基本情况
姓名：宋化灿
性别：男
出生年月：1959-04
籍贯：山东
职位：
博士、教授，有机化学专业博士生导师
联系方式电话：+86-
传真：暂未填写
邮箱：yjhxhc@mail.sysu.edu.cn
通讯地址：广东省广州市中山大学化学与化学工程学院
邮编：510275
个人网站：暂未填写
教育经历1978年2月—1982年1月，山东大学化学系有机化学专业，本科；
1993年9月—1996年7月，中山大学化学系有机化学专业，博士。
工作经历1996年6月中山大学有机化学专业博士毕业留校任教至今，先后任讲师、副教授、教授。先后于1998和1999年赴美国Brigham Young University和2001—2002年赴台湾大学做博士后研究各一年。主讲过《有机化学》、《有机分析》、《有机化学实验》、《物理有机化学》等课程。公开发表研究论文60余篇。
1982年1月—1993年8月，郑州轻工业学院化工系任教；
1996年7月—1998年8月，中山大学化学系，副教授；
1998年9月—1999年8月，美国Brigham Young University，博士后；
1999年8月—2001年9月，中山大学化学院，副教授；
2001年9月—2002年8月，台湾大学化学系，博士后；
2002年8月—2004年3月，中山大学化学院，副教授；
2004年4月至今，中山大学化学院，教授，博士生导师。
讲授课程《物理有机化学》（本科生，36学时）；
《物理有机化学》（研究生，60学时）。
科研方向药物设计与合成、有机发光材料。
科研项目1、顺德科技局产学研结合项目“水基喷柒产品技术的研究与应用”，2007-2009。
2、广东省教育部产学研结合项目“高性能氯化聚丙烯改性树脂的研发”? 2009-2010。
3、广东省教育部产学研结合项目“低硫低碳制革工艺和助剂的研究开发”， 2010-2011。
4、广东中烟公司项目“主要烟用香料转移行为对卷烟品质的影响及其应用研究” 2009-2011。
5、广东省科技计划重点项目“广东凉茶的数字化质量控制技术研究”，2011-2012。
6、长江生命科技国际有限公司项目（香港）“用于抗癌药物活性测试的化合物的合成”，2010-2012。
获奖情况暂无资料
论著一览《物理有机化学》英柏宁、宋化灿，化学工业出版社，2010年。
相关成果04年前主要论文：
1. Ning Su, Jerald S. Bradshaw, Xian Xin Zhang,?Hua-Can Song, Paul B. Savage, Guaoping Xue, Krzysztof, Krakowiak, and Reed M. Izatt, Synthesis and metal ion complexation of novel 8-Hydroxyquinoline-containing diaza-18-crown-6 ligands and analogs,?J. Org. Chem. 1999, 64, 8855?
2. Jerald S. Bradshaw,?Hua-Can Song, Guoping Xue, R. Todd Bronson, Joseph A. Chiara, and Reed, M. Izatt, Synthesis of diazadi(and tri)thiacrown ethers containing two 5-substituent(or 2-methyl)-8-hydroxyquinoline side arms?Supramol. Chem. 2001, 13, 499.?
3.?Hua-Can, Song, Yi-Wen Chen, Xiang-Li Zheng, Bai-Ning Ying, Study on second harmonic generation of 10-hydrocarbylacridiones,?Spectrochimica Acta Part A, 2001, 57 , 1717.?
4. Guo-ping Xue, Jerald S. Bradshaw,?Hua-Can Song, R. Todd, Bronson, Paul B. Savage, Reed, M. Izatt, A convenient synthesis and preliminary photophysical study of novel fluoroionophores: macrocyclic polyamines containing two dansylaminoethyl side arms.?Tetrahedron, 2001, 57, 87.?
5.?Hua-Can Song, Rui Jiang Jin, Xiang Li Zheng, Bai Ning Ying. Study on second harmonic generation of 9-(substituted-benzylidene-10-methyl)-9,10-dihydroacridines,?Spectrochimica Acta Part A, 2001, 57, 2729.?
