删除或更新信息，请邮件至freekaoyan#163.com(#换成@)

广西医科大学药学院导师教师师资介绍简介-郭宏伟-导师简介

本站小编 Free考研考试/2021-06-13
郭宏伟，中药学博士，教授，药学院副院长，首批广西千名中青年骨干教师培育计划人选。中华中医药学会临床中药学分会青年委员，广西药学会常务理事、副秘书长。先后受国家留学基金委和广西教育厅资助公派至美国密歇根大学和澳大利亚墨尔本大学访问学习2年。现兼任“长寿与老年相关疾病”教育部重点实验室的项目负责人（PI），一直从事中药学和生药学相关的教学和科研工作，研究方向为中药抗肿瘤药理及网络药理学研究、靶向肿瘤干细胞药物研发等。作为项目负责人先后主持国家自然科学基金，中国博士后科学基金，广西科技开发项目，广西自然科学基金等科研课题15项。发表相关科研论文50篇，其中以第一或通讯作者发表论文27篇，SCI收录16篇（总IF 55.98），出版学术专著2部（副主编1部），参编教材2部，申请国家发明专利24项，已授权5项。目前担任国家自然科学基金、广西科技项目同行评议专家，《中国癌症防治杂志》第四届编辑委员会编委，Frontiers in pharmacology、Oncology Reports、Cancer Chemotherapy and Pharmacology等SCI杂志审稿人。

