姓名： 张哲
性别： 男
职称： 教授
研究方向： 主要从事头颈恶性肿瘤的临床诊疗和研究。研究领域集中于鼻咽癌的分子机制和病因。先后主持国家自然科学基金项目4项、中国科技部973前期研究专项1项、广西科学基金****基金1项及教育部重点课题1项及多项省部级课题。作为主要学术骨干参与国家973项目1项、美国 NIH项目1项。近年来在相关领域发表论文50余篇，参编英文专著

张哲，男，博士。2006年在广西医科大学获耳鼻咽喉头颈外科学博士。其后先后赴日本及瑞典Karolinska医学院从事访问****及博士后研究。现任广西医科大学第一附属医院耳鼻咽喉头颈外科教授、博士研究生生导师。主要从事头颈恶性肿瘤的临床诊疗和研究。研究领域集中于鼻咽癌的分子机制和病因。先后主持国家自然科学基金项目4项、中国科技部973前期研究专项1项、广西科学基金****基金1项及教育部重点课题1项及多项省部级课题。作为主要学术骨干参与国家973项目1项、美国NIH项目1项。近年来在相关领域发表论文50余篇，参编英文专著两部。2009年获得“中国医师协会耳鼻咽喉-头颈外科分会优秀青年医师奖”。2013年入选国家教育部新世纪优秀人才支持计划。曾任中华医学会耳鼻咽喉头颈外科学会青年委员。现任中华医学会耳鼻咽喉头颈外科学会嗓音组委员、中国抗癌协会鼻咽癌专业委员会委员、中国病理生理学会肿瘤学分会青年委员、中国抗癌协会肿瘤标志物专业委员会鼻咽癌专家委员会副主任委员、广西医学会耳鼻咽喉头颈外科学分会常委兼学会秘书、青年委员会副主任委员。

Selectedpublications：

1.ZhengS,MatskovaL,ZhouX,XiaoX,HuangG,ZhangZ,ErnbergI:DownregulationofadiposetriglyceridelipasebyEBviral-encodedLMP2Alinkslipidaccumulationtoincreasedmigrationinnasopharyngealcarcinoma.MolOncol2020.2020Dec;14(12):3234-3252.IF=9.5
2.DebeliusJW,HuangT,CaiY,PlonerA,BarrettD,ZhouX,XiaoX,LiY,LiaoJ,ZhengY,HuangG,AdamiHO,ZengY,ZhangZ,YeW:SubspeciesNicheSpecializationintheOralMicrobiomeIsAssociatedwithNasopharyngealCarcinomaRisk.mSystems2020,5(4).IF=6.633
3.LiB,LiaoZ,MoY,ZhaoW,ZhouX,XiaoX,CuiW,FengG,ZhongS,LiangY,DuC,HuangG,LiP,XiaoX,ZhouX,WangR,ZhangZ:Inactivationof3-hydroxybutyratedehydrogenasetype2promotesproliferationandmetastasisofnasopharyngealcarcinomabyironretention.BrJCancer2020,122(1):102-110.IF=5.784
4.FengG,QinL,LiaoZ,XiaoX,LiB,CuiW,LiangL,MoY,HuangG,LiP,ZhouX,ZhangZ,XiaoX:KnockdownRab11-FIP2inhibitsmigrationandinvasionofnasopharyngealcarcinomaviasuppressingRhoGTPasesignaling.JCellBiochem2020,121(2):1072-1086.IF=3.918
5.ZhouX,ZhaoW,ChenY,ZhangZ:Patient-derivedtumormodelsforhumannasopharyngealcarcinoma.Enzymes2019,46:81-96.
