---个人基本信息---
姓名:
苏桂发

出生年月：
1963.7

籍贯：
广西桂林

学历：
理学博士

职称：
教授

专业：
有机化学、药物化学



------教育和主要工作经历------
苏桂发，理学博士，二级教授，1982-7参加工作，1987-7到广西师大工作。1996年开始独立指导研究生，1998年晋升为教授，2001年获广西科技进步二等奖(排名第1)，2003年获广西第七届青年科技奖，2003年入选广西高校百名中青年学科带头人资助计划，2005年入选广西“新世纪十百千人才工程”资助计划。2011年被遴选为有机化学专业博士研究生导师。获广西高校优秀教学成果二等奖一项(2012，排名第1)、一等奖两项(排名第2，2012，2017)。2014年获广西高等学校教学名师奖。
主持20多项厅级以上科研课题的研究，在国内外公开发表学术论文160多篇，获授权中国发明专利8项。作为主编、副主编、参编公开出版教材及学习指导书9部(国家规划教材4部)。

------讲授的课程------
高等有机化学(研究生)，物理有机化学(研究生)，有机化学(本科生)、有机合成(本科生) 、精细有机合成化学与工艺(本科生)。

------研究领域------
主要研究和感兴趣的领域：杂环化合物的合成及生物活性研究、高效有机合成反应研究。
---近年研究项目---
目前主持的主要科研项目：
1.利用分子内去芳构化环化策略合成螺环吡咯[2,1-b]喹唑酮化合物的反应研究(国家自然科学基金课题,直接经费40万，项目批准号: **，2020.1–2023.12,主持)。
2.基于靶标药效团模型的Aromathecins及Luotonin A的结构改造和构效关系研究(广西自然科学基金重点项目,项目编号2017GXNSFDA198045, 40万, 2017.9–2021.9,主持)。
3. 3-苯并噻吩喹啉-4-酮类化合物的合成及其诱导的肿瘤细胞旁凋亡研究(省部共建国重室科研课题，项目编号CMEMR2018-A1, 30万, 2018.5–2021.4,主持)。

