姓 名
周鹤峰

性 别
男

通讯地址
广东省珠海市金湾区遵医珠海校区

邮 编
519041

邮 箱
hfztim@163.com

职 称
教授，硕士研究生导师

职 务
生物工程教研室副主任

简 介
山东莱阳人，中共党员，教授，硕士生导师，博士。中国药理学会会员、中国生物工程学会会员、中国细胞生物学会会员，入选河北省科技奖励专家库专家。主要从事医药生物技术研究和中药天然化合物神经保护机制的研究。承担本科生《基因工程》、《生物技术制药综合实验》和研究生《基因工程》等课程教学。国际SCI期刊Toxicology、Frontiers in Pharmacology等杂志特邀审稿人。现主持省部级科研项目 2 项，校级科研项目 1 项，参与国家级科研项目 2 项，主持完成省级课题 2 项，主持完成校级教改项目 1 项，发表教改论文 2 篇。。发表在Neurotherapeutics、Aging and disease、Oxid Med Cell Longev等SCI文章16篇，北图核心论文30篇。

教育背景
1、2013.9-2018.4澳门大学中华医药研究院生物医药专业 哲学博士学位
2、2001.9-2004.7遵义医学院生物化学与分子生物学专业 理学 硕士学位
3、2002.4-2006.3烟台师范学院生物教育专业 理学 学士学位

学术组织任职
1、中国药理学会会员；
2、中国生物工程学会会员；
3、中国细胞生物学会会员；
4、河北省科技奖励专家库专家；
5、国际SCI期刊Toxicology、Frontiers in Pharmacology等杂志特邀审稿人
SCI期刊Toxicology、Frontiers in Pharmacology等杂志特邀审稿人。

主讲课程
1、本科生《基因工程》、《生物技术制药综合实验》
2、研究生《基因工程》》

科研项目
1、杜仲苷逆转卵巢癌细胞紫杉醇耐药的作用及机制研究，贵州省自然科学基金，主持；
2、基于双靶点的杜仲苷逆转卵巢癌耐药的作用和机制研究，贵州省中医药管理局基金，主持；
3、益智素上调PSMB8表达的转录调控机制，遵义医科大学2018年度学术新苗培养及创新探索专项项目，主持；

