张小坡教授简介
1、个人情况概括
男，博士，教授，硕士生导师，海南省“南海名家”青年项目获得者，海南省拔尖人才，海南省“515”二层次人才。2010年毕业于沈阳药科大学，获药学博士学位。主持国家自然科学基金3项、中国博士后面上项目1项、海南省自然科学基金1项。以第一或通讯作者在Acta Pharmaceutica Sinica B, Scientific Reports,?Journal of Natural Products,?Records of Natural Products,?PlosOne,?Journal of Nutritional Biochemistry,?Fitotoerapia, Phytochemistry Letters,?Chem Pharm Bull,?Nat Prod Res等SCI源刊收录的期刊上发表论文36篇。主编专著2部，授权专利3项。
2、研究方向
药物化学
3、以第一作者或通讯作者身份发表的SCI收录论文
（1）2020年发表的论文
[1]Sun WY, Zhang Y, Li YY, Chen LZ, Zhang L, Zhang CY*, Zhang XP*. Two new labdane diterpenoids from Scoparia dulcis to attenuate palmitate-induced viability in MIN6 cells [J]. Phytochem. Lett., 2020, 38: 25-27.
[2]Zhang CY#, Chen LZ#, Li YY, Wei N, Zhang L, Dong L, Zhang Y*, Zhang XP*. Scoparic acid E: A new labdane diterpenoid on attenuating palmitate-induced viability in MIN6 cells from Scoparia dulcis [J]. Rec. Nat. Prod., 2020, 14(5): 383-386.
[3]Xiaowan Lin, Xinxin Zhou, Wanying Sun, Lu Zhang, Caiyun Zhang, Xiaopo Zhang*. Anti-diabetic effect of the polyphenol-rich extract from Tadehagi triquetrum in ob/ob diabetic mice. Tropical Journal of Pharmaceutical Research, 2020, 19(4): 829-835.
[4]Miao JN, Shi W, Zhang JQ, Zhang XP*, Zhang H*, Wang ZY, Qiu JQ*. Response surface methodology for the fermentation of polysaccharides from Auricularia auricula using trichoderma viride and their antioxidant activities. International Journal of Biological Macromolecules, 2020, DOI: 10.1016/j.ijbiomac.2020.03.183.
（2）2019年发表的论文
[5]Wanying Sun, Yan Jin, Lu Zhang, Yan Jin, Caiyun Zhang, Lin Dong*, Xiaopo Zhang*. Two new aminoethylstilbene isoquinoline alkaloids with glucose consumption increasing activity from the root barks of Litsea glutinosa. Phytochemistry Letters, 2019, 34: 96-98.
[6]Yu Tian, Xiaoxue Cao, Hai Shang, Chongming Wu, Xi Zhang, Peng Guo,*Xiaopo Zhang*,Xudong Xu*.Synthesis and in vitro evaluation of caffeoylquinic acid derivatives as potential hypolipidemic agents. Molecules, 2019, 24, 964.
[7]Guihong Qi#, Yue Zhou#, Xiaopo Zhang#, Jiaqi Yu, Xin Li, Xiaoxue Cao, Chongming Wu*, Peng Guo*. Cordycepin promotes browning of white adipose tissue through an AMP-activated protein kinase (AMPK)-dependent pathway. Acta Pharm Sin B,?2019, 9(1):135-143.
[8]Yubin Ji, Chenxu Wang, Yuchen Zhang, Caiyun Zhang, Di Cui*, Xiaopo Zhang*. Glutinosine A: A new morphinandienone alkaloid from Litsea glutinosa. Records of Natural Products, 2019, 13(4): 363-366.
[9]Yan Jin, Younan Wu, Yiying Li, Caiyun Zhang, Wanying Sun, Lin Dong*, Xiaopo Zhang*. Litsine A: a new aporphine alkaloid from the root barks of Litsea glutinosa. Records of Natural Products, 2019, 13(2): 167-171.
[10]Shuai Wang#, Xiaopo Zhang#, Xin Li, Qibing Liu, YueZhou, Peng Guo*, Zhengqi Dong*, Chongming Wu*. Phenylpropanoid glucosides from Tadehagi triquetrum inhibit oxLDL-evoked foam cell formation through modulating cholesterol homeostasis in RAW264.7 macrophages [J]. Natural Product Research, 2019, 33(6): 893-896.
（3）2018年发表的论文
[11]Xiaopo Zhang, Yan Jin, Younan Wu, Caiyun Zhang, Dejun Jin, Qingxia Zheng*, Youbin Li*. Anti-hyperglycemic and anti-hyperlipidemia effects of the alkaloid-rich extract from barks of Litsea glutinosa in ob/ob mice. Sci Rep. 2018, 8(1):12646.
