个人简介：教授，硕/博导。国家高层次引进人才青年项目入选者。? 主要研究方向为基因组学、系统生物学、生物信息学。2006年本科毕业于中山大学生物技术与应用专业，并完成了计算机科学第二专业的学习。? 2011年于中山大学取得生化与分子生物学博士学位。2010至2016年于美国密歇根大学生态与进化生物学系作为访问****与博士后完成研究工作。2016年作为中山大学“****”人才引进，受聘为中山医学院教授。? 迄今已发表SCI论文25篇，包括作为通讯作者7篇，作为（共同）第一作者9篇，累计引用>2000，H指数15（据Google Scholar）。? 其中2016年至今作为通讯作者已在Nature Ecology & Evolution(IF=12.5)，Molecular Biology & Evolution(IF=11.1)，Genomics Proteomics & Bioinformatics(IF=7.1)等多本国际一流杂志发表论文。
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About meI am a professor in Department of Biomedical Informatics, Zhongshan School of Medicine, Sun Yat-sen University.? My research interests can be broadly categorized under Evolutionary Genomics, Systems Biology and Bioinformatics. I got my Bachelor's degree in 2006 from the School of Life Science, Sun Yat-sen University, with first major in Applied Biotechnology and second major in Computer Science. Then I got my Ph.D. from Sun Yat-sen University in 2011 under the supervision of Prof. Shi-Mei Zhuang, and did post-doctoral research?with?Prof. Jianzhi "George" Zhang?in Department of Ecology and Evolution,?University of Michigan. I joined Zhongshan School of Medicine as a professor?in 2016.
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实验室研究方向：生命活动的本质是具有一定随机性的生化反应。这种随机性可以通过各种方式影响生物的功能与进化，并与人类健康具有深入的联系。例如DNA的随机突变可以导致癌症，基因表达的随机扰动可以启动细胞的分化发育，翻译的随机错误可以引起细胞衰老。我们从基因组与系统生物学的角度，分析生物活动各个层面的随机现象，并发展相关的研究方法和分析工具，揭示随机现象对细胞正常生理功能和相关疾病的潜在重大影响。
围绕生命活动中的随机现象，我们研究的相关生物学问题包括但不限于：
癌症基因组的演化，是由癌细胞间的自然选择控制下的定向进化，还是由随机突变积累而成的偶然事件？
病原微生物耐药基因的随机突变如何影响耐药性的进化？
如何测定细胞发育谱系树？如何分析及解读其生物学意义？谱系树中的哪些部分是固定的，哪些部分是可调节的，哪些部分是随机的？
RNA二级结构如何影响翻译时核糖体的移动速率与翻译的准确率？如何影响转录时RNA合成酶的移动速率与DNA随机突变的频率？
tRNA与密码子的供需关系如何影响宿主（供）与病毒（需）的相互作用？其中密码子的随机遗传漂变与定向的自然选择各自的贡献为何？
蛋白质合成过程中的随机错误（包括蛋白质翻译错误、误折叠、误结合等）如何调节基因序列演化的速率？
更多信息请参见实验室主页?https://www.labxing.com/yangjrlab
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Research InterestsStochastic errors are common at all levels of life. ?The long-term?goal?of our research is to unravel the role of stochastic errors in biological evolution and human diseases at the genomic scale. ?The types of stochastic errors that we currently?investigating?included by not limited to (i) molecular errors on individual genes, such as incorporation of missense amino acids during translation, (ii) genomic level errors that involve cytotoxic (mis-)interaction of multiple genes or proteins, and (iii) cellular errors that are deteriorative to the organismal fitness, such as unprogrammed cell deaths triggered by somatic mutation or environmental perturbation. I want to understand the general impact of the stochastic errors on biological systems, the origins of the biological robustness against stochastic errors, and to gauge mechanistic insight to the fundamental systemic properties underlying such robustness. To achieve this goal, both computational and experimental approaches are needed, and will be conducted at the genomic and organism level.
More detailed introduction about our lab can be found at?https://www.labxing.com/yangjrlab
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本研究组欢迎有志于在相关学科从事科学研究的同行/同学加入，包括特聘正/副研究员、博士后、博士/硕士研究生。
该信息长期有效。有意者请与杨建荣教授（yangjianrong@mail.sysu.edu.cn）联系。
If you are also enthusiastic about research?in Genomics, Evolutionary Biology, Systems Biology or Bioinformatics, and want to join us. Please feel free to contact me (yangjianrong@mail.sysu.edu.cn)
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学术任职：
Professional ServiceEditorial Board member:?Journal of Genetics and Genomics (2020-now);?Frontiers in Ecology and Evolution (2020-now); Frontiers in Genetics (2020-now)
Ad hoc reviewer for National Science Review; Molecular Biology and Evolution;?Genome Biology;?EMBO?Reports;?PLoS Genetics;?PLoS Computational Biology; iScience;?BMC Genomics;??Genome Biology and Evolution;?Evolution; ?BMC Evolutionary Biology;??Infection, Genetics and Evolution; iScience;?Journal of Gene Medicine; Journal of Molecular Evolution; Journal of Theoretical Biology; PLoS ONE; Scientific Reports.
