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单 位食品与制药工程学院
职 称教授
学 历博士
E-mailhonghaosuncn@gmail.com
研究方向1、蒽醌类抗癌药物等小分子药物合成。2、金属，二氧化硅，高分子凝胶，脂质体等纳米球的制备和应用研究。纳米微球的表面修饰，以及微球和生物膜之间的相互作用机理研究。3、针对正常细胞和癌细胞之间微小的差别，实现靶向于癌细胞的分子水平成像和治疗。
详细描述基本信息
孙宏浩，男，2002年12月毕业于中科院长春应用化学研究所，教授，硕士生导师，
美国化学学会会员。
电话：**
联系地址：武汉市湖北工业大学轻工部食品与制药工程学院（430068）
科研成果
一、科研项目
1.2012年楚天学者特聘教授启动基金
2.Kr?ftens Bek?mpelse and the Danish Research Council for Technology and Production (Grant 274-07-0172)
3.the Danish Council for Independent Research (Technology and Production Sciences (FTP) grant no. (LiMeS) 274-07-0172)；
4.the Danish Strategic Research Council (NABIIT) No. 2106-070033
5.the Human Frontier Science Program, Grant RGP0041/2004C；
6.国家自然科学基金NSFC**,**和**.
7.中科院创新基金KJ951-A1-501-01。
二、主要代表作
1. Honghao Sun.; Tong, H.; Zhang, Y.; Wang, L.; Ma, D.; Jing, X.; and Wang, F. Novel PPV-based Light-emitting polymers contain a siloxane moiety Synthetic Metals 135-136 (2003) 231-233 IF 1.871
2. Honghao Sun.; Tu, G. ; Min, C. ; Li, H. ; Cheng, Y. ; Wang, L.; Jing, X.; and Wang, F; Wu, H.; Peng, J.; Cao, Y. Enhanced efficiency of light-emitting polymers through intra-molecular energy transfer Synthetic Metals 137 (2003) 1121-1122 IF 1.871
3. Tong, H.; Honghao Sun.; Xie. Z.; Wang, L.; Jing, X.; and Wang, F. Novel polyquinolines containing phenylamine moiety Synthetic Metals 137 (2003) 1115-1116 IF 1.871
4. Honghao Sun; Wang. L.; Ma.D.; Jing. X.; and Wang. F Cross-linkable Poly(phenylenyvinylene) derivatives Journal of Polymer Science. Part A. Polymer Chemistry, 42 (2004) 2124-2129 IF 3.894
5. Honghao Sun, Lixiang Wang, Dongge Ma, Xiabin Jing and Fosong Wang, Phenylene Vinylene Based Electroluminescent Polymers with Electron Transport Block in the Main Chain Journal of Polymer Science. Part A. Polymer Chemistry, 44 (2006) 3469-3478 IF 3.894
6. Honghao Sun, Anne Marie Scharff-Poulsen, Hong Gu, Kristoffer Almdal Synthesis and characterization of ratiometric, pH sensing nanoparticles with covalently attached fluorescent dyes Chemistry of Materials 18 (2006) 3381-3384 IF 5.368
7. Kristoffer Almdal, Honghao Sun, Allan K. Poulsen, Lise Arleth, Iver Jakobsen, Hong Gu and Anne Marie Scharff-Poulsen Fluorescent gel particles in the nanometer range for detection of metabolites in living cells Polym. Adv. Technol. 2006 17: 790–793 IF 1.776
8. Honghao Sun, Kristoffer Almdal, Hong Gu, Anne Marie Scharff-Poulsen, Iver Jacobsen and Wolf B. Frommer Phosphate sensing by fluorescent reporter proteins embedded in polyacrylamide nanoparticles ACS Nano 2008 vol 2 19-24 IF 11.400
9. Honghao Sun, Thomas L. Andresen, Rikke V. Benjaminsen, Kristoffer Almdal. Polymeric Nanosensors for Measuring the full Dynamic pH Range Endosomes and Lysosomes in Mammalian Cells. Jouranl of Biomedical Nanotechnology. 2009 Vol 5 1-7 IF 4.626
10. Rasmus I. J?lck, Honghao Sun, Rolf H. Berg, and Thomas L. Andresen, Catalyst-Free Conjugation and In Situ Quantification of Nanoparticle Ligand Surface Density Using Fluorogenic Cu-Free Click Chemistry, Chemistry. European. Journal. 2011, 17, 3326 – 3331 IF 5.382
11. Honghao Sun, Kristoffer Almdal and Thomas L. Andresen, Expanding the dynamic measurement range for polymeric nanoparticle pH sensors. Chemical Communications, 2011, 47, 5268–5270 IF 6.169
