姓名：林兴
性别：男
职称：副教授
研究方向：肝纤维化靶向诊断和治疗研究

林兴
副教授，硕士研究生导师，现任广西医科大学医学科学实验中心大仪办主任。主攻研究方向：肝炎、肝纤维化靶向诊断和治疗研究。科研课题：承担国家自然科学基金项目2项、广西自然科学基金课题3项、广西教育厅面上项目2项。科研成果：获得广西自然科学奖二等奖1项（排名第2）、广西科技进步奖三等奖1项（排名第3）、中国药学会科技奖三等奖1项（排名第3）。发明专利：获得授权发明专利2件。发表科研论文105篇：SCI论文30篇（总的影响因子67.377），其中，第一作者或通讯作者SCI论文16篇（影响因子为42.808）；中文核心期刊论文76篇，其中，第一作者或通讯作者25篇。目前是SCI杂志《AntiviralResearch》、《FoodandChemicalToxicology》和《JournalofEthnopharmacology》论文评审专家。

联系方式：Email:gxLx60@163.com，QQ:22038146，电话：**（办），手机：**,**

一、承担的科研课题（目前研究经费总计：119万元）：

1.2013.1-2016.12，Raf激酶抑制蛋白在肝纤维化发生机制中的调控作用，55万元（国家自然科学基金，编号81260505）

2.2013.1-2016.12，满天星异荭草苷对肝纤维化NF-κB信号通路的干预作用及其机制研究，49万元（国家自然科学基金，编号81260674）

3.2013.4-2016.3，基于Raf-1/MEK/ERK1,2信号通路研究RKIP在肝纤维化中的调控作用，5万元（广西自然科学基金，编号2013GXNSFAA019150）
4.2011.12-2014.11，山芝麻酸甲酯对免疫性肝纤维化大鼠NF-κB的干预作用，5万元（广西自然科学基金，编号KFJJ2011-37）
3.2013.04-2016.03，满天星异荭草苷对肝纤维化NF-κB信号通路的干预的初探，5万元（广西自然科学基金，编号2013GXNSFAA019146）。
二、发明专利
1.林兴,何敏,黄权芳,廖明,黄仁彬,张士军.山芝麻提取物在制备抗肝纤维化药物中的应用，授权专利号：ZL**7.6
2.林兴,何敏,黄权芳,廖明,黄仁彬,张士军.山芝麻提取物在制备抗乙型肝炎药物中的应用，授权专利号：ZL**3.3

三、SCI论文（“*”为通讯作者）：

1.HuangQF,HuangRB,WeiL,ChenY,LvS,LiangC,ZhangX,YinF,LiHT,ZhuoL,LinX*.AntiviralactivityofmethylhelicterateisolatedfromHelicteresangustifolia(Sterculiaceae)againsthepatitisBvirus.Antiviralresearch.100(2):373-381,2013(IF3.925)

2.HuangJC,TangXJ,LiangX,WenQ,ZhangSJ,XuanF,JianJ,LinX,HuangRB.Theeffectsof17-methoxyl-7-hydroxy-benzene-furanchalconeonthepressureoverload-inducedprogressionofcardiachypertrophytocardiacfailure.PLOSONE,2014（Accepted,IF3.73）

3.LinX,HuangZ,ChenX,RongY,ZhangSJ,JiaoY,HuangQF,HuangRB.ProtectiveeffectofMillettiapulchrapolysaccharideoncognitiveimpairmentinducedbyd-galactoseinmice.Carbohydratepolymers.101:533-543,2014(IF3.479)

4.HuangQF,HuangRB,ZhangZJ,LinJ,WeiL,HeM,ZhuoL,LinX*.ProtectiveeffectofgenisteinisolatedfromHydrocotylesibthorpioidesonhepaticinjuryandfibrosisinducedbychronicalcoholinrats.ToxicologyLetters.217(2):102-110,2013(IF3.145)

5.ZhengN,LinX,WenQ,ZhangSJ,HuangJ,XuX,HuangRB.Effectof2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione,isolatedfromAverrhoacarambolaL.(Oxalidaceae)roots,onadvancedglycationend-product-mediatedrenalinjuryintype2diabeticKKAymice.Toxicologyletters.219(1):77-84,2013（IF3.145）