6.XuM,ZhangWL,ZhuQ,ZhangS,YaoYY,XiangT,FengQS,ZhangZ,PengRJ,JiaWH,HeGP,FengL,ZengZL,LuoB,XuRH,ZengMS,ZhaoWL,ChenSJ,ZengYX,JiaoY.Genome-wideprofilingofEpstein-BarrvirusintegrationbytargetedsequencinginEpstein-Barrvirusassociatedmalignancies.Theranostics2019;9:1115-1124.IF=8.537
7.FengRM,ChangET,LiuZ,LiuQ,CaiY,ZhangZ,ChenG,HuangQH,XieSH,CaoSM,ZhangY,YunJ,JiaWH,ZhengY,LiaoJ,ChenY,LinL,ErnbergI,HuangG,ZengY,ZengYX,AdamiHO,etal.Reproductivehistoryandriskofnasopharyngealcarcinoma:Apopulation-basedcase-controlstudyinsouthernChina.OralOncol.2019Jan;88:102-108.IF=4.636
8.FengR,ChangET,LiuZ,LiuQ,CaiY,ZhangZ,ChenG,HuangQH,XieSH,CaoSM,ZhangY,YunJ,JiaWH,ZhengY,LiaoJ,ChenY,LinL,ErnbergI,HuangG,ZengY,ZengYX,AdamiHO,etal.Bodymassindex,bodyshape,andriskofnasopharyngealcarcinoma:Apopulation-basedcase-controlstudyinSouthernChina.CancerMed.2019Feb21.IF=3.202
9.LiangY,FengG,WuL,ZhongS,GaoX,TongY,CuiW,QinY,XuWQ,XiaoX,ZhangZ,HuangG,ZhouX.CaffeicacidphenethylestersuppressedgrowthandmetastasisofnasopharyngealcarcinomacellsbyinactivatingtheNF-κBpathway.DrugDesign,DevelopmentandTherapy2019:13:1335-1345.IF=2.935
10.YeJ,HuangJ,HeQ,ZhaoW,ZhouX,ZhangZ,LiY,WeiJ,ZhangJ.Blockageofstore-operatedCa(2+)entryantagonizesEpstein-Barrvirus-promotedangiogenesisbyinhibitingCa(2+)signaling-regulatedVEGFproductioninnasopharyngealcarcinoma.CancerManagRes.2018May10;10:1115-1124.IF=3.702
11.XiaoX,ZhangZ*,ChangET,LiuZ,LiuQ,CaiY,ChenG,HuangQH,XieSH,CaoSM,ShaoJY,JiaWH,ZhengY,LiaoJ,ChenY,LinL,ErnbergI,HuangG,ZengY,ZengYX,AdamiHO,YeW.MedicalHistory,MedicationUse,andRiskofNasopharyngealCarcinoma.AmJEpidemiol.2018Oct1;187(10):2117-2125.IF=4.322
12.HeF,MaN,MidorikawaK,HirakuY,OikawaS,ZhangZ,HuangG,TakeuchiK,MurataM.Taurineexhibitsanapoptosis-inducingeffectonhumannasopharyngealcarcinomacellsthroughPTEN/Aktpathwaysinvitro.AminoAcids.2018Dec;50(12):1749-1758.IF=2.906
13.ChenY,XuY,ZhaoW,XiaoX,ZhouX,LinL,HuangT,LiaoJ,LiY,ZengX,HuangG,YeW,ZhangZ*.LackofassociationbetweencigarettesmokingandEpsteinBarrvirusreactivationinthenasopharynxinpeoplewithelevatedEBVIgAantibodytitres.BMCCancer.2018Feb14;18(1):190.IF=3.288
14.ZhaoW,MoY,WangS,MidorikawaK,MaN,HirakuY,OikawaS,HuangG,ZhangZ,MurataM,TakeuchiK.QuantitationofDNAmethylationinEpstein-Barrvirus-associatednasopharyngealcarcinomabybisulfiteampliconsequencing.BMCCancer.2017Jul17;17(1):489.IF=3.288