[12]Lei Yu, Bo Jiang, Zhifeng Chen, Xin Wang, Dongxue Shang, Xiaopo Zhang*, Yongxue Sun, Jinghui Yang, Yubin Ji. Cytisine induces endoplasmic reticulum stress caused by calcium overload in HepG2 cells[J].Oncol Rep.?2018, 39(3):1475-1484.
（4）2017年发表的论文
[13]Shuai Wang, Chongming Wu, Xin Li, Yue Zhou, Jianhe Wei, Xiaopo Zhang*, Peng Guo*. Syringaresinol-4-O-β-D-glucoside alters lipid and glucose metabolism in HepG2 cells and C2C12 myotubes[J].Acta Pharm Sin B,?2017, 7(4):453-460.
[14]Yixin Qian, Jichuan Kang*, Yikai Luo, Jun He, Lu Wang, Xiaopo Zhang*. Secondary metabolites of an endophytic fungus pestalotiopsis uvicola[J]. Chemistry of Natural Compounds,2017, 53(4): 756-757.
[15]Younan Wu, Yan Jin, Lin Dong, Yiying Li, Caiyun Zhang, Mei Gui*, Xiaopo Zhang*. New lignan glycosides from the root barks of Litsea glutinosa[J]. Phytochemistry Letters, 2017, 20: 259-262.
[16]Lin Na, Bo Yi, Juan Li, Wanke Zhang*, Xiaopo Zhang*. A new sugar ester from the roots of Acanthus ilicifolius[J]. Records of Natural Products, 2017,?11(1):74-76.
[17]Xiaopo Zhang, Mei Gui, Caiyun Zhang, Changyu Chen, Lei Yu*, Jie Liu*. Leucasinoside: A new abietane diterpenoid glycoside from Leucas zeylanica[J]. Records of Natural Products, 2017,?11(1):74-76.
（5）2016年发表的论文
[18]Yinfeng Tan, Ni An, Yonghui Li, Shouqian Chen, Junqing Zhang, Xiaopo Zhang*, Youbin Li*. Two new isoflavonoid glucosides from the roots of Achyranthes bidentata and their activities against nitric oxide production[J]. Phytochemistry Letters, 2016, 17:187-189.
[19]Xiaopo Zhang, Changyu Chen, Yonghui Li, Deli Chen, Lin Dong, Na Wei, Chongming Wu, Junqing Zhang, Youbin Li. Tadehaginosides A-J, phenylpropanoid glucosides from Tadehagi triquetrum, enhance glucose uptake via the upregulation of PPARγ and GLUT-4 in C2C12 myotubes[J]. Journal of Natural Products, 2016, 79(5): 1249-1258.
4、科研奖励
1、张小坡，许旭东，郭鹏，吴崇明，靳德军.几种海南特色热带药用植物化学和生物活性成分研究，海南省自然科学奖三等奖， 2018年（第一完成人）；
2、张俊清,黄艳,钟霞,刘侠,张小坡.融合南药黎药特色的药学人才培养模式探索与实践.2017年度海南省教学成果奖一等奖，2017年11月（第五完成人）。
5、授权的发明专利：
1、张小坡，张彩云，桂梅，金燕.一个苯丙素苷类化合物、其提取方法及其应用（ZL201510323207.7），授权日：2017年5月17日.
2、张小坡，桂梅，张彩云，金燕.一种木脂素类化合物的应用，授权号：ZL201510376630.3，授权日：2020年6月2日.
3、张小坡，李友宾，张彩云，吴悠楠，金燕. 一种治疗胰岛素抵抗的药物、制备方法及应用，授权号：ZL201710126857.1，授权日：2020年6月5日.
6、主持的科研项目
[1]国家自然自科学基金，潺槁木阿朴菲生物碱类PTP1B抑制剂的发现及其改善胰岛素抵抗作用机制研究（81760628），2018.01-2021.12
[2]国家自然自科学基金，黎药-葫芦茶中新颖苯丙素苷类Nrf2激活剂的发现及其糖尿病肾病保护机制研究（81560696），2016.01-2019.12
[3]国家自然自科学基金，基于AMPK激活作用的黎药-野菠萝双四氢呋喃型木脂素降脂活性成分及其构效关系研究（81202994），2013.01--2015.12
[4]中国博士后面上项目，黎药野菠萝降血脂活性分子群及其效应关系的研究（2012M510361），2012.05-2013.12。
[5]海南省科技厅，黎药来源-新木姜子碱靶向调控PTP1B改善IR的分子机制研究（2019RC208），2020.01-2022.12。
[6]海南省教育科学“十三五”规划重点课题，构建基于RBL的海洋药学专业人才培养新模式（QJZ20181010），2018.10-2022.05。
7、主编的专著：
1、魏娜，张小坡，戴水平，张俊清.高良姜现代研究.科学出版社.2015.12 ISBN 978-7-03-048193-1.
2、李可意，葛喜珍，张小坡.制药工程技术及进展研究，吉林大学出版社，2015.04 ISBN 978-7-5677-3449-4.