科研获奖
广西科技进步二等奖(排名第一, 2001),第七届广西青年科技奖(2003)。

------近年代表性科研成果------

1. Hong-Ping Zhao,^?Gui-Chao Liang,^?Shu-Min Nie, Xiuqiang Lu, Cheng-Xue Pan, Xin-Xian Zhong,* Gui-Fa Su,*and Dong-Liang Mo*. Metal-Free Graphene Oxide-Catalyzed Aza-Semi- -pinacol Rearrangement to Prepare 2-(Indol-2-yl)phenols and Benzofuro[3,2-b]indolines Containing Quaternary Carbon Centers, Green Chem.2020, 22, 404–410.
2.Xin-Wei Wei^?, Jing-Mei Yuan^?, Wan-Yun Huang, Nan-Ying Chen, Xiao-Juan Li, Cheng-Xue Pan*, Dong-Liang Mo*, Gui-Fa Su*. 2-Styryl-4-aminoquinazoline derivatives as potent DNA-cleavage, p53-activation and in vivoeffective anticancer agents,Eur.J. Med. Chem.2020, 186, 111851.
3. Zengbo Wang,^?ChengTian^?, Qingqing Liu, Wei Zhang, Chengxue Pan*, Gui-Fa Su*. Study on the Synthesis of Benzophenanthridine Analogues via the Cyclization Reaction of Aryl-enamine Ester and Their Cytotoxicity, Chin. J. Org. Chem. 2019, 39, 1962–1969 (in Chinese).
4.Zhengmin Yang, Wenxiu Li, Hua Chen, Qingyuan Mo, Jun Li,* Shulin Zhao, Cheng Hou, Jiangke Qin*, and Gui-Fa Su. Inhibitor structure-guided design and synthesis of near-infrared fluorescent probes for monoamine oxidase A (MAO-A) and its application in living cells and in vivo, Chem. Commun. 2019, 55, 2477–2480.
5.Jun-Yi Liao,Qing-Yan Wu,Xiuqiang Lu,Ning Zou,Cheng-Xue Pan,Cui Liang,Gui-Fa SU*andDong-LiangMo*.Copper-Catalyzed Diastereoselective O-Transfer Reaction of N-Vinyl-α,β- -Unsaturated Nitrones with Ketenes into γ-Lactones through [5+2] Cycloaddition and N-O Bond Cleavage, Green Chem.2019, 21,6567–6573.
6. Jing-Mei Yuan, Kai Wei, Guo-Hai Zhang, Nan-Ying Chen, Xin-Wei Wei, Cheng-Xue Pan*, Dong-Liang Mo*, Gui-Fa Su*. Cryptolepine and Aromathecin based Mimics as Potent DNA-cleavage and Anticancer Agents: Design, Synthesis and DNA Targeting-Induced Apoptosis, Eur.J. Med. Chem.2019, 169, 144?158.7.Si-Yi Wu,^?Wei-Li Chen,^?Xiao-Pan Ma, Cui Liang, Gui-Fa Su,* and Dong-Liang Mo*. Copper-Catalyzed [3+2] Cycloaddition and Interrupted Fischer Indolization to Prepare Polycyclic Furo[2,3-b]indolines from N-Aryl Isatin Nitrones and Methylenecyclopropanes,Adv. Synth.& Catal.2019,361(5), 965?970.
8.Qing-Qing Liu, Ke Lu, Hai-Miao Zhu, Shi-Lin Kong, Jing-Mei Yuan, Guo-Hai Zhang, Nan-Ying Chen, Chen-Xi Gu, Cheng-Xue Pan*, Dong-Liang Mo*, Gui-Fa Su*. Identification of 3-(benzazol-2-yl)quinoxaline derivatives as potent anticancer compounds: Privileged structure-based design, synthesis, and bioactive evaluation in vitroand in vivo, Eur. J. Med. Chem. 2019, 165, 293?308.
9. Ning Zou, Ji-Wen Jiao, Yu Feng, Cheng-Xue Pan, Cui Liang, Gui-Fa Su,* and Dong-Liang Mo*. Iron(III)/Copper(II)-Cocatalyzed Cycloaddition/[3,3]-Rearrangement/N?O Bond Cleavage To Prepare Polysubstituted Pyrrolizines from NVinyl-α,β-Unsaturated Nitrones and ActivatedAlkynes, Org. Lett.2019, 21, 481?485.
10. Yan-Xiao Jiao, Lin-Su Wei, Chun-Yang Zhao, Kai Wei, Dong-Liang Mo,* Cheng-Xue Pan,* and Gui-Fa Su*. Isobutyl Nitrite-Mediated Synthesis of Quinoxalines through Double C?H Bonds Amination of N-Aryl Enamines,Adv. Synth. Catal.2018, 360(22), 4446–4451.