6.?Hua-Can Song, Jearld S. Bradshaw, Yi-Wen Chen, et al. Synthesis of diazadithiacrwn ethers containing two 8-hydroxyquinoline side arms, ARKIVOC, 2001 ISSUE in Honor of Prof.?Miha Tisler. 2001, 2, Part3, ms 0116.?
7.?Hua-Can Song, Yi-Wen Chen, Ji-Guo Song, Paul B. Sarage, Guo-Ping Xue, Jeseph A. Chiara, Krzysztof E. Krakowoak, Reed M. Izatt and Jerald S. Bradshaw. New diazdi (and tri) thia-21-crown-7 ethers containing 8-hydroxyquinoline side arms,?J. Heterocyclic Chem. 2001, 38, 1369.?
8.?Hua-Can Song, Jerald S. Bradshaw, Yi-Wen Chen, Guo-Ping Xue, Wei-Ming Li, Krzysztof E. Krakowoak, Paul B. Sarage, Zun-le Xu and Reed M. Izatt. Synthesis of new crown ethers containing appended pyridine, 10-hydroxybenzoquinoline, 8-hydroxyquinoline and 2-amino-1-hydroxybiphenyl sidearms,?Supramol. Chem. 2002, 14, 263.?
9. Chin-Fa Lee, Liu Chin-Yuan,?Hua-Can Song, et al, Bidirectional iterative synthesis of alternating benzene-furan oligomers towards molecular wires,?Chem. Commun. 2002, 2824.?
10.?Hua-Can Song, Ping Huan, Bai-Ning Ying, Molecular complexes of antipsychotic pharmaceutical parent molecule phenothiazine and unsaturated acid anhydrides.?Spectrochimica Acta Part A, 2003, 59, 1509.?
11.?Hua-Can Song, Wei-Ming Li, Guang-Rong Liu, Zun-Le Xu. Study on the optical properties of 4,4’-bis-(2-(substituted-styryl))-biphenyl and 1,4-bis-(2-(substituted-styryl)) benzene?Spectrochimica Acta Part A,?2003, 59, 2041.?
12.?Hua-Can Song, Yi-Wen Chen, Jun-Hua Yao, Zun-Le Xu, Jeaald S. Bradshaw and Reed M. Izatt. Syntheses of diazadithiacrown ethers containing appended coumarin or 1-aminonaphthene as sidearms?J. Heterocyclic Chem. 2003, 40, 475.?
13. Huang, Z.-L.; Li, N.; Sun, Y.-F.; Wang, H.-Z.;?Song, H.-C.; Xu, Z.-L. Synthesis and photophysical characterization of two new coumarinyl-based organic molecules with two-photon induced fluorescent emission,?J. Mol. Structure, 2003, 657, 343.?
14.?Hua-Can Song, Huan Wen, Wei-Ming Li, Study on the second-order optical behavior of 4-(substituted-benzylidene)-2-phenyl-4H-oxazol-5-one,?Spectrochimica Acta Part A.?2004, 60, 1587.
近期主要论文：?
1. 1-(1-Arylethylidene)Thiosemicarbazide derivatives: A new class of tyrosinase inhibitors,?Bioorganic and Medicinal Chemistry, 2008, 1096;?
2. Synthesis and cytotoxic activities of 1-benzylidine substituted β-carboline derivatives,?Bioorganic & Medicinal Chemistry Letters, 2008, 6558;?
3. Synthesis and in vitro cytotoxic evaluation of novel 3,4,5-trimethoxyphenyl substituted β-carboline derivatives,European Journal Medicinal Chemistry,2008, 533;?
4. Synthesis and biological evaluation of helicid analoguesas novel acetylcholinester as einhibitors,?European Journal Medicinal Chemistry, 2008, 166;??