15.ZhaoW,MaN,WangS,MoY,ZhangZ,HuangG,MidorikawaK,HirakuY,OikawaS,MurataM,TakeuchiK.RERGsuppressescellproliferation,migrationandangiogenesisthroughERK/NF-κBsignalingpathwayinnasopharyngealcarcinoma.JExpClinCancerRes.2017Jun28;36(1):88.IF=6.217
16.LuoW,QinL,LiB,LiaoZ,LiangJ,XiaoX,XiaoX,MoY,HuangG,ZhangZ,ZhouX,LiP.InactivationofHMGCLpromotesproliferationandmetastasisofnasopharyngealcarcinomabysuppressingoxidativestress.SciRep.2017Sep20;7(1):11954.IF=4.122
17.YeW,ChangET,LiuZ,LiuQ,CaiY,ZhangZ,ChenG,HuangQH,XieSH,CaoSM,ShaoJY,JiaWH,ZhengY,LiaoJ,ChenY,LinL,LiangL,ErnbergI,VaughanTL,HuangG,ZengY,ZengYX,etal.Developmentofapopulation-basedcancercase-controlstudyinsouthernchina.Oncotarget.2017Jul29;8(50):87073-87085.IF=5.168
18.LiuZ,ChangET,LiuQ,CaiY,ZhangZ,ChenG,HuangQH,XieSH,CaoSM,ShaoJY,JiaWH,ZhengY,LiaoJ,ChenY,LinL,LiangL,ErnbergI,VaughanTL,AdamiHO,HuangG,ZengY,ZengYX,etal.Quantificationoffamilialriskofnasopharyngealcarcinomainahigh-incidencearea.Cancer.2017Jul15;123(14):2716-2725.IF=3.519
19.LiangJ,ZhengS,XiaoX,WeiJ,ZhangZ,ErnbergI,MatskovaL,HuangG,ZhouX.Epstein-Barrvirus-encodedLMP2AstimulatesmigrationofnasopharyngealcarcinomacellsviatheEGFR/Ca2+/calpain/ITGβ4axis.BiolOpen.2017Jun15;6(6):914-922.IF=2.217
20.ChangET,LiuZ,HildesheimA,LiuQ,CaiY,ZhangZ,ChenG,XieSH,CaoSM,ShaoJY,JiaWH,ZhengY,LiaoJ,ChenY,LinL,ErnbergI,VaughanTL,AdamiHO,HuangG,ZengY,ZengYX,YeW.ActiveandPassiveSmokingandRiskofNasopharyngealCarcinoma:APopulation-BasedCase-ControlStudyinSouthernChina.AmJEpidemiol.2017Jun20;185(12):1272-1280.IF=4.322
21.WangS,MaN,ZhaoW,MidorikawaK,KawanishiS,HirakuY,OikawaS,ZhangZ,HuangG,MurataM.Inflammation-RelatedDNADamageandCancerStemCellMarkersinNasopharyngealCarcinoma.MediatorsInflamm.2016;2016:**.IF=3.549
22.ZhouX,XiaoX,HuangT,DuC,WangS,MoY,MaN,MurataM,LiB,WenW,HuangG,ZengX,ZhangZ*.Epigeneticinactivationoffollistatin-like1mediatestumorimmuneevasioninnasopharyngealcarcinoma.Oncotarget.2016Mar29;7(13):16433-44.IF=5.008
23.HeF,WeiL,LuoW,LiaoZ,LiB,ZhouX,XiaoX,YouJ,ChenY,ZhengS,LiP,MurataM,HuangG,ZhangZ*.Glutaredoxin3promotesnasopharyngealcarcinomagrowthandmetastasisviaEGFR/AktpathwayandindependentofROS.Oncotarget.2016Jun14;7(24):37000-37012.IF=5.008
24.LiuZ,ChangET,LiuQ,CaiY,ZhangZ,ChenG,XieSH,CaoSM,ShaoJY,JiaWH,ZhengY,LiaoJ,ChenY,ErnbergI,VaughanTL,AdamiHO,HuangG,ZengY,ZengYX,YeW.OralHygieneandRiskofNasopharyngealCarcinoma-APopulation-BasedCase-ControlStudyinChina.CancerEpidemiolBiomarkersPrev.2016Aug;25(8):1201-7.IF=4.554
