联系方式
职　　称：教授
所在部门：生命分析化学与原子分子工程研究所

研究方向：分析化学计量学、化学与生物信息学、药物分子与功能材料设计及计算机技术应用
办 公 室 ：第一化学楼2039
联系电话：
电子邮件：zhaihl@lzu.edu.cn


个人简介
科研成果
论文专著
教学情况

翟红林教授(Prof. H. L. Zhai)，男，博士生导师。1964年出生，1986年6月兰州大学化学系物理化学本科专业毕业获学士学位并留校进入国家重点实验室，1993年转入化学院工作至今。2004年12月获兰州大学分析化学博士学位，2007年1月至2008年1月赴台湾长庚大学分子医学研究中心开展抗癌药物设计及癌症早期诊断的博士后研究工作。专业特长为数据建模与分析、程序设计与应用；目前主要从事复杂体系中多组分的同时定性定量分析、药物分子与功能材料设计的分子模拟等化学与生物信息学及其在相关领域中应用的教学与科研工作。已在TrAC-Trends in Analytical Chemistry、Analyst、Analytica Chimica Acta、Food Chemistry、J. Chromatography A、Talanta、J. Separation Science、J. Chemical Information and Modeling、Chemometrics and Intelligent Laboratory Systems、Chemical Biology & Drug Design、Computational Biology & Chemistry等国内外学术期刊上发表研究论文六十余篇；已主持并完成国家自然科学基金面上项目及多项校企横向课题；出版《化学信息学》本科生教材一部。


近期发表的代表性论文：
1. Applications of Discrete Shmaliy Moments on the Quantitative Analysis of Multi-target Compounds Based on The Chemical Spectra. J. Chemical Information and Modeling, 2019, 59(10): 4159-4166.
2. Simultaneous quantification of multiple endogenous biothiols in cancer cell based on multi-signal fluorescent probe. Analyst, 2019, 144(15): 4575-4581.
3. Molecular mechanism study of several inhibitors binding to BRD9 bromodomain based on molecular simulations. Journal of Biomolecular Structure and Dynamics, 2019, 37(11): 2970-2979.
4. The rapid quantitative analysis of three pesticides in cherry tomatoes and red grape samples with Tchebichef image moments. Food Chemistry, 2019, 290: 72-78.
5. Molecular mechanisms of tetrahydropyrrolo[1,2-c]pyrimidines as HBV capsid assembly inhibitors. Archives of Biochemistry and Biophysics, 2019, 663: 1-10.
6. Molecular inhibitory mechanism study on the potent inhibitor brigatinib against four crizotinib-resistant ALK mutations. Journal of Cellular Biochemistry, 2019, 120: 562-574.
7. Chemical image moments and their applications. TrAC-Trends in Analytical Chemistry, 2018, 103: 119-125.
8. Molecular modeling study on resistance of WT/D473H SMO to antagonists LDE-225 and LEQ-506. Pharmacological Research, 2018, 129: 491-499.
9. An effective approach to quantitative analysis of ternary amino acids in foxtail millet substrate based on Terahertz Spectroscopy. Food Chemistry, 2018, 246: 220-227.
10. Prediction of phosphorylation sites based on Krawtchouk image moments. PROTEINS: Structure, Function, and Bioinformatics, 2017, 85: 2231-2238. 11. Exploring the binding mechanism of Heteroaryldihydropyrimidines and Hepatitis B Virus capsid combined 3D-QSAR and molecular dynamics. Antiviral Research, 2017, 137: 151-164.
12. Krawtchouk image moment method for the simultaneous determination of three drugs in human plasma based on fluorescence three-dimensional spectra. Talanta, 2016, 161: 99-104.
13. An approach to the quantitative analysis of multiple components based on liquid chromatography mass spectrometry in full scan mode. Journal of Separation Science, 2016, 39(15): 3054-3061.
14. The determination of multi-components utilizing 1H NMR three-dimensional spectra combined Tchebichef moments. Chemometrics and Intelligent Laboratory Systems, 2016, 156: 128-136.
15. Study on the active mechanism of β-secretase inhibitors by molecular simulations. European Journal of pharmaceutical sciences, 2015, 76: 138-148.
16. The application of Tchebichef moment method on the quantitative analysis of multiple compounds based on three-dimensional HPLC fingerprint spectra. Analyst, 2015, 140(2): 630-636.



1、本科教学《化学信息学》、《化学化工应用软件》2. 研究生教学《MATLAB在化学中的应用》（硕士生课程）、《分离科学与技术》（博士生课程）3、编著教材普通高等教育“十三五”规划教材《化学信息学》，主编，北京：化学工业出版社，2019.114、教学研究项目一流学科化学信息技术教学体系的构建与优化. 主持，兰州大学教学研究重点项目(No. **)5. 教学研究论文大学本科化学信息学课程的设计与优化. 大学化学, 2019, 34(3): 11-15.6. 教学获奖2018年度甘肃省优秀博士学位论文指导教师. 兰州大学, 2019.05.2017年度甘肃省优秀硕士学位论文指导教师. 兰州大学, 2018.05.