6.HuangQF,ZhangSJ,ZhengL,LiaoM,HeM,HuangRB,ZhuoL,LinX*.Protectiveeffectofisoorientin-2″-O-α-L-arabinopyranosylisolatedfromGypsophilaelegansonalcoholinducedhepaticfibrosisinrats.Foodandchemicaltoxicology.50(6):1992-2001,2012(IF3.010)

7.HuangQF,ZhangSJ,ZhengL,HeM,HuangR.B,LinX*.HepatoprotectiveeffectsofTotalSaponinsIsolatedfromTaraphochlamysaffinisagainstcarbontetrachlorideinducedliverinjuryinrats.Foodandchemicaltoxicology.50,713-718,2012(IF3.010)

8.LinX,HuangRB,ZhangSJ,ZhengL,WeiL,HeM,ZhouY,ZhuoL,HuangQF.MethylhelicterateprotectsagainstCCl4-inducedliverinjuryinratsbyinhibitingoxidativestress,NF-κBactivation，Fas/FasLpathwayandcytochromeP4502E1level.Foodandchemicaltoxicology.50(10):3413-3420,2012(IF3.010)

9.HeM,ZhangSJ,JiaoY,LinX,HuangJ,ChenC,ChenZN,HuangRB.Effectsandmechanismsofrifampinonhepatotoxicityofacetaminopheninmice.Foodandchemicaltoxicology.50(9):3142-3149,2012(IF3.010）

10.Chen1ZN,Lin1X,ZhangZ.W,HuangJC,FuSJ,HuangRB.EXO70proteininfluencesdenguevirussecretion.MicrobesandInfection,13(2):143-150,2011(IF2.920，并列第一作者）

11.HuangQF,ZhangSJ,HuangRB,WeiL,ChenY,LvS,LiangC,TanS,ZhuoL,LinX*.Isolationandidentificationofananti-hepatitisBviruscompoundfromHydrocotylesibthorpioidesLam.Journalofethnopharmacology.150(2):568-575,2013(IF2.755)

12.HuangQF,LiYW,ZhangSJ,HuangRB,ZhengL,WeiL,HeM,LiaoM,LiL,ZhuoL,LinX*.EffectandmechanismofmethylhelicterateisolatedfromHelicteresangustifolia(Sterculiaceae)onhepaticfibrosisinducedbycarbontetrachlorideinrats.JournalofEthnopharmacology.143(3):889-895,2012(IF2.755)

13.LinX,ZhangSJ,HuangQF,WeiL,ZhengL,ChenZ.N,JiaoY,HuangJC,FuSJ,HuangR.B.ProtectiveeffectofFufang-Liu-Yue-Qing，atraditionalChineseherbalformula，onCCl4inducedliverfibrosisinrats.JournalofEthnopharmacology.142(2):548-56,2012(IF2.755)

14.DongY,HuangJ,LinX,ZhangSJ,JiaoY,LiangT,ChenZ,HuangRB.HepatoprotectiveeffectsofYulangsanpolysaccharideagainstisoniazidandrifampicin-inducedliverinjuryinmice.Journalofethnopharmacology.15(1):201-206,2014（IF2.755）

15.LinX,ZhangSJ,HuangRB,TanS,LiangS,WuX,ZhuoL,HuangQF.ProtectiveeffectoftormenticacidfromPotentillachinensisagainstlipopolysaccharide/D-galactosamineinducedfulminanthepaticfailureinmice.InternationalImmunopharmacology,http://dx.doi.org/10.1016/j.intimp.2014.02.009,2014(IF2.417)

16.LiY,LuoY,ZhangX,LinX,HeM,LiaoM.CombinedTaurine,EpigallocatechinGallateandGenisteinTherapyReducesHSC-T6CellProliferationandModulatestheExpressionofFibrogenicFactors.Internationaljournalofmolecularsciences.14(10):20543-20554,2013(IF2.464）

17.LinX,HuangRB,ZhangSJ,WeiL,ZhuoL,WuX,TangA,HuangQF.Beneficialeffectsofasiaticosideoncognitivedeficitsinsenescence-acceleratedmice.Fitoterapia.87:69-77,2013(IF2.231)

18.LiangX,HuangJ,LinX,QinF,WenQ,ChenC,LiY,GeW,HuangRB.TheEffectof17-Methoxyl-7-Hydroxy-Benzene-FuranchalconeonNF-κBandtheInflammatoryResponseDuringMyocardialIschemiaReperfusionInjuryinRats.Journalofcardiovascularpharmacology.63(1):68-75,2014（IF2.383）

