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2006年毕业于南京大学化学化工学院，获理学博士学位；2006-2008于日本京都大学化学研究所从事药物设计方向的博士后研究；2013年9月—2014年1月在中科院上海有机化学研究所从事海星皂甙衍生物全合成的访问研究；2009-2017，广西大学化学化工学院教授，博士生导师；2018至今为广西大学医学院教授，博士生导师。主要从事：肝癌靶向药物分子设计、合成及药理学评价；肝癌的早期诊断及实时监控治疗；糖化学生物学；基于小分子探针的药物作用靶点发现与确证等方面的研究。主持国家自然科学基金2项，教育部重点项目1项，广西自然科学基金重点项目1项，横向项目多项；参与国家自然科学基金3项。以第一作者或通讯作者发表SCI论文40多篇，其中JCR一区Top论文8篇：ACS Catal.（IF 12.35）Chem. Sci.（IF 9.5）, Org. Lett.（IF 6.7）, Sensors Actuat. B-Chem. (IF 7.1)，Chem. Comm.（IF 6.2）, Eur. J. Med. Chem.(IF 5.572); 影响因子4.0以上的JCR二区Top 论文10多篇。授权专利3项。多次为J. Am. Chem. Soc.（IF14.3）, Chem. Comm. （IF 6.2），J. Org. Chem. (IF 4.8）, Organometallics（IF 4.1）等杂志审稿。教育部学位与研究生教育评估专家；江西省、河北省、河南省科学技术奖评审专家；广西化工与制药教指委委员。 热忱欢迎相关专业优秀的本科生、研究生来攻读硕士/博士学位或从事博士后研究。
xsjz
J. Am. Chem. Soc., Chem. Sci., Chem. Comm., Organometallics, Phys. Chem. Chem. Phys., Org. Bio. Chem., Org. Chem. Fron. 等杂志审稿人中国化学会员广西化工与制药教指委委员
zyyjskc
药物化学高等药物化学新药设计与开发
zyyjfx
1.肝癌靶向药物分子的设计与合成 2.物理有机化学 3. 化学生物学
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1 具ASGPR/SA双重识别动力及肿瘤微环境触发起效的肝癌靶向探针及抗肿瘤化合物的设计、合成及生物学评价 2 源于广西莪术的β-榄香烯的肝靶向抗肿瘤化合物的设计、合成与生物学评价3 乳糖基小分子肝靶化合物的设计、合成物的设计、合成及生物学评价 4 基于β-榄香烯的肝癌治疗剂的设计与合成5 兼治动脉粥样硬化的降糖化合物设计、合成及机制研究6 磺酰脲类降糖化合物的设计、合成及分子机理研究 7 松香基多杂环生物活性化合物的合成及构效关系研究8 基于枞酸等萜烯的光诱导环加成反应构建含张力小环多环体系的立体选择性调控研究 9 基于NHS-Diazirine 的光点击化学对松香基天然活性萜烯分子改性研究10 靶向HCC和TAFs的共载氯化两面针碱和阿霉素脂质体用于肝癌化学免疫治疗的研究
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1)Xiao-Yan Qin, Fan-Tao Meng, Mian Wang, Shu-Jiang Tu*, Wen-Juan Hao, Jianyi Wang*, and Bo Jiang*, Gold-Catalyzed Skeletal Rearrangement of Alkenes: Regioselective Synthesis of Skeletally Diverse Tricyclic Heterocycles and Mechanistic Investigations, ACS Catal. 2021, 11, 6951?6959 (IF: 12.35, JCR一区，Top)2)Yan Wang, Ruihua Ding, Zan Zhang, Cheng Zhong, Jianyi Wang*, Mian Wang*, Curcumin-Loaded Liposomes with the Hepatic and Lysosomal Dual-Targeted Effects for Therapy of Hepatocellular Carcinoma, International Journal of Pharmaceutics, 2021, 602，120628 (IF: 4.845, JCR二区，Top)3)Xia Lin, Chunxian Liang, Lianjia Zou, Yanchun Yin, Jianyi Wang*, Dandan Chen, Weisen Lan, Advance of structural modification of nucleosides scaffold, European Journal of Medicinal Chemistry, 2021，214，113233 (IF5.572, JCR一区，Top）4)Chunyan Tang , Cheng Zhong, Danyang Chen and Jianyi Wang，Drug-target interactions prediction using marginalized denoising model on heterogeneous networks，BMC Bioinformatics，2020, 21, 3305)Honghui Liu, Yan Wang, Mingxia Lv, Yi Luo, Bu-Ming Liu, Yan Huang, Mian Wang*, Jianyi Wang*, Flavonoid analogues as urease inhibitors: Synthesis, biological evaluation, molecular docking studies and in-silico ADME evaluation, Bioorganic Chemistry 2020,105, 104370 (IF 4.831, JCR二区）6)Ke Chen, Ting Xu, Jian Liang, Meng Zhou, Jie Zhang, Wen-Juan Hao,* Jianyi Wang,* Shu-Jiang Tu and Bo Jiang*，Completely regioselective insertion of unsymmetrical alkynes into electron-deficient alkenes for the synthesis of new pentacyclic indoles，Chem. Commun，2019，55, 14757--14760 (IF 6.2, JCR一区，Top）7)Tian-Shu Zhang, Hongping Zhang, Rong Fu, Jianyi Wang,* Wen-Juan Hao,* Shu-Jiang Tu and Bo Jiang*，tert-Butyl peroxide (TBHP)/KI-mediated