姓名
贺海波
联系电话
**


电子邮箱
hjy219@126.com

招收专业


研究方向


个人简介
贺海波，男，出生1972年1月，湖北鄂州人，中国药科大学药学博士，浙江大学药学博士后、副教授、硕士研究生导师，中国药理学会会员、中国中医药学会会员、中华中医药学会中药基础理论分会青年委员、世界中联药膳食疗研究专业委员会常务理事、中国民族医药学会理事、宜昌市药学会副会长、中医药学会副秘书长、三峡大学第二人民医院****。主要从事三峡库区及神农架林区民间药物化学成分分离纯化、活性评价，中药药理、毒理学研究，中药抗肿瘤及防治心脑血管、消化及内分泌代谢疾病研究，食品、保健品和新药的研究与开发，茶叶、青钱柳、湖北海棠、木瓜等相关药食同源产品的应用开发研究。近5年来，主持了国家、省部级及横向合作等科研项目20余项，发表科研论文60余篇，其中SCI/EI收录30余篇，获湖北省科技进步奖三等奖1项、中华中医药学会科技进步奖三等奖1项、宜昌市科技进步奖一等奖2项，获国家发明专利5项，主编专著2部，参与完成了“地奥心血康”、“更年安神胶囊”等新药的研究开发，主持完成了“复方杜仲降压胶囊”、“参芪咀嚼片”等保健品的研究与开发，主持完成 “活血益肾颗粒”、“祛风活络颗粒”、“痔疮颗粒”等医院制剂的研究与开发，主持完成了鱼腥草复合袋泡茶、青钱柳茶等相关茶产品的研究与开发，木瓜食品的研究开发，保健型柑橘果醋的研究与开发，天麻保鲜、深加工等研究。

