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生物医学工程（可授工学、理学、医学学位）
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广西大学生命科学与技术学院
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博士后合作导师, 博士研究生导师, 硕士研究生导师
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生命科学与技术学院
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何正国，教授，国家****基金获得者，广西八桂********教育背景1998.9—2001.7 中国科学院微生物研究所，博士1992.9—1995.7 华中农业大学生命科学技术学院，硕士1988.9—1992.7 华中农业大学微生物学专业，本科主要工作经历2019.6—今 广西大学生命科学与技术学院，二级岗教授、博导2005. 9— 2019.5 华中农业大学生命科学技术学院，二级岗教授、博导2001.7—2004.6 美国哈佛大学医学院生物化学与分子药物系，博士后
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主要从事微生物生长和耐药调控网络及病原-宿主相互作用研究
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主持项目情况1.十三五国家重点研发计划项目2017-2020，畜禽重要胞内菌基因调控及其与宿主互作的分子机制（首席科学家，在研）2.十三五国家重点研发计划课题2017-2020，病原感染致病相关因子及其表达和代谢调控机制（主持，在研）3.国家自然科学基金重点项目2018-2022，c-di-GMP分子驱动耻垢分枝杆菌抗氧化调控的信号通路与分子机制研究（主持，在研）4. 国家自然科学基金重点项目2010-2013，结核分枝杆菌的DNA复制调控网络及其与耐药性突变偶联的遗传机制研究（主持，已结题）5. 国家****科学基金2011-2014， 微生物生物大分子相互作用（**）（主持，已结题）
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代表论文（*为通讯作者）：1. Weihui Li, Lihua Hu, Zhiwei Xie, Hui Xu, Meng Li,Tao Cui, Zheng-Guo He* (2018) Cyclic di-GMP integrates functionally divergent transcription factors into a regulation pathway for antioxidant defense. Nucleic Acids Res. 46(14):7270-7283. 2. Weihui Li, Meng Li, Lihua Hu, Jingpeng Zhu, Zhiwei Xie, Jiarui Chen, Zheng-Guo He* (2018) HpoR, a novel c-di-GMP effective transcription factor, links the second messenger’s regulatory function to the mycobacterial antioxidant defense. Nucleic Acids Res. 46(7):3595-3611. 3.Weihui Li, Tao Cui1, Lihua Hu, Ziqing Wang, Zongqiang Li, Zheng-Guo He* (2015) Cyclic diguanylate monophosphate directly binds to human siderocalin and inhibits its antibacterial activity. Nat Commun 6: 8330 . 4.Manman Guo, Hui Feng, Jun Zhang, Wenqin Wang, Yi Wang, Yuqing Li, Chunhui Gao, Huanchun Chen, Ying Feng, Zheng-Guo He* (2009) Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 19(7): 1301-1308. 5.Lu Zhang, Lei Zhang, Yi Liu, Shifan Yang, Chunhui Gao, Hongchao Gong, Ying Feng, Zheng-Guo He* (2009) Archaeal eukaryote-like Orc1/Cdc6 initiators physically interact with DNA polymerase B1 and regulate its functions. Proc Natl Acad Sci USA. 106(19):7792-7797.6. Weihui Li, Zheng-Guo He* (2012) LtmA, a novel cyclic di-GMP responsive activator, broadly regulates the expression of lipid transport and metabolism genes in Mycobacterium smegmatis. Nucleic Acids Res. 40(22):11292-30. 7. Min Yang, Chunhui Gao, Tao Cui, Jingning An, Zheng-Guo He* (2012) A TetR-like regulator broadly affects the expressions of diverse genes in Mycobacterium smegmatis. Nucleic Acids Res. 40(3):1009-1020. 8.Feng Huang, Zheng-Guo He* (2010) Characterization of an interplay between a Mycobacterium tuberculosis MazF homolog, Rv1495, and its sole DNA topoisomerase I. Nucleic Acids Res. 38(22):8219-8230. 