dual C(sp2)–H bond amination of arylamines with α-diazo carbonyls toward 1,2,4-benzotriazines，Chem. Commun., 2019, 55, 13231-13234 (IF 6.2, JCR一区，Top）8)Hui Zhang, Zhenjie Li, Mian Wang,* Tingrong Luo, Liang Yi and Jianyi Wang *, Novel Hepatocyte-Targeting Fluorescent Probes for Detection of Hypochlorous Acid: Synergistic Effect of Phosphate and Galactose, Sensors & Actuators: B. Chemical, 2019，279，102–110 (IF 7.1, JCR一区，Top）9)Yamin Zhang, Zhenjie Li, Haibo Ge, Xueyan Zhu, Zhuang Zhao, Zhong-quan Qi, Mian Wang*, Jianyi Wang*，Dual Hepatocyte-Targeting Fluorescent Probe with High Sensitivity to Tumorous pH: Precise Detection of Hepatocellular Carcinoma Cells，Sensors & Actuators: B. Chemical，2019，285，584-589 (IF 7.1, JCR一区，Top）10)Liang Yi，Yan Wang，Tingrong Luo，Wei Hu，Mian Wang*，Jianyi Wang*，Design, synthesis and evaluation of a novel hepatocyte-targeting fluorescent probe to accurately detect H2S in mitochondria, Dyes and Pigments, 2019，166，460-466 (IF 4.6，JCR 二区，Top)11)Ruihua Ding, Zhenjie Li, Jianyi Wang*, Xueyan Zhu, Zhuang Zhao, Mian Wang*, Design and synthesis of galactose/biotin lipid materials for liposomes to promote the hepatoma-cell targeting effect, Journal of Pharmaceutical Sciences, 2019, 108, 3074-3081, (IF 3.2，JCR 三区)12)Hongping Zhang，Xueyan Zhu，Mian Wang*，Bu-Ming Liu，Yan Huang，Jianyi Wang*，A theoretical study of Fe(PMe3)4-catalyzed anti-Markovnikov addition of aromatics to alkenes to provide linear alkylation products，Transition Metal Chemistry，2019，291, 117-125，IF 1.213)Heng Li, Wen-Juan Hao, Mian Wang, Xue Qin, Shu-Jiang Tu*, Peng Zhou, Guigen Li, Jianyi Wang,* and Bo Jiang*，Catalytic Double [2+2] Cycloaddition Relay Enabled C-C Triple Bond Cleavage of Yne-Allenones, Organic Letters, 2018, 20, 4362-4366 (IF 6.7, JCR一区，Top）14)Wei Hu, Zhengjun Chen, Mian Wang, Tingrong Luo, Jianyi Wang*, Design, synthesis and evaluation of HepDirect fluorescence probes mediated by asialoglycoprotein receptor, Dyes and Pigments, 2018，159，471–478 (IF 4.6，JCR 二区，Top)15)Lujuan Liao, Zhenjie Li, Wei Hu, Yan Huang, Bu-min Liu, Lisheng Wang, Mian Wang*, Jianyi Wang*，Design, synthesis and evaluation of a novel fluorescent probe to accurately detect H2S in lysosomes, Tetrahedron Letters, 2018，59（27），2683-2687 (IF 2.3，JCR 三区)16)Yiran Huang*, Cheng Zhong*, Hai Xiang Lin , Jianyi Wang and Yuzhong Peng，Reconstructing Phylogeny by Aligning Multiple Metabolic Pathways Using Functional Module Mapping, Molecules, 2018, 23, 486; doi:10.3390/molecules**17)陈清，王坚毅*，Ponatinib 抑制野生型和T315I 突变型BCR-ABL1 激酶的分子模拟，化工进展，2018，37，702-707 (EI)18)Feiyang Liu, Piaoping Tang, Ruihua Ding, Lujuan Liao, Lisheng Wang, Mian Wang* and Jianyi Wang* A glycosylation strategy to develop low toxic naphthalimide fluorescent probe for the detection of Fe3+ in aqueous medium， Dalton Transactions, 2017, 46，7515-7522 (IF 4.18，JCR 二区，Top) 19)Jianyi Wang, Qing Chen, Mian Wang and Cheng Zhong, The opening/closure of P-loop and hinge of BCR-ABL1 decodes the low/high bioactivities of dasatinib and axitinib, Phys. Chem. Chem. Phys., 2017, 19, 22444-22453 (IF 4.12，JCR 二区, Top)20)Wang Mian，Zhou Shuilian，Chen Qing，Wang Lisheng，Liang Zhiqun*,Wang Jianyi*, Understanding the molecular mechanism for the differential inhibitory activities of compounds against MTH1，Sci. Rep.