学习工作经历 Resume
l 学习经历
l 2002/09–2005/07， 华中科技大学同济医学院， 病理学与病理生理学， 博士
l 1999/09–2002/06， 华中科技大学同济医学院， 病理学与病理生理学， 硕士
l 工作经历
l 2008/06-至今，华中师范大学，生命科学学院，副教授
l 2005/07-2008/06，华中师范大学，生命科学学院，讲师
l 1997/07-1999/07，赤壁市人民医院，内科，住院医
l （英文简历内容）
l EDUCATION
l 2002/09–2005/07, Department of Pathophysiology, Tongji Medical College of Huazhong University of Science and Technology, Ph.D.
l 1999/09–2002/06, Department of Pathophysiology, Tongji Medical College of Huazhong University of Science and Technology, M.D.
l WORK EXPERIENCE
l 2005-present: Work in the Central China Normal University,Wuhan, China
l 1997-1999: Work in the Physician of the People’s hospital of Chibi, Hubei,China


l 承担科研项目情况Research Grants：（从最近的项目写起，中+英）
项目类别（编号）：项目名称，起止时间，主持/参加
l 1. 湖北省自然科学基金面上项目（2016CFB561），HDAC6在tau蛋白降解过程中的作用和机制研究，2016.01- 2017.12，3万元，主持；
l 2. 中央高校基本科研业务费基金项目，(CCNU15A02024):UCHL1对异常聚集tau蛋白经自噬途径降解作用的研究，2015.06-2017.06，8万元，主持；
l 3. 中央高校基本科研业务费基金项目，CCNU09B01009，奖惩刺激对学习与记忆的影响及其机制研究，2010/01-2011/12，20万元，主持；
l 4. 国家自然科学基金青年项目，**，蛋白酶体活性抑制在神经原纤维缠结形成中的作用和机制研究，2008/01－2010/12，16万元，主持；
l 5. 武汉市青年科技晨光计划，2，基于蛋白酶体活性下降的阿尔茨海默病脑片模型的建立，2008/01－2010/12，5万元，主持；
l 6. 湖北省自然科学基金面上项目，2007ABA150，听中枢tau蛋白过度磷酸化对声信号加工的影响及其机制研究，2007/01－2008/12，4万元，主持。
GRANTS FUNDED
l 1. Natural Science Foundation of Hubei Privince(2016CFB561)，Effects of HDAC6 on taudegradation and its underlying mechanisms, 2016.01- 2017.12, PI.
l 2. Fundamental Research Funds for the Central-affiliated Universities (CCNU15A02024): Effects of UCHL1 on aggregated tau degradation by autophagy pathway. 2015.06-2017.06, PI
l 3. Fundamental Research Funds for the Central-affiliated Universities（CCNU09B01009）：Effects of reward and punishment on learning and memory and the underlying mechanisms. 2010.01-2011.12, PI.
l 4. National Natural Science Foundation of China (**): Effects of proteasome inhibition on the formation of neurofibrillary tangle, 2008.01- 2010.12，PI.
l 5. Wuhan Chenguang Project for Youth Scholar (2): The establishment of Alzheimer’s disease slice model based on the down-regulation of proteasome. 2008.01-2010.12, PI.
l 6. Natural Science Foundation of Hubei Privince(2007ABA150): Effect of tau hyperphosphorylation on acoustic signal processing and its underlying mechanisms, 2007.01-2009.12, PI.