12. R. V. Benjaminsen, Honghao Sun, Kristoffer Almdal and Thomas L. Andresen Evaluating Nanoparticle Sensor Design for Intracellular pH Measurements. ACS nano 2011, 5, 5864-5873. IF 11.400
13. Honghao Sun, Kristoffer Almdal and Thomas L. Andresen, Hyaluronic Acid Immobilized Polyacrylamide Nanoparticle Sensors for CD44 Receptor Targeting and pH Measurement in Cells，Bioconjugate Chem. 2012, 23, 2247?2255， IF 5.002
14. Honghao Sun, Kristoffer Almdal and Thomas L. Andresen, Polymeric pH nanosensor with
extended measurement range bearing octaarginine as cell penetrating peptide Chemical Communications, 2013
15. Honghao Sun, Kristoffer Almdal and Thomas L. Andresen, Polymeric nanoparticle pH sensors using folate as targeting group, Bioconjugate Chemistry 2012 submitted
三、专利
1. Lixiang Wang, Honghao Sun, Yanxiang Cheng, Chongyu Mei Tittle: Energy-transfer type light-emitting polymer based on poly(p-phenylene vinylene) and preparation thereof. US Patent, 2005, Class: ** (USPTO), B32B019/00 (Intl Class)
2. M.T. Molina, Honghao Sun, S. Taliansky, A. Carnero, F. Blanco, M.V. Moneo, B. Tittle: Antitumor quinonoid compunds and derivatives thereof, obtention procedures and their applications. García. Sol. Pat. Esp. Spainsh Patent ** (139 pp.).
3. Lixiang Wang, Honghao Sun, Yanxiang Cheng, Chongyu Mei Tittle: Preparation of 4. poly(p-phenylene vinylene) with energy transfer property Chinese Patent Applied No: CN**6.4 Published No: CN**
5. M.T. Molina, Honghao Sun, S. Taliansky, A. Carnero, F. Blanco, M.V. Moneo, B. Tittle: Compuestos quinónicos antitumorales y sus derivados, procedimiento de obtención y sus aplicaciones. Publication Number:WO/2007/026041 International Application No.:PCT/ES2006/000499
6. 刘明星, 孙宏浩, 戴康, 等. Tivozanib酸性盐及其制备方法和晶型. 专利申请号: **6.5
主要经历
1990.7月-1994.6月学士武汉工程大学化学工程系
1996.8月-1999.6 月硕士,武汉工程大学化学工程系 导师 马文展
1999.9 月-2002.12月博士,高分子化学和物理中国科学院长春应用化学研究所 高分子化学与物理国家重点实验室导师 王利祥
2003.6月- 2005.6月Postdoc asscociate 西班牙科技部，药物化学研究所 导师M.T. Molina
http://www.iqm.csic.es/antihumoralesing.html
2005.6月 -2006.7月丹麦Ris? 国家实验室，高分子中心, (DTU) Postdoc，美国斯坦福大学卡内基研究所. 导师Kristoffer Almdal and Thomas L. Andresen, http://www.cbio.dk
2006.7月-2011年10月Researcher, Technical University of Denmark, Department of Micro & Nanotechnology. 合作者Kristoffer Almdal and Thomas L. Andresen
dal and Thomas L. Andresen
2011.11月-2012年7月Researcher, Department of Biochemistry and Molecular Biology, University of Southern Denmark
2012.8-至今 湖北工业大学轻工学部食品与制药工程学院
研究方向
1、蒽醌类抗癌药物等小分子药物合成。
2、金属，二氧化硅，高分子凝胶，脂质体等纳米球的制备和应用研究。纳米微球的表面修饰，以及微球和生物膜之间的相互作用机理研究。
3、针对正常细胞和癌细胞之间微小的差别，实现靶向于癌细胞的分子水平成像和治疗。
孙宏浩，男，2002年12月毕业于中科院长春应用化学研究所，教授，硕士生导师，
美国化学学会会员。
电话：**
联系地址：武汉市湖北工业大学轻工部食品与制药工程学院（430068）
科研成果
一、科研项目
1.2012年楚天学者特聘教授启动基金
2.Kr?ftens Bek?mpelse and the Danish Research Council for Technology and Production (Grant 274-07-0172)
3.the Danish Council for Independent Research (Technology and Production Sciences (FTP) grant no. (LiMeS) 274-07-0172)；
4.the Danish Strategic Research Council (NABIIT) No. 2106-070033
5.the Human Frontier Science Program, Grant RGP0041/2004C；
6.国家自然科学基金NSFC**,**和**.