11. Chun-Hua Chen, Qing-Yan Wu, Cui Wei, Cui Liang, Gui-Fa Su* and Dong-Liang Mo*. Iron(III)-catalyzed selective N–O bond cleavage to prepare tetrasubstituted pyridines and 3,5-disubstituted isoxazolines from N-vinyl-α,β-unsaturated ketonitrones, Green Chem.,2018, 20, 2722?2729. (Inside Front CoverPaper)
12. Lin-Su Wei, Guo-Xue He, Xiang-Fei Kong, Cheng-Xue Pan,* Dong-Liang Mo,* and Gui-Fa Su*. Gold(III)-Catalyzed Selective Cyclization of Alkynyl Quinazolinone-Tethered Pyrroles: Synthesis of Fused Quinazolinone Scaffolds, J. Org. Chem. 2018, 83, 6719?6727.
13. Chun-Yang Zhao, Kun Li, Yu Pang, Jia-Qing Li, Cui Liang, Gui-Fa Su*, and Dong-Liang Mo*. Iodine(III) Reagent-Mediated Intramolecular Amination of 2-Alkenylanilines to Prepare Indoles, Adv. Synth. Catal. 2018,360, 1919–1925.
14.Hong-Yan Bi, Feng-Ping Liu, Cui Liang, Gui-Fa Su*, and Dong-Liang Mo*. A Tunable Route to Prepare ɑ,β-Unsaturated Esters and ɑ,β-Unsaturated-γ-Keto Esters through Copper-Catalyzed Coupling of Alkenyl Boronic Acids with Phosphorus Ylides, Adv. Synth. Catal. 2018, 360, 1510– 1516.
15.Xiang-Fei Kong,Feng Zhan, Guo-Xue He, Cheng-Xue Pan, Chen-Xi Gu, Ke Lu, Dong-Liang Mo,* and Gui-Fa Su*. Gold-Catalyzed Selective 6-exo-dig and 7-endo-dig Cyclizations of Alkyn-Tethered Indoles To Prepare Rutaecarpine Derivatives, J. Org. Chem. 2018,83(4), 2006– 2017.
16. Xiao-Pan Ma, Kun Li, Si-Yi Wu, Cui Liang, Gui-Fa Su* and Dong-Liang Mo*. Construction of 2,3-quaternary fused indolines from alkynyl tethered oximes and diaryliodonium salts through a cascade strategy of N-arylation/ cycloaddition/[3,3]- rearrangement, Green Chem.2017, 19(24), 5761–5766.2017 Green Chemistry Hot Articles. (Inside Front CoverPaper)
17. Ning Zou, Ji-Wen Jiao, Yu Feng,a Chun-Hua Chen, Cui Liang, Gui-Fa Su,* and Dong-Liang Mo.*Diastereoselective Synthesis of Nine-Membered Heterocycles via the Cycloaddition and Sequential Rearrangement of N-Vinyl Nitrones with Isocyanates, Adv. Synth. Catal.2017, 359, 3545–3350.
18. Wei-Min Shi, Feng-Ping Liu, Zhi-Xin Wang, Hong-Yan Bi, Cui Liang, Li-Ping Xu,* Gui-Fa Su,*and Dong-Liang Mo.* Synthesis of 1-Vinyl/Aryl Benzotriazole 3-Oxides through Copper-Catalyzed C-N Bond Coupling Reaction, Adv. Synth. Catal., 2017, 359(16), 2741-2746.
19. Guo-Hai Zhang, Jing-Mei Yuan, Gang Qian, Chen-Xi Gu, Kai Wei, Dong-Liang Mo, Jiang-Ke Qin, Yan Peng, Zu-Ping Zhou, Cheng-Xue Pan*, and Gui-Fa Su*. Phthalazino[1,2-b]- -quinazolinones as p53 Activators: Cell Cycle Arrest, Apoptotic Response and Bak–Bcl-xl Complex Reorganization in Bladder Cancer Cells, J. Med. Chem.2017, 60(16), 6853? 6866.
20.Chun-Hua Chen,Qing-Qing Liu,Xiao-Pan Ma, Yu Feng, Cui Liang, Cheng-Xue Pan, Gui-Fa Su,* and Dong-Liang Mo*. Copper-Catalyzed Selective NVinylation of 3(Hydroxyimino)--indolin-2-ones with Alkenyl Boronic Acids: Synthesis of NVinyl Nitrones and Spirooxindoles, J. Org. Chem. 2017,82, 6417?6425.
21. Yan-Xiao Jiao, Ling-Ling Wu, Hai-Miao Zhu, Jiang-Ke Qin, Cheng-Xue Pan,* Dong-Liang Mo,* and Gui-Fa Su*. Tandem C–N Bonds Formation through Condensation and Metal-Free N-Arylation: Protocol for Synthesizing Diverse Functionalized Quinoxalines, J. Org. Chem.2017, 82(8), 4407?14.
