一般情况
姓名：沈建良，性别： 男
学科专业：药理学和临床药学
学历及学位： 博士研究生
职称：研究员
职务：中国科学院大学温州研究院课题组长
Email: shenjl@wibe.ac.cn或shenjl@wiucas.ac.cn

学习经历
2012年6月－2014年6月：博士研究生、康奈尔医学院休斯顿卫理公会研究所，沈海法教授
2010年9月－2014年6月：博士研究生，无机化学，中山大学，毛宗万教授
2007年9月－2010年6月：硕士研究生，无机化学，湘潭大学，谭黎峰教授
2003年9月－2007年6月：本科，应用化学，湖南科技大学， 周智华教授

工作经历
2017年10月－至今：研究员、中国科学院大学温州研究院
2017年10月－至今：研究员、温州医科大学眼视光学院及眼视光学和视觉科学国家重点实验室
2014年6月－2017 年6月：博士后、康奈尔医学院休斯顿卫理公会研究所，沈海法教授
2012年6月－2014 年6月：助理研究员、康奈尔医学院休斯顿卫理公会研究所，沈海法教授

社会主要兼职
担任Coordination Chemistry Reviews, Theranostics, Nanoscale, Angewandte International Edition Chemie和 ACS Nano 等40余个SCI杂志的独立审稿人，同时担任American Journal of Nanotechnology &Nanomedicine荣誉主编,Chinese Chemical Letters (中国化学快报）青年编委会委员，Advanced Applied Materials 主编，FrontiersinChemistry 客座编辑，Biosensors客座编辑。

研究方向
1)智能化纳米材料递送基因药物；
2)肿瘤微环境响应的多级靶向递送体系；
3)功能化水凝胶的生物医药应用
4)纳米免疫治疗；
研究主要集中于纳米材料、纳米技术等在生物医学领域中的探究。通过合理的设计和优化具有智能多功能化的纳米/微米材料解决药物递送的瓶颈。主要应用于癌症的成像和治疗、眼科以及其他疾病的诊疗一体化应用。利用纳米材料技术和多学科的交叉优势解决癌症和其他疾病医疗诊断等领域所面临的挑战和瓶颈。已申报授权专利20项，其中美国专利授权1 项。在国际权威学术期刊已发表 70 多篇相关学术论文，5篇 ESI 1%论文。研究工作以第一/通讯作者发表在ACS Nano, Nano Letters, Materials Today, Chemical Society Reviews和IScience等专业领域主流期刊上，被引达1800余次。并受邀国内会议邀请报告和口头报考20余次。目前主持国家自然科学基金面上和青年项目、浙江省自然科学基金重点项目、温州研究院重点专项和温州市创新自然基金等10个科研项目。

主要科研工作简介
一、主要科研项目：(近5年)
1.温州医科大学重大项目培育工程、KYWY201901、微环境响应的siRNA载体制备和应用、202001-202312、50万、在研、本人作用(主持)。
2.中国科学院大学温州研究院新型冠状病毒感染肺炎应急科研公关项目、WIUCASYJ200001-2、202003-202101、30万、在研、本人作用(主持)。
3.国家自然科学基金面上项目、**、肿瘤微环境逐级靶向的小干扰RNA载体制备及康三阴性乳腺癌活性的研究、202001-202312、66万、在研、本人作用(主持)。
4.温州市基础项目、Y**、多级靶向近红外纳米探针用于介导管胰腺癌早期诊断的研究、202001-202106、3万、在研、本人作用(主持)。
5.国家自然科学基金青年项目、**、多核铂类配合物与siRNA自组装纳米粒的制备及活性研究、201901-202112、27万、在研、本人作用(主持)。
6.浙江省自然基金重点项目、LZ19H180001、多级靶向响应肿瘤微环境的小干扰RNA载体构建及抗三阴性乳腺癌活性研究、201901-202212、35万、在研、本人作用(主持)。
7.温州市基础项目、Y**、多级靶向小干扰RNA载体构建及抗三阴性乳腺癌活性研究、201901-202012、3万、在研、本人作用(主持)。
8.温州市产学研项目、顺铂衍生物与siRNA自组装纳米颗粒的制备与抗癌活性研究、201806-202005、2万、在研、本人作用(主持)。
9.温州医科大学启动项目、QTJ18119、肿瘤微环境响应的功能化材料设计与应用、201805-202305、150万、在研、本人作用(主持)。
10.温州生物材料与工程研究所重大专项、WIBEZD**-03、肿瘤微环境多级响应的功能化材料设计与应用、201709-202208、150万、在研、本人作用(主持)。
11.国家自然科学基金重点项目、**、环糊精功能化无机纳米材料的构建及其介导的肿瘤多靶点治疗研究、201301-201712、320万、结题、本人作用(参与)。
12.国家自然科学基金面上项目、**、多齿NHC卡宾高价过度金属配合物的合成及其催化性质研究、201301-2016.12、80万、结题、本人作用(参与)。
