姓 名：陈怀侠

出生年月：1966年7月

职称职务：博士、教授、博士生导师

专业方向：分析化学（现代分离技术、环境和食品毒物分析、药物代谢分析）

办公电话：**

Email：　hxch@hubu.edu.cn
研究领域与兴趣：

（1） 现代分离技术：样品前处理方法、色谱-质谱联用技术

（2） 环境分析：新型环境微污染物分析

（3） 食品分析：食品农残等毒物分析和食品安全

（4） 药物分析：药物代谢分析、中药活性成分提取分离分析、药物杂质分析
教育与研究经历：

武汉大学本科、硕士和博士毕业。

长期从事分析化学本科和研究生教学，以及现代分离技术科研工作。教育部入库专家，中国化学学会会员；获得国家自然科学基金、教育部重点基金项目、省自然科学基金项目、省教育厅重点基金项目和省科技厅科技攻关项目等资助；发表科研论文80余篇，其中SCI收录近40篇
教学情况：

主讲“分析化学”及实验、“仪器分析”及实验和“现代分离技术”（本科生和研究生）等课程，教学质量评价优秀，主持多项省级及校级教研项目，发表教研论文十余篇，多次获得湖北大学本科教学质量优秀奖。科学出版社“无机及分析化学”副主编，2009
承担项目与课题：

（1） 2012年湖北省教育厅重点项目“湖北省水环境中防晒剂污染分析及自然光降解研究”（No. D**），主持人；

（2） 2010年国家自然科学基金“新型微污染物PPCPs及其代谢转化物分布调查和迁移转化规律研究”（No. **），主持人；

（3） 2009年湖北省自然科学基金“新型微污染物PPCPs及其代谢转化物分析研究”（2009CDB364），主持人；

（4） 2008年教育部科学技术研究重点项目“湖北地道药材黄连活性成分代谢及其与血浆蛋白结合研究”（No.208090），主持人；

（5） 湖北省科技厅科技攻关项目“莨菪烷类生物碱药代动力学药代产物研究”（No.2004AA301C106），主持人；

（6） 省部共建教育部重点实验室项目“中药黄酮类化合物指纹图谱及含量测定研究”（No.2005-KL-009），主持人；

（7） 湖北省中药生物技术重点实验室开放基金“中药生物碱活性成分的代谢研究”（No. 2005CTM001），主持人；

（8） 湖北大学人才专项基金“中药复方药物代谢研究”（No.ky**），主持人；

（9） 2010年中科院武汉植物园“乌桕活性成分分析”横向项目，主持人；

（10） 2007年国家自然科学基金重点项目“确有疗效复方中药痹祺胶囊的药代动力学研究”（No.**），主要成员；

国家自然科学基金项目“新荧光探针标记磷酸化蛋白的毛细管电泳测定和细胞成像研究”（No.**），主要成员。
获奖与荣誉：

2012年指导的本科论文获湖北省优秀学士论文

2011年湖北大学本科教学质量优秀奖

2011年指导的本科论文获湖北省优秀学士论文

2009年湖北大学首届本科教学质量优秀奖

2009年湖北大学工会优秀女会员

2009年湖北大学优秀教师

2008年指导的本科论文获湖北省首届大学生化学学术创新成果二等奖

2007年指导的本科论文获湖北省优秀学士学位论文提名奖

2004年所讲授的“分析化学”课程被评为湖北省精品课程

2003年获学校优秀教案三等奖
代表性成果：

(1) Juan Li, Huaixia Chen*, Hui Chen and Yong Ye. Selective determination of trace thiamphenicol in milk and honey by molecularly imprinted polymer monolith microextraction and high-performance liquid chromatography. Journal of Separation Science, 2012, 35 (1): 137–144.

(2) Shu Zhou, Huaixia Chen*, Bo Wu, Chao Ma, Yong Ye. Sensitive determination of carbamates in fruit and vegetables by a combination of solid-phase extraction and dispersive liquid-liquid microextraction prior to HPLC. Microchim Acta, 2012, 176: 419–427.

(3) Shu Zhou, Bo Wu, Chao Ma, Yong Ye. Huaixia Chen*. Solid-phase extraction followed by dispersive liquid-liquid microextraction for the sensitive determination of carbamates in environmental water by high-performance liquid chromatography. Journal of Liquid Chromatography & Related Technologies. 2012, 35: 1-13.

(4) Bo Wu, Ting Zhang, Jinxia Li, Yong Ye. Huaixia Chen*. The photodegradation of metronidazole in the presence of coexisting pharmaceuticals. Water Science and Technology, 2012, 735-740.

(5) Na Sun, Shengli Wu, Huaixia Chen*, Daijun Zheng, Junwen Xu, Yong Ye. Determination of sulfamethoxazole in milk using molecularly imprinted polymer monolith microextraction coupled to HPLC. Microchim Acta, 2012, 179: 33-40.

(6) Chao Ma, Hui Chen, Na Sun, Yong Ye, Huaixia Chen*. Preparation of Molecularly Imprinted Polymer Monolith with an Analogue of Thiamphenicol and Application to Selective Solid-Phase Microextraction. Food Anal. Methods, 2012, 5: 1267–1275.

