梁东　[教授]
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电子邮箱：liangdonggxnu@163.com
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研究方向天然药物化学、天然产物化学生物学
学历背景2009.9–2012.7，中国医学科学院 & 北京协和医学院药物研究所，药物化学专业，理学博士学位；
2006.9–2009.7，沈阳药科大学中药学院，天然药物化学专业，理学硕士学位；
2002.9–2006.7，云南中医药大学中药学院，制药工程专业，工学学士学位。
讲授课程天然药物化学、波谱分析

论著专利独立工作以来发表的SCI论文(*为通讯作者, #为共同第一作者)：
1. Fan Yang#, Bao-Jun Su#, Ya-Jie Hu#, Jin-Long Liu, Hua Li, Ya-Qi Wang, Hai-Bing Liao, Dong Liang*. Piperhancins A and B, Two Pairs of Antineuroinflammatory Cycloneolignane Enantiomers from Piper hancei. The Journal of Organic Chemistry, 2021, 86, 5284?5291.
2. Feng Qin#, Cai Yi Wang#, Donghwa Kim, Heng-Shan Wang, Yan-Kui Zhu, Sang Kook Lee*, Gui-Yang Yao*, Dong Liang*. Nitidumpeptins A and B, Cyclohexapeptides Isolated from Zanthoxylum nitidumvar. tomentosum: Structural Elucidation, Total Synthesis, and Antiproliferative Activity in Cancer Cells. The Journal of Organic Chemistry, 2021, 86, 1462?1470.
3. Yuan-kun Zheng#, Bao-jun Su#, Ya-qi Wang, Heng-shan Wang, Hai-bing Liao*, Dong Liang*. New Tyramine- and Aporphine-Type Alkamides with NO Release Inhibitory Activities from Piper puberulum. Journal of Natural Products, 2021, 84, 1316?1325.
4. Hai-Yan Zhao, Ya-Qi Wang, Yan-Cai Li, Qian Lan, Hai-Bing Liao, Heng-Shan Wang, Dong Liang*. Flavonol glycosides and phenylpropanoid glycosides with inhibitory effects on microglial nitric oxide production from Neoshirakia japonica. Fitoterapia, 2021, 151, 104877.
5. Feng Hu#, Ya-Jie Hu#, Bao-Jun Su, Ya-Qi Wang, Hai-Bing Liao, Dong Liang*. Enantiomeric lignans with antineuroinflammatory activities from Mappianthus iodoides. Phytochemistry Letters, 2021, 42, 18?23.
6. Hai-Yan Zhao, Bao-Jun Su, Wang-Jing Zhou, Ya-Qi Wang, Hai-Bing Liao, Heng-Shan Wang*, Dong Liang*. Diterpenoids and triterpenoids from Triadica rotundifoliaand their effects on microglial nitric oxide production. Bioorganic Chemistry, 2020, 105, 104332.
7. Zi-Ni Yang#, Bao-Jun Su#, Ya-Qi Wang, Hai-Bing Liao*, Zhen-Feng Chen, Dong Liang*. Isolation, Absolute Configuration, and Biological Activities of Chebulic Acid and Brevifolincarboxylic Acid Derivatives from Euphorbia hirta. Journal of Natural Products, 2020, 83, 985?995.
8. Cui He#, Yaqi Wang#, Tingmi Yang#, Hengshan Wang, Haibing Liao*, Dong Liang*. Quassinoids with Insecticidal Activity against Diaphorina citriKuwayama and Neuroprotective Activities from Picrasma quassioides. Journal of Agricultural and Food Chemistry, 2020, 68, 117?127.
9. Cai Yi Wang, Donghwa Kim, Yan Kui Zhu, Dong-Chan Oh, Ri Zhen Huang, Heng-Shan Wang, Dong Liang*, Sang Kook Lee*. Glechomanamides A?C, Germacrane Sesquiterpenoids with an Unusual Δ8?7,12-Lactam Moiety from Salvia scapiformisand Their Antiangiogenic Activity. Journal of Natural Products, 2019, 82, 3056?3064.
