袁成福，博士，教授，湖北省“楚天****”，三峡****，博士/硕士生导师。国家自然科学基金通讯评审专家，湖北省科技奖评审专家，教育部学位中心学位论文评审专家；Seminars in Cancer Biology、ACS Applied Materials & Interfaces、Food and function、Food and Nutrition Research、Scientific Reports、Anti-Cancer Agents in Medicinal Chemistry、Current Pharmaceutical Analysis、Journal of Basic and Clinical Physiology and Pharmacology、Carbohydrate Polymers、Natural Product Research、Genes & Diseases等30余种国际期刊审稿专家。
2010年至2014年于美国University of Minnesota等大学进行医学分子生物学博士后研究；2017年8月至2018年8月于美国The University of Chicago访问学习。主持、参加国家级、省部级等科研课题十余项；以第一完成人获省部级科技二等奖三项；在Cancer Research、J Biol Chem、Cell cycle、RNA Biol等国内外杂志发表研究论文100余篇（其中SCI收录40余篇）；授权发明专利2项。
主要研究方向：
1.代谢性疾病（如肥胖、胰岛素抵抗等）的发病机制及其药物防治研究；
2.恶性肿瘤相关新基因的挖掘、筛选、功能解析及其临床应用评价研究。
招生方向：临床医学（学术型）；基础医学（学术型）；药学
联系方式：yuancf46@ctgu.edu.cn; yuancf46@163.com；@qq.com
近几年代表性研究论文（第一、共同第一^#或通讯作者^*发表的SCI收录论文）：
1.Yue Shi, Zhengtai Liu, Liyue Gai, Yan Gao, Yumin He, Chaoqi Liu, Changcheng Zhang, Gang Zhou, Ding Yuan, Chengfu Yuan*. The preventive effect of total saponins from Panax japonicus on inflammation and insulin resistance in adipose tissue of mice induced by a high-fat diet. Journal of Functional Foods, 2021,78. doi.org/10.1016/j.jff.2021.104369
2. Yan Gao, Ding Yuan, Liyue Gai, Xuelian Wu, Yue Shi, Yumin He, Chaoqi Liu, Changcheng Zhang, Gang Zhou, Chengfu Yuan*. Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NF-kB and TGF-β1/Smad signaling and suppression of oxidative stress via activation of Nrf2-ARE signaling. Journal of Ginseng Research, 2020,8. doi.org/10.1016/j.jgr.2020.08.005
3. Luoying Li, Gang Zhou, Rui Fu, Yumin He, Li Xiao, Fan Peng, Chengfu Yuan*. Polysaccharides extracted from balanophora polyandra Griff (BPP) ameliorate renal fibrosis and EMT via inhibiting the hedgehog pathway. J Cell Mol Med, 2021, doi: 10.1111/jcmm.16313. PMID:**
4. Hao Yuan, Xuelian Wu, Xiaomin Wang, Chengfu Yuan*. Chinese herbal decoction astragalus and angelica exerts its therapeutic effect on renal interstitial fibrosis through the inhibition of MAPK, PI3K-Akt and TNF signaling pathways. Genes & Diseases, 2020,6. doi.org/10.1016/j.gendis.2020.06.001
5. Bei Wang, Wen Xu, Chengyu Hu, Kai Liu, Jinlan Chen,Chong Guo, Chengfu Yuan*. Critical roles of the lncRNA CASC11 in tumor progression and cancer metastasis: The biomarker and therapeutic target potential. Genes & Diseases, 2020,11. doi.org/10.1016/j.gendis.2020.11.016
6. Chong Guo, Chaoying Song, Jiali Zhang, Yisong Gao,Yuying Qi, Zongyao Zhao, Chengfu Yuan*. Revisiting chemoresistance in ovarian cancer: Mechanism, biomarkers, and precision medicine. Genes & Diseases, 2020,11. doi.org/10.1016/ j.gendis.2020.11.017
7. Bei Wang, Wen Xu, Yuxuan Cai, Chong Guo, Gang Zhou, Chengfu Yuan*. CASC15: A Tumor-Associated Long Non-Coding RNA. Curr Pharm Des, 2021;27(1):127-134.