25.WangH,WuS,HuangS,YinS,ZouG,HuangK,ZhangZ,TangA,WenW.Follistatin-likeprotein1contributestodendriticcellandT-lymphocyteactivationinnasopharyngealcarcinomapatientsbyalteringnuclearfactorκbandJunN-terminalkinaseexpression.CellBiochemFunct.2016Dec;34(8):554-562.IF=2.186
26.SongY,ZhangZ,TanX,JiangY,GaoJ,LinL,WangZ,RenJ,WangX,QinL,ChengW,QiJ,KuaiB.Associationofthemolecularregulationofearleafsenescence/stressresponseandphotosynthesis/metabolismwithheterosisatthereproductivestageinmaize.SciRep.2016Jul20;6:29843.IF=4.122
27.22.ZhouX,WeiJ,ChenF,XiaoX,HuangT,HeQ,WangS,DuC,MoY,LinL,XieY,WeiL,LanY,MurataM,HuangG,ErnbergI,MatskovaL,ZhangZ.EpigeneticdownregulationoftheISG15-conjugatingenzymeUbcH8impairslipolysisandcorrelateswithpoorprognosisinnasopharyngealcarcinoma.Oncotarget.2015Dec1;6(38):41077-91.IF=6.359通讯
28.23.ZhuY,ZouC,ZhangZ,QianCN,YangX,ShiJ,XiaY,ZhangJ,LuY.MEKinhibitordiminishesnasopharyngealcarcinoma(NPC)cellgrowthandNPC-inducedosteoclastogenesisviamodulatingCCL2andCXCL16expressions.TumourBiol.2015Nov;36(11):8811-8.IF=2.926
29.24.ZhangJ,WeiJ,HeQ,LinY,LiangR,YeJ,ZhangZ,LiY.SKF95365inducesapoptosisandcell-cyclearrestbydisturbingoncogenicCa(2+)signalinginnasopharyngealcarcinomacells.OncoTargetsTher.2015Oct27;8:3123-33.IF=2.656
30.25.XiaoX,ZhouX,MingH,ZhangJ,HuangG,ZhangZ*,LiP.ChickChorioallantoicMembraneAssay:A3DAnimalModelforStudyofHumanNasopharyngealCarcinoma.PLoSOne.2015Jun24;10(6):e**.IF=2.766
31.WeiJ,ZhangJ,SiY,KanadaM,ZhangZ,TerakawaS,WatanabeH.BlockageofLMP1-modulatedstore-operatedCa(2+)entryreducesmetastaticpotentialinnasopharyngealcarcinomacell.CancerLett.2015May1;360(2):234-44.IF=6.491
32.NawazI,MoumadK,MartorelliD,EnnajiMM,ZhouX,ZhangZ,DolcettiR,KhyattiM,ErnbergI,HuLF.DetectionofnasopharyngealcarcinomainMorocco(NorthAfrica)usingamultiplexmethylation-specificPCRbiomarkerassay.ClinEpigenetics.2015Aug22;7:89.IF=6.091
33.MingH,LanY,HeF,XiaoX,ZhouX,ZhangZ,LiP,HuangG.Cytochromeb5reductase2suppressestumorformationinnasopharyngealcarcinomabyattenuatingangiogenesis.ChinJCancer.2015Aug15;34(10):459-67.IF=3.822
34.ChenY,ZhaoW,LinL,XiaoX,ZhouX,MingH,HuangT,LiaoJ,LiY,ZengX,HuangG,YeW,ZhangZ.NasopharyngealEpstein-BarrVirusLoad:AnEfficientSupplementaryMethodforPopulation-BasedNasopharyngealCarcinomaScreening.PLoSOne.2015Jul7;10(7):e**.IF=2.766通讯
