姓名： 张艳菊
无 女 计算机科学技术系 邮箱:yanjuzhang@guet.edu.cn





研究领域数据挖掘、机器学习、深度学习;生物信息学、精准医疗、医疗信息学;;
个人简介

张艳菊，博士，研究员。2003-2005年在德国德累斯顿工业大学取得分子生物工程硕士学位；2006-2011年在荷兰莱顿大学高级计算机学院图像和生物信息组获得博士学位；之后在莱顿大学医学中心从事博士后以及研究员的工作，主要研究方向为生物信息学。以第一完成人或主要参与者的身份完成了多项荷兰国家级科研项目。2015年作为海外高层次引进人才就职于桂林电子科技大学计算机科学与工程学院。


在Nature Communications，Bioinformatics等国际顶级期刊上发表多篇论文。其中，以第一作者身份发表论文9篇，最高影响因子8.99；合作论文10篇，最高影响因子10.7。于2010年获得欧洲科学基金“功能基因组学研究前沿(FFG)”的奖励。2015年广西壮族自治区“****”海外高层次引进人才。2019年被评选为广西第一批高层次人才E层次人才。

领导独立科研课题小组，实验室面积40m2。近年来，主持国家自然科学基金1项、广西自然科学基金2项。并指导研究生10名，其中3人已获学位，1人获得校级优秀论文。

主要研究方向：
高通量基因测序技术算法开发
机器学习、深度学习和数据挖掘算法的研究
使用机器学习进行生物模式挖掘
高效算法软件的研发
异构数据整合以及数据压缩算法的研究
利用生物信息学方法解释生物表现类型的多样性，以及引起病理变化的原因

教育背景


工作经历

主要荣誉

2010年获得欧洲科学基金“功能基因组学研究前沿(FFG)”的奖励。
2015年广西壮族自治区“****”海外高层次引进人才。
2019年被评选为广西第一批高层次人才E层次人才。