5. The synthesis and preliminary optical study of 1-alkyl-2,4,5-triphenylimidazole derivatives,?Dyes and Pigments, 2008, 17;?
6. Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors,?Bioorganic & Medicinal Chemistry Letters, 2008, 6490;?
7. A class of potent tyrosinase inhibitors: Alkylidenethiosemicarbazide compounds,?European Journal Medicinal Chemistry, 2009, 1773;?
8. Synthesis and antibacterial evaluation of novel 4-alkyl substituted phenyl β-aldehyde ketone derivatives,European Journal Medicinal Chemistry, 2009, 1737;??
9. Discovery of 4-functionalized phenyl-O-β-d-glycosides as a new class of mushroom tyrosinase inhibitors,Bioorganic & Medicinal Chemistry Letters, 2009, 6157;?
10. Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors,European Journal of Medicinal Chemistry, 2009, 1737;?
11. Synthesis and evaluation of 5-benzylidene(thio)barbiturate-β-d-glycosides as mushroom tyrosinase inhibitors,Bioorganic & Medicinal Chemistry Letters, 2009, 4055;?
12. Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities,?European Journal of Medicinal Chemistry, 2009, 4235;?
13. Synthesis and antibacterial evaluation of novel 4-alkyl substituted phenyl β-aldehyde ketone derivatives,European Journal of Medicinal Chemistry, 2009, 1737;?
14. Synthesis and optical behaviors of 2-(9-phenanthrenyl)-, 2-(9-anthryl)-, and 2-(1-pyrenyl)-1-alkylimidazole homologues,?Spectrochimica Acta Part A, 2009, 233;??
15. Biological evaluations of novel vitamin C esters as mushroom tyrosinase inhibitors and antioxidants,?Food Chemistry, 2009, 381;?
16. Synthesis of 4-[(diethylamino)methyl]phenol derivatives as novel cholinesterase inhibitors with selectivity towards butyryl cholinesterase,?Bioorganic & Medicinal Chemistry Letters,2010, 3254;?
17. Synthesisandcytotoxicevaluationof N-benzylatedquaternary b-carboline amino acid ester conjugates,?European Journal of Medicinal Chemistry, 2010, 1515;?
18. Synthesis and preliminary optical study of 1,3,4-oxadiazole derivatives containing imidazole units,?Dyes and Pigments, 2010, 249;??
19. Synthesis of novel β-carbolines with efficient DNA-binding capacity and potent cytotoxicity,?Bioorganic & Medicinal Chemistry Letters, 2010, 3876;?
20. Design, synthesis and 3D-QSAR of β-carboline derivatives as potent antitumor agents,?European Journal of Medicinal Chemistry, 2010,2503;??
21. Synthesis, cytotoxic activities and DNA binding properties of β-carboline derivatives, ?European Journal of Medicinal Chemistry, 2010, 4740;?
22. Synthesis and cytotoxic evaluation of 1-carboxamide and 1-amino side chain substituted β-carbolines,European Journal of Medicinal Chemistry, 2010, 5513;?
23. Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors, ?European Journal of Medicinal Chemistry, 2010, 639;??
24. α-Glucosidase and α-amylase inhibitory activities of guava leaves,?Food Chemistry, 2010, 6;?
25. Design, synthesis and biological evaluation of 3-(4-halophenyl)-3-oxopropanal and their derivatives as novel antibacterial agents,?Chem. Pharm. Bull. 2010, 1127;?
26. Rational design and synthesis of 4-O-substituted phenylmethylene thiosemi- carbazones as novel tyrosinase inhibitors,?Chem. Pharm. Bull. 2010, 752;??
27, Design, synthesis and evaluation of difunctionalized 4-hydroxybenzaldehyde derivatives as novel cholinesterase inhibitors,?Chem. Pharm. Bull. 2010, 1216;?
28. Synthesis and biological evaluation of novel B-Carbolines as potent cytotoxic and DNA intercalatingagents,Chem. Pharm. Bull. 2010, 901.