代表学术论著：（完整论著列表请见?https://orcid.org/0000-0002-7807-9455）
Selected Publications：(Full list of pulications can be found on https://orcid.org/0000-0002-7807-9455)
(*:?Corresponding author; #: Authors with equal contribution)
Ning Mo, Xiaoyu Zhang, Wenjun Shi, Gongwang Yu, Xiaoshu Chen*, Jian-Rong Yang* ;Bidirectional genetic control of phenotypic heterogeneity and its implication for cancer drug resistance ; Molecular Biology and Evolution ; 2021 (in press)
Feng Chen, Peng Wu, Shuyun Deng, Heng Zhang, Yutong Hou, Zheng Hu, Jianzhi Zhang*, Xiaoshu Chen*, Jian-Rong Yang* ; Dissimilation of synonymous codon usage bias in virus-host coevolution due to translational selection ; Nature Ecology and Evolution; 2020; 4(3);??589-600 ?(Highlighted?as "Very Good")
Meng Yuan#, Xujiang Yang#, Jinghua Lin#, Xiaolong Cao#, Feng Chen, Xiaoyu Zhang, Zizhang Li, Guifeng Zheng, Xueqin Wang, Xiaoshu Chen*, Jian-Rong Yang*;?Alignment of Cell Lineage Trees Elucidates Genetic Programs for the Development and Evolution of Cell Types; iScience; 2020; 23(7); 101273?
Gongwang Yu, Hanbing Zhu, Xiaoshu Chen*, Jian-Rong Yang* ; Specificity of RNA Folding and Its Association with Evolutionarily Adaptive mRNA Secondary Structures ; Genomics, Proteomics and Bioinformatics; 2020; (in press)?
Calum J. Maclean#, Brian P.H. Metzger#, Jian-Rong Yang#, Wei-Chin Ho, Bryan Moyers, Jianzhi Zhang*; Deciphering the Genic Basis of Yeast Fitness Variation by Simultaneous Forward and Reverse Genetics, Molecular Biology and Evolution; 2017; 34 (10), 2486-2502 . (#: co-first author)
Jian-Rong Yang, Calum J. Maclean, Chungoo Park, Huabin Zhao, Jianzhi Zhang*（2017）; Intra and Interspecific Variations of Gene Expression Levels in Yeast Are Largely Neutral: (Nei Lecture, SMBE 2016, Gold Coast), Molecular Biology and Evolution; 34（9）2125–2139
Jianzhi Zhang*, Jian-Rong Yang; Determinants of the rate of protein sequence evolution; Nature Reviews Genetics; 2015; 16(7): 409-420
Jian-Rong Yang, Xiaoshu Chen, Jianzhi Zhang*; Codon-by-codon modulation of translational speed and accuracy via mRNA folding; PLoS Biology (2014); 12:e** (14 pages)
Jian-Rong Yang, Shuxiang Ruan, Jianzhi Zhang*; Determinative Developmental cell lineages are robust to cell deaths; PLoS Genetics; 2014; 10:e** (17 pages)
Jian-Rong Yang, Ben-Yang Liao, Shi-Mei Zhuang, Jianzhi Zhang*; Protein misinteraction avoidance causes highly expressed proteins to evolve slowly; Proc Natl Acad Sci USA; 2012; 109 (14): E831-E840
Jian-Rong Yang, Shi-Mei Zhuang, Jianzhi Zhang*; Impact of translational error-induced and error-free misfolding on the rate of protein evolution; Molecular Systems Biology; 2010; 6 (1): 421 (13 pages);
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科研项目研究课题：
Fundings中山大学“****二期”（主持）；时间：2016-2021
国自然面上项目 “利用高通量测序技术检测新生RNA二级结构及检验其对突变率的调节作用”（主持）；时间：2017-2020
国家高层次引进人才青年项目（主持）；时间：2017-2020
国自然面上项目 “细胞发育谱系树比对算法的设计与应用”（主持）；时间：2019-2022
国自然重点项目 “质粒介导多粘菌素耐药新机制MCR-1传播、进化和抑制剂研究”（第一参与人）；时间：2019-2023
科技部重点研发项目 “人乳头瘤病毒靶向治疗新技术研发” （骨干）；时间：2018-2021