(7) Jinfang Zhou, Chao Ma, Shu Zhou, Peili Ma, Fangrong Chen, Yue Qi, Huaixia Chen*. Preparation, evaluation and application of molecularly imprinted solid - phase microextraction monolith for selective extraction of pirimicarb in tomato and pear. J. Chromatogr. A, 2010, 1217: 7478-7483.

(8) Huaixia Chen*, Jianlin Huang, Juan Li. Characterization of metabolites of worenine in rat biological samples using liquid chromatography–tandem mass spectrometry. J. Pharm. Biomed. Anal., 2010, 51: 236-243.

(9) Huaixia Chen*, Hui Chen, Lei Liao, Jun Ying, and Jianlin Huang. Determination of thiamphenicol in honey by dispersive liquid-liquid microextractionwith high-performance liquid chromatography. J. Chromatogr. Sci., 2010, 48: 450-455.

(10) Huai-Xia Chen*, Jian-Lin Huang, Juan Li. Structural elucidation of in vivo and in vitro metabolites of epiberberine in rat and its liver and intestines by liquid chromatography -tandem mass spectrometry. Anal. Lett., 2010, 43: 2505-2517.

(11) F.M. Han; M.M. Zhu; H.X. Chen;Y. Chen. IdentificationofSophoridineandIts Metabolites in Rat Urine by Liquid Chromatography-Tandem Mass Spectrometry. Anal. Lett. 2010, 43: 1, 45-54.

(12) Huaixia Chen*, Hui Chen, Jun Ying, Jianlin Huang, Lei Liao. Dispersive liquid-liquid microextraction followed by high-performance liquid chromatography as an efficient and sensitive technique for simultaneous determination of chloramphenicol and thiamphenicol in honey. Anal. Chim. Acta, 2009, 632：80-85.

(13) Huaixia Chen*, Yong Chen, Peng Du, Fengmei Han. Liquid chromatography-electrospray ionization ion trap mass spectrometry for analysis of in vivo and in vitro metabolites of scopolamine in rats. J. Chromatogr. Sci., 2008, 46: 74-80.

(14) Huaixia Chen*, Jun Ying, Hui Chen, Jianlin Huang, Lei Liao. LC Determination of Chloramphenicol in Honey Using Dispersive Liquid–Liquid Microextraction. Chromatographia, 2008, 68, 629-634.

(15) Huaixia Chen*, Yong Chen, Peng Du, Fengmei Han. Structural elucidation of in vivo and in vitro metabolites of anisodine by liquid chromatography-tandem mass spectrometry. J. Pharm. Biomed. Anal., 2007, 44: 773-778.

(16) H.X. Chen*, Y. Chen, P. Du, F. M. Han. LC-MS for identification and elucidation of the structure of in-vivo and in-vitro metabolites of atropine. Chromatographia, 2007, 65: 413-418.

(17) Huaixia Chen*, Peng Du, Fengmei Han. Characterization of in Vivo and in Vitro Metabolic Pathway of Anisodamine by Liquid Chromatography-Tandem mass Spectrometry. J. Liq. Chromatogr. R.T., 2007, 60: 1933-1149.

(18) B.Y. Ge, H.X. Chen, F.M. Han, Y. Chen*. Identification of Amygdalin and its major metabolites in Rat Urine by LC-MS/MS. J. Chromatogr. B, 2007, 857：281-286.

(19) Mingming Zhu, Fengmei Han, Huaixia Chen, Zhihong Peng, Yong Chen*. Identification of palmatine and its metabolites in rat urine by liquid chromatography-tandem mass spectrometry. Rapid communications in mass spectrometry, 2007, 21(13): 2019-2022.

(20) Zhihong Peng, Wei Song, Fengmei Han, Huaixia Chen, Mingming Zhu, Yong Chen*. Chromatographic tandam mass spectrometric setection of papaverine and its major metabolites in rat urine. International Journal of Mass Spectrometry，2007, 266: 114-121.

(21) Huaixia Chen, Yong Chen, Peng Du, Fenmei Han, Hong Wang, Huashan Zhang*, Sensitive and specific liquid chromatographic-tandem mass spectrometric assay for atropine and its eleven metabolites in rat urine. J. Pharm. Biomed. Anal., 2006, 40: 142-150.

(22) M.M. Zhu, H.X. Chen, F.M. Han, Y. Chen*. Analysis of arecoline in rat urine and identification of its metabolites by liquid chromatography-tandem mass spectrometry. Chromatographia, 2006, 64: 705-708.

(23) Huaixia Chen, Yong Chen, Hong Wang, Peng Du, Fengmei Han, Huashan Zhang*. Analysis of scopolamine and its eighteen metabolites in rat urine by Liquid chromatography-tandem mass spectrometry. Talanta, 2005, 67/5: 984-991.

(24) Huaixia Chen, Hong Chen, Yong Chen, Huashan Zhang*, Liquid chromatography-tandem mass spectrometry analysis of anisodamine and its phase and metabolites in rat urine. J. Chromatogr. B, 2005, 824: 21-29.

(25) Yong Chen, Huaixia Chen, Peng Du, Fengmei Han, Huashan Zhang*, Analysis of anisodine and identification of twenty of its metabolites in rat urine by liquid chromatography-tandem mass spectrometry. Chromatographia, 2005, 62: 563-569.
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