7.中科院创新基金KJ951-A1-501-01。
二、主要代表作
1. Honghao Sun.; Tong, H.; Zhang, Y.; Wang, L.; Ma, D.; Jing, X.; and Wang, F. Novel PPV-based Light-emitting polymers contain a siloxane moiety Synthetic Metals 135-136 (2003) 231-233 IF 1.871
2. Honghao Sun.; Tu, G. ; Min, C. ; Li, H. ; Cheng, Y. ; Wang, L.; Jing, X.; and Wang, F; Wu, H.; Peng, J.; Cao, Y. Enhanced efficiency of light-emitting polymers through intra-molecular energy transfer Synthetic Metals 137 (2003) 1121-1122 IF 1.871
3. Tong, H.; Honghao Sun.; Xie. Z.; Wang, L.; Jing, X.; and Wang, F. Novel polyquinolines containing phenylamine moiety Synthetic Metals 137 (2003) 1115-1116 IF 1.871
4. Honghao Sun; Wang. L.; Ma.D.; Jing. X.; and Wang. F Cross-linkable Poly(phenylenyvinylene) derivatives Journal of Polymer Science. Part A. Polymer Chemistry, 42 (2004) 2124-2129 IF 3.894
5. Honghao Sun, Lixiang Wang, Dongge Ma, Xiabin Jing and Fosong Wang, Phenylene Vinylene Based Electroluminescent Polymers with Electron Transport Block in the Main Chain Journal of Polymer Science. Part A. Polymer Chemistry, 44 (2006) 3469-3478 IF 3.894
6. Honghao Sun, Anne Marie Scharff-Poulsen, Hong Gu, Kristoffer Almdal Synthesis and characterization of ratiometric, pH sensing nanoparticles with covalently attached fluorescent dyes Chemistry of Materials 18 (2006) 3381-3384 IF 5.368
7. Kristoffer Almdal, Honghao Sun, Allan K. Poulsen, Lise Arleth, Iver Jakobsen, Hong Gu and Anne Marie Scharff-Poulsen Fluorescent gel particles in the nanometer range for detection of metabolites in living cells Polym. Adv. Technol. 2006 17: 790–793 IF 1.776
8. Honghao Sun, Kristoffer Almdal, Hong Gu, Anne Marie Scharff-Poulsen, Iver Jacobsen and Wolf B. Frommer Phosphate sensing by fluorescent reporter proteins embedded in polyacrylamide nanoparticles ACS Nano 2008 vol 2 19-24 IF 11.400
9. Honghao Sun, Thomas L. Andresen, Rikke V. Benjaminsen, Kristoffer Almdal. Polymeric Nanosensors for Measuring the full Dynamic pH Range Endosomes and Lysosomes in Mammalian Cells. Jouranl of Biomedical Nanotechnology. 2009 Vol 5 1-7 IF 4.626
10. Rasmus I. J?lck, Honghao Sun, Rolf H. Berg, and Thomas L. Andresen, Catalyst-Free Conjugation and In Situ Quantification of Nanoparticle Ligand Surface Density Using Fluorogenic Cu-Free Click Chemistry, Chemistry. European. Journal. 2011, 17, 3326 – 3331 IF 5.382
11. Honghao Sun, Kristoffer Almdal and Thomas L. Andresen, Expanding the dynamic measurement range for polymeric nanoparticle pH sensors. Chemical Communications, 2011, 47, 5268–5270 IF 6.169