13.The National Institute of Health (RO1), 1R01CA193880-01A1, Tumor Vasculature-targeted Nanotherapeutics for DNA Damage Response, 201512-202011, $**，结题、本人作用(参与)。
14.Department of Defense, U54CA151668, Multistage vector-enabled breast oncology, 2012.9-2017.9, $**，结题、本人作用(参与)。
15.Nationals Cancer Institute (U54), U54CA143837, Texas Center for Cancer Nanomedicine,2010.9-2015.8, $**，结题、本人作用(参与)。
二、主要教改课题(近5年)
无
三、获得的主要科研奖项：(近5年)
无
四、获得的主要教学奖项：(近5年)
无

五、个人荣誉：(近5年)
1.2019年湖湘青年英才
2.2019年温州市青年拔尖人才
3.2020年浙江省青年优秀人才
4.2020年浙江省钱江人才

六、研究生培养
招收生物医学工程、眼视光学硕士研究生6名，其中博士和硕士研究生各一名国际留学生。以及7名联合培养博士研究生，中山大学2名，温州医科大学3名，湘雅医学院1名和南京理工大学1名，联合培养硕士研究生20名。

七、近期代表性论文及成果
近年发表代表性论文：(近5年)
(74) Su, T., Zhang, M., Pan, W., Qian, Y., Zhou, Z., He, X., Shen, L., Dong, W., Qi, X.^*, Shen, J.^*,Mussel-inspired Agarose Hydrogel Scaffolds for Skin Tissue Engineering. BioactiveMaterials 2020, Accpted.
(73) He,X., Zheng, Z., Zhang, F., Xu, C., Xu, W., Ye, L., Sun, X., Zhou, Z.^*, Shen, J.^*,Mitochondria-Targeted Chemosensor for Discriminately and Continuously Visualize HClO and H2S with Multi-Response Fluorescence Signals to Bioimaging in Vitro and in Vivo.ACS Applied Bio Materials 2020,https://doi.org/10.1021/acsabm.0c01029.
(72) He, X., Xu, W., Ding, F., Li, Y., Chen, H.^*, Shen, J.^*,A Reaction-Based Ratiometric and Colorimetric Chemosensor for Bioimaging of Biosulfite in Live Cells, Zebrafish and Food Samples. Journal of Agricultural and Food Chemistry.2020, https://doi.org/10.1021/acs.jafc.0c03983.
(71) Liu, S.; Li, R.; Qian, J.; Sun, J.; Li, G.; Shen, J.; Xie, Y. Combination Therapy of Doxorubicin and Quercetin on Multidrug-Resistant Breast Cancer and Their Sequential Delivery by Reduction-Sensitive Hyaluronic Acid-Based Conjugate/d-α-Tocopheryl Poly(ethylene glycol) 1000 Succinate Mixed Micelles. Molecular Pharmaceutics 2020, 17, 1415-1427.
(70) Zhang, L., Mu, C., Zhang, T., Wang, Y., Wang, Y., Fan, L., Liu, C., Chen, H., Shen, J.^*, Wei, K., Li, H. Systemic Delivery of Aptamer-Conjugated XBP1 siRNA Nanoparticles for Efficient Suppression of HER2+ Breast Cancer.ACS Applied Materials & Interfaces. 2020;12(29), 32360–32371.