主要研究成果
近年来发表SI/EI论文：
1) He Haibo, Li Xiaomei, Li Daojun, Ding Yonghong, Zhang Yongfeng, Xu Haiyan, Feng Minlu, Xiang Changqing, Zhou Jigang, Zhang Jihong, Liu Hongjun, Chen Maohua. Saponins from Rhizoma Panacis Majoris attenuate myocardial ischemia/reperfusion injury via the activation of the Sirt1/FoxO1/ Pgc-1α and Nrf2/antioxidant defense pathways in rats. Pharmacogn Mag, 2018, 14(54): 1-11.
2) Wang Junzhi, Zhang Pan, He Haibo*, Se Xinxin, Sun Wenjun, Chen Beiyan, Zhang Lin, Yan Ximing, Zou Kun. Eburicoic acid from Laetiporus sulphureus (Bull.:Fr.) Murrill attenuates inflammatory responses through inhibiting LPS-induced activation of PI3K/Akt/mTOR/NF-κB pathways in RAW264.7 cells. Naunyn Schmiedebergs Arch Pharmacol, 2017, 390(8):845-856.
3) Bai Caihong, Yang Xiaojiao, Zou Kun, He Haibo*, Wang Junzhi, Qin Huilin, Yu Xiaoqin , Liu Chengxiong, Zheng Juyan, Cheng Fan, Chen Jianfeng. Antiproliferative effect of RCE-4 from Reineckia carnea on human cervical cancer HeLa cells by inhibiting the PI3K/Akt/mTOR signaling pathway and NF-κB activation. Naunyn Schmiedebergs Arch Pharmacol, 2016, 389(6):573-584.
4) Zhang Qioayin, Wang Junzhi, He Haibo*, Liu Hongbin, Yan Ximing, Zou Kun. Trametenolic acid B reverses multidrug resistance in breast cancer cells through regulating the expression level of P-glycoprotein. Phytother Res, 2014, 28(7):1037-1044.
5) Wei Na, Zhang Changcheng, He Haibo*, Wang Ting, Liu Zhaoqi, Liu Guangyao, Sun Zhiwei, Zhou Zhiyong, Bai Caihong, Yuan Ding. Protective effect of saponins extract from Panax japonicus on myocardial infarction: involvement of NF-κB, Sirt1 and mitogen-activated protein kinase signalling pathways and inhibition of inflammation. J Pharm Pharmacol, 2014, 66 (11): 1641-1651.
6) Wang Sa, He Haibo*, Xiao Shuzhang, Wang Jun zhi, Bai Caihong, Na Wei, Kun Zou. Comparison between the cardioprotective effects of labeled and unlabeled oleanoic acid with new BOPIM dye on primary neonatal rat cardiomyocytes following hypoxia/reoxgenation injury. Pharmacological Rep, 2014, 66 (4): 677-685.
7) Huang Shaolan, He Haibo*, Zou Kun, Bai Caihong, Xue Yanhong, Wang Junzhi, Chen Jianfeng. Protective effect of tomatine against hydrogen peroxide-induced neurotoxicity in neuroblastoma (SH-SY5Y) cells. J Pharm Pharmacol, 2014, 66 (4): 844-854.
8) Yuan Ding, Wang Hongwu, He Haibo*, Jia Liangliang, He Yumin, Wang Ting, Zeng Xiao, Li Yuzhou, Li Shouchao, Zhang Changcheng. Protective Effects of total Flavonoids from Epimedium on the male mouse reproductive system against cyclophosphamide-induced oxidative injury by up-regulating the expressions of SOD3 and GPX1. Phytother Res, 2014, 28 (1): 88-97.
9) Jin Guilan, Qin Huilin, He Haibo*, Cheng Fan, Gong Dachun, Xu Bang, Jia Liangliang, Xi Wei, Wang Hongwu, Xiang Xiangfei. Neuroprotective effects of breviscapine against oxidative-stress- Induced cell death in PC12 cells: Involvement of Nrf2/HO-1 pathway. Medicine Sciences and Bioengineering, 2014, 277-282.
10)Bai Caihong, He Haibo*, Cheng Fan, Zou Kun, Wang Junzhi, Liu Guangyao, Deng Wei, Chen Zhifeng, Chen Xiao, Chen Jianfeng. A steroidal saponin RCE-4 inhibits lipopolysaccharide-stimulated inflammatory responses via blocking PI3K/Akt-mediated NF-κB activation in RAW264.7 cells. Applied Mechanics and Materials, 2014, 568-570: 1901-1906.
11)Wei Na, Yuan Ding, He Haibo*, Xu Yuanqing, Zhang Changcheng, Wang Ting, Liu Chaoqi, Liu Guangyao. Saponins from Panax japonicas reduces myocardial infarction induced Reactive Oxygen Species production and cardiomyocyte apoptosis via activation of the Nrf-2 pathway. Advanced Materials Research, 2014, 881-883: 339-346.
12)Bai Caihong, He Haibo*, Cheng Fan, Wang Junzhi, Chen Xiao, Zou Kun, Liu Guangyao, Chen Zhifeng, Chen Jianfeng. Cardioprotective effects of saponins from Rhizoma Panacis Majoris on myocardial ischemia/reperfusion injury via scavenging excessive reactive oxygen species. Advanced Materials Research, 2014, 165-172: 165-172.
13)Zhang Jihong, Shi Mengqiong, He Haibo*, Bai Caihong, Wang Junzhi, Cheng Fan, Liu Guangyao, Deng Wei, Zou Kun, Chen Zhifeng. Hepatoprotective effects of saponins from Rhizoma Panacis Majoris on hepatic fibrosis induced by carbon tetrachloride in rats. Applied Mechanics and Materials, 2014, 568-570, 1915-1920.
14)Wei Na, Yuan Ding, He Haibo*, Xu Yuanqing, Zhang Changcheng, Wang Ting, Liu Chaoqi, Liu Guangyao. Saponins from Panax japonicas reduces myocardial infarction induced Reactive Oxygen Species production and cardiomyocyte apoptosis via activation of the Nrf-2 pathway. Advanced Materials Research, 2013, 784-789: 367-371.
15)Deng gaigai, Wang junzhi, Zhang Qiaoyin, He Haibo*, Wu Fangfang, Feng Tianyan, Zhou Jigang, Zou Kun, Masao Hattoric. Hepatoprotective effects of Phloridzin on hepatic fibrosis induced by carbon tetrachloride against oxidative stress-triggered damage and fibrosis in rats. Biol. Pharm. Bull, 2012, 35(7):1118-112.
16)Huilin Qin, Yongfeng Zhang, Haibo He*, Junzhi Wang, Huajun Luo. Total triterpene from haenomeles speciosa (sweet) Nakaion attenuates the adjuvant induced arthritis by regulating MAPK/NF-κB pathway and pro-inflammatory cytokine in rats. (submitted to J Ethnopharmacol).
17)Haibo He, Huilin Qin, Yongfeng Zhang, Xiaomei LI, Xiaoqin Li, Weihong Yan, Yuling Li. Protective effects of total triterpene from Chaenomeles speciosa (Sweet) Nakai against indomethacin-induced gastric ulcer in rats and potential underlying mechanisms. (submitted to J Pharm Pharmacol).
已申请专利和专著：
1. 贺海波, 邹坤, 杨小姣, 刘呈雄, 白彩虹, 王倩, 汪鋆植, 郭志勇, 薛艳红, 杨进. 载体皂苷RCE-4在制备预防或治疗肿瘤的药物中的用途, 2015, 中国, 专利号: ZL2.0.
2. 张继红, 贺海波, 刘雄, 周继刚, 石孟琼, 罗涛, 段砚方, 李玉倩, 蔡燕, 覃慧林, 珠子参皂苷诱导干细胞分化肝细胞及治疗肝病药物的应用. 2015，中国，申请号: CN5.7.
3. 贺海波, 张永峰, 石孟琼, 汪鋆植, 覃慧林, 刘呈雄, 张继红. 木瓜总三萜及其组分在制药中的应用, 2015, 中国, 申请号：CN 2.4.
4. 贺海波, 覃慧林, 石孟琼, 张永峰, 刘呈雄, 汪鋆植, 张继红, 一种皱皮木瓜提取物，提取方法及其应用, 2015, 申请号：CN 5.8.
5. 贺海波, 邹坤, 石孟琼, 汪鋆植, 覃慧林, 刘光耀, 梅志刚, 程凡, 柳蔚, 文宏桥. 一种含鱼腥草叶的复合保健茶及其应用, 2014, 中国, 申请号: CN8.9.
6. 易国之, 卢训丛, 贺海波, 陈涛. 芦荟种植新技术[M], 湖北: 湖北科学技术出版社, 2011.
7. 贺海波, 宋先仁, 石孟琼, 冯芹, 汪鋆植.《肿瘤科中医特效药膳精粹》，华中科技大学出版社，127千字，2015.
近年来获得的科研奖励：
1. 贺海波(2/13), 益贞颗粒的研制及其在治疗围绝经期综合症中的应用.中华中医药学会, 科学技术奖, 三等奖, 2016.
2. 贺海波(2/7), 益贞颗粒的研制及其在治疗围绝经期综合症中的应用, 湖北省人民政府, 湖北省科技进步奖, 三等奖, 2016.
3. 贺海波(2/15), 益贞颗粒的研制及其在治疗围绝经期综合症中的应用，宜昌市人民政府, 宜昌市科技进步奖, 一等奖, 2014.