9. Yu Liu, Hongyang Wang, Tao Cui, Xiling Zhou, Yanxia Jia, Hua Zhang*, Zheng-Guo He* (2016) NapM, a new nucleoid-associated protein, broadly regulates gene expression and affects mycobacterial resistance to anti-tuberculosis drugs. Mol Microbiol. 101(1): 167-181.10. Yi Wang, Tao Cui, Cong Zhang, Min Yang, Yuanxia Huang, Weihui Li, Lei Zhang, Chunhui Gao, Yang He, Yuqing Li, Feng Huang, Jumei Zeng, Cheng Huang, Qiong Yang, Yuxi Tian, Chunchao Zhao, Huanchun Chen, Hua Zhang, Zheng-Guo He* (2010) Global protein-protein interaction network in the human pathogen Mycobacterium tuberculosis H37Rv. J Proteome Res. 9(12): 6665 - 6677.11.Yuqing Li, Jumei Zeng, Jianfang Shi, Mingchao Wang, Muding Rao, Chaolun Xue, Yanli Du, Zheng-Guo He* (2010) A proteome-scale identification of novel antigenic proteins in Mycobacterium tuberculosis towards diagnostic and vaccine development. J Proteome Res. 9(9): 4812 – 4822. 12. Jumei Zeng,Tao Cui, Zheng-Guo He* (2012) A Genome-wide Regulator-DNA Interaction Network in the human pathogen Mycobacterium tuberculosis H37Rv. J Proteome Res. 11(9), 4682-4692. 13.Qinbing Hu, Jiaxun Zhang, Yu Chen, Lihua Hu, Weihui Li*, Zheng-Guo He*. (2019) Co-activation of two-component regulator DevR by cyclic di-GMP in Mycobacterium smegmatis. J Biol Chem. 294(34):12729-12742.14. Lei Liu, Cheng Huang, Zheng-Guo He*. (2014)A TetR-family transcriptional factor directly regulates the expression of a 3-methyladenine DNA glycosylase and physically interacts with the enzyme to stimulate its base excision activity in Mycobacterium bovis BCG. J Biol Chem. 289(13):9065-9075. 15. Shifan Yang, Zengqiang Gao, Tingting Li, Min Yang, Tianyi Zhang, Yuhui Dong*, Zheng-Guo He* (2013) Structural basis for interaction between M. smegmatis Ms6564, a TetR family master regulator, and its target DNA. J Biol Chem. 288(33):23687-95. 16. Lei Zhang, Zheng-Guo He* (2013) Radiation-sensitive gene A (RadA) targets DisA, DNA integrity scanning protein A, to negatively affect its cyclic-di-AMP synthesis activity in Mycobacterium smegmatis. J Biol Chem. 288(31):22426-22436. 17. Lei Zhang, Weihui Li, Zheng-Guo He* (2013) DarR, a TetR-like transcriptional factor, is a cyclic-di-AMP responsive repressor in Mycobacterium smegmatis. J Biol Chem. 288 (5): 3085-3096. 18. Muding Rao, Huicong Liu, Min Yang, Chunchao zhao, Zheng-Guo He* (2012) A copper-responsive global repressor regulates expression of diverse membrane-associated transporters and bacterial drug resistance in mycobacteria. J Biol Chem. 287(47):39271-39371.19. Yi Wang, Yuanxia Huang, Chaolun Xue, Yang He, Zheng-Guo He* (2011) A ClpR-like regulator specifically recognizes a RecA-independent promoter motif and broadly regulates expression of DNA damage inducible genes in mycobacteria. J Biol Chem. 286(36): 31159-31167. 20.Bin Wang, Shifan Yang, Lei Zhang, Zheng-Guo He*（2010）Archaeal eukaryote-like serine/threonine protein kinase interacts with and phosphorylates a forkhead-associated domain-containing protein. J Bacteriol. 192(7): 1956-1964. 热烈欢迎大家以青年教师、博士后、科研助理、博士生和硕士生等身份加入团队！
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