(69) Qi, X., Zeng, Q., Tong, X., Su, T., Xie, L., Yuan, K., Xu, J., Shen, J.^*Polydopamine/montmorillonite-embedded pullulan hydrogels as efficient adsorbents for removing crystal violet.Journal of Hazardous Materials. 2020;402, 123359.
(68) Chen H., Ding F., Zhou Z., He X., Shen, J.^*FRET-based sensor for visualizing pH variation with colorimetric/ratiometric strategy and application for bioimaging in living cells, bacteria and zebrafish.Analyst. 2020;145(12):4283-4294.
(67) He, X., Deng Z., Xu W., Li Y., Xu C., Chen H., Shen, J.^*A novel dual-response chemosensor for bioimaging of Exogenous/Endogenous hypochlorite and hydrazine in living cells, Pseudomonas aeruginosa and zebrafish. Sensors and Actuators B: Chemical, 2020. 321: p. 128450.
(66) Tong, X., X. Qi, R. Mao, W. Pan, M. Zhang, X. Wu, G. Chen, Shen, J.^*H. Deng, and R. Hu, Construction of functional curdlan hydrogels with bio-inspired polydopamine for synergistic periodontal antibacterial therapeutics. Carbohydrate Polymers, 2020. 245: p. 116585.
(65) He, X., Xu W., Xu C., Ding F., Chen H., and Shen, J.^*Reversible spiropyran-based chemosensor with pH-switches and application for bioimaging in living cells, Pseudomonas aeruginosa and zebrafish. Dyes and Pigments, 2020. 180: p. 108497.
(64) He, X., Ding F., Xu W., Xu C., Li Y., Qian Y., Zhao S., Chen H., and Shen, J.^*FRET-based colorimetric and ratiometric sensor for visualizing pH change and application for bioimaging in living cells, bacteria and zebrafish. Analytica Chimica Acta, 2020. 1127: p. 29-38.
(63) Shen, L., Y. Li, Q. Lu, X. Qi, X. Wu, Shen, J.^*Facile preparation of one-dimensional nanostructures through polymerization-induced self-assembly mediated by host–guest interaction. Polymer Chemistry, 2020. 11(26): p. 4208-4212.
(62) Zhao S, Yu X, Qian Y, Chen W, Shen, J.^*Multifunctional magnetic iron oxide nanoparticles: an advanced platform for cancer theranostics. Theranostics. 2020 May 15;10(14):6278-6309.
(61) Li Z, Xiong W, He X, Qi X, Ding F, Shen, J.^*A novel strategy for rhodamine B-based fluorescent probes with a selective glutathione response for bioimaging in living cells.Analyst. 2020;145(12):4239-4244.
(60) Chen, H.; He, X.; Yu, Y.; Qian, Y.; Shen, J.;^*Zhao, S.^* Execution of aggregation-induced emission as nano-sensors for hypochlorite detection and application for bioimaging in living cells and zebrafish. Talanta2020, 214, 120842.
(59) Chen, H.; Qian, Y.; Jia, H.; Yu, Y.; Zhang, H.; Zhao, S.; Shen, J.^*Synthesis and pharmacological evaluation of naftopidil-based arylpiperazine derivatives containing the bromophenol moiety. Pharmacological Reports2020.
(58) Chen, H.; Yang, P.; Li, Y.; Zhang, L.; Ding, F.; He, X.; Shen, J.^*Insight into triphenylamine and coumarin serving as copper (II) sensors with “OFF” strategy and for bio-imaging in living cells. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2020, 224, 117384.
(47) He, X.; Chen, H.; Xu, C.; Fan, J.; Xu, W.; Li, Y.; Deng, H.; Shen, J.^*Ratiometric and colorimetric fluorescent probe for hypochlorite monitor and application for bioimaging in living cells, bacteria and zebrafish. Journal of Hazardous Materials2020, 388, 122029.