，2017，7: 40557 （IF 4.2, JCR 二区）21)Cuicui Jiang, Mian Wang, Yanxiu Wang, Xiuneng Tang, Yamin Zhang, Hui Zhang, Lin Ma, Jianyi Wang*，Synthesis and evaluation of two novel rhodamine-based fluorescence probes for specific recognition of Fe3+ ion，Tetrahedron Letters，2017，58，2560-2565 (IF 2.3，JCR 三区)22)Wang Lisheng，Wu Yi，Liu Yang，Yang Hua，Liu Xu， Li Xiaoxun, Wang Jianyi，Jiang Jun，Copper-Catalyzed P-H Insertions of α-Imino Carbenes for the Preparation of 3-Phosphinoylindoles，Organic Letters，2017，19(4), 782-785 (IF 6.7, JCR 一区，Top）23)Huang Yiran，Zhong Cheng，Lin Hai Xiang，Wang Jianyi, A Method for Finding Metabolic Pathways Using Atomic Group Tracking，Plos One，2017，12（1），e** (IF 3.0，JCR 三区)24)Zhengjun Chen, Wei Hu, Mian Wang, Lisheng Wang, Guifa Su, Jianyi Wang*. Synthesis and evaluation of a water-solubility glycosyl-rhodamine fluorescent probe detecting Hg2+. Carbohydrate Research, 2016, 429, 81-86 （IF 2.0）25)Shuilian Zhou, Mian Wang, Zhangfa Tong*, Jianyi Wang*,The Recognition Mechanism of Crizotinib on MTH1: Influence of Chirality on the Bioactivity, Mol. Phys.2016 , 114(16-17), 2364-2372 （IF 1.8， JCR 三区）26)Lichuan Wu, Shuaibing Liu, Jinrui Wei, Dong Li, Xu Liu, Jianyi Wang, Lisheng Wang, Synthesis and biological evaluation of matrine derivatives as anti-hepatocellular cancer agents, Bioorganic & Medicinal Chemistry Letters, 2016, 26, 4267–4271 (IF 2.5，JCR 三区)27)Richard Kleingeld, Jianyi Wang, Matthias Lein, Buckminster fullerene adhesion on graphene flakes: Numerical accuracy of dispersion corrected DFT, Polyhedron, 2016, 114, 110-117 (IF 2.1，JCR 三区)28)Zhang Yan，Tian Yan，Xiang Pei，Huang Ning，Wang Jianyi，Xu Jian-Hua，Zhang Min，A metal-free one-pot synthesis of benzo[c]chromen-6-ones from 3,4-dichlorocoumarins and butadienes using tandem photo-thermal-photo reactions，Organic and Biomolecular Chemistry，2016，14(41), 9874~9882 (IF 3.6, JCR 二区)29)Sheng Liu ，Yubin Li，Wanxing Wei，Kuiwu Wang，Lisheng Wang，Jianyi Wang，Design, synthesis, molecular docking studies and anti-HBV activity of phenylpropanoid derivatives，Chemico-Biological Interactions，2016，251, 1~9 (IF 2.6， JCR 三区)30)Xuesong Wu, Mian Wang, Guangwu Zhang, Yan Zhao, Jianyi Wang* and Haibo Ge*, Copper-Catalyzed Diastereoselective Aerobic Intramolecular Dehydrogenative Cyclization of Hydrazones via sp3 C-H Functionalization, Chem. Sci., 2015, 6, 5882-5890 （IF 9.5, JCR 一区，Top）31)Mian Wang, Hao Luo, Min Zhang and Jianyi Wang*, Why trans- or cis-Dimethyl Fumarate Addition to 2,5-Dimethylpyrrole Gives Exclusively trans-7-Azanorbornane, J. Phys. Chem. A, 2015, 119, 6563-73 （IF 2.8， JCR 三区）32)Mian Wang, Hao Luo, Lisheng Wang, Jianyi Wang*,What factors cause the complete substrate-controlled selectivity in Rh2(Piv)4-catalyzed cycloadditions of 1,2,3-triazoles with isocyanates or isothiocyanates, J. Organomet. Chem. 2015, 788, 58-67 （IF 2.3， JCR 三区）33)Xueqiu Huang, Mian Wang, Lisheng Wang, Jianyi Wang*, How rhodium (III) complexes catalyze alkenylation of C(sp3)-H bond of 8-methyquinolines, J. Organomet. Chem. 2015, 787, 1-7 (IF 2.3，SCI 三区）34)Mian Wang, Marc Baaden, Jianyi Wang*, Zhiqun Liang，A Cooperative Mechanism of Clotrimazoles in P450 revealed by the Dissociation Picture of Clotrimazole from P450，J. Chem. Inf. Model.