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单 位食品与制药工程学院
职 称特聘教授
学 历博士
E-mail
研究方向生物医药
详细描述详细描述：
朱曙光(1962-)，男，博士，湖北省“3551”人才计划特聘专家。1996年获加拿大纽芬兰纪念大学有机化学博士学位。2000年起先后任职加拿大DaltonChemicalLaboratoriesInc.,Toronto,Canada化学研究经理，美国ChironCorporation/PathoGenesis,Seattle,WA化学开发CMC总监，美国AscentaTherapeutics,SanDiego,CA化学开发总监，美国ArdeaBiosciences,SanDiego,CA资深工艺化学总监，英国AstaTech,Inc.,Bristol,PA管理副总裁。朱曙光博士在美国制药工业从事新药工艺研发、生产和市场化发展链上的一系列工作达20年，包括小分子化学新药工艺研究和开发和生产项目的管理、新药工艺的表征和验证、选择与监管生产承包商、构建生产供应链等。在新药开发和质量管理、商务开发等方面具备专业知识和丰富的管理经验。2013年6月被聘为湖北工业大学特聘教授。
代表性专利：
1. Zhu, Shuguang and et al. Process for preparing R-gossypol L-phenylalninol dienamine. US Pat. Appl. Publ. US 2009/088590 A1
2.Zhu, Shuguang and et al. Crystalline and other forms of 4-amino-5-fluoro-3- [6-(4- methylpiperazine-1-yl)- 1H- benzimidazol-2-yl]- 1H-quinolin-2-one lactic acid salts. PCT Int. Appl. Publ., WO 2006/127926 A2
3.Zhu, Shuguang and et al. Process for preparation of 5-(4-methylpiperazin-1-yl)-2- nitroaniline from 1-methylpiperazine and 5-halo-2-nitroaniline. PCT Int. Appl. Publ., WO 2006/125130 A1.
4.Zhu, Shuguang and et al. Pharmaceutically acceptable salts of quinolinon compounds having improved pharmaceutical properties. U.S. Pat. Appl. Publ., US 2005/** A1.
5.Zhu, Shuguang and et al. Methods for synthesizing quinolinone compounds. U.S. Pat. Appl. Publ., US 2005/** A1.
6.Zhu, Shuguang and et al. Preparation of benzimidazole quinolinones for inhibiting FGFR3 and treating multiple myeloma. U.S. Pat. Appl. Publ., 239 pp, US 2005/**.
7.Zhu, Shuguang and et al. Process for preparation of benzimidazolylquinolones by reaction of aminobenzonitriles with benzimidazolylacetates. PCT Int. Appl. Publ., 77 pp, WO 2005/046590.
8.Zhu, Shuguang and et al. Preparation of benzimidazole quinolinones and lactate salts thereof for inhibiting vascular endothelial growth factor receptor tyrosine kinase. PCT Int. Appl. Publ., 215 pp, WO 2005/046589.
9.Zhu, Shuguang and et al. Preparation of benzimidazole quinolinones for inhibiting FGFR3 and treating multiple myeloma. PCT Int. Appl. Publ., 567 pp, WO 2005/047244.
10.Zhu, Shuguang and et al. Methods of treating cancer with a methylpiperazinyl benzimidazolyl quinolinone and related methods. PCT Int. Appl. Publ., 76 pp, WO 2004/043389.
11.Zhu, Shuguang and et al. Preparation of 1,2-diphenyl-1-naphthylethenes effective against human estrogen-dependent cancer cell lines. PCT Int. Appl. Publ., 61 pp. WO 2002/066451.
12.Zhu, Shuguang and et al. Preparation of aminoalkoxyphenylbenzochromenes and -phenanthrenes as nonsteroidal estrogen receptor ligands. PCT Int. Appl. Publ., 70 pp. WO 2002/066428.
13.Zhu, Shuguang and et al. Preparation of benzochromenones as antiproliferative agents. U.S. Pat. Appl. Publ. Publ., 17 pp. US 2002/115711.
代表性论文：
1.Zhu, Shuguang and et al. The chemical development of CHIR-258, CHIMIA. 2006, 60(9): 584-592.
2.Zhu, Shuguang and et al. Identification of Potent, Novel in vitro Inhibitors of the Pseudomonas aeruginosa Deacetylase LpxC. J. Med. Chem., 2002, 45: 3112-3129.