8. Yujie Shen, Yexiang Lin, Kai Liu, Jinlan Chen, Juanjuan Zhong, Yisong Gao, Chengfu Yuan*. XIST: A Meaningful Long Noncoding RNA in NSCLC Process. Curr Pharm Des, 2020, doi: 10.2174/**413.PMID: **
9. Yexiang Lin , Yujie Sheng , Jinlan Chen , Chengyu Hu , Zixian Zhou , Chengfu Yuan*. The Function of LncRNA FTX in Several Common Cancers. Curr Pharm Des, 2020, doi: 10.2174/**036.PMID:**
10.Chengyu Hu, Kai Liu, Bei Wang, Wen Xu, Yexiang Ling, Chengfu Yuan*. DLX6-AS1: An Indispensable Cancer-related Long Non-coding RNA. Curr Pharm Des, 2020, doi: 10.2174/**151.PMID:**
11. Wen Xu, Bei Wang, Yuxuan Cai, Chong Guo, Kai Liu, Chengfu Yuan*. DLEU2: A Meaningful Long Noncoding RNA in Oncogenesis. Curr Pharm Des, 2020, doi: 10.2174/**857. PMID: **
12. Li Xiao, Yumin He, Fan Peng, Jianlin Yang, Chengfu Yuan*. Endometrial Cancer Cells Promote M2-Like Macrophage Polarization by Delivering Exosomal miRNA-21 under Hypoxia Condition. J Immunol Res, 2020,2020:**. doi: 10.1155/2020/**. eCollection 2020.PMID:**
13.Yuying Qi, Chaoying Song, Jiali Zhang, Chong Guo, Chengfu Yuan*. Oncogenic LncRNA CASC9 in Cancer Progression. Curr Pharm Des, 2020, doi: 10.2174/**130. PMID:**
14. Chong Guo, Yumin He, Liyue Gai, Jiayuan Qu, Yue Shi, Wen Xu, Yuxuan Cai, Bei Wang, Jiali Zhang, Zongyao Zhao, Chengfu Yuan*. Balanophora polyandra Griff. prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-κB and NLRP3 inflammasome. Food Funct, 2020,11(7):6104-6114.
15. Jiayuan Qu, Yumin He, Yue Shi, Liyue Gai, Li Xiao, Fan Peng, Zicheng Li, Xiaomin Wang, Chengfu Yuan*. Polysaccharides derived from Balanophora polyandra significantly suppressed the proliferation of ovarian cancer cells through P53-mediated pathway. J Cell Mol Med, 2020,24(14):8115-8125.
16. Chaoying Song, Yuying Qi, Jiali Zhang, Chong Guo, Chengfu Yuan*. CDKN2B-AS1: An Indispensable Long Non-coding RNA in Multiple Diseases. Curr Pharm Des, 2020,26(41):5335-5346.
17. Yue Shi, Jiayuan Qu, Liyue Gai, Ding Yuan, Chengfu Yuan*. Long Non-coding RNAs in Metabolic and Inflammatory Pathways in Obesity. Curr Pharm Des, 2020,26(27):3317-3325.
18. Chaoying Song, Jiali Zhang, Zongyao Zhao, Yuxia Yang, Di Meng, Jing Wang, Chong Guo, Chengfu Yuan*. DLEU1: A Functional Long Noncoding RNA in Tumorigenesis. Curr Pharm Des, 2020,26(15):1742-1748.
19. Chong Guo, Yuying Qi, Jiayuan Qu, Liyue Gai, Yue Shi, Chengfu Yuan*. Pathophysiological Functions of the lncRNA TUG1. Curr Pharm Des, 2020,26(6):688-700.
20. Jiayuan Qu, Mohammad Amjad Kamal, Chengfu Yuan*. The Regulatory Roles of Long Non-Coding RNA in the Chemoresistance Process of Ovarian cancer. Curr Pharm Des. 2019;25(8):856-861.
21. Yan He, Chengfu Yuan*, Lichan Chen, Mingjuan Lei, Lucas Zellmer, Hai Huang, and Dezhong Joshua Liao. Transcriptional-Readthrough RNAs Reflect the Phenomenon of “A Gene Contains Gene(s)” or “Gene(s) within a Gene” in the Human Genome, and Thus Are Not Chimeric RNAs. Genes (Basel), 2018, 9(1). pii: E40. doi: 10.3390/genes**.
22. Yan He, Chengfu Yuan*, Lichan Chen, Yanjie Liu, Haiyan Zhou, Ningzhi Xu, and Dezhong Joshua Liao.?While it is not deliberate, much of today’s biomedical research contains logical and technical flaws, showing a need for corrective action. Int J Med Sci, 2018, 15(4):309-322. doi: 10.7150/ijms.23215. eCollection 2018.
23. Chengfu Yuan*, Yaping Han, Lucas Zellmer, Wenxiu Yang, Zhizhong Guan, Wenfeng Yu, Hai Huang, D. Joshua Liao. It is imperative to establish a pellucid definition of chimeric RNA and to clear up a lot of confusion in the relevant research. Int J Mol Sci, 2017, 18(4). pii: E714. doi: 10.3390/ijms**.
24. Chengfu Yuan，Chaoqi Liu，Ting Wang，Yumin He，Zhiyong Zhou，Yaoyan Dun，Haixia Zhao，Dongming Ren，Junjie Wang^*，Changcheng Zhang，Ding Yuan. Chikusetsu saponin IVa ameliorates high fat diet-induced inflammation in adipose tissue of mice through inhibition of NLRP3 inflammasome activation and NF-κB signaling. Oncotarget, 2017,8(19):31023-31040. DOI: 10.18632/oncotarget.16052.