，2014，54, 1218?1225 （IF 4.549, JCR 二区，Top）35)Chuanan Liao, Jianyi Wang*, Bin Li*，Mechanism of Mo-catalyzed C-S Cleavage of Thiophene， J. Organomet. Chem., 2014, 749，275-286 （IF 2.3， JCR 三区）36)Wenhao Sheng, Mian Wang, Matthias Lein, Linbin Jiang, Wanxing Wei, Jianyi Wang*, Mechanism of Cu(I)-catalyzed allylic alkylation of phosphorothioate esters: influence of the leaving group on α-regioselectivity, Chem. Eur. J., 2013，19, 14126–14142 （IF 5.8, JCR 二区, Top）37)Jingxi Wu, Mian Wang, Lisheng Wang, Jianyi Wang*, Linbin Jiang， How the bicyclo[4.1.0] substrate isomerizes into 4,5-dihydrobenzo[b]furan: the contribution from W(CO)5 and NEt3, J. Org. Chem，2013, 78, 10812-10820 （IF 4.8, JCR 二区， Top）38)Jianyi Wang*, Dinglong Cai, Min Zhang, Mian Wang*. The addition mechanism of TMSCN into N-acetylpyridinum to give 2-cyanoacetylpyridinum: the roles of TpW(NO)(PMe3) and DABCO, J.Organomet. Chem., 2013, 724, 117–128 （IF 2.3， JCR 三区）39)Xuetang Xu , Xianli Ma, Wengui Duan, Li Chen, Bo Cen, Qijin Mo and Jianyi Wang. Synthesis and fungicidal activity of dehydroabietyl-1,2,4-triazolo-thiazolidinones, Holzforschung, 2013，67, 107–112. （IF 1.7， JCR 三区）40)Dinglong Cai, Mian Wang, Jianyi Wang*, Wengui Duan. Quantum chemical study on the mechanism of intramolecular cyclization of 2-benzyloxyphenyl trimethylsilyl ketone to give the benzofuran derivatives, J. Phys. Org. Chem., 2012，25, 400–408（IF1.6）41)Liao Chuanan, Li Bin, Wang Jianyi*, Wang Yipin. Mechanism of Silver(I)-Catalyzed Enantioselective Synthesis of Axially Chiral Allenes Based on Propargylamines, Chin. J. Chem., 2012，30, 951–958 （IF 3.8）42)Wang Mian, Yang jipeng, Wang Jianyi*, Wang Xiaojuan. Structural effects of L16Q, S20G, and L16Q-S20G mutations on hIAPP: a comparative molecular dynamics study, Chin. J. Chem., 2012, 30, 241–248 （IF 3.8）43)Mian Wang, Yun Du, Jianyi Wang, Xiaomin Luo, Hualiang Jiang, Naixia Zhang, Yechun Xu. Dynamic behavior of ubiquitin receptor S5a in free and complex with K48-linked diubiquitin. Mol. Simul., 2012，38, 1015–1021. （IF 1.3）44)Yin, Yanchun, Wang Mian, Wang Jianyi*, Zhou Longchang, Duan Wengui. Mechanism of Gold(I)–Catalyzed Conia-ene Reaction of β-Ketoesters with Alkynes: A DFT Study，Chin. J. Chem., 2011, 29, 2320–2326（IF 3.8）45)Jianyi Wang and Shuhua Li, The Catalytic Mechanism of 6-Phosphogluconate Dehydrogenase: A Theoretical Investigation，J. Phys. Chem. B. 2006，110，7029-7035. （IF 3.2， JCR 三区）46)Jianyi Wang, Hao Dong, Shuhua Li and Hongwu He，Theoretical Study toward Understanding the Catalytic Mechanism of Pyruvate Decarboxylase，J. Phys. Chem. B. 2005, 109, 18664-18672. （IF 3.2， JCR 三区）47)Jianyi Wang and Shuhua Li，Theoretical Study toward Understanding the Catalytic Mechanism of Pyruvate Dehydrogenase Multienzeme Complex E1 Component， J. Theor. Comput. Chem. 2006, 5, 447-459. (IF 1.0)
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热忱欢迎相关专业优秀的本科生、研究生来攻读硕士/博士学位，或从事博士后研究。"}},