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桂林理工大学化学与生物工程学院导师教师师资介绍简介-蒋光彬 博士

本站小编 Free考研考试/2021-06-13



蒋光彬,男,汉族,广西桂林人,理学博士。现于桂林理工大学化学与生物工程学院从事教学与科研工作。

一、教学与工作经历
2018.07月--至今 桂林理工大学,化学与生物工程学院,化学与化工教研室任教。
2015.09-2018.06 华南理工大学,化学与化工学院,有机化学专业,博士。
2012.09-2015.06 广东药科大学,药学院,药物化学专业,硕士。
2008.09-2012.06 齐齐哈尔医学院,药学院,药学专业,学士。

二、研究工作
主要研究方向:1、绿色有机合成方法学研究(主要研究对象为活性杂环化合物的绿色合成及结构修饰)。
2、小分子药物的合成及抗肿瘤、抗菌活性研究(合成新颖的金属配合物筛选它们抑制肿瘤细胞(A549、HepG-2、Hela等)和金黄色葡萄球菌的活性,并进一步探索抗菌抗肿瘤的分子机制);
目前主持的在研项目:桂林理工大学科研启动经费项目;广西基金-青年项目;广西科技基地和人才专项;广西基金-面上项目。

三、近期主要论著
目前已在Org. Lett.; Chem. Commun.; Org. Chem. Front.Adv. Synth. Catal.; Eur. J. Med. Chem.; J. Inorg. Biochem.; New. J. Chem.; JPhotoch. Photobio. B;PloS one等国内外学术期刊上发表SCI收录论文30余篇,引用频次已超600;H-因子 = 16。其中通讯作者或第一作者SCI论文近20篇,代表性成果如下:
2020年:
1. Showcai Wang, Siyu Zhang, Meichen Liu, Jiawang Zang, Guangbin Jiang*and Fanghua Ji.* Palladium-catalyzed C3-selective C–H oxidative carbonylation of imidazo[1,2-a]pyridines with CO and alcohols: a way to access esters; Org. Chem. Front. 2020, 7, 697-701.
2. Shoucai Wang, Xuan Li, Jiawang Zang, Meichen Liu, Siyu Zhang, Guangbin Jiang*and Fanghua Ji.*Palladium-Catalyzed Multistep Tandem Carbonylation/N-Dealkylation/Carbonylation Reaction: Access to Isatoic Anhydrides; J. Org. Chem.2020, 85, 2672-2679.
3. Guang-Bin Jiang,*Wen-Yao Zhang, Miao He, Yi-Ying Gu, Lan Bai, Yang-Jie, Wang, Qiao-Yan Yi, Fan Du. New ruthenium polypyridyl complexes functionalized with fluorine atom or furan: Synthesis, DNA-binding, cytotoxicity and antitumor mechanism studies; Spectrochim. Acta. A Mol. Biomol. Spectrosc., 2020, 227, 117534.
4. Guang-Bin Jiang,*Wen-Yao Zhang, Miao He, Yi-Ying Gu, Lan Bai, Yang-Jie, Wang, Qiao-Yan Yi, Fan Du. Development of four ruthenium polypyridyl complexes as antitumor agents: Design, biological evaluation and mechanism investigation; J. Inorg. Biochem., 2020208, 111104.
5. Xuan Li, Shoucai Wang, Jiawang Zang, Meichen Liu, Guangbin Jiang*and Fanghua Ji.*Copper- and DMF-mediated switchable oxidative C–H cyanation and formylation of imidazo[1,2-a]pyridines using ammonium iodide; Org. Biomol. Chem., 2020, 18, 9100.
6. Xiangwen Liao,*Guijuan Jiang, Jintao Wang, Xuemin Duan, Zhouyuji Liao, Xiaoli Lin, Jihong Shen, Yanshi Xiong and Guangbin Jiang.*Two ruthenium polypyridyl complexes functionalized with thiophen: synthesis and antibacterial activity against Staphylococcus aureus; New J. Chem., 2020, 44, 17215.
7.Guangbin Jiang,*Guang Yang, Xinqiang Liu, Shoucai Wang, and Fanghua Ji.*Palladium-Catalyzed Sequential Acylation/Annulation of Indoles with Acyl Chlorides Using Primary Amine as the Directing Group; New J. Chem., 2020, DOI: 10.1039/D0NJ04406G
8. Simeng Bu,?Guijuan Jiang,?Guangbin Jiang,?Jinyao Liu, Xiaoli Lin, Jihong Shen, Yanshi Xiong, Xuemin Duan, Jintao Wang, Xiangwen Liao, J. Biol. Inorg. Chem., 2020, 25, 747-757. (? = 共同一作)