(56) He, X.; Xie, Q.; Fan, J.; Xu, C.; Xu, W.; Li, Y.; Ding, F.; Deng, H.; Chen, H.; Shen, J.^* Dual-functional chemosensor with colorimetric/ratiometric response to Cu(II)/Zn(II) ions and its applications in bioimaging and molecular logic gates. Dyes and Pigments2020, 177, 108255.
(55) He, X.; Xiong, W.; LileiZhang; Xu, C.; Fan, J.; Qian, Y.; Wen, J.; Ding, F.; Shen, J.^* ESIPT-based ratiometric fluorescent probe for highly selective and sensitive sensing and bioimaging of group IIIA ions in living cancer cells and zebrafish. Dyes and Pigments2020, 174, 108059.
(54) He, X.; Xu, C.; Xiong, W.; Qian, Y.; Fan, J.; Ding, F.; Deng, H.; Chen, H.; Shen, J.^* The ICT-based fluorescence and colorimetric dual sensing of endogenous hypochlorite in living cells, bacteria, and zebrafish. Analyst2020, 145, 29-33.
(53) Qi, X.; Su, T.; Zhang, M.; Tong, X.; Pan, W.; Zeng, Q.; Shen, J.^*Sustainable, flexible and biocompatible hydrogels derived from microbial polysaccharides with tailorable structures for tissue engineering. Carbohydrate Polymers2020, 237, 116160.
(52) Qi, X.; Su, T.; Zhang, M.; Tong, X.; Pan, W.; Zeng, Q.; Zhou, Z.; Shen, L.; He, X.; Shen, J.^*Macroporous Hydrogel Scaffolds with Tunable Physicochemical Properties for Tissue Engineering Constructed Using Renewable Polysaccharides. ACS Applied Materials & Interfaces2020. (Back Cover)
(51) Qi, X.; Zhang, M.; Su, T.; Pan, W.; Tong, X.; Zeng, Q.; Xiong, W.; Jiang, N.; Qian, Y.; Li, Z.; He, X.; Shen, L.; Zhou, Z.; Shen, J.^*Biocompatible Hydrogels Based on Food Gums with Tunable Physicochemical Properties as Scaffolds for Cell Culture. Journal of Agricultural and Food Chemistry2020.(Back Cover)
(50) Sang, Z.; Qian, J.; Han, J.; Deng, X.; Shen, J.; Li, G.; Xie, Y. Comparison of three water-soluble polyphosphate tripolyphosphate, phytic acid, and sodium hexametaphosphate as crosslinking agents in chitosan nanoparticle formulation. Carbohydrate Polymers2020, 230, 115577.
(49) Shen, L.; Li, Y.; Lu, Q.; Qi, X.; Wu, X.; Zhou, Z.; Shen, J.^*Directed arrangement of siRNA via polymerization-induced electrostatic self-assembly. Chemical Communications2020, 56, 2411-2414.
(48) Zeng, Q.; Qi, X.; Zhang, M.; Tong, X.; Jiang, N.; Pan, W.; Xiong, W.; Li, Y.; Xu, J.; Shen, J.^*, Xu, L.^*Efficient decontamination of heavy metals from aqueous solution using pullulan/polydopamine hydrogels. International Journal of Biological Macromolecules2020, 145, 1049-1058.
(47) Chen, H.; Yu, Y.-Z.; Tian, X.-M.; Wang, C.-L.; Qian, Y.-N.; Deng, Z.-A.; Zhang, J.-X.; Lv, D.-J.; Zhang, H.-B.; Shen, J.^*.; Yuan, M.; Zhao, S.-C.^*Synthesis and biological evaluation of arylpiperazine derivatives as potential anti-prostate cancer agents. Bioorganic & Medicinal Chemistry2019, 27, 133-143.
(46) Chen, H.; Zhang, J.; Hu, P.; Qian, Y.; Li, J.; Shen, J.^*Synthesis, biological evaluation and molecular docking of 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs containing the piperazine moiety. Bioorganic & Medicinal Chemistry2019, 27, 115081.
(45) Fitzgerald, E. J.; Shen, J.; Fenniri, H. A Barcoded Polymer-Based Cross-Reactive Spectroscopic Sensor Array for Organic Volatiles. Sensors2019, 19.