22. Guo-Xue He, Jing-Mei Yuan, Hai-Miao Zhu, Kai Wei, Ling-Yun Wang, Shi-Lin Kong, Dong-Liang Mo, Cheng-Xue Pan* and Gui-Fa Su*. Synthesis and antitumor evaluation of 2,3-diarylbenzofuran derivatives on HeLa cells, Bioorg. Med.Chem.Lett. 2017, 27, 1660–1664.
23. Yan-Xiao Jiao, Xiao-Pan Ma, Gui-Fa Su* and Dong-Liang Mo*. Recent Advances in Arylation and Alkenylation of N–O bonds, Synthesis, 2017,49, 933-959.
24. Xiao-Pan Ma, Jie-Feng Zhu, Si-Yi Wu, Chun-Hua Chen, Ning Zou, Cui Liang, Gui-Fa Su,*and Dong-Liang Mo*. Cycloaddition of Fluorenone NAryl Nitrones with Methylenecyclopropanes and Sequential 1,3-Rearrangement: An Entry to Synthesis ofSpirofluorenylpiperidin-4-ones, J. Org. Chem.2017, 82, 502?511.
25. Zhi-Xin Wang, Wei-Min Shi, Hong-Yan Bi, Xiao-Hua Li, Gui-Fa Su* and Dong-Liang Mo*. Synthesis of N-(2-Hydroxyaryl)benzotriazoles viaMetal-Free O-Arylation and N?O Bond Cleavage, J. Org. Chem. 2016, 81, 8014-8021.
26. Chun-Yang Zhao, Liang-Gui Li, Qing-Rong Liu, Cheng-Xue Pan, Gui-Fa Su* and Dong-Liang Mo*. Synthesis of β-acetoxy alcohols by PhI(OAc)₂-mediated metal-free diastereoselective β-acetoxylation of alcohols, Org. Biomol. Chem.,2016, 14, 6795–803.
27. Wei-Min Shi, Xiao-Pan Ma, Gui-Fa Su*, Dong-Liang Mo*. New developments of ketonitrones in organic synthesis, Org. Chem. Front.2016, 3, 116–130.
28. Guo-Hai Zhang, Wen-Bin Xue, Yun-Feng An, Jing-Mei Yuan, Jiang-Ke Qin, Cheng-Xue Pan*, Gui-Fa Su*. Distinct novel quinazolinone exhibits selective inhibition in MGC-803 cancer cells by dictating mutant p53 function, Eur. J. Med. Chem.2015, 95, 377-387.
29. Wei-Min Shi, Xiao-Pan Ma, Cheng-Xue Pan, Gui-Fa Su,* and Dong-Liang Mo*. Tandem C―O and C―N Bonds Formation Through O-Arylation and [3,3]-Rearrangement by Diaryliodonium Salts: Synthesis of N-Aryl Benzo[1,2,3]triazin-4(1H)-one Derivatives, J. Org. Chem.2015, 80, 11175- 11183.
30. Xiao-Pan Ma,Wei-Min Shi,Xue-Ling Mo,Xiao-Hua Li,Liang-Gui Li,Cheng-Xue Pan,Bo Chen,* Gui-Fa Su,* and Dong-Liang Mo*. Synthesis of α,β-Unsaturated N-Aryl Ketonitrones from Oximes and Diaryliodonium Salts: Observation of a Metal-Free N-Arylation Process,J. Org. Chem.2015, 80, 10098-10107.
31. Qing-Rong Liu, Cheng-Xue Pan, Xiao-Pan Ma, Dong-Liang Mo,* and Gui-Fa Su*. (Diacetoxyiodo)benzene–Mediated Reaction of Ethynylcarbinols: Entry to α,α′-Diacetoxy Ketones and Glycerol Derivatives, J. Org. Chem.2015, 80, 6496?6501.
32. Yan-Li Xu, Ying-Ming Pan,* Pei Liu, Heng-Shan Wang, Xiao-Yan Tian, and Gui-Fa Su*. Indium (III) chloride catalyzed conjugate addition reaction of alkynylsilanes to acrylate esters,J. Org. Chem.2012, 77, 3557?3562.
33.潘成学,苏桂发,焦艳晓,魏凯,莫冬亮.一种喹喔啉衍生物的高效合成方法, 2018-6-5授权,中国发明专利号ZL 8.8.
34.潘成学,魏凯,苏桂发,袁静梅,莫冬亮.一种新的[1,2,b]茚并喹啉类衍生物及其制备方法和在抗肿瘤药物中的应用, 2018-7-11授权,中国发明专利号ZL 8.8.
35.潘成学，苏桂发，孔石林，戴求资，朱海妙，刘晴晴。萘并[1,2-h][1,6]萘啶-3(4H)-酮类化合物及其制备方法和应用，中国发明专利号ZL 6.4。
36.苏桂发，潘成学，钱刚，袁静梅，张国海，何国学。酞嗪并[1,2,b]喹唑啉-8-酮化合物及其制备方法和抗肿瘤药物中的应用，中国发明专利号ZL 9.8。
37. 潘成学，苏桂发，焦艳晓，吴玲玲，覃江克。2, 3-二取代喹喔啉衍生物的制备方法,中国发明专利号ZL3.6。
38. 苏桂发，焦艳晓，潘成学，韦罗山，孔石林，黄婉云。川芎嗪茋类衍生物及其制备方法与应用, 中国发明专利号ZL 3.8。
39. 苏桂发，郑志兵，农娟，李松，王莉莉，覃江克，潘成学，唐煌，邓业成。新的哌嗪和高哌嗪类衍生物及其制备方法和应用，中国发明专利号ZL 5.0.
40. 苏桂发，潘成学，冯凯熙，戴支凯，覃江克，唐煌，刘华钢。2,3-二氧乙基-5-甲基-8,9-二甲氧基苯并菲啶衍生物及其制备方法和应用，中国发明专利号ZL 2.2.