近五年科研项目
1. 宜昌市科技局项目，A18-302-a02，青砖茶珍的制备及对肠道菌群失衡的调节作用研究，2019/01-2020/12，3万元，在研，主持；
2. 省部级科研机构发布的开放基金，2016KXN03，基于清除ROS及自噬与凋亡互反馈调控研究珠子参皂苷抗心肌缺血/再灌注损伤的分子机制，2016/07-2018/06，2万元，在研，主持；
3. 省部级科研机构发布的开放基金，2016NP05，鄂西土家族传统发酵豆豉后发酵期间菌相分析、纤溶酶高产菌株分离筛选及其活性评价，2016/07-2018/06，2万元，在研，主持；
4. 宜昌市青钱柳生物科技有限公司合作项目，SDHZ**，青砖茶珍的制备及对肠道菌群失衡的调节作用研究，2016/03-2019/03，10万元，在研，主持；
5. 安琪酵母股份有限公司合作项目，SDHZ**，酵母浸出物(Yeast extract)内毒素检测方法和去除工艺的建立及无血清培养基产品(含质量标准)的研发，2013/04-2016/03，30万元，在研，主持；
6. 宜昌市中医院合作项目，SDHZ**，基于系统生物学理论的胸痹心痛证方证证治规律研究，2012/04-2014/12，10万元，已结题，主持；