姓名：刘珂
学科：生物化学
专业方向：结构生物学
电子邮件：keliu2015@mail.ccnu.edu.cn
主要研究领域：结合分子生物学、生物化学、生物物理学和X-射线衍射等技术，主要从事表观遗传学相关蛋白的结构与功能研究，并基于相关蛋白进行靶向药物设计及筛选。
人才计划及现任职务：湖北省晶体学会理事；湖北省生物物理学会武汉市常务理事。
学习工作经历：
u 2015/07– 至 今， 华中师范大学，生命科学学院，副教授；
u 2012/07–2015/07，华中师范大学，生命科学学院，讲师；
u 2012/06–2014/05，多伦多大学，SGC 研究所，博士后；
u 2010/03–2012/03，多伦多大学，SGC 研究所，博士联合培养；
u 2007/09–2012/06，华中师范大学，生命科学学院，博士；
u 2002/09–2006/06，鲁东大学，生命科学学院，学士；
科研经历：
l 国家自然科学基金面上项目，编号：**，MIS复合物介导酵母孢子形成的分子机制研究，2018/01 - 2021/12，主持；
l 湖北省自然科学基金面上项目，编号：2017CFB513，生物标记物hNGAL多价高灵敏免疫检测抗体的研发，2017/01-2018/12，主持；
l 国家自然科学基金面上项目，编号：**，蓝细菌TonB-ExbB-ExbD依赖的铁吸收机制研究，2016/01 - 2019/12，主要参与；
l 国家自然科学基金面上项目，编号：**，豆野螟嗅觉识别的分子机理研究，2016/01 - 2019/12，主要参与；
l 国家自然科学基金青年项目，编号：**，WDR82介导Setd1A复合物定位于基因转录起始位点进而调控基因转录的分子机理研究，2014/01-2017/12，主持；
l 湖北省自然科学基金面上项目，编号：2013CFB206，2013/01-2014/12，WDR82识别底物的分子机理研究，主持。
代表性论文：
1. Ke Liu (Co-Corresponding author), Min Jinrong, Structural basis for the recognition of non-methylated DNA by the CXXC domain, Journal of Molecular Biology, 2019
2. Ke Liu, Ming Lei, Zhibin Wu, Bing Gan,Harry Cheng, Yanjun Li, Jinrong Min, Structural analyses reveal that MBD3 is a methylated CG binder, FEBS J. 2019, 286(16):3240-3254.
3. Bing Gan, Sizhuo Chen, Huan Liu, Jinrong Min, Ke Liu. Structure and function of eTudor domain containing TDRD proteins, Critical Reviews in Biochemistry and Molecular Biology, 2019, 54(2):119-132.
4. Ming Lei, Wolfram Tempel, Sizhuo Chen, Ke Liu (Co-Corresponding author), Jinrong Min, Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain, Biochimica Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2019, 1862(9):194409.
5. Sizhuo Chen, Weilian Zhang, Jinrong Min, Ke Liu, Lesson from a Fab-enabled co-crystallization study of TDRD2 and PIWIL1, Methods, 2019, S1046-2023(19)30126-4.
6. Ke Liu, Chao Xu, Ming Lei, Ally Yang, Peter Loppnau, Timothy R Hughes, and Jinrong Min. Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA, Journal of Biological Chemistry, 2018, doi: 10.1074/jbc.RA118.001785.
7. Chao Xu, Ke Liu (co-first author), Ming Lei, Ally Yang,Yanjun Li, Timothy R. Hughes, Jinrong Min, DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants, Structure, 2018, 26(1):85-95.
8. Heng Zhang, Ke Liu (co-first author), Natsuko Izumi, Haiming Huang, Deqiang Ding, Zuyao Ni, Sachdev S. Sidhu, Chen Chen, Yukihide Tomari, and Jinrong Min, Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2, Proc Natl Acad Sci U S A (PNAS), 2017, 114(47):12483-12488.
9. Ke Liu, Yumin Ding, Weiyuan Ye, Yanli Liu, Jihong Yang, Jinlin Liu and Chao Qi, Structural and Functional Characterization of the Proteins Responsible for N6-Methyladenosine Modification and Recognition, Current Protein and Peptide Science, 2016, 17, 306-318.
10. Ke Liu, Yanli Liu, Johnathan L. Lau, Jinrong Min. Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation. Pharmacology & Therapeutics, 2015, 151, 121–140.
11. Chao Xu, Xiao Wang, Ke Liu (co-first author), Ian A Roundtree, Wolfram Tempel, Yanjun Li, Zhike Lu, Chuan He, Jinrong Min. Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain. Nature Chemical Biology, 2014, 10(11), 927-929.
12. Yanli Liu, Ke Liu (co-first author), Su Qin, Chao Xu, Jinrong Min. Epigenetic targets and drug discovery Part 1: histone methylation. Pharmacology & Therapeutics, 2014, 143(3), 275-294.
13. Chao Xu, Ke Liu (co-first author), Wolfram Tempel, Marina Demetriades, WeiShen Aik, Christopher J. Schofield, Jinrong Min. Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single stranded m6A RNA demethylation. Journal of Biological Chemistry, 2014, 289(25), 17299-17311.
14. Su Qin, Yanli Liu, Wolfram Tempel, Mohammad S. Eram, Chuanbing Bian, Ke Liu, Guillermo Senisterra, Lissete Crombet, Masoud Vedadi & Jinrong Min*.Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1. Nature Communication, 2014, doi: 10.1038/ ncomms 4952.
15. Ke Liu, Chen Chen, Yahong Guo, Robert Lam, Chuanbing Bian, Chao Xu, Dorothy Y. Zhao, Jing Jin, Farrell MacKenzie, Tony Pawson, Jinrong Min. Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2010, 107, 18398-18403.
16. Ke Liu, Yahong Guo, Haiping Liu, Chuanbing Bian, Robert Lam, Yongsong Liu, Farrell Mackenzie, Luis Alejandro Rojas, Danny Reinberg, Mark T. Bedford, Rui-Ming Xu, Jinrong Min. Crystal Structure of TDRD3 and methyl-arginine binding characterization of TDRD3, SMN and SPF30 [J]. PLoS One, 2012, 7(2), e30375.