19.WenQ,LinX,LiuY,XuX,LiangT,ZhengN,HuangRB.PhenolicandLignanGlycosidesfromtheButanolExtractofAverrhoacarambolaL.Root.Molecules.17(10):12330-12340,2012(IF2.428）

20.LiR,LiangT,ChenZ,ZhangSJ,LinX,HuangRB.l-Dopamethylesterattenuatesamblyopia-inducedneuronalinjuryinvisualcortexofamblyopiccat.Gene.527(1):115-122,2013（IF2.196）

21.LinX,ZhangSJ,HuangRB,WeiL,LiangC,ChenY,LvS,LiangS,WuX,HuangQF.ProtectiveEffectofGenisteinonLipopolysaccharide/D-galactosamine-inducedHepaticFailureinMice.Biologicalandpharmaceuticalbulletin.37(4):1-8,2014(IF1.849）

22.WeiJ,HuangQF,HuangRB,ChenY,LvS,WeiL,LiangC,LiangS,ZhuoL,LinX*.AsiaticacidfromPotentillachinensisattenuateethanol-inducedhepaticinjuryviasuppressionofoxidativestressandKupffercellactivation.Biological&pharmaceuticalbulletin.36(12):1980-1989,2013(IF1.849）

23.ZhuoL,MingM,ZhengL,HeM,HuangQF,WeiL,HuangRB,ZhangZJ,LinX*.Combinationtherapywithtaurine，epigallocatechingallateandgenisteinforprotectionagainsthepaticfibrosisinducedbyalcoholinrats.BiologicalandPharmaceuticalBulletin.35(10),1802-1810,2012(IF1.849）

24.LinX,LiuX,HuangQF,ZhangSJ,ZhengL,WeiL,HeM,JiaoY,HuangJC,FuSJ,ChenZN,LiYW,ZhuoL,HuangRB.HepatoprotectiveeffectsofthepolysaccharideisolatedfromTarphochlamysaffinis(Acanthaceae)againstCCl4-inducedhepaticinjury.BiologicalandPharmaceuticalBulletin.35(9),1574-1580,2012(IF1.849）

25.ZhouXL,WenQW,LinX,ZhangSJ,LiYX,GuoYJ,HuangRB.Anewphenylethanoidglycosidewithantioxidantandanti-HBVactivityfromTarphochlamysaffinis.Archivesofpharmacalresearch.1-6,2013(IF1.538）

26.LiuL,FanH,QiP,MeiY,ZhouL,CaiL,LinX,LinJ.SynthesisandhepatoprotectivepropertiesofAcanthusilicifoliusalkaloidAanditsderivatives.Experimentalandtherapeuticmedicine.6(3):796-802,2013（IF0.344）

27.LiangS,HuangRB,LinX,HuangJC,HuangZS,LiuHG.EffectsofYulangsanpolysaccharideonmonoamineneurotransmitters,adenylatecyclaseactivityandbrain-derivedneurotrophicfactorexpressioninamousemodelofdepressioninducedbyunpredictablechronicmildstress.NeuralRegenerationResearch(NRR),7(3):191-196,2012（IF0.144）

28.LiYW,LinX,ZhangSJ,LiR,JiangWZ,HuangRB.Levodopamethylesterincreasesnervegrowthfactorexpressioninvisualcortexarea17infelinemodelofstrabismicamblyopia.NeuralRegenerationResearch(NRR),6(26):2026-2031,2011（IF0.144）

29.YangZ,HuangRB,HuangJC,ZhangSJ,LinX,JiaoY,JiangWZ.Sidimingattenuatesmorphinewithdrawalsyndromeandnitricoxide(synthase)levelsinmorphine-dependentratsandrhesusmonkeys.NeuralRegenerationResearch(NRR),6(33):2589-2593,2011（IF0.144）

30.HuangZS,ZhangSJ,XieHY,LinX,JiangWZ,HuangRB.Keygeneandproteinchangesintheβ-amyloidpathwayfollowingLongyanshenpolysaccharidetreatmentinamousemodelofAlzheimer’sdisease.NeuralRegenerationResearch(NRR),4(10):756-762,2009（IF0.144）