张付贤副教授
所在系所:动物医学系
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电子邮件:zhangfuxian99@163.com
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教育背景 2009-2014，中国科学院大学，生物化学与分子生物学，博士2006-2009，吉林大学，预防兽医，硕士2001-2006，河南科技学院，动物科学，学士
工作经历 2020/7- 长江大学 动物科学学院 副教授2018/2-2020/7 武汉动物疫病预防控制中心 兽医师2014/2-2017/12 中国科学院武汉病毒研究所 助理研究员
出访及挂职经历 2018/5-2019/5 挂职 武汉市农业委员会 一级主任科员
研究方向 研究方向为人兽共患病病原微生物致病机理及疫病的防控。主要研究内容为致病病原病原与宿主、环境互作的分子机制、宿主免疫应答及信号通路、宿主嗜性与共感染、跨种感染及传播机制；疫病快速检测技术、新型生物制品与药物的研究。

科研项目 GCRV内衣壳的自组装及与细胞相互作用机制研究，**，国家自然科学基金委青年基金，2015-2017,24万

代表性论文专著 1.Chuntong Bao, Hexiang Jiang, Rining Zhu, Baijun Liu, Jiameng Xiao, Ziheng Li, Peiru Chen, Paul R Langford, Fuxian Zhang*, Liancheng Lei*. Differences in pig respiratory tract and peripheral blood immune responses to Actinobacillus pleuropneumoniae. Vet Microbiol. 2020;247:**.Fuxian Zhang, Hong Guo, Qingxiu Chen, Zheng Ruan, Qin Fang*. Endosomes and Microtubles are Required for Productive Infection in Aquareovirus. Virol Sin. 2020;35(2):200-211.3.Xurong Wang#, Fuxian Zhang#, Rui Su, Xiaowu Li, Wenyuan Chen, Qingxiu Chen, Tao Yang, Jiawei Wang, Hongrong Liu*, Qin Fang*, and Lingpeng Cheng*. Structure of RNA polymerase complexand genome within a dsRNA virus provides insights into the mechanisms of transcription and assembly. Proceedings of the NationalAcademy of Sciences (PNAS), June 25, 2018. **.4.Zhang Fuxian; Zheng Zhenhua; Liu Shu Lin; Lu Wen; Zhang Zhenfeng; Zhang Cuiling; Zhou Peng; Zhang Yuan; Long Gang; He Zhike; Pang Dai Wen; Hu Qinxue; Wang Hanzhong*; Self-biotinylation and site-specific double labeling of baculovirus using quantum dots for single-virus in-situ tracking, Biomaterials, 2013, 34(30): 7506-7518.5.Pan Yangang#; Zhang Fuxian#; Zhang Liuyang; Liu Shuheng; Cai Mingjun; Shan Yuping*; Wang Xianqiao*; Wang Hanzhong*; Wang Hongda*; The Process of Wrapping Virus Revealed by a Force Tracing Technique and Simulations , Advanced Science, 2017, 4(9): 0-**.6.Fuxian Zhang, Hong Guo, Jie Zhang, Qingxiu Chen, Fang Qin*. Identification of the caveolae/raft-mediated endocytosis as the primary entry pathway for aquareovirus, Virology, 2018, 513(2018): 195-207.7.Fuxian Zhang#; Shicui Yan#; Hong Guo; Qingxiu Chen; Qin Fang*. Characterization of viral entry and infection of quantum dot-labeled grass carp reovirus, virologica sinica, 2017, 32(2): 163-166.8.Jie Zhang, Hong Guo, Fuxian Zhang, Qingxiu Chen, Mingxian Chang, Qin Fang*. NS38 is required for aquareovirus replication via interaction with viral core proteins and host eIF3A. Virology. 2019;529:216-25.9.Qingxiu Chen, Hong Guo, Fuxian Zhang, Qin Fang*. N-Terminal Myristoylated VP5 is Required for Penetrating Cell Membrane and Promoting Infectivity in Aquareoviruses. Virologica Sinica. 2018;33:287-90.10.Qingxiu Chen, Jie Zhang, Fuxian Zhang, Hong Guo, Qin Fang*. Identification and characterization of two cleavage fragments from the Aquareovirus nonstructural protein NS80. Virologica Sinica. 2016;31:314-23.11.Pen Zhou, Zhenhua Zheng, Wen Lu, Fuxian Zhang, Zhenfeng Zhang, Daiwen Pang, hanzhong wang*. Multicolor labeling of living-virus particles in live cells. Angewandte Chemie International Edition. 2012;51:670-4.

教学工作 拟讲授兽医微生物学本科课程。

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