12. R. V. Benjaminsen, Honghao Sun, Kristoffer Almdal and Thomas L. Andresen Evaluating Nanoparticle Sensor Design for Intracellular pH Measurements. ACS nano 2011, 5, 5864-5873. IF 11.400
13. Honghao Sun, Kristoffer Almdal and Thomas L. Andresen, Hyaluronic Acid Immobilized Polyacrylamide Nanoparticle Sensors for CD44 Receptor Targeting and pH Measurement in Cells，Bioconjugate Chem. 2012, 23, 2247?2255， IF 5.002
14. Honghao Sun, Kristoffer Almdal and Thomas L. Andresen, Polymeric pH nanosensor with
extended measurement range bearing octaarginine as cell penetrating peptide Chemical Communications, 2013
15. Honghao Sun, Kristoffer Almdal and Thomas L. Andresen, Polymeric nanoparticle pH sensors using folate as targeting group, Bioconjugate Chemistry 2012 submitted
三、专利
1. Lixiang Wang, Honghao Sun, Yanxiang Cheng, Chongyu Mei Tittle: Energy-transfer type light-emitting polymer based on poly(p-phenylene vinylene) and preparation thereof. US Patent, 2005, Class: ** (USPTO), B32B019/00 (Intl Class)
2. M.T. Molina, Honghao Sun, S. Taliansky, A. Carnero, F. Blanco, M.V. Moneo, B. Tittle: Antitumor quinonoid compunds and derivatives thereof, obtention procedures and their applications. García. Sol. Pat. Esp. Spainsh Patent ** (139 pp.).
3. Lixiang Wang, Honghao Sun, Yanxiang Cheng, Chongyu Mei Tittle: Preparation of 4. poly(p-phenylene vinylene) with energy transfer property Chinese Patent Applied No: CN**6.4 Published No: CN**
5. M.T. Molina, Honghao Sun, S. Taliansky, A. Carnero, F. Blanco, M.V. Moneo, B. Tittle: Compuestos quinónicos antitumorales y sus derivados, procedimiento de obtención y sus aplicaciones. Publication Number:WO/2007/026041 International Application No.:PCT/ES2006/000499
6. 刘明星, 孙宏浩, 戴康, 等. Tivozanib酸性盐及其制备方法和晶型. 专利申请号: **6.5
主要经历
1990.7月-1994.6月学士武汉工程大学化学工程系
1996.8月-1999.6 月硕士,武汉工程大学化学工程系 导师 马文展
1999.9 月-2002.12月博士,高分子化学和物理中国科学院长春应用化学研究所 高分子化学与物理国家重点实验室导师 王利祥
2003.6月- 2005.6月Postdoc asscociate 西班牙科技部，药物化学研究所 导师M.T. Molina
http://www.iqm.csic.es/antihumoralesing.html
2005.6月 -2006.7月丹麦Ris? 国家实验室，高分子中心, (DTU) Postdoc，美国斯坦福大学卡内基研究所. 导师Kristoffer Almdal and Thomas L. Andresen, http://www.cbio.dk
2006.7月-2011年10月Researcher, Technical University of Denmark, Department of Micro & Nanotechnology. 合作者Kristoffer Almdal and Thomas L. Andresen
dal and Thomas L. Andresen
2011.11月-2012年7月Researcher, Department of Biochemistry and Molecular Biology, University of Southern Denmark
2012.8-至今 湖北工业大学轻工学部食品与制药工程学院
研究方向
1、蒽醌类抗癌药物等小分子药物合成。
2、金属，二氧化硅，高分子凝胶，脂质体等纳米球的制备和应用研究。纳米微球的表面修饰，以及微球和生物膜之间的相互作用机理研究。
3、针对正常细胞和癌细胞之间微小的差别，实现靶向于癌细胞的分子水平成像和治疗。