发表论文
1、Zhou HF, Li SN, Li CW, Yang XJ, Li HT, Zhong HB, Lu JH*, Lee SM*. Oxyphylla A Promotes Degradation of α-Synuclein for Neuroprotection via Activation of Immunoproteasome.Aging and disease.2020,11(3): 559–574.
2、Zhou HF, Shao M, Yang XJ, Li CW, Cui GZ, Gao C, Di LJ, Zhong HB, Wang YQ, Zhang ZJ*, Lee SM*. Tetramethylpyrazine Analogue T-006 Exerts Neuroprotective Effects against 6-Hydroxydopamine-Induced Parkinson's Disease In Vitro and In Vivo.Oxid Med Cell Longev. 2019 Nov 14;2019:**. doi: 10.1155/2019/**.
3、Zhou HF, Shao M, Guo BJ, Li CW, Lu YC, Yang XJ, Li SN, Li HT, Zhu Q, Zhong HB, Wang YQ, Zhang ZJ, Lu JH*, Lee SM*. Tetramethylpyrazine Analogue T-006 Promotes the Clearance of Alpha-synuclein by Enhancing Proteasome Activity in Parkinson's Disease Models. Neurotherapeutics. 2019,16(4):1225-1236.
4、Zhang Y, Deng HK, Zhou HF, Lu YC, Shan LC, Lee SM, Cui GZ*, A novel agent attenuates cardiotoxicity and improves antitumor activity of doxorubicin in breast cancer cells. J Cell Biochem. 2019, 120(4):5913-5922.
5、Cai CZ,Zhou HF, Yuan NN, Wu MY, Lee SM, Ren JY, Su HX, Lu JJ, Chen XP, Li M, Tan JQ*, Lu JH*. Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation.Phytomedicine. 2019 Jan 30;61:152842.
6、Li CW, Chen TK,Zhou HF, Feng Y, Hoi MPM, Ma D, Zhao C, Zheng Y, Lee SM*, BHDPC Is a Novel Neuroprotectant That Provides Anti-neuroinflammatory and Neuroprotective Effects by Inactivating NF-κB and Activating PKA/CREB.Front Pharmacol. 2018 Jun 25;9:614.
7、Li CW, Chen TK,Zhou HF, Zhang C, Feng Y, Tang F, Hoi MP, He CW, Zheng Y, Lee SM*, Schisantherin A Attenuates Neuroinflammation in Activated Microglia: Role of Nrf2 Activation Through ERK Phosphorylation.Cell Physiol Biochem. 2018;47(5):1769-1784.
8、Li CW^#, Zhang C^#, Zhou HF, Feng Y, Tang F, Hoi MPM, He CW, Ma D, Zhao C, Lee SM*, Inhibitory Effects of Betulinic Acid on LPS-Induced Neuroinflammation Involve M2 Microglial Polarization via CaMKKβ-Dependent AMPK Activation.Front Mol Neurosci. 2018,11:98.
9、Tang F^#, Zhou XH^#, Wang L, Shan L, Li CW,Zhou HF, Lee SM*, Hoi MP*, A novel compound DT-010 protects against doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by inhibiting reactive oxygen species-mediated apoptotic and autophagic pathway,Eur J Pharmacol, 2018, 820: 86-96.
10、Chan JY^#,Zhou HF^#, Kwan YW, Chan SW, Radis-Baptista G*, Lee SM*, Evaluation in zebrafish model of the toxicity of rhodamine B-conjugated crotamine, a peptide potentially useful for diagnostics and therapeutics.J Biochem Mol Toxicol. 2017, 31(11). doi: 10.1002/jbt.21964.
11、Xin QQ, Yang BR,Zhou HF, Wang Y, Yi BW, Cong WH, Lee SM*, Chen KJ*, Paeoniflorin promotes angiogenesis in a vascular insufficiency model of zebrafish in vivo and in human umbilical vein endothelial cells in vitro, Chin J Integr Med, 2016, 22(6): 153-171.
12、Cui GZ, Shan L, Chen Y,Zhou HF, Wang Y, Lee SM*, A New Danshensu Derivative Protects Against 6-Hydroxydopamine-Induced Neurotoxicity In Vitro and In Vivo,Am J Chin Med, 2016, 44 (7):1349-1361.
13、Huang C, Morlighem JR,Zhou HF, Lima éP, Gomes PB, Cai J, Lou I, Pérez CD, Lee SM, Rádis-Baptista G. The Transcriptome of the Zoanthid Protopalythoa variabilis (Cnidaria, Anthozoa) Predicts a Basal Repertoire of Toxin-like and Venom-Auxiliary Polypeptides. Genome Biol Evol. 2016, 8(9): 3045-3064.
14、Chong CM, Kou MT, Pan P,Zhou HF, Ai NN, Li CW, Zhong HJ, Leung CH, Hou TJ, Lee SM. Discovery of a novel ROCK2 inhibitor with anti-migration effects via docking and high-content drug screening.Mol Biosyst. 2016, 12(9):2713-2721.
15、Shen M, Tian S, Pan P, Sun H, Li D, Li Y,Zhou HF, Li CW, Lee SM, Hou TJ. Discovery of Novel ROCK1 Inhibitors via Integrated Virtual Screening Strategy and Bioassays.Sci Rep. 2015 Nov 16;5:16749. doi: 10.1038/srep16749.
16、Liu MH#, Yang BR#, Cheung WF , Yang KY, Zhou HF, Kwok JS, Liu GC, Li XF, Zhong S, Lee SM,, Tsui SK*. Transcriptome analysis of leaves, roots and flowers of Panax notoginseng identifies genes involved in ginsenoside and alkaloid biosynthesis.BMC Genomics. 2015, 3;16:265. doi: 10.1186/s12864-015-1477-5.
17、邵敏, 王新颖, 刘星, 王燕,周鹤峰*, 葛正龙, hISO基因原核表达载体的构建及其在大肠杆菌中的表达及鉴定, 吉林大学学报(医学版), 2016, (01): 59-63.
18、邵敏,王新颖,卢毓璁,王敏,冯昆,魏妮娜,杜凤霞,周鹤峰*. 抗人蔗糖酶卵黄抗体的制备及其稳定性和体外活性研究, 中国免疫学杂志,2016,32(12):1785-1789.
19、邵敏,王新颖,张青峰,牛宪立,王燕,周鹤峰*, 葛正龙,人蔗糖酶蛋白在大肠杆菌的诱导表达与纯化,细胞与分子免疫学杂志,2015,12:1629-1632.

教材、专著编写
无

奖 励
无