代表性论文Selected Publications：
l 1. Yu Quntao^(#), Zhang Hongmao^(#), Li Yuan, Liu Chao, Wang Shaohui^(*), LiaoXiaome^(*), UCH-L1 Inhibition Suppresses tau Aggresome Formation during Proteasomal Impairment. Molecular Neurobiology, 2018, 55:3812–3821.
l 2. Cheng Liang^(#), Wang Shaohui ^(#), Kang Peng, Liao Xiaomei ^(*), Long-Term Impairment of Sound Processing in the Auditory Midbrain by Daily Short-Term Exposure to Moderate Noise. Neural Plasticity, 2017, DOI: 10.1155/2017/**.
l 3. Xie Min^(#), Li Yuan^(#), Wang Shaohui^(#), Yu Quntao, Meng Xin, Liao Xiaomei^(*),The Involvement of NR2B and tau Protein in MG132-Induced CREB Dephosphorylation. Journal of Molecular Neuroscience, 2017, 62:154–162.
l 4. Wang shaohui^(#), Zhang Pengyan^(#), Liu Ruifang, Li Yuan, Liu Chao and Liao Xiaomei ^(*), DEHP Plasticizer Alters Synaptic Proteins Via Peroxidation, Toxicol. Res., 2017,6: 89-97.
l 5. Xie Min^(#), Han Yun^(#), Yu Quntao, Wang Xia, Wang Shaohui, Liao Xiaomei^(*), UCH-L1 inhibition decreases the microtubule-binding function of tau protein, Journal of Alzheimer’s Disease , 2016,49:353 -363.
l 6. Cheng Liang^(#), Wang Shaohui ^(#), Huang Yun, Liao Xiaomei ^(*), The hippocampus may be more susceptible to environmental noise than the auditory, Hearing Research, 2016 , 333: 93-97.
l 7. Tang Jiaqi^(#), Yuan Ye^(#),Wei Chenxi, Liao Xiaomei,Yuan Junlin,Nanberg Eewa, Zhang Yinping, Bornehag Carl-Gustaf^(*), Yang Xu^(*) , Neurobehavioral changes induced by di(2-ethylhexyl) phthalate and the protective effects of vitamin E in Kunming mice，Toxicology Research，2015，4: 1006-1015.
l 8. Xie Min^(#), Shi Ruihong^(#), Pan Ying^(#), Zeng Tao, Chen Qicai, Wang Shaohui, Liao Xiaomei^(*), Proteasome inhibition induced downregulation of Akt/GSK-3β pathway contributes to abnormality of tau in hippocampal slice, Molecular Neurobiology, 2014, 50: 888-895.
l 9. Xie Min^(#), Wang Shaohui^(#), Lu Zhimin, Pan Ying, Chen Qicai, Liao Xiaomei^(*), UCH-L1 inhibition involved in CREB dephosphorylation in hippocampal slices, Journal of Molecular Neuroscience , 2014,53: 59-68.
l 10. Cheng Liang^(#), Wang Shaohui^(#), Jia Nan, Xie Min, Liao Xiaomei^(*), Environmental stimulation influence the cognition of developing mice by inducing changes in oxidative and apoptosis status, Brain & Development , 2014,36: 51-56.
l 11. Wang Shaohui ^(#), Liao XiaoMei, Liu Dan, Hu Juan, Yin Yangyang, Wang Jianzhi^(*), Zhu Lingqiang^(*), NGF promotes long-term memory formation by activating poly (ADP-ribose) polymerase-1, Neuropharmacology, 2012, 63: 1085- 1092.
l 12. Cheng Liang^(#), Wang Shaohui^(#), Chen Qicai, Liao Xiaomei^(*), Moderate noise induced cognition impairment of mice and its underlying mechanisms, Physiology & Behavior, 2011, 104: 981-988.
l 13. 谢敏^(#)，陈其才，廖晓梅^(*)， 泛素C末端水解酶L1对神经元的保护作用， 生物化学与生物物理进展,2010，37：1054-1058.
l 14. Ren Qingguo^(#) , Liao Xiaomei^(#) ,Wang Zefen, Qu Zhongshen, Wang Jianzhi^(*), The involvement of glycogen synthase kinase-3 and protein phosphatase- 2A in lactacystin-induced tau accumulation，FEBS Letters, 2006，580: 2503- 2511.
l 15. Ren Qingguo^(#), Liao Xiaomei^(#), Chen Xiaoqian, Liu GongpPing, Wang Jianzhi^(*)，Effects of tau phosphorylation on proteasome activity, FEBS Letters, 2007, 581: 1521- 1528.