3.Zhu, Shuguang and et al. Adamantane-based nitrile sulfides: the generation of the synthetic equivalent of the first bis(nitrile sulfide). Can. J. Chem. 1995, 73(2): 212-22.
4.Zhu, Shuguang and et al. X-ray structure of 1,3-adamantanedicarbonamide. J. Chem. Crystallogr., 1995, 25(1): 11-14.
5.Zhu, Shuguang and et al. X-ray structure of tetramethyl thiophenetetracarboxylate. J. Chem. Crystallogr., 1994, 24(12): 801-3.
6.Zhu, Shuguang and et al. Heterocycles and polymers containing group 15 and 16 elements from the 1,3-dipolar cycloaddition reaction. Phosphorus, Sulfur Silicon Relat. Elem., 1994, 93-94(1-4): 457-8.
7.Zhu, Shuguang and et al. The preparation of 1,2,3,5-dithiadiazolium chlorides from the reaction of nitrile sulfides with thiazyl chloride. Can. J. Chem., 1994, 72(4): 1143-53.
8.Zhu, Shuguang and et al. Study on Configuration of Meso Tetrasubstituted Phenyl Porphyring by EHMO Method and Four Circular X-Ray Diffraction on Singlecrystal. J. Mol. Sci., 1990, 6(2): 86-92.
主要经历:
1978.9-1982.7四川大学化学专业，理学学士
1982.9-1985.6四川大学化学专业，理学硕士
1985.7-1992.8华中科技大学，讲师，化学系主任
1992.9-1996.6加拿大纽芬兰纪念大学有机化学专业，理学博士
1997-2000美国道尔顿化学实验室（DaltonChemicalLaboratoriesInc.），研发生产经理/课题主管
2000-2006美国凯朗生物医药（ChironCorporation），工艺开发部主管
2006-2007美国亚生（Ascenta）生物医药研发公司，工艺开发部总监
2007-2009美国阿迪亚（Ardea）生物科技公司，工艺化学部总监
2009-2010美国爱斯特（AstaTech）医药公司，首席科学官
2010-2012重庆博腾制药科技股份有限公司副总经理
2012-2014中美华世通生物医药科技（武汉）有限公司副总经理
2013-至今湖北工业大学特聘教授
朱曙光(1962-)，男，博士，湖北省“3551”人才计划特聘专家。1996年获加拿大纽芬兰纪念大学有机化学博士学位。2000年起先后任职加拿大DaltonChemicalLaboratoriesInc.,Toronto,Canada化学研究经理，美国ChironCorporation/PathoGenesis,Seattle,WA化学开发CMC总监，美国AscentaTherapeutics,SanDiego,CA化学开发总监，美国ArdeaBiosciences,SanDiego,CA资深工艺化学总监，英国AstaTech,Inc.,Bristol,PA管理副总裁。朱曙光博士在美国制药工业从事新药工艺研发、生产和市场化发展链上的一系列工作达20年，包括小分子化学新药工艺研究和开发和生产项目的管理、新药工艺的表征和验证、选择与监管生产承包商、构建生产供应链等。在新药开发和质量管理、商务开发等方面具备专业知识和丰富的管理经验。2013年6月被聘为湖北工业大学特聘教授。
代表性专利：
1. Zhu, Shuguang and et al. Process for preparing R-gossypol L-phenylalninol dienamine. US Pat. Appl. Publ. US 2009/088590 A1
2.Zhu, Shuguang and et al. Crystalline and other forms of 4-amino-5-fluoro-3- [6-(4- methylpiperazine-1-yl)- 1H- benzimidazol-2-yl]- 1H-quinolin-2-one lactic acid salts. PCT Int. Appl. Publ., WO 2006/127926 A2
3.Zhu, Shuguang and et al. Process for preparation of 5-(4-methylpiperazin-1-yl)-2- nitroaniline from 1-methylpiperazine and 5-halo-2-nitroaniline. PCT Int. Appl. Publ., WO 2006/125130 A1.
4.Zhu, Shuguang and et al. Pharmaceutically acceptable salts of quinolinon compounds having improved pharmaceutical properties. U.S. Pat. Appl. Publ., US 2005/** A1.
5.Zhu, Shuguang and et al. Methods for synthesizing quinolinone compounds. U.S. Pat. Appl. Publ., US 2005/** A1.