10. Jin-Long Liu, Min Yu, Hai-Bing Liao, Ting Liu, Yan-Hui Tan, Dong Liang*, Gui-Jie Zhang*. Sesquiterpenes and diterpenes from Euphorbia thymifolia. Fitoterapia, 2019, 139, 104408.
11. Xi-Lin Ouyang, Wen-Hua Mao, Chun-Gu Wang, Ying-Ming Pan, Dong Liang*, Heng-Shan Wang*. Five 11α, 12α-epoxy pentacyclic triterpenoid saponins with antithrombus activities from Glechoma longituba. Fitoterapia, 2019, 138, 104345.
12. Hai-Bing Liao, Wu-Ying Feng, Heng-Shan Wang, Dong Liang*. Sesquiterpenoid compounds from Curcuma kwangsiensis. Chemistry & Biodiversity, 2019, 16, e**.
13. Shan-Shan Zhu, Gui-Jie Zhang, Hai-Bing Liao, Heng-Shan Wang, Dong Liang*. A new chlorinated diphenyl ether and a new sesquilignan from the stems of Mappianthus tomentosus. Phytochemistry Letters, 2019, 30, 49?52.
14. Yong-Li Zhang#, Qi-Min Pan#, Hai-Bing Liao, Jiang-Ke Qin, Ning Li, Dong Liang*, Gui-Jie Zhang*. Coumarinolignoids and lignanoids from the stems and leaves of Sapium discolor. Fitoterapia, 2019, 133, 17–22.
15. Gui-Jie Zhang#, Qi-Ming Pan#, Yong-Li Zhang, Hai-Bing Liao,Yan-Qiu Yang, Yue Hou*, Dong Liang*. Coumarinolignoids and Taraxerane Triterpenoids from Sapium discolorand Their Inhibitory Potential on Microglial Nitric Oxide Production. Journal of Natural Products, 2018, 81, 2251–2258.
16. Huan Jiang, Gui-Jie Zhang, Hai-Bing Liao*, Dong Liang*. New terpenoid and phenylpropanoid glycosides from Tinospora sinensis. Fitoterapia, 2018, 131, 127–133.
17. Yuan Zhu#, Ri-Zhen Huang#, Chun-Gu Wang, Xi-Lin Ouyang, Xiao-Teng Jing, Dong Liang*, Heng-Shan Wang*. New inhibitors of matrix metalloproteinases 9 (MMP-9): Lignans from Selaginella moellendorffii. Fitoterapia, 2018, 130, 281–289.
18. Shu-Lin Zhang, Ri-Zhen Huang, Hai-Bing Liao*, Heng-Shan Wang, Zhen-Feng Chen, Dong Liang*. Cyclic pentapeptide type compounds from Clerodendrum japonicum(Thunb.) Sweet. Tetrahedron Letters, 2018, 59, 3481–3484.
19. Chun-Gu Wang#, Wei-Na Yao#, Bin Zhang, Jing Hua, Dong Liang*, Heng-Shan Wang*. Lung cancer and matrix metalloproteinases inhibitors of polyphenols from Selaginella tamariscinawith suppression activity of migration. Bioorganic & Medicinal Chemistry Letters, 2018, 28, 2413–2417.
20. Shu-Lin Zhang#, Zi-Ni Yang#, Cui He, Hai-Bing Liao*, Heng-Shan Wang, Zhen-Feng Chen, Dong Liang*. Oleanane-type triterpenoid saponins from Lysimachia fortunei Maxim. Phytochemistry, 2018, 147, 140–146.
21. Gui-Jie Zhang#, Feng Hu#, Huan Jiang, Lu-Mei Dai, Hai-Bing Liao, Ning Li, Heng-Shan Wang, Ying-Ming Pan*, Dong Liang*. Mappianines A–E, structurally diverse monoterpenoid indole alkaloids from Mappianthus iodoides. Phytochemistry, 2018, 145, 68–76.
22. Lu-Mei Dai#, Ri-Zhen Huang#, Bin Zhang, Jing Hua, Hai-Bing Liao, Heng-Shan Wang*, Dong Liang*. Three new triterpenoid saponins from the aerial parts of Lysimachia foenum-graecum. Phytochemistry Letters, 2017, 22, 133–137.