2019年:
9. Guangbin Jiang,*Shoucai Wang, Jun Zhang, Jianwen Yu, Ziang Zhang, Fanghua Ji.*Palladium-Catalyzed Primary Amine-Directed Decarboxylative Annulation of α-Oxocarboxylic Acids: Access to Indolo[1,2-a] quinazolines; Adv. Synth. Catal. 2019, 361, 1798–1802.
10. Guang-Bin Jiang,*Wen-Yao Zhang, Miao He, Yi-Ying Gu, Lan Bai, Yang-Jie, Wang, Qiao-Yan Yi, Fan Du. Design and Synthesis of New Ruthenium Polypyridyl Complexes with Potent Antitumor Activity in Vitro; Spectrochim. Acta. A Mol. Biomol. Spectrosc., 2019, 220, 117132.
11. Guang-Bin Jiang,*Wen-Yao Zhang, Miao He, Yi-Ying Gu, Lan Bai, Yang-Jie, Wang, Qiao-Yan Yi, Fan Du. Anticancer Activity of Two Ruthenium(II) Polypyridyl Complexes Toward Hepatocellular Carcinoma HepG-2 cells, Polyhedron, 2019, 169, 209-218.
12. Shoucai Wang, Kai, Wang, Xiangfei Kong, Shuhua Zhang, Guangbin Jiang,*Fanghua Ji.*DMF as Methine Source: Copper-Catalyzed Direct Annulation of Hydrazides to 1,3,4‐Oxadiazoles; Adv. Synth. Catal. 2019, 361, 3986-3990.
13. Wanqing Wu,*Songjia Fang, Guangbin Jiang, Meng Li, Huanfeng Jiang.*Palladium-catalyzed regioselective C–H alkynylation of indoles with bromoalkynes in water; Org. Chem. Front. 2019, 6, 2200-2204.
14.Songjia Fang, Guangbin Jiang, Meng Li, Zhenying Liu, Huanfeng Jiang,*Wanqing Wu.*Palladium-catalyzed regioselective C–H alkynylation of indoles with haloalkynes: access to functionalized 7-alkynylindoles; Chem. Commun.2019, 55, 13769-13772.