研究方向：
(1)中药抗肿瘤药理及网络药理学研究
(2)肿瘤干细胞机制及靶向肿瘤干细胞药物研发
(3)中药保健产品研发
科研项目
(1)国家自然科学基金地区项目（**），荔枝核总黄酮抑制前列腺癌生长及骨转移的分子机制，主持，在研。
(2)广西自然科学基金面上项目（2020GXNSFAA259030），基于网络药理学探讨雷公降压颗粒降血压的分子机制及有效成分群发现，主持，在研。
(3)广西自然科学基金联合资助培育项目（2018GXNSFAA294080），基于网络药理学的荔枝核调控乳腺癌干性与转移的效应物质及靶点网络，主持，在研。
(4)中国博士后科学基金面上项目（第58批），芒果苷对哮喘小鼠CD4+T细胞亚群的调控及机制，主持，已结题。
(5)广西自然科学基金面上项目（2015GXNSFAA139105），芒果苷对哮喘小鼠Th9、Treg和Th17 等T细胞亚群的调控及机制，主持，已结题。
(6)广西自然科学基金青年基金项目（2013GXNSFBA019177），芒果苷调控哮喘小鼠Th1/Th2细胞分化及其信号通路的研究，主持，已结题。
(7)广西科学研究与技术开发计划项目（桂科攻**-8），壮药配方雷公降压颗粒的研制，主持，已结题。
(8) 广西科学研究与技术开发计划项目（桂科转**-22），15个中药配方颗粒毒性品种的质量控制标准的研究，主持，已结题。
代表论著
(1)Sisi Cao#, Yaoyao Han#, Qiaofeng Li#, Yanjiang Chen, Dan Zhu, Zhiheng Su*, Hongwei Guo*. Mapping pharmalogical network of multi-targeting Litchi ingredients in cancer therapeutics. Frontiers in pharmacology, 2020, doi: 10.3389/fphar.2020.00451. (IF 3.85)
(2)Huimin Huang#, Jinxia Wu#, Rigang Lu#, Xi Liu, Bonnie Chin, Hongjia Zhu, Chunli Yin, Bang Cheng, Zheng Wu, Xiaojun Chen, Yonghong Liang, Hui Song, Hua Zheng*, Hongwei Guo*, Zhiheng Su*. Dynamic urinary metabolomics analysis based on UHPLC-Q-TOF/MS to investigate the potential biomarkers of blood stasis syndrome and the effects of Danggui Sini decoction. Journal of Pharmaceutical and Biomedical Analysis. 2020 Feb 5;179:112986. (IF: 2.983).
(3)Hongyan Zhu#, Weili Han#, Ye Gan, Qiaofeng Li, Xiaolan Li, Lanlan Shao, Dan Zhu*, Hongwei Guo*. Combined modality therapy based on hybrid gold nanostars coated with temperature sensitive liposomes to overcome paclitaxel-resistance in hepatic carcinoma. Pharmaceutics 2019 Dec 15; 11(12), 683. (IF: 4.773).
(4)Chun-li Yin#, Ri-gang Lu#, Jin-fang Zhu#, Hui-min Huang, Xi Liu, Qiao-feng Li, Yi-yi Mo, Hong-jia Zhu, Bonnie Chin, Jin-xia Wu, Xu-wen Liu, Bang Cheng, Jun-xiang Ruan,Yong-hong Liang, Hui Song, Hong-wei Guo*, Zhi-heng Su*, Hua Zheng*. The study of neuroprotective effect of ferulic acid based on cell metabolomics. European journal of pharmacology, 2019 Dec 1;864:172694. (IF: 3.17).
(5)Chenxia Yun#, Ming Chang#, Guanghan Hou#, Taijin Lan, Hebao Yuan, Zhiheng Su, Dan Zhu, Weiping Liang, Qiaofeng Li, Hongyan Zhu, Jian Zhang, Yi Lu*, Jiagang Deng*, Hongwei Guo*. Mangiferin suppresses allergic asthma symptoms by decreased Th9 and Th17 responses and increased Treg response. Molecular Immunology, 2019 Oct;114:233-242. (IF: 3.064).
(6)Xi Liu#, Hua Zheng#, Rigang Lu#, Huimin Huang, Hongjia Zhu, Chunli Yin, Yiyi Mo, Jinxia Wu, Xuwen Liu, Ming Deng, Danfeng Li, Bang Cheng, Fang Wu, Yonghong Liang, Hongwei Guo*, Hui Song*, Zhiheng Su*. Intervening Effects of Total Alkaloids of Corydalis saxicola Bunting on Rats With Antibiotic-Induced Gut Microbiota Dysbiosis Based on 16S rRNA Gene Sequencing and Untargeted Metabolomics Analyses. Frontiers in Microbiology. 2019 May 31;10:1151. (IF: 4.259).
(7)Jin-Xia Wu#, Hua Zheng#, Xia Yao#, Xu-Wen Liu, Hong-Jia Zhu, Chun-Li Yin, Xi Liu, Yi-Yi Mo, Hui-Min Huang, Bang Cheng, Fang Wu, Zhao-Ni Chen, Fang-Ming Song, Jun-Xiang Ruan, Hong-Ye Zhang, Ping Liu, Yong-Hong Liang, Hui Song, Hong-Wei Guo*, Zhi-Heng Su*. Comparative analysis of the compatibility effects of Danggui-Sini Decoction on a blood stasis syndrome rat model using untargeted metabolomics. Journal of Chromatography B, 15 January 2019, 1105:164-175. (IF: 2.813).
(8)Xu-Wen Liu#, Chao-Ling Tang#, Hua Zheng#, Jin-Xia Wu, Fang Wu, Yi-Yi Mo, Xi Liu, Bang Cheng, Hong-Jia Zhu, Chun-Li Yin, Bang Cheng, Jun-Xiang Ruan, Fang-Ming Song, Zhao-Ni Chen, Hui Song,Hong-Wei Guo*, Yong-Hong Liang*, Zhi-Heng Su*. Investigation of the hepatoprotective effect of Corydalis saxicola bunting on carbon tetrachloride-induced liver fibrosis in rats by 1H-NMR-based metabonomics and network pharmacology approaches. Journal of Pharmaceutical and Biomedical Analysis. 2018 Sep 10;159:252-261. (IF: 2.98)
(9)Bang Cheng, Hua Zheng, Fang Wu, Jinxia Wu,Xuwen Liu, Chaoling Tang, Shiyin Lu, Zhaoni Chen,Fangming Song, Junxiang Ruan, Hongye Zhang, Hui Song,Wei Liu, Hongwei Guo*, Yonghong Liang, Zhiheng Su. Metabolomics analysis of Danggui Sini decoction ontreatment of collagen-induced arthritis in rats. J Chromatogr B Analyt Technol Biomed Life Sci,2017 Jul 24;1061-1062:282-291. (IF:2.60).
(10)Hongwei Guo, Hua Luo, Hebao Yuan, Yudui Xia, Pan Shu, Xin Huang, Yi Lu,Xia Liu, Evan T. Keller, Duxin, Sun, Jiagang Deng, Jian Zhang. Litchi seed extracts diminish prostate cancer progression viainduction of apoptosis and attenuation of EMT throughAkt/GSK-3β signaling. Scientific Report,2017 Jan 30;7:41656. (IF:4.23).
(11)Hongwei Guo, Xiaolin Zhou, Yi Lu, Liye Xie, Qian Chen, Evan T. Keller, Qian Liu, Qinghua Zhou,Jian Zhang. Translational progress on tumor biomarkers. Thoracic Cancer. 2015 Nov;6(6):665-71. (IF:1.13)
(12)Hong-Wei Guo, Chen-Xia Yun, Guang-Han Hou, Jun Du, Xin Huang, Yi Lu, Evan T. Keller, Jian Zhang, Jia-Gang Deng.Mangiferin attenuates Th1/Th2 cytokine imbalance in an ovalbumin-induced asthmatic mouse model. PLoS One. 2014 Jun 23;9(6):e100394（IF:3.23）.
授权专利
(1)郭宏伟，张健，卢奕，夏玉对，罗花，一种防治前列腺癌的荔枝核提取物的制备方法及其应用，2014.10，中国，ZL 8.7
(2)郭宏伟、兰太进、罗雪菲、冯秋瑜、苏志恒、朱丹，壮药组合物的提取工艺及应用，2017.08，中国，ZL20**
(3)张健，郭宏伟，卢奕，黄昕，邹春林，具有治疗前列腺癌作用的火麻仁提取物及其制备方法和应用，2014.09，中国，ZL 5.9

联系方式
(1)邮箱：hwguo88@126.com
(2)办公电话：
(3)通讯地址：广西南宁市双拥路22号




相关话题/广西医科大学 药学院

Free考研考试FreeKaoYan.Com
欢迎来到Free考研考试，"为实现人生的Free而奋斗"

© 2020 FreeKaoYan! . All rights reserved.