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兰州大学基础医学院导师简介-张伟

兰州大学 免费考研网/2014-09-09



张伟,博士,讲师。2011年于兰州大学生命科学院获得博士学位。2011-2013年在兰州大学第一临床医学院从事博士后研究。

科研方向:
1.抗菌肽药物的设计及多功能研究
发展多类高效低毒的抗菌肽药物,用于肿瘤、细菌感染以及炎症的治疗。
2.多肽载体的设计及应用
基于穿膜肽发展高效低毒的载体,用于基因和抗肿瘤药物的的靶向运输。

荣誉称号及奖励:
1.2013年,中国药学会科学技术奖一等奖(第五完成人)

主持的科研项目:
1.主持中国博士后科学基金特别资助一项(2013T60896),双功能抗菌肽的设计及抗菌活性研究,2013.5-2014.12

2.主持中国博士后科学基金面上资助一项(2012M512047),新型酸激活基因载体的设计及应用,2012.5-2013.12

参与科研项目情况:
1.以项目组主要成员(2/9)参与国家自然科学基金委——面上项目一项(**),高稳定性酸敏感穿膜肽的设计与应用,2013.1-2016.12
2.以项目组主要成员(2/8)参与国家自然科学基金委——青年科学基金项目一项(**),具有重要医药用途的神经肽的化学修饰及作用机制研究,2013.1-2015.12

发表论文:
1.ZhangWei,SongJJ,LiangRR,ZhengX,ChenJB,LiGL,ZhangBZ,YanX,WangR*.Stearylatedantimicrobialpeptidemelittinanditsretroisomerforefficientgenetransfection.BioconjugateChem,2013.(accepted)(SCI二区,影响因子4.58)
2.张伟,宋竟婧,张邦治,杨雯乐,王锐*.多肽新药研发策略的研究进展.中国科学:化学,2013,43,939-940.
3.ZhangWei,SongJJ,LiangRR,ZhengX,ChenJB,LiGL,ZhangBZ,WangKR,YanX,WangR*.Stearylatedantimicrobialpeptide[D]-K6L9withcellpenetratingpropertyforefficientgenetransfer.Peptides,2013,46C:33-39.(SCI三区,影响因子2.522)
4.ZhangWei,SongJingjing,ZhangBZ,LiuLW,WangKR,WangR*.Designofacid-activatedcellpenetratingpeptidefordeliveryofactivemoleculesintocancercells.BioconjugateChem,2011,22:1410-1415.(SCI二区,影响因子4.58)
5.ZhangWei,SongJJ,MuLY,ZhangBZ,LiuLW,XingYH,WangKR,LiZY,WangR*.ImprovinganticanceractivityandselectivityofcamptothecinthroughconjugationwithreleasablesubstanceP.BioorgMedChemLett,2011,21:1452-1455.(SCI三区,影响因子2.338)
6.ZhangWei,LiJ,LiuLW,WangKR,SongJingjing,YanJX,LiZY,ZhangBZ,WangR*.AnovelanalogofantimicrobialpeptidePolybia-MPI,withthioamidebondsubstitution,exhibitsincreasedtherapeuticefficacyagainstcanceranddiminishedtoxicityinmice.Peptides,2010,31:1832-1838.(SCI三区,影响因子2.522)
7.SongJ,ZhangWei,KaiM,ChenJ,LiangR,ZhengX,LiG,ZhangB,WangK,ZhangY,YangZ,NiJ,WangR.DesignofanAcid-ActivatedAntimicrobialPeptideforTumorTherapy.MolPharm.2013,10:2934-2941(共同第一作者)(SCI二区,影响因子4.57)
8.XingY,ZhangWei,SongJ,ZhangY,JiangX,WangR.Anticancereffectsofanovelclassrosin-derivativeswithdifferentmechanisms.BioorgMedChemLett.2013,23:3868-72.(共同第一作者)(SCI三区,影响因子2.338)
9.LiuJ,ZhangWei,ZhangH,YangZ,LiT,WangB,HuoX,WangR,ChenH.AmultifunctionalnanoprobebasedonAu-Fe3O4nanoparticlesformultimodalandultrasensitivedetectionofcancercells.ChemCommun(Camb).2013,49:4938-40.(SCI二区,影响因子6.378)
10.ZhiLH,LiuJ,WangY,ZhangWei,WangBD*,XuZG,YangZY,HuoX,LiGM.MultifunctionalFe3O4nanoparticlesforhighlysensitivedetectionandremovelofAl(III)inaqueoussolution.Nanoscale,2013,5:1552-1556.(SCI一区,影响因子6.233)
11.WangK,YanJ,DangW,LiuX,ChenR,ZhangJ,ZhangB,ZhangWei,KaiM,YanW,YangZ,XieJ,WangR*.Membraneactiveantimicrobialactivityandmoleculardynamicsstudyofanovelcationicantimicrobialpeptidepolybia-MPI,fromthevenomofPolybiapaulista.Peptides,2013,39:80-8.(SCI三区,影响因子2.522)
12.WangKR,YanJX,ChenR,DangW,ZhangBZ,ZhangWei,SongJJ,WangR*.Membrane-activeactionmodeofPolybia-CP,anovelantimicrobialpeptideisolatedfromthevenomofPolybiaPaulista.AntimicrobAgentsChemother,2012,56:3318-3323.(SCI二区,影响因子4.565)
13.YanJX,WangKR,ChenR,SongJJ,ZhangBZ,DangW,ZhangWei,WangR*.MembraneactiveantitumoractivityofNK-18,amammalianNK-lysin-derivedcationicantimicrobialpeptide.Biochimie,2012,94:184-191.(SCI三区,影响因子3.142)
14.SongJingjing,KaiM,ZhangWei,ZhangJD,LiuLW,ZhangBZ,LiuX,WangR*.Cellularuptakeoftransportan10anditsanalogsinlivecells:Selectivityandstructure–activityrelationshipstudies.Peptides,2011,32:1934-1941.(SCI三区,影响因子2.522)
15.WangKR,YanJX,LiuX,ZhangJD,ChenR,ZhangBZ,DangW,ZhangWei,KaiM,SongJingjing,WangR*.Novelcytotoxityexhibitionmodeofpolybia-CP,anovelantimicrobialpeptidefromthevenomofthesocialwaspPolybiapaulista.Toxicology,2011,288:27-33.(SCI二区,影响因子4.017)
16.ZhangBZ,WangKR,YanJX,ZhangWei,SongJingjing,NiJM,WangR*.InvitroandinvivoantitumoreffectsofnovelactinomycinDanalogswithaminoacidsubstitutedinthecyclicdepsipeptides.Peptides,2010,31:568-573.(SCI三区,影响因子2.522)
17.WangKR,ZhangBZ,ZhangWei,YanJX,LiXL,WangR*.PotentantitumoreffectsofanovelactinomycinDanalogLeu5AMD.CancerLett,2008,268:38-45.(SCI二区,影响因子4.258)
18.WangKR,ZhangBZ,ZhangWei,YanJX,LiJ,WangR*.Antitumoreffects,cellselectivityandstructure-activityrelationshipofanovelantimicrobialpeptidepolybia-MPI.Peptides,2008,29:963-938.(SCI三区,影响因子2.522)

专利
[1]王锐,宋竟婧,张伟,开明,张邦治;“具有酸激活特性的抗菌肽AMitP及其合成和在制备抗肿瘤药物中的应用”,2012,中国,申请号:**0.4
[2]王锐,张伟,宋竟婧,张邦治;“基于N末端18烷酰化抗菌肽构建的非病毒基因载体”,2012,中国,申请号:**2.3申请日期:2012.06.29

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