2019年以前:
15. Guangbin Jiang, Weigao Hu, Jianxiao Li, Chuanle Zhu, Wanqing Wu, Huanfeng Jiang.*Palladium-catalyzed primary amine-directed regioselective mono- and di-alkynylation of biaryl-2-amines. Chem. Commun., 2018, 54, 1746-1749.
16. Guangbin Jiang, Songjia Fang, Weigao Hu, Jianxiao Li, Chuanle Zhu, Wanqing Wu, Huanfeng Jiang.*Palladium-Catalyzed Sequential C(sp2)-H Alkynylation/Annulation of 2-Phenylphenols with Haloalkynes Using Phenolic Hydroxyl as the Traceless Directing Group. Adv. Synth. Catal.2018, 360, 2297-2302.
17. Guangbin Jiang, Jianxiao Li, Chuanle Zhu, Wanqing Wu, Huanfeng Jiang.* Palladium-Catalyzed Sequential Nucleophilic Addition/Oxidative Annulation of Bromoalkynes with Benzoic Acids To Construct Functionalized Isocoumarins. Org. Lett., 2017, 19, 44440-4443.
18. Guangbin Jiang, Chuanle Zhu, Jianxiao Li, Wanqing Wu, Huanfeng Jiang.* Silver-Catalyzed Regio- and Stereoselective Thiocyanation of Haloalkynes: Access to (Z)-Vinyl Thiocyanates. Adv. Synth. Catal.2017, 359, 1208-1212.
19. Guangbin Jiang, Junhua Yao, Ji Wang, Wei Li, Binjie Han, Yangyin Xie, GanJian Lin, Hongliang Huang, Yunjun Liu.* The induction of apoptosis in BEL-7402 cells through the ROS-mediated mitochondrial pathway by a ruthenium(II) polypyridyl complex.New. J. Chem., 2014, 38, 2554-2563.
20. Guangbin Jiang, Xiang Zheng, Junhua Yao, Binjie Han, Wei Li, Ji Wang, Hongliang Huang, Yunjun Liu.* Ruthenium(II) polypyridyl complexes induce BEL-7402 cell apoptosis by ROS-mediated mitochondrial pathway. J. Inorg. Biochem.; 2014, 141, 170-179.
21. Guangbin Jiang, Yangyin Xie, Ganjian Lin, Hongliang Huang, Zhenghua Liang, Yunjun Liu.* Synthesis, characterization, DNA interaction, antioxidant and anticancer activity studies of ruthenium(II) polypyridyl complexes.J Photoch. Photobio. B., 2013, 129, 48-56.
22. Guangbin Jiang, Wei Li, Ji Wang, Binjie Han, Ganjian Lin, Yangyin Xie, Hongliang Huang, Yunjun Liu.* Apoptosis in BEL-7402 cells induced by ruthenium(II) complexes through a ROS-mediated mitochondrial pathway. Transit. Metal. Chem., 2014, 39, 849-858.
23. Weigao Hu, Meng Li, Guangbin Jiang, Wanqing Wu, Huanfeng Jiang.* Synthesis of 2,3-Difunctionalized Benzofuran Derivatives through Palladium-Catalyzed Double Isocyanide Insertion Reaction. Org. Lett., 2018, 29, 3500-3503.
24. Chuanle Zhu, Pengquan Chen, Rui Zhu, Guangbin Jiang, Zhiming Lin, Wanqing Wu, Huanfeng Jiang.* Conversion of Triple Bonds to Single Bonds in a Domino Carbopalladation with Norbornene. Chem. Asian J.,2017, 12, 2991-2995.
25. Bingjie Han, Guangbin Jiang, Ji Wang, Wei Li, Hongliang Huang, YunJun Liu.* The studies on bioactivity in vitro of ruthenium(II) polypyridyl complexes towards human lung carcinoma A549 cells. RSC Adv., 2014, 4, 40899-40906.
26. Xiuzhen Wang, Guangbin Jiang, Ganjian Lin, Hongliang Huang, Yangyin Xie, Yunjun Liu.* Synthesis, molecular structure, DNA-binding, cytotoxicity, apoptosis and antioxidant activity of compounds containing aryloxazole. Eur. J. Med. Chem., 2014, 80, 192-200.

四、授权专利
1. 江焕峰,蒋光彬,马志强,伍婉卿, 一种合成烯基硫氰酸酯衍生物的新方法, 2018.09.14, 中国, ZL7.2.
2. 刘云军,蒋光彬,黄宏靓,李伟,韩冰洁, 一种对称性钌金属化合物及其作为制备抗肿瘤药物的应用, 2017.05.03, 中国, ZL1.8.
五、联系方式
通信地址:桂林市雁山区雁山街319号,桂林理工大学化学与生物工程学院(541004)
E-mail:jianggb@glut.edu.cn


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