25. Fan Peng，Xin Guo，Zhihong L^#，Changzheng Li，Changdong Wang，Weiran Lv，Junjie Wang，Fangxiang Xiao，Mohammad Amjad Kamal，Chengfu Yuan*. Antimutagenic Effects of Selenium-Enriched Polysaccharides from Pyracantha fortuneana through Suppression of Cytochrome P450 1A Subfamily in the Mouse Liver. Molecules, 2016, 21(12). pii: E1731. doi: 10.3390/molecules**.
26. Qianling Sun，Mengmeng Dong，Zhihui Wang，Changdong Wang，Deqiao Sheng，Zhihong Li，Debin Huang，Chengfu Yuan*. Selenium-enriched polysaccharides from Pyracantha fortuneana (Se-PFPs) inhibit the growth and invasive potential of ovarian cancer cells through inhibiting β-catenin signaling. Oncotarget，2016,7（19）：28369-28383. doi: 10.18632/oncotarget.8619.
27.Chengfu Yuan*，Changdong Wang，Junjie Wang，Vikas Kumar，Firoz Anwar，Fangxiang Xiao，Gohar Mushtaq，Yufei Liu，Mohammad Amjad Kamal，Ding Yuan. Inhibition on the growth of human MDA-MB-231 breast cancer cells in vitro and tumor growth in a mouse xenograft model by Se-containing polysaccharides from Pyracantha fortuneana. Nutr Res, 2016, 36（11）：1243-1254.
28. Chengfu Yuan*，Zhihong Li，Fan Peng，Fangxiang Xiao，Dongming Ren，Hui Xue，Tao Chen，GoharMushtaq，Mohammad Amjad Kamal.Combination of selenium-enriched green tea polysaccharides and Huo-ji polysaccharides synergistically enhances antioxidant and immune activity in mice. J Sci Food Agric, 2015, 95（15）: 3211-3217.
29. Chengfu Yuan*，Zhihong Li，Muhua Yi，Xiaoxing Wang，Fan Peng，Fangxiang Xiao，Tao Chen，Changdong Wang，Gohar Mushtaq，Mohammad Amjad Kamal. Effects of polysaccharides from selenium-enriched Pyracantha fortuneana on mice liver injury. Med Chem, 2015, 11（8）：780-788.
30.Jinglei Zhang，Chengfu Yuan，Jianguo Wu，Zeinab Elsayed，Zheng Fu，Polo-like Kinase 1-mediated Phosphorylation of Forkhead Box Protein M1b Antagonizes Its SUMOylation and Facilitates Its Mitotic Function.J Biol Chem, 2015, 290（6）：3708-3719.
31. Chengfu Yuan，Lei Wang，Liang Zhou，Zheng Fu. The function of FOXO1 in the late phases of the cell cycle is suppressed by PLK1-mediated phosphorylation. Cell Cycle，2014, 13（5）：807-819.
32. Chengfu Yuan，Yongming Liu，Min Yang，Joshua Liao. New methods as alternative or corrective measures for the pitfalls and artifacts of reverse transcription and polymerase chain reactions (RT-PCR) in cloning chimeric or antisense-accompanied RNA.RNA Biol,2013,10（6）：958-967.
33. Chengfu Yuan，Ningzhi Xu，Joshua Liao^*. Switch of FANCL, a key FA-BRCA component, between tumor suppressor and promoter by alternative splicing. Cell Cycle，2012, 11（18）：3356-3356.
34. Chengfu Yuan，Youquan Bu，Changdong Wang，Faping Yi，Zhengmei Yang，Xiuning Huang，Li Cheng，Geli Liu，Yong Wang，Fangzhou Song^*. NFBD1/MDC1 is a protein of oncogenic potential in human cervical cancer. Mol Cell Biochem，2012, 359（1-2）: 333-346.
35. Chengfu Yuan，Changdong Wang，Youquan Bu，Tingxiu Xiang，Xiuning Huang，Zhiwei Wang，Faping Yi，Guosheng Ren，Geli Liu，Fangzhou Song. Antioxidative and immunoprotective effects of Pyracantha fortuneana (Maxim.) Li polysaccharides in mice. Immunol Lett，2010, 133（1）：14-18.
36. Chengfu Yuan，Weiping Lu，Tingxiu Xiang，Faping Yi，Geli Liu，Guosheng Ren，Fangzhou Song. Generation of mammalian cell lines with gene knock-down for human MCHR2.Cell.Mol.Biol.,2010,56：OL1359-OL1365.
37. Chengfu Yuan，Xiuning Huang，Li Cheng，Youquan Bu，Geli Liu，Faping Yi，Zhengmei Yang，Fangzhou Song^*. Evaluation of antioxidant and immune activity of Phellinus ribis glucan in mice. Food Chem，2009，115（2）：581-584.
38. Chengfu Yuan，Youquan Bu，Joyeeta Sengupta，Junxia Yang，Xiuning Huang，Li Cheng，Qin Zhang，Faping Yi，Geli Liu，Fangzhou Song^*. Establishment of CHO cell line expressing human MCHR2 gene and research of its molecular characteristics. Indian J Exp Biol, 2009，47（11）：862-870.se-accompanied RNA.RNA Biology，2013.6.01，10（6）：958-967.