35.WangS,MoY,MidorikawaK,ZhangZ,HuangG,MaN,ZhaoW,HirakuY,OikawaS,MurataM.ThepotenttumorsuppressormiR-497inhibitscancerphenotypesinnasopharyngealcarcinomabytargetingANLNandHSPA4L.Oncotarget.2015Nov3;6(34):35893-907.IF=6.359
36.XiaoX,ZhaoW,TianF,ZhouX,ZhangJ,HuangT,HouB,DuC,WangS,MoY,YuN,ZhouS,YouJ,ZhangZ,HuangG,ZengX.Cytochromeb5reductase2isanovelcandidatetumorsuppressorgenefrequentlyinactivatedbypromoterhypermethylationinhumannasopharyngealcarcinoma.TumourBiol.2014Apr;35(4):3755-63.IF=2.926
37.WangS,MaN,KawanishiS,HirakuY,OikawaS,XieY,ZhangZ,HuangG,MurataM.Relationshipsofalpha-SMA-positivefibroblastsandSDF-1-positivetumorcellswithneoangiogenesisinnasopharyngealcarcinoma.BiomedResInt.2014;2014:507353.IF=2.583
38.ZhangZ,SunD,HutajuluSH,NawazI,NguyenVanD,HuangG,HaryanaSM,MiddeldorpJM,ErnbergI,HuLF.Developmentofanon-invasivemethod,multiplexmethylationspecificPCR(MMSP),forearlydiagnosisofnasopharyngealcarcinomaPloSone.2012;7(11):e45908IF=2.766
39.HuQ,ZhuSY,ZhangZ,LuoF,MaoYP,GuanXH.Assessmentofglotticsquamouscellcarcinoma:comparisonofsonographyandnon-contrast-enhancedmagneticresonanceimaging.JUltrasoundMed.2011Nov;30(11):1467-74.IF=1.53
40.HeQ,WeiJ,ZhangJ,JiangH,WangS,ZhouX,ZhangZ,HuangG,WatanabeH,SuJ.Aberrantmethylationofsecretedprotein,acidicandrichincysteineinhumanlaryngealandhypopharyngealcarcinoma.OncolLett.2011Jul;2(4):725-729.Epub2011May5.IF=1.664
41.DuC,HuangT,SunD,MoY,FengH,ZhouX,XiaoX,YuN,HouB,HuangG,ErnbergI,ZhangZ*.CDH4asanovelputativetumorsuppressorgeneepigeneticallysilencedbypromoterhypermethylationinnasopharyngealcarcinoma.CancerLett.2011Oct1;309(1):54-61.IF=6.491
42.ChenF,MoY,DingH,XiaoX,WangSY,HuangG,ZhangZ*,WangSZ.FrequentepigeneticinactivationofMyocardininhumannasopharyngealcarcinoma.Head&neck.2011;33(1):54-59IF=2.641
43.WangS,XiaoX,ZhouX,HuangT,DuC,YuN,MoY,LinL,ZhangJ,MaN,MurataM,HuangG,ZhangZ*.TFPI-2isaputativetumorsuppressorgenefrequentlyinactivatedbypromoterhypermethylationinnasopharyngealcarcinoma.BMCCancer.2010Nov9;10:617.IF=3.288
44.XieY,WeiZB,ZhangZ,WenW,HuangGW.Effectof5-ALA-PDTonVEGFandPCNAexpressioninhumanNPC-bearingnudemice.OncolRep.2009Dec;22(6):1365-71.IF=2.976
45.ZhangZ,SunD,VandoN,TangA,HuL,HuangG.InactivationofRASSF2Abypromotermethylationcorrelateswithlymphnodemetastasisinnasopharyngealcarcinoma.IntJCancer.2007Jan1;120(1):32-8.IF=7.36
46.SunD1,ZhangZ,VandoN,HuangG,ErnbergI,HuL.AberrantmethylationofCDH13geneinnasopharyngealcarcinomacouldserveasapotentialdiagnosticbiomarkerOraloncology.2007;43(1):82-87.IF=4.636