(44) Gao, J.; Chen, L.; Qi, R.; Zhou, Z.; Deng, Z.; Shi, J.; Qin, T.; Zhao, S.; Qian, Y.; Shen, J.^*Simultaneous delivery of gene and chemotherapeutics via copolymeric micellar nanoparticles to overcome multiple drug resistance to promote synergistic tumor suppression. Journal of Biomaterials Applications2019, 34, 130-140.
(43) He, X.; Wu, C.; Qian, Y.; Li, Y.; Ding, F.; Zhou, Z.; Shen, J.^*Symmetrical bis-salophen probe serves as a selectively and sensitively fluorescent switch of gallium ions in living cells and zebrafish. Talanta2019, 205, 120118.
(42) He, X.; Wu, C.; Qian, Y.; Li, Y.; Zhang, L.; Ding, F.; Chen, H.; Shen, J.^*Highly sensitive and selective light-up fluorescent probe for monitoring gallium and chromium ions in vitro and in vivo. Analyst2019, 144, 3807-3816.
(41) Huang, L.; Zhang, H.; Wu, S.; Xu, X.; Zhang, L.; Ji, H.; He, L.; Qian, Y.; Wang, Z.; Chen, Y.; Shen, J.^*; Mao, Z.-W.^*; Huang, Z^*. Charge Regulation of Self-Assembled Tubules by Protonation for Efficiently Selective and Controlled Drug Delivery. IScience2019, 19, 224-231.
(40) Liu, M.; Sun, X.; Liao, Z.; Li, Y.; Qi, X.; Qian, Y.; Fenniri, H.; Zhao, P.; Shen, J.^*Zinc oxide end-capped Fe3O4@mSiO2 core-shell nanocarriers as targeted and responsive drug delivery system for chemo-/ions synergistic therapeutics. Drug Delivery2019, 26, 732-743.
(39) Qi, X.; Chen, M.; Qian, Y.; Liu, M.; Li, Z.; Shen, L.; Qin, T.; Zhao, S.; Zeng, Q.; Shen, J.^*Construction of macroporous salecan polysaccharide-based adsorbents for wastewater remediation. International Journal of Biological Macromolecules2019, 132, 429-438.
(38) Qi, X.; Li, Z.; Shen, L.; Qin, T.; Qian, Y.; Zhao, S.; Liu, M.; Zeng, Q.;Shen, J.^*Highly efficient dye decontamination via microbial salecan polysaccharide-based gels. Carbohydrate Polymers2019, 219, 1-11.
(37) Qi, X.; Lin, L.; Shen, L.; Li, Z.; Qin, T.; Qian, Y.; Wu, X.; Wei, X.; Gong, Q.; Shen, J.^*Efficient Decontamination of Lead Ions from Wastewater by Salecan Polysaccharide-Based Hydrogels. ACS Sustainable Chemistry & Engineering2019, 7, 11014-11023.
(36) Qi, X.; Liu, R.; Chen, M.; Li, Z.; Qin, T.; Qian, Y.; Zhao, S.; Liu, M.; Zeng, Q.; Shen, J.^*Removal of copper ions from water using polysaccharide-constructed hydrogels. Carbohydrate Polymers2019, 209, 101-110.(ESI 1%)
(35) Qi, X.; Su, T.; Tong, X.; Xiong, W.; Zeng, Q.; Qian, Y.; Zhou, Z.; Wu, X.; Li, Z.; Shen, L.; He, X.; Xu, C.; Chen, M.; Li, Y.; Shen, J.^*Facile formation of salecan/agarose hydrogels with tunable structural properties for cell culture. Carbohydrate Polymers2019, 224, 115208.
(34) Qi, X.; Wei, W.; Shen, J.^*; Dong, W. Salecan polysaccharide-based hydrogels and their applications: a review. Journal of Materials Chemistry B2019, 7, 2577-2587.
(33) Qian, Y.; Zhao, S.; Shen, H.; Shen, J.^*NanotechnologyAdvances in Medicine:Focus on Cancer. Engineered Science2019.
