1.导师的个人情况概括
王珍珍，女，1980.01，中共党员，博士，教授，博士导师，海南医学院药物组学信息学教研室主任、科研团队PI、学院年级主任。2003年到哈尔滨医科大学生物信息科学与技术学院工作，2005年攻读硕士学位，2011年获博士学位，2012年进入哈尔滨医科大学基础医学院病原微生物博士后工作站，2016年到纽约西奈山医学院微生物系从事博士后研究工作，2018年人才引进到海南医学院院工作。主要从事非编码RNA（miRNA, lncRNA, circRNA）在复杂疾病中的作用机制的研究；P53肿瘤抑制因子在泛癌中的分子致病机制的研究；利用4SU-seq数据识别病毒转染后基因的转录、合成、降解的动态性变化；基于单细胞测序识别肿瘤微环境中的免疫信号；RNA-seq数据处理及pipeline的搭建。
近年来在《CELL》,《Briefings in Bioinformatics》,《Journal of Experimental & Clinical Cancer Research》,《Scientific Reports》等杂志发表SCI论文21篇，以第一、共一和通讯作者身份，发表SCI论文9篇， SCI单篇最高影响因子30.409，SCI累计影响因子100余点，主持国家自然青年科学基金，黑龙江省自然科学基金、黑龙江省教育厅项目，黑龙江省卫生厅项目等多项课题。参与国自然重大、面上、青年基金及黑龙江省各级、各类项目共7项。作为学业指导教师、毕业设计指导教师、研究生导师共培养27名本科生，3名硕士研究生，其中2名学生获本科优秀毕业论文，多名本科生在本科阶段发表SCI论文。独立主讲《分子生物软件工程 》、《生物医学网络平台分析 》、《生物网络医学资源》等11门生物信息学专业基础及专业课程，教学效果优秀，多次被评为校级“我心目中的好老师”。
2.研究方向
生物信息学，基于深度学习的系统生物学，主要关注单细胞测序的研究内容，及利用利用免疫特征挖掘肿瘤微环境特征。
3.发表的学术论文和专著
1A Rialdi#, J Hultquist, D Jimenez-Morales, Z Peralta, L Campisi, R Fenouil, N Moshkina, Z. Z. Wang, B Laffleur, RM Kaake, M. J. McGregor, K. Haas, E Pefanis, R. A. Albrecht, L.Pache, S.Chanda, J. Jen, J. Ochando, M. Byun, U. Basu, A. Garcia-Sastre, N. Krogan#, H. van Bakel#, I. Marazzi*, 'The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity', Cell 5 (2017), 169(4):679-692 e614.
2L. Cheng#, H. Yang#, H. Zhao#, . Pei, H. Shi, J. Sun, Y. Zhang*, Z. Z. Wang* and M Zhou* 'MetSigDis: a manually curated resource for the metabolic signatures of diseases', Briefings in bioinformatics, 1 (2019), 20(1):203-209.通讯作者
3H. Shi*#, J. Li#, Q. Song#, L. Cheng, H. Sun, W. Fan, J. Li, Z. Z. Wang*, and G. Zhang*, 'Systematic identification and analysis of dysregulated miRNA and transcription factor feed-forward loops in hypertrophic cardiomyopathy', Journal of cellular and molecular medicine, 1 (2019), 23(1):306-316.
4SY. He#, WJ. Xi#, X. Wang, CH. Xu, L. Cheng, SY. Liu, QQ. Meng, B. Li, Y. Wang, HB. Shi*, HJ. Wang* and Z. Z. Wang*, 'Identification of a Combined RNA Prognostic Signature in Adenocarcinoma of the Lung. Medical science monitor', International medical journal of experimental and clinical research, 5 (2019), 25:3941-3956.
5H. Shi*#, G. Zhang#, M. Zhou, L. Cheng, H. Yang, J. Wang, J. Sun*, and Z. Z. Wang*, 'Integration of Multiple Genomic and Phenotype Data to Infer Novel Mirna-Disease Associations', PLoS One, 11 (2016), e0148521.
6Y. Hu, Y. Zhang, J. Ren, Y. Wang*, Z. Z. Wang*, and J. Zhang*, 'Statistical Approaches for the Construction and Interpretation of Human Protein-Protein Interaction Network', Biomed Res Int, 2016 (2016), 5313050.
7H. J. Wang#, M. Zhou#, L. Jia#, J. Sun, H. B. Shi, S. L. Liu*, and Z. Z. Wang*, 'Identification of Aberrant Chromosomal Regions in Human Breast Cancer Using Gene Expression Data and Related Gene Information', Med Sci Monit, 21 (2015), 2557-66.
8L. Cheng#, H. Shi#, Z. Z. Wang #, Y. Hu, H. Yang, C. Zhou, J. Sun*, and M. Zhou*, 'Intnetlncsim: An Integrative Network Analysis Method to Infer Human Lncrna Functional Similarity', Oncotarget, 7 (2016), 47864-74.
9M. Zhou#, H. Zhao#, Z. Z. Wang #, L. Cheng, L. Yang, H. Shi, H. Yang, and J. Sun*, 'Identification and Validation of Potential Prognostic Lncrna Biomarkers for Predicting Survival in Patients with Multiple Myeloma', J Exp Clin Cancer Res, 34 (2015), 102.
10J. Sun#, X. Chen#, Z. Z. Wang#, M. Guo, H. Shi, X. Wang, L. Cheng, and M. Zhou*, 'A Potential Prognostic Long Non-Coding Rna Signature to Predict Metastasis-Free Survival of Breast Cancer Patients', Sci Rep, 5 (2015), 16553.