6.Zhu, Shuguang and et al. Preparation of benzimidazole quinolinones for inhibiting FGFR3 and treating multiple myeloma. U.S. Pat. Appl. Publ., 239 pp, US 2005/**.
7.Zhu, Shuguang and et al. Process for preparation of benzimidazolylquinolones by reaction of aminobenzonitriles with benzimidazolylacetates. PCT Int. Appl. Publ., 77 pp, WO 2005/046590.
8.Zhu, Shuguang and et al. Preparation of benzimidazole quinolinones and lactate salts thereof for inhibiting vascular endothelial growth factor receptor tyrosine kinase. PCT Int. Appl. Publ., 215 pp, WO 2005/046589.
9.Zhu, Shuguang and et al. Preparation of benzimidazole quinolinones for inhibiting FGFR3 and treating multiple myeloma. PCT Int. Appl. Publ., 567 pp, WO 2005/047244.
10.Zhu, Shuguang and et al. Methods of treating cancer with a methylpiperazinyl benzimidazolyl quinolinone and related methods. PCT Int. Appl. Publ., 76 pp, WO 2004/043389.
11.Zhu, Shuguang and et al. Preparation of 1,2-diphenyl-1-naphthylethenes effective against human estrogen-dependent cancer cell lines. PCT Int. Appl. Publ., 61 pp. WO 2002/066451.
12.Zhu, Shuguang and et al. Preparation of aminoalkoxyphenylbenzochromenes and -phenanthrenes as nonsteroidal estrogen receptor ligands. PCT Int. Appl. Publ., 70 pp. WO 2002/066428.
13.Zhu, Shuguang and et al. Preparation of benzochromenones as antiproliferative agents. U.S. Pat. Appl. Publ. Publ., 17 pp. US 2002/115711.
代表性论文：
1.Zhu, Shuguang and et al. The chemical development of CHIR-258, CHIMIA. 2006, 60(9): 584-592.
2.Zhu, Shuguang and et al. Identification of Potent, Novel in vitro Inhibitors of the Pseudomonas aeruginosa Deacetylase LpxC. J. Med. Chem., 2002, 45: 3112-3129.
3.Zhu, Shuguang and et al. Adamantane-based nitrile sulfides: the generation of the synthetic equivalent of the first bis(nitrile sulfide). Can. J. Chem. 1995, 73(2): 212-22.
4.Zhu, Shuguang and et al. X-ray structure of 1,3-adamantanedicarbonamide. J. Chem. Crystallogr., 1995, 25(1): 11-14.
5.Zhu, Shuguang and et al. X-ray structure of tetramethyl thiophenetetracarboxylate. J. Chem. Crystallogr., 1994, 24(12): 801-3.
6.Zhu, Shuguang and et al. Heterocycles and polymers containing group 15 and 16 elements from the 1,3-dipolar cycloaddition reaction. Phosphorus, Sulfur Silicon Relat. Elem., 1994, 93-94(1-4): 457-8.
7.Zhu, Shuguang and et al. The preparation of 1,2,3,5-dithiadiazolium chlorides from the reaction of nitrile sulfides with thiazyl chloride. Can. J. Chem., 1994, 72(4): 1143-53.
8.Zhu, Shuguang and et al. Study on Configuration of Meso Tetrasubstituted Phenyl Porphyring by EHMO Method and Four Circular X-Ray Diffraction on Singlecrystal. J. Mol. Sci., 1990, 6(2): 86-92.
主要经历:
1978.9-1982.7四川大学化学专业，理学学士
1982.9-1985.6四川大学化学专业，理学硕士
1985.7-1992.8华中科技大学，讲师，化学系主任
1992.9-1996.6加拿大纽芬兰纪念大学有机化学专业，理学博士
1997-2000美国道尔顿化学实验室（DaltonChemicalLaboratoriesInc.），研发生产经理/课题主管
2000-2006美国凯朗生物医药（ChironCorporation），工艺开发部主管
2006-2007美国亚生（Ascenta）生物医药研发公司，工艺开发部总监
2007-2009美国阿迪亚（Ardea）生物科技公司，工艺化学部总监
2009-2010美国爱斯特（AstaTech）医药公司，首席科学官
2010-2012重庆博腾制药科技股份有限公司副总经理
2012-2014中美华世通生物医药科技（武汉）有限公司副总经理
2013-至今湖北工业大学特聘教授
