-level extracellular expression of a new β-N-Acetylglucosaminidase in Escherichia coli for producing GlcNAc. Frontiers in Microbiology 12, 478.
2. Du C, Zhao X, Song W, He N, Jiang S, Zhou Y, Zhang G* (2021) Combined strategies to improve the expression of acidic mammalian chitinase in Pichia pastoris for the production of N, N'-diacetylchitobiose Biochemical Engineering Journal 167, 107907.
3. Song, W, Zhang, N, Yang, M, Zhou, Y, He N*, Zhang G*. (2020) Multiple strategies to improve the yield of chitinase a from Bacillus licheniformis in Pichia pastoris to obtain plant growth enhancer and GlcNAc. Microbial Cell Factories 19, 1–11.
4. Cheng Y, Xu J, Fu Y, He N*. (2020) Expression and regulation of pde6h by thyroid hormone during metamorphosis in Paralichthys olivaceus. Frontiers in Physiology 11, 244.
5. Hu X, Yuan X, He N, Zhuang TZ, Wu P, Zhan, G*. (2019) Expression of Bacillus licheniformis α–amylase in Pichia pastoris without antibiotics-resistant gene and effects of glycosylation on the enzymic thermostability. 3 Biotech 9, 1–9.
6. He N^#, Wu P^#, Lei Y, Xu B, Zhu X, Xu G, Chen W*, Xiao Y*. (2017) Construction of an octosyl acid backbone catalyzed by a radical S-adenosylmethionine enzyme and a phosphatase in the biosynthesis of high–carbon sugar nucleoside antibiotics. Chemical science 8, 444–451.
7. Qi X, Lin W, Ma M, Wang C, He Y, He N, Zhang P* (2016) Structural basis of rifampin inactivation by rifampin phosphotransferase. Proceedings of the National Academy of Sciences of the United States of America 113, 3803–3808.