学术活动

教学信息

主要论文 Ruopeng Xie, Jiahui Li, Jiawei Wang, Wei Dai, André Leier, Tatiana T Marquez-Lago, Tatsuya Akutsu, Trevor Lithgow, Jiangning Song,Yanju Zhang. DeepVF: a deep learning-based hybrid framework for identifying virulence factors using the stacking strategy, Briefings in Bioinformatics, June 2020 https://doi.org/10.1093/bib/bbaa12
Yanju Zhang, Sha Yu, Ruopeng Xie, Jiahui Li, André Leier, Tatiana T Marquez-Lago, Tatsuya Akutsu, A. Ian Smith, Zongyuan Ge, Jiawei Wang, Trevor Lithgow, Jiangning Song; PeNGaRoo, a combined gradient boosting and ensemble learning framework for predicting non-classical secreted proteins, Bioinformatics, Volume 36, Issue 3, 1 February 2020, Pages 704–712, https://doi.org/10.1093/bioinformatics/btz629
Yanju Zhang, Ruopeng Xie, Jiawei Wang, André Leier, Tatiana T Marquez-Lago, Tatsuya Akutsu, Geoffrey I Webb, Kuo-Chen Chou, Jiangning Song; Computational analysis and prediction of lysine malonylation sites by exploiting informative features in an integrative machine-learning framework, Briefings in Bioinformatics, bby079, Aug 2018, https://doi.org/10.1093/bib/bby079
Yanju Zhang, Eric-Wubbo Lameijer, Peter A. C. 't Hoen, Zemin Ning, P. Eline Slagboom, Kai Ye: PASSion: a pattern growth algorithm-based pipeline for splice junction detection in paired-end RNA-Seq data. Bioinformatics 28(4): 479-486 (2012).
Yanju Zhang, Elia Stupka, Christiaan V. Henkel, Hans J. Jansen, Herman P. Spaink and Fons J. Verbeek. Identi？cation of Common Carp Innate Immune Genes with Whole-Genome Sequencing and RNA-Seq Data. Journal of Integrative Bioinformatics, 8(2):169, 2011. Online Journal: http://journal.imbio.de/index.php?paper id=169.
Yanju Zhang and Fons J. Verbeek. Comparison and Integration of Target Prediction Algorithms for microRNA Studies. Journal of Integrative Bioinformatics, 7(3):127, 2010. Online Journal: http://journal.imbio.de/index.php?paper id=127.
Yanju Zhang, Joost M. Woltering, Fons J. Verbeek. Screen of microRNA targets in zebra？sh using heterogeneous data sources: a case study for dre-miR-10 and dre-miR-196. International Journal of Mathematical, Physical and Engineering Sciences, Vol. 2 (1), 10-17, 2007.
Jiawei Wang, Bingjiao Yang, André Leier, Tatiana T Marquez-Lago, Morihiro Hayashida, Andrea Rocker, Yanju Zhang, Tatsuya Akutsu, Kuo-Chen Chou, Richard A Strugnell, Jiangning Song, Trevor Lithgow; Bastion6: a bioinformatics approach for accurate prediction of type VI secreted effectors, Bioinformatics, Volume 34, Issue 15, 1 August 2018, Pages 2546–2555, https://doi.org/10.1093/bioinformatics/bty155
Shengtao Xu，Guangyu Wang，Yan Lin，Yanju Zhang，Lingling Pei，Hong Yao，Mei Hu，Yangyi Qiu，Zhangjian Huang，Yihua Zhang，Jinyi Xu. Novel anticancer oridonin derivatives possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: Design, synthesis, biological evaluation and nitric oxide release studies. Bioorganic & Medicinal Chemistry Letters, 2016/4/24.
Tobi EW, Goeman JJ, Monajemi R, Gu H, Putter H, Zhang Y, Slieker RC, Stok AP, Thijssen PE, Müller F, van Zwet EW, Bock C, Meissner A, Lumey LH, Eline Slagboom P, Heijmans BT. DNA methylation signatures link prenatal famine exposure to growth and metabolism. Nat Commun. 2014 Nov 26;5:5592. doi: 10.1038/ncomms6592.
Kai Ye, Marian Beekman, Eric-Wubbo Lameijer, Yanju Zhang, Matthijs H. Moed, Erik B. van den Akker, Joris Deelen, Jeanine J. Houwing-Duistermaat, Dennis Kremer, Seyed Yahya Anvar, Jeroen F. J. Laros, David Jones, Keiran Raine, Ben Blackburne, Shobha Potluri, Quan Long, Victor Guryev, Ruud van der Breggen, Rudi G. J. Westendorp, Peter A. C. ‘t Hoen, Johan den Dunnen, Gert Jan B. van Ommen, Gonneke Willemsen, Steven J. Pitts, David R. Cox, Zemin Ning, Dorret I. Boomsma, and P. Eline Slagboom. Aging as Accelerated Accumulation of Somatic Variants: Whole-Genome Sequencing of Centenarian and Middle-Aged Monozygotic Twin Pairs. Twin Research and Human Genetics. Vol. 16, No. 6. (December 2013), pp. 1026-1032, doi:10.1017/thg.2013.73.
Roderick C Slieker, Steffan D Bos, Jelle J Goeman, Judith VMG Bovée, Rudolf P Talens, Ruud van der Breggen, H Eka D Suchiman, Eric-Wubbo Lameijer, Hein Putter, Erik B van den Akker, Yanju Zhang, J Wouter Jukema, P Eline Slagboom, Ingrid Meulenbelt, and Bastiaan T Heijmans. Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array. Epigenetics & Chromatin, 2013, 6:26.
Gihan Dawelbait, Christof Winter, Yanju Zhang, Chrisitian Pilarky, Robert Grtz-mann, Jrg-Chrisitan Heinrich and Michael Schroeder. Structural templates predict novel protein interactions and targets from pancreas tumour gene expression data. Bioinformatics, 23:i115–24, 2007.
学术著作

科研项目


专利及知识产权

联系信息