11H. K. Wang#, Z. Z. Wang# X. Li*, B. S. Gong, L. Feng and Y. Zhou. "A Robust Approach Based on Weibull Distribution for Clustering Gene Expression Data." Algorithms Mol Biol, (2011) ,14.
12Z. Z. Wang#, B. S. Gong#, H. K. Wang,# H. J. Wang, M. Zhou, Q. H. Wang, X. Chen, T. Liu, and X. Li*, 'Microrna Regulation Constrains the Organization of Target Genes on Mammalian Chromosomes', FEBS Lett, 585 (2011), 1897-904.
13M. Zhou#, W. Xu#, X. Yue#, H. Zhao, Z. Z. Wang, H. Shi, L. Cheng, and J. Sun*, 'Relapse-Related Long Non-Coding Rna Signature to Improve Prognosis Prediction of Lung Adenocarcinoma', Oncotarget, 7 (2016), 29720-38.
14M. Zhou#, X. Wang#, H. Shi, L. Cheng, Z. Z. Wang, H. Zhao, L. Yang, and J. Sun*, 'Characterization of Long Non-Coding Rna-Associated Cerna Network to Reveal Potential Prognostic Lncrna Biomarkers in Human Ovarian Cancer', Oncotarget, 7 (2016), 12598-611.
15J. Sun*, L. Cheng#, H. Shi#, Z. Zhang, H. Zhao, Z. Z. Wang, and M. Zhou*, 'A Potential Panel of Six-Long Non-Coding Rna Signature to Improve Survival Prediction of Diffuse Large-B-Cell Lymphoma', Sci Rep, 6 (2016), 27842.
16H. Shi#, G. Zhang#, J. Z. Z. Wang. Wang, X. Liu, L. Cheng, and W. Li*, 'Studying Dynamic Features in Myocardial Infarction Progression by Integrating Mirna-Transcription Factor Co-Regulatory Networks and Time-Series Rna Expression Data from Peripheral Blood Mononuclear Cells', PLoS One, 11 (2016), e0158638.
17L. Cheng*, Y. Jiang, Z. Z. Wang, H. Shi, J. Sun, H. Yang, S. Zhang, Y. Hu*, and M. Zhou*, 'Dissim: An Online System for Exploring Significant Similar Diseases and Exhibiting Potential Therapeutic Drugs', Sci Rep, 6 (2016), 30024.
18M. Zhou, X. Wang, J. Li, D. Hao, Z. Z. Wang, H. Shi, L. Han*, H. Zhou*, and J. Sun*, 'Prioritizing Candidate Disease-Related Long Non-Coding Rnas by Walking on the Heterogeneous Lncrna and Disease Network', Mol Biosyst, 11 (2015), 760-9.
19G. Zhang#, H. Shi, L#. Wang, M. Zhou, Z. Z. Wang, X. Liu, L. Cheng, W. Li*, and X. Li*, 'Microrna and Transcription Factor Mediated Regulatory Network Analysis Reveals Critical Regulators and Regulatory Modules in Myocardial Infarction', PLoS One, 10 (2015), e0135339.
20M. Zhou#, L. Han#, J. Zhang, D. Hao, Y. Cai, Z. Z. Wang, H. Zhou*, and J. Sun*, 'A Computational Frame and Resource for Understanding the Lncrna-Environmental Factor Associations and Prediction of Environmental Factors Implicated in Diseases', Mol Biosyst, 10 (2014), 3264-71.
21J. Sun#, H. Shi#, Z. Z. Wang, C. Zhang, L. Liu, L. Wang, W. He, D*. Hao, S. Liu*, and M. Zhou*, 'Inferring Novel Lncrna-Disease Associations Based on a Random Walk Model of a Lncrna Functional Similarity Network', Mol Biosyst, 10 (2014), 2074-81.
22J. Sun#, M. Zhou#, Z. T. Mao, D. P. Hao, Z. Z. Wang, and C. X. Li*, 'Systematic Analysis of Genomic Organization and Structure of Long Non-Coding Rnas in the Human Genome', FEBS Lett, 587 (2013), 976-82.
23J. Sun#, B. Gao#, M. Zhou*#, Z. Z. Wang, F. Zhang, J. E. Deng, and X. Li*, 'Comparative Genomic Analysis Reveals Evolutionary Characteristics and Patterns of Microrna Clusters in Vertebrates', Gene, 512 (2013), 383-91
4.获得的学术成果奖励（标注名次）
无
5.获得的发明专利（标注名次）
无
6.主持过的科研项目（项目名称；项目编号；级别；经费；起止日期）
主持的课题：
1)海南省自然科学基金青年基金项目：融合多组学数据识别肿瘤免疫亚型及其T细胞障碍机制，5万，2021.04-2023.12
2)海南医学院引进人才科研启动金项目（XRC202107）：基于深度学习的肿瘤微环境景观检测，25万，2021.01-2025.12
3)国家自然科学基金委（青年科学基金）：基于遗传变异驱动的个性化分子网络识别复杂疾病亚型（31701159），22万，2018.01-2020.12
4)黑龙江省科技厅（黑龙江省自然青年基金）：应用新一代测序数据识别癌基因组的染色体变异谱(QC2013C019)，5万，2013.01-2020.15
5)黑龙江省教育厅（科技面上)：应用表达谱及基因整合信息挖掘肝癌染色体变异区域的研究 (12521307)，1万，2011.01-2013.12
6)黑龙江省卫生厅（计划项目)：应用基因的融合信息识别乳腺癌中变异的染色体区域 (2011-252) 2011.01-2013.12
8.学术兼职
黑龙江省科学技术协会会员，黑龙江省生物信息学学会会员。