23. Wei-Na Yao#, Ri-Zhen Huang#, Jing Hua, Bin Zhang, Chun-Gu Wang, Dong Liang*, Heng-Shan Wang*. Selagintamarlin A: A Selaginellin Analogue Possessing a 1H?2-Benzopyran Core from Selaginella tamariscina. ACS Omega, 2017, 2, 2178–2183.
24. Huan Jiang, Gui-Jie Zhang, Yan-Fei Liu, Heng-Shan Wang, Dong Liang*. Clerodane Diterpenoid Glucosides from the Stems of Tinospora sinensis. Journal of Natural Products, 2017, 80, 975–982.
25. Lu-Mei Dai#, Ri-Zhen Huang#, Bin Zhang, Jing Hua, Heng-Shan Wang*, Dong Liang*. Cytotoxic triterpenoid saponins from Lysimachia foenum-graecum. Phytochemistry, 2017, 136, 165–174.
26. Bin Zhang#, Ri-Zhen Huang#, Jing Hua, Hong Liang, Ying-Ming Pan, Lu-Mei Dai, Dong Liang*, Heng-Shan Wang*. Antitumor lignanamides from the aerial parts of Corydalis saxicola. Phytomedicine, 2016, 23, 1599–1609.
27. Qi-Ming Pan#, Gui-Jie Zhang#, Ri-Zhen Huang, Ying-Ming Pan, Heng-Shan Wang, Dong Liang*. Cytisine-type alkaloids and flavonoids from the rhizomes of Sophora tonkinensis. Journal of Asian Natural Products Research, 2016, 18, 429–435.
28. Qi-Ming Pan, Yu-Huan Li, Jing Hua, Fu-Ping Huang, Heng-Shan Wang, Dong Liang*. Antiviral Matrine-Type Alkaloids from the Rhizomes of Sophora Tonkinensis. Journal of Natural Products, 2015, 78, 1683–1688.

发明专利：
1. 梁东, 张贵杰, 潘其明, 廖海兵. 蒲公英烷型三萜及其制备方法和用途. 中国发明专利, 授权号ZL8.5.
2. 梁东, 张贵杰, 潘其明, 廖海兵. 香豆素并木脂素及其制备方法和用途. 中国发明专利, 授权号ZL7.X.
3. 王恒山, 梁东, 姚维娜, 黄日镇, 王春姑, 潘英明, 张斌, 代禄梅. 一种含吡喃环酚类化合物及其制备方法和应用. 中国发明专利, 授权号ZL3.2.
4. 潘英明, 杨漓, 梁东. 治疗高尿酸血症的中药及其制备方法. 中国发明专利, 申请号6.9.
5. 梁东, 张贵杰, 胡峰, 潘英明. 铜钻抗炎成分的分离提取及其抗炎活性的测试. 中国发明专利, 授权号ZL2.1.
科研项目
1. 国家自然科学基金地区项目，瑶药山蒟和毛蒟中新木脂烷型小胶质细胞活化抑制剂的发现及其抗AD作用机制研究（**），2020/1-2023/12，34万元，在研，主持。
2. 国家自然科学基金地区项目，三种广西特色珍珠菜属植物中抗肿瘤三萜皂苷及其构效关系和作用机制研究（**），2015/1-2018/12，53万元，已结题，主持。
3. 国家自然科学基金青年项目，广西产定心藤属植物中新颖结构β-咔啉生物碱的发现及其抗肿瘤活性研究（**），2015/1-2017/12，24万元，已结题，主持。
4. 广西自然科学基金****项目，广西瑶药抗神经炎症天然产物化学（2017GXNSFFA198004），2017/9-2021/9，60万元，在研，主持。
5. 广西自然科学基金青年项目，两种珍珠菜属植物抗肿瘤活性成分及其构效关系的研究（2014GXNSFBA118042），2014/6-2017/5，5万元，已结题，主持。
获奖情况1. 广西第一批八桂青年****（天然药物化学）
2. 2017年度广西自然科学****基金获得者
3. 广西师范大学第五届教学新秀