(32) Sun, X.-Y.; Liu, M.-C.; Chen, X.-L.; Lin, H.-C.; Liu, B.; Peng, Y.-B.; Zhang, L.-Y.; Shen, J.^*; Zhao, P. A dual-targeted nucleic acid moiety decorated SPION nanoparticles for chemo-photodynamic synergistic therapy. Journal of Luminescence2019, 209, 387-397.
(31) Yang, Z.; Sun, Z.; Ren Yi; Xin, C.; Wei, Z.; Zhu, X.; Zongwan, M.; Shen, J.; Nie, S. Advances in nanomaterials for use in photothermal and photodynamic therapeutics Molecular Medicine Reports2019, 5-20.
(30) Zhang, J.; Mai, J.; Li, F.; Shen, J.; Zhang, G.; Li, J.; Hinkle, L. E.; Lin, D.; Liu, X.; Li, Z.; Wang, R.-f.; Mittendorf, E. A.; Ferrari, M.; Shen, H. Investigation of parameters that determine Nano-DC vaccine transport. Biomedical Microdevices2019, 21, 39.
(29) Ding, F.; Qian, Y.; Deng, Z.; Zhang, J.; Zhou, Y.; Yang, L.; Wang, F.; Wang, J.; Zhou, Z.; Shen, J.^*. Size-selected silver nanoparticles for MALDI-TOF mass spectrometry of amyloid-beta peptides. Nanoscale2018, 10, 22044-22054. (2018 Nanoscale HOT Article Collections)
(28) Liu, H.; Mai, J.; Shen, J.; Wolfram, J.; Li, Z.; Zhang, G.; Xu, R.; Li, Y.; Mu, C.; Zu, Y.; Li, X.; Lokesh, G. L.; Thiviyanathan, V.; Volk, D. E.; Gorenstein, D. G.; Ferrari, M.; Hu, Z.; Shen, H. A Novel DNA Aptamer for Dual Targeting of Polymorphonuclear Myeloid-derived Suppressor Cells and Tumor Cells. Theranostics2018, 8, 31-44.
(27) Mu, C.; Wu, X.; Zhou, X.; Wolfram, J.; Shen, J.; Zhang, D.; Mai, J.; Xia, X.; Holder, A. M.; Ferrari, M.; Liu, X.; Shen, H. Chemotherapy sensitizes therapy-resistant cells to mild hyperthermia by suppressing heat shock protein 27 expression in triple negative breast cancer. Clinical Cancer Research2018, clincanres.3872.2017. (Top Story in Mamarry Cell News)
(26) Mu, C.-F.; Shen, J.; Liang, J.; Zheng, H.-S.; Xiong, Y.; Wei, Y.-H.; Li, F. Targeted drug delivery for tumor therapy inside the bone marrow. Biomaterials2018, 155, 191-202.
(25) Shen, J.; Zhang, W.; Qi, R.; Mao, Z.-W.; Shen, H. Engineering functional inorganic-organic hybrid systems: advances in siRNA therapeutics. Chem Soc Rev2018, 47, 1969-1995.(Front Cover)
(24) Sun, J. H.; Zhang, W.; Zhang, D.-Y.; Shen, J.; Tan, C.-P.; Ji, L.-N.; Mao, Z.-W. Multifunctional mesoporous silica nanoparticles as efficient transporters of doxorubicin and chlorin e6 for chemo-photodynamic combinatorial cancer therapy. Journal of Biomaterials Applications2018, 32, 1253-1264.
(23) Wang, F.; Xia, X.; Yang, C.; Shen, J.; Mai, J.; Kim, H.-C.; Kirui, D.; Kang, Y.; an; Fleming, J. B.; Koay, E. J.; Mitra, S.; Ferrari, M.; Shen, H. SMAD4 Gene Mutation Renders Pancreatic Cancer Resistance to Radiotherapy through Promotion of Autophagy. Clinical Cancer Research2018, 24, 3176.
(22) Deng, B.; Xia, M.; Qian, J.; Li, R.; Li, L.; Shen, J.; Li, G.; Xie, Y. Calcium Phosphate-Reinforced Reduction-Sensitive Hyaluronic Acid Micelles for Delivering Paclitaxel in Cancer Therapy. Molecular Pharmaceutics2017, 14, 1938-1949.
(21) Shen, J.; Kim, H.-C.; Wolfram, J.; Mu, C.; Zhang, W.; Liu, H.; Xie, Y.; Mai, J.; Zhang, H.; Li, Z.; Guevara, M.; Mao, Z.-W.; Shen, H. A Liposome Encapsulated Ruthenium Polypyridine Complex as a Theranostic Platform for Triple-Negative Breast Cancer. Nano Letters2017, 17, 2913-2920. (Top Story in Mamarry Cell News)
(20) Shen, J.; Liu, H.; Mu, C.; Wolfram, J.; Zhang, W.; Kim, H.-C.; Zhu, G.; Hu, Z.; Ji, L.-N.; Liu, X.; Ferrari, M.; Mao, Z.-W.; Shen, H. Multi-step encapsulation of chemotherapy and gene silencing agents in functionalized mesoporous silica nanoparticles. Nanoscale2017, 9, 5329-5341.
(19) Shen, J.; Wolfram, J.; Ferrari, M.; Shen, H. Taking the vehicle out of drug delivery. Mater Today (Kidlington)2017, 20, 95-97.
(18) Mu, C.; Wu, X.; Ma, H.; Tao, W.; Zhang, G.; Xia, X.; Shen, J.; Mai, J.; Sun, T.; Sun, X.; Arlinghaus, R. B.; Shen, H. Effective Concentration of a Multikinase Inhibitor within Bone Marrow Correlates with In Vitro Cell Killing in Therapy-Resistant Chronic Myeloid Leukemia. Mol Cancer Ther2016, 15, 899-910.
(17) Scott, B.; Shen, J.; Nizzero, S.; Boom, K.; Persano, S.; Mi, Y.; Liu, X.; Zhao, Y.; Blanco, E.; Shen, H.; Ferrari, M.; Wolfram, J. A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells. Pharmacological Research2016, 111, 413-421.
(16) Wolfram, J.; Scott, B.; Boom, K.; Shen, J.; Borsoi, C.; Suri, K.; Grande, R.; Fresta, M.; Celia, C.; Zhao, Y.; Shen, H.; Ferrari, M. Hesperetin Liposomes for Cancer Therapy. Curr Drug Deliv2016, 13, 711-719.
(15) Xu, R.; Zhang, G.; Mai, J.; Deng, X.; Segura-Ibarra, V.; Wu, S.; Shen, J.; Liu, H.; Hu, Z.; Chen, L.; Huang, Y.; Koay, E.; Huang, Y.; Liu, J.; Ensor, J. E.; Blanco, E.; Liu, X.; Ferrari, M.; Shen, H. An injectable nanoparticle generator enhances delivery of cancer therapeutics. Nature Biotechnology2016, 34, 414-418. (Hot Paper, ESI 1%)
(14) Zhang, W.; Shen, J.; Su, H.; Mu, G.; Sun, J.-H.; Tan, C.-P.; Liang, X.-J.; Ji, L.-N.; Mao, Z.-W. Co-Delivery of Cisplatin Prodrug and Chlorin e6 by Mesoporous Silica Nanoparticles for Chemo-Photodynamic Combination Therapy to Combat Drug Resistance. ACS Applied Materials & Interfaces2016, 8, 13332-13340.
(13) Shen, J.; Wu, X.; Lee, Y.; Wolfram, J.; Yang, Z.; Mao, Z.-W.; Ferrari, M.; Shen, H. Porous Silicon Microparticles for Delivery of siRNA Therapeutics. JoVE2015, e52075.
(12) Wolfram, J.; Zhu, M.; Yang, Y.; Shen, J.; Gentile, E.; Paolino, D.; Fresta, M.; Nie, G.; Chen, C.; Shen, H.; Ferrari, M.; Zhao, Y. Safety of Nanoparticles in Medicine. Current Drug Targets2015, 16, 1671-1681.
(11) Shen, J.; Kim, H.-C.; Mu, C.; Gentile, E.; Mai, J.; Wolfram, J.; Ji, L.-n.; Ferrari, M.; Mao, Z.-w.; Shen, H. Multifunctional Gold Nanorods for siRNA Gene Silencing and Photothermal Therapy. Advanced Healthcare Materials2014, 3, 1629-1637.
(10) Shen, J.; Kim, H.-C.; Su, H.; Wang, F.; Wolfram, J.; Kirui, D.; Mai, J.; Mu, C.; Ji, L.-N.; Mao, Z.-W.; Shen, H. Cyclodextrin and polyethylenimine functionalized mesoporous silica nanoparticles for delivery of siRNA cancer therapeutics. Theranostics2014, 4, 487-497. (ESI 1%)
(9) Wolfram, J.; Suri, K.; Yang, Y.; Shen, J.; Celia, C.; Fresta, M.; Zhao, Y.; Shen, H.; Ferrari, M. Shrinkage of pegylated and non-pegylated liposomes in serum. Colloids and Surfaces B: Biointerfaces2014, 114, 294-300.
(8) Wolfram, J.; Yang, Y.; Shen, J.; Moten, A.; Chen, C.; Shen, H.; Ferrari, M.; Zhao, Y. The nano-plasma interface: Implications of the protein corona. Colloids and Surfaces B: Biointerfaces2014, 124, 17-24.
(7) Shen, J.; Xu, R.; Mai, J.; Kim, H.-C.; Guo, X.; Qin, G.; Yang, Y.; Wolfram, J.; Mu, C.; Xia, X.; Gu, J.; Liu, X.; Mao, Z.-W.; Ferrari, M.; Shen, H. High capacity nanoporous silicon carrier for systemic delivery of gene silencing therapeutics. ACS nano2013, 7, 9867-9880. (ESI 1%)
(6) Yang, Y.; Shen, J.; Yu, X.; Qin, G.; Zhang, M.; Shen, H.; Mao, Z.; Ferrari, M. Identification of an inhibitory mechanism of luteolin on the insulin-like growth factor-1 ligand-receptor interaction. Chembiochem2013, 14, 929-933.
(5) Yang, Y.; Wolfram, J.;Shen, J.; Zhao, Y.; Fang, X.; Shen, H.; Ferrari, M. Live-cell single-molecule imaging reveals clathrin and caveolin-1 dependent docking of SMAD4 at the cell membrane. FEBS Lett2013, 587, 3912-3920.
(4) Tan, L.; Shen, J.; Liu, J.; Zeng, L.; Jin, L.; Weng, C. Spectral characteristics, DNA-binding and cytotoxicity of two functional Ru(ii) mixed-ligand complexes. Dalton Transactions2012, 41, 4575-4587.
(3) Tan, L.-F.; Chen, X.-J.; Shen, J.; Liang, X.-L. Synthesis, DNA-binding and photocleavage studies of Ru(II) complexes of phenyl-(4,5,9,14-tetraaza-benzo[b]triphenylen-1,1-yl)-methanone. Journal of Chemical Sciences2009, 121, 397-405.
(2) Tan, L.-F.; Liu, J.; Shen, J.; Liu, X.-h.; Zeng, L.-L.; Jin, L.-H. First Ruthenium(II) Polypyridyl Complex As a True Molecular “Light Switch” for Triplex RNA Structure: [Ru(phen)₂(mdpz)]²⁺Enhances the Stability of Poly(U)·Poly(A)*Poly(U). Inorganic Chemistry2012, 51, 4417-4419.
(1) Tan, L.-F.; Shen, J.; Chen, X.-J.; Liang, X.-L. In vitro study on DNA binding of ruthenium(II) complexes with polypyridyl ligands. DNA and Cell Biology2012, 28, 461-468.

八、近年出版著作与教材：(近5年)
1. Qian Y., Zhao S., Shen H., Shen J.,*Nanotechnology Advances in Medicine: Focus on Cancer. Engineered Science